A Brunet

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    A Brunet
    Division of Neuroscience, Children s Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Neurobiol 11:297-305. 2001
  2. pmc Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    A Brunet
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:952-65. 2001
  3. ncbi request reprint Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  4. ncbi request reprint Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    A Bonni
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 286:1358-62. 1999
  5. ncbi request reprint Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    A Brunet
    Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:857-68. 1999

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    A Brunet
    Division of Neuroscience, Children s Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Neurobiol 11:297-305. 2001
    ..In addition, recent experiments suggest that Akt may also use metabolic pathways to regulate cell survival...
  2. pmc Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
    A Brunet
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 21:952-65. 2001
    ..These findings indicate that SGK acts in concert with Akt to propagate the effects of PI3K activation within the nucleus and to mediate the biological outputs of PI3K signaling, including cell survival and cell cycle progression...
  3. ncbi request reprint Cellular survival: a play in three Akts
    S R Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA
    Genes Dev 13:2905-27. 1999
  4. ncbi request reprint Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    A Bonni
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 286:1358-62. 1999
    ....
  5. ncbi request reprint Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    A Brunet
    Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 96:857-68. 1999
    ..Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene...