S E Browne
Affiliation: Harvard University
- The cerebral metabolic effects of manipulating glutamatergic systems within the basal forebrain in conscious ratsS E Browne
Wellcome Surgical Institute, University of Glasgow, Scotland
Eur J Neurosci 10:649-63. 1998..Results support a dissociation between the functional sequelae of NMDA and non-NMDA receptor-mediated events in the basal forebrain, and long-term compensatory functional adaptation following cortical denervation...
- Oxidative stress in Huntington's diseaseS E Browne
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Brain Pathol 9:147-63. 1999..Here we review the evidence for oxidative damage and potential mechanisms of neuronal death in HD...
- Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's diseaseO A Andreassen
Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusets, USA
Neurobiol Dis 8:479-91. 2001..These results are similar to those observed using dietary creatine supplementation in the R6/2 transgenic mouse model of HD and provide further evidence that creatine may exert therapeutic effects in HD...
- The cerebral metabolic consequences of nitric oxide synthase deficiency: glucose utilization in endothelial and neuronal nitric oxide synthase null miceS E Browne
Laboratory of Neurochemistry, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Cereb Blood Flow Metab 19:144-8. 1999..Glucose utilization levels did not significantly differ between nNOS and eNOS knockout mice and C57B1/6 mice in any of the 48 brain regions examined, but were relatively lower in some subcortical regions in SV129 mice...