Ritchie E Brown

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Involvement of hypocretins/orexins in sleep disorders and narcolepsy
    Ritchie E Brown
    Department of Psychiatry, Harvard Medical School, Brockton VA, Massachusetts 02301, USA
    Drug News Perspect 16:75-9. 2003
  2. pmc Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice
    Ritchie E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Harvard Medical School and VA Boston Healthcare System, 940 Belmont Street, Research 151 C, Brockton, MA 02301, USA
    Eur J Neurosci 27:352-63. 2008
  3. pmc Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins
    R E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VA Medical Center Brockton, Research 151C, 940, Belmont Street, Brockton, MA 02301, USA
    Neuroscience 143:739-55. 2006
  4. ncbi request reprint Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
    Ritchie E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 22:8850-9. 2002
  5. ncbi request reprint Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurochem 85:1547-52. 2003
  6. pmc Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons
    Chun Yang
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301
    J Neurosci 34:2832-44. 2014
  7. ncbi request reprint Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
    Tatiana M Korotkova
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 23:7-11. 2003
  8. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
  9. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
  10. pmc Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine
    Jaime L Tartar
    VA Boston Healthcare System and Harvard Medical School, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Neurosci Lett 469:1-5. 2010

Detail Information

Publications27

  1. ncbi request reprint Involvement of hypocretins/orexins in sleep disorders and narcolepsy
    Ritchie E Brown
    Department of Psychiatry, Harvard Medical School, Brockton VA, Massachusetts 02301, USA
    Drug News Perspect 16:75-9. 2003
    ..Preliminary findings also indicate that it may malfunction in a variety of other conditions where the normal sleep-wake cycle is compromised...
  2. pmc Characterization of GABAergic neurons in rapid-eye-movement sleep controlling regions of the brainstem reticular formation in GAD67-green fluorescent protein knock-in mice
    Ritchie E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Harvard Medical School and VA Boston Healthcare System, 940 Belmont Street, Research 151 C, Brockton, MA 02301, USA
    Eur J Neurosci 27:352-63. 2008
    ..Orexinergic suppression of REM during waking is probably mediated in part via excitation of acetylcholine-inhibited GABAergic neurons...
  3. pmc Electrophysiological characterization of neurons in the dorsolateral pontine rapid-eye-movement sleep induction zone of the rat: Intrinsic membrane properties and responses to carbachol and orexins
    R E Brown
    In Vitro Neurophysiology Section, Laboratory of Neuroscience, Department of Psychiatry, Harvard Medical School, VA Medical Center Brockton, Research 151C, 940, Belmont Street, Brockton, MA 02301, USA
    Neuroscience 143:739-55. 2006
    ..Some or all carbachol-excited neurons are presumably REM-on neurons...
  4. ncbi request reprint Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline)
    Ritchie E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 22:8850-9. 2002
    ..43 and 1, respectively)...
  5. ncbi request reprint Co-expression of non-selective cation channels of the transient receptor potential canonical family in central aminergic neurones
    Olga A Sergeeva
    Department of Neurophysiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Neurochem 85:1547-52. 2003
    ..We conclude that several TRPC channel populations exist in individual neurones and that their subunit co-expression pattern is region and cell-type specific...
  6. pmc Cholinergic neurons excite cortically projecting basal forebrain GABAergic neurons
    Chun Yang
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301
    J Neurosci 34:2832-44. 2014
    ..Loss of cholinergic neurons in Alzheimer's disease may impair cortical activation, in part, through disfacilitation of BF cortically projecting GABAergic/PV neurons. ..
  7. ncbi request reprint Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
    Tatiana M Korotkova
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001 Dusseldorf, Germany
    J Neurosci 23:7-11. 2003
    ..In narcolepsy, in which the orexin system is disrupted, dysfunction of the orexin modulation of VTA neurons may be important in triggering attacks of cataplexy...
  8. pmc GAD67-GFP knock-in mice have normal sleep-wake patterns and sleep homeostasis
    Lichao Chen
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroreport 21:216-20. 2010
    ..Our results suggest GAD67-GFP knock-in mice are an excellent tool for study of GABAergic neurons involved in sleep-wake regulation...
  9. pmc Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period
    Lichao Chen
    Research Service, VA Boston Healthcare System, and Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    Eur J Neurosci 32:1528-36. 2010
    ..The results indicate that a modest knockdown of OxR1 is sufficient to induce observable sleep changes. Moreover, orexin neurons, by acting on OxR1 in the LC, play a role in the diurnal gating of REM sleep...
  10. pmc Sleep fragmentation reduces hippocampal CA1 pyramidal cell excitability and response to adenosine
    Jaime L Tartar
    VA Boston Healthcare System and Harvard Medical School, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Neurosci Lett 469:1-5. 2010
    ..Instead, the reduced excitability of CA1 pyramidal neurons observed here may contribute to the loss of hippocampal long-term potentiation and hippocampus-dependent cognitive impairments associated with sleep disruption...
  11. pmc Animal models of narcolepsy
    Lichao Chen
    Research Service, VA Boston Healthcare System, Department of Psychiatry, Harvard Medical School, Brockton, MA 02301, USA
    CNS Neurol Disord Drug Targets 8:296-308. 2009
    ..To facilitate further research, it is imperative that researchers reach a consensus concerning the evaluation of narcoleptic behavioral and EEG phenomenology in these models...
  12. ncbi request reprint Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro
    Tatiana M Korotkova
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Regul Pept 104:83-9. 2002
    ..The orexin excitation of SN reticulata cells may help to maintain their high firing rate during waking. Furthermore, the absence of orexin effects in narcolepsy may predispose affected individuals to attacks of cataplexy...
  13. pmc Control of sleep and wakefulness
    Ritchie E Brown
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Brockton, Massachusetts 02301, USA
    Physiol Rev 92:1087-187. 2012
    ....
  14. pmc Distribution and intrinsic membrane properties of basal forebrain GABAergic and parvalbumin neurons in the mouse
    James T McKenna
    Laboratory of Neuroscience, VA Boston Healthcare System and Harvard Medical School, Department of Psychiatry, Brockton, Massachusetts, 02301, USA
    J Comp Neurol 521:1225-50. 2013
    ....
  15. pmc Knockdown of orexin type 2 receptor in the lateral pontomesencephalic tegmentum of rats increases REM sleep
    Lichao Chen
    Research Service, VA Boston Healthcare System, Brockton, MA, USA
    Eur J Neurosci 37:957-63. 2013
    ..Orexin type 1 receptor mRNA level was unaffected. Our results indicate that removal of OxR2 neurotransmission in the lPMT enhances REM sleep by increasing the duration of REM episodes...
  16. ncbi request reprint Influence of lung volume on pulmonary microvascular pressure-volume characteristics
    G P Topulos
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Appl Physiol (1985) 89:1591-600. 2000
    ..Hysteresis was small (0.013) at all lung volumes, suggesting that, although surface tension may set basal capillary shape, it does not strongly affect capillary compliance...
  17. ncbi request reprint Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Neuropharmacology 40:457-9. 2001
    ..The depolarization persisted in the presence of tetrodotoxin (TTX, 0.5 microM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy...
  18. pmc Impact of ketamine on neuronal network dynamics: translational modeling of schizophrenia-relevant deficits
    Bernat Kocsis
    Laboratory of Neurophysiology, Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    CNS Neurosci Ther 19:437-47. 2013
    ..g. impaired event-related gamma-band oscillations) correlated with cognitive impairments in schizophrenia...
  19. pmc Adenosine inhibits the excitatory synaptic inputs to Basal forebrain cholinergic, GABAergic, and parvalbumin neurons in mice
    Chun Yang
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Brockton, MA, USA
    Front Neurol 4:77. 2013
    ..Conversely, caffeine and theophylline promote attentive wakefulness by inhibiting these A1 receptors in BF thereby promoting the high-frequency oscillations in the cortex required for attention and cognition. ..
  20. pmc Impaired GABAergic neurotransmission in schizophrenia underlies impairments in cortical gamma band oscillations
    JAMES M MCNALLY
    Laboratory of Neuroscience, VA Boston Healthcare System and Department of Psychiatry, Harvard Medical School, 940 Belmont St, Research 151C, Brockton, MA, USA
    Curr Psychiatry Rep 15:346. 2013
    ....
  21. pmc Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation
    Jaime L Tartar
    Harvard Medical School and VA Boston Healthcare System, Laboratory of Neuroscience, Research 151 C, 940 Belmont Street, Brockton, MA 02301, USA
    Eur J Neurosci 23:2739-48. 2006
    ..The results suggest that sleep fragmentation negatively impacts spatial learning. Loss of N-methyl-D-aspartate (NMDA) receptor-dependent LTP in the hippocampal CA1 region may be one mechanism involved in this deficit...
  22. ncbi request reprint Effects of arousal- and feeding-related neuropeptides on dopaminergic and GABAergic neurons in the ventral tegmental area of the rat
    T M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001 Dusseldorf, Germany
    Eur J Neurosci 23:2677-85. 2006
    ..These findings suggest a link between the ability of neuropeptides to promote arousal and their action on VTA neurons...
  23. ncbi request reprint Mice deficient in endothelial nitric oxide synthase exhibit a selective deficit in hippocampal long-term potentiation
    R I Wilson
    Institut fur Neurophysiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Neuroscience 90:1157-65. 1999
    ..These results support a selective role for endothelial nitric oxide synthase in long-term potentiation, but also demonstrate that nitric oxide synthase is not involved in this process under all conditions...
  24. ncbi request reprint Defective hippocampal mossy fiber long-term potentiation in endothelial nitric oxide synthase knockout mice
    N Doreulee
    , , , Germany
    Synapse 41:191-4. 2001
    ..Thus, eNOS is not directly involved in mfLTP, but lack of eNOS during development leads to a deficit downstream of adenylyl cyclase...
  25. ncbi request reprint The physiology of brain histamine
    R E Brown
    Institut fur Neurophysiologie, Heinrich Heine Universitat, D 40001, Dusseldorf, Germany
    Prog Neurobiol 63:637-72. 2001
    ..A role for the neuronal histamine system as a danger response system is proposed...
  26. ncbi request reprint Histamine excites GABAergic cells in the rat substantia nigra and ventral tegmental area in vitro
    Tatiana M Korotkova
    Institute for Neurophysiology, Heinrich Heine University, D 40001, Duesseldorf, Germany
    Neurosci Lett 320:133-6. 2002
    ..Our results suggest that histamine does not directly inhibit dopaminergic neurons in SN and VTA, but rather that this inhibition is mediated through histamine-induced excitation of GABAergic neurons...
  27. ncbi request reprint Functional diversity of ventral midbrain dopamine and GABAergic neurons
    Tatiana M Korotkova
    Institute of Neurophysiology, Heinrich Heine University, D 40001 Duesseldorf, Germany
    Mol Neurobiol 29:243-59. 2004
    ....