M Christian Brown

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Response adaptation of medial olivocochlear neurons is minimal
    M C Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 86:2381-92. 2001
  2. ncbi request reprint Responses of medial olivocochlear neurons. Specifying the central pathways of the medial olivocochlear reflex
    M C Brown
    Department of Otology and Laryngology, Harvard Medical School, USA
    Exp Brain Res 153:491-8. 2003
  3. pmc Olivocochlear neuron central anatomy is normal in alpha 9 knockout mice
    M Christian Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 10:64-75. 2009
  4. pmc Identification of inputs to olivocochlear neurons using transneuronal labeling with pseudorabies virus (PRV)
    M Christian Brown
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, 02114, USA
    J Assoc Res Otolaryngol 14:703-17. 2013
  5. ncbi request reprint Ultrastructure of synaptic input to medial olivocochlear neurons
    Thane E Benson
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 499:244-57. 2006
  6. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005
  7. ncbi request reprint Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
  8. pmc Tensor tympani motoneurons receive mostly excitatory synaptic inputs
    Thane E Benson
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Anat Rec (Hoboken) 296:133-45. 2013
  9. pmc Commissural axons of the mouse cochlear nucleus
    M Christian Brown
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 521:1683-96. 2013
  10. pmc Postsynaptic targets of type II auditory nerve fibers in the cochlear nucleus
    Thane E Benson
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Assoc Res Otolaryngol 5:111-25. 2004

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Response adaptation of medial olivocochlear neurons is minimal
    M C Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 86:2381-92. 2001
    ..Such sustained responses may enable the MOC system to produce sustained effects in the periphery, supporting a role for this efferent system during ongoing stimuli of long duration...
  2. ncbi request reprint Responses of medial olivocochlear neurons. Specifying the central pathways of the medial olivocochlear reflex
    M C Brown
    Department of Otology and Laryngology, Harvard Medical School, USA
    Exp Brain Res 153:491-8. 2003
    ..Thus, the most likely pathway for the sound-evoked MOC reflex begins with the responses of hair cells, proceeds with type I auditory-nerve fibers, PVCN chopper units, and MOC neurons, and ends with the MOC terminations on OHC...
  3. pmc Olivocochlear neuron central anatomy is normal in alpha 9 knockout mice
    M Christian Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA
    J Assoc Res Otolaryngol 10:64-75. 2009
    ....
  4. pmc Identification of inputs to olivocochlear neurons using transneuronal labeling with pseudorabies virus (PRV)
    M Christian Brown
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA, 02114, USA
    J Assoc Res Otolaryngol 14:703-17. 2013
    ..These data provide information on the identity of neurons providing input to OC neurons, which are located in auditory as well as non-auditory centers. ..
  5. ncbi request reprint Ultrastructure of synaptic input to medial olivocochlear neurons
    Thane E Benson
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 499:244-57. 2006
    ..This input may thus provide the sound-evoked input to MOC neurons that causes their reflexive response to sound...
  6. pmc Medial olivocochlear reflex interneurons are located in the posteroventral cochlear nucleus: a kainic acid lesion study in guinea pigs
    Ronald K de Venecia
    Department of Otology and Laryngology, Harvard Medical School, and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 487:345-60. 2005
    ..We suggest that multipolar cells within the PVCN have the distribution and response characteristics appropriate to be the MOC reflex interneurons...
  7. ncbi request reprint Central auditory pathways mediating the rat middle ear muscle reflexes
    Daniel J Lee
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:358-69. 2006
    ..Preliminary findings using surgical transection and focal lesioning of the auditory brainstem to interrupt the MEM reflexes suggest that MEM reflex interneurons are located in the ventral cochlear nucleus...
  8. pmc Tensor tympani motoneurons receive mostly excitatory synaptic inputs
    Thane E Benson
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Anat Rec (Hoboken) 296:133-45. 2013
    ..Having a high proportion of excitatory inputs, the TTMN innervation is like that of stapedius motoneurons but proportionately different from other types of motoneurons...
  9. pmc Commissural axons of the mouse cochlear nucleus
    M Christian Brown
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Comp Neurol 521:1683-96. 2013
    ..Radiate commissural axons could mediate the broadband inhibition observed in responses to contralateral sound, and they may balance input from the two ears with a quick time course...
  10. pmc Postsynaptic targets of type II auditory nerve fibers in the cochlear nucleus
    Thane E Benson
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    J Assoc Res Otolaryngol 5:111-25. 2004
    ..The diverse nature of the type II targets and the examples of segregated convergence of other inputs illustrates the synaptic complexity of type II input to the cochlear nucleus...
  11. pmc Dendrites of medial olivocochlear neurons in mouse
    M C Brown
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02115, USA
    Neuroscience 154:147-59. 2008
    ....
  12. ncbi request reprint Fast, but not slow, effects of olivocochlear activation are resistant to apamin
    N Yoshida
    Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurophysiol 85:84-8. 2001
    ..The results suggest that in vivo fast OC effects are dominated by a conductance that is not apamin sensitive...
  13. pmc Diverse synaptic terminals on rat stapedius motoneurons
    Daniel J Lee
    Department of Otolaryngology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 9:321-33. 2008
    ..These were generally the same kinds of terminals found on other motoneurons, but the high proportion of round vesicle synapses indicate that SMNs receive mostly excitatory inputs...
  14. pmc Essential role of retinoblastoma protein in mammalian hair cell development and hearing
    Cyrille Sage
    Neurology Service, Center for Nervous System Repair, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:7345-50. 2006
    ....
  15. pmc Effects of anesthesia on efferent-mediated adaptation of the DPOAE
    K P Boyev
    Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 3:362-73. 2002
    ..These results suggest that previous studies using anesthetized preparations may have underestimated the magnitude of sound-evoked responses in the OC pathway...
  16. pmc A morphologic study of Fluorogold labeled tensor tympani motoneurons in mice
    Sudeep Mukerji
    Department of Otolaryngology, Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, and Harvard Medical School, Boston, Massachusetts, USA
    Brain Res 1278:59-65. 2009
    ..The mean size of mouse TTMNs was 13.0 microm (minor axis) and 23.5 microm (major axis). Compared with studies of TTMNs in larger species (cats and rats), mouse TTMNs are both fewer in number and smaller in size...
  17. pmc Auditory responses to electric and infrared neural stimulation of the rat cochlear nucleus
    Rohit U Verma
    School of Medicine, University of Manchester, UK Eaton Peabody Laboratories, Massachusetts Eye and Ear Infirmary, USA Department of Otology and Laryngology, Harvard Medical School, Boston, MA 02114, USA
    Hear Res 310:69-75. 2014
    ..Thus, for deaf individuals who use the auditory brainstem implant, INS alone did not appear promising as a new approach. ..
  18. ncbi request reprint Changes in Sef levels influence auditory brainstem development and function
    Victoria E Abraira
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:4273-82. 2007
    ..These results show both increases and decreases in Sef levels affect the assembly and function of the auditory brainstem...
  19. ncbi request reprint Vascular defects and sensorineural deafness in a mouse model of Norrie disease
    Heidi L Rehm
    Neurosurgery Service, Massachusetts General Hospital, Boston, Massachusetts 02114, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 22:4286-92. 2002
    ..We propose that one of the principal functions of norrin in the ear is to regulate the interaction of the cochlea with its vasculature...
  20. pmc Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 15:1629-39. 2006
    ..Thus, Tbx1 in the surrounding mesenchyme in both sets of conditional mutants cannot suppress the defects in the OV that occur in the null mutants...

Research Grants19

  1. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2010
    ..An understanding of the neural pathways is important to understand how these reflexes accomplish their functions. ..
  2. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 2009
    ..An understanding of the neural pathways is important to understand how these reflexes accomplish their functions. ..
  3. Descending Systems to the Cochlea and Cochear Nucleus
    M Brown; Fiscal Year: 2007
    ..It will also greatly increase our understanding of both the descending and the ascending auditory pathways. ..
  4. Descending Systems to the Cochlea and Cochear Nucleus
    M Brown; Fiscal Year: 2006
    ..It will also greatly increase our understanding of both the descending and the ascending auditory pathways. ..
  5. Descending Systems to the Cochlea and Cochear Nucleus
    M Brown; Fiscal Year: 2005
    ..It will also greatly increase our understanding of both the descending and the ascending auditory pathways. ..
  6. Descending Systems to the Cochlea and Cochear Nucleus
    M Brown; Fiscal Year: 2004
    ..It will also greatly increase our understanding of both the descending and the ascending auditory pathways. ..
  7. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 2003
    ..This knowledge would greatly increase our understanding of both the descending and the ascending auditory pathways, and elucidate their roles in the hearing process. ..
  8. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 2002
    ..This knowledge would greatly increase our understanding of both the descending and the ascending auditory pathways, and elucidate their roles in the hearing process. ..
  9. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 2001
    ..This knowledge would greatly increase our understanding of both the descending and the ascending auditory pathways, and elucidate their roles in the hearing process. ..
  10. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 2000
    ..This knowledge would greatly increase our understanding of both the descending and the ascending auditory pathways, and elucidate their roles in the hearing process. ..
  11. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 1993
    ..Questions such as the fields innervated by single 0C fibers in both the cochlea and cochlear nucleus will influence theoretical formulations of how the MOC system controls afferent signals sent to more central regions of the brain...
  12. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 1992
    ..Questions such as the fields innervated by single 0C fibers in both the cochlea and cochlear nucleus will influence theoretical formulations of how the MOC system controls afferent signals sent to more central regions of the brain...
  13. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Brown; Fiscal Year: 1999
    ..This knowledge would greatly increase our understanding of both the descending and the ascending auditory pathways, and elucidate their roles in the hearing process. ..
  14. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2011
    ..An understanding of the neural pathways is important to understand how these reflexes accomplish their functions. ..