Edward M Brown

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint G protein-coupled, extracellular Ca2+ (Ca2+(o))-sensing receptor enables Ca2+(o) to function as a versatile extracellular first messenger
    E M Brown
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cell Biochem Biophys 33:63-95. 2000
  2. ncbi request reprint The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Nutr 20:507-33. 2000
  3. ncbi request reprint Calcium sensing by endocrine cells
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Endocr Pathol 15:187-219. 2004
  4. ncbi request reprint Calcium-sensing receptors in bone cells
    E M Brown
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Musculoskelet Neuronal Interact 4:412-3. 2004
  5. ncbi request reprint Calcium receptor and regulation of parathyroid hormone secretion
    E M Brown
    Endocrine Hypertension Division, Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Rev Endocr Metab Disord 1:307-15. 2000
  6. ncbi request reprint Extracellular calcium sensing and extracellular calcium signaling
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Rev 81:239-297. 2001
  7. ncbi request reprint Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 29:503-22. 2000
  8. ncbi request reprint Clinical lessons from the calcium-sensing receptor
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension at Brigham and Women s Hospital in Boston, MA, USA
    Nat Clin Pract Endocrinol Metab 3:122-33. 2007
  9. ncbi request reprint Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas
    Olga Kifor
    Endocrine Hypertension Division and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:4455-64. 2003
  10. ncbi request reprint Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Beth Israel Seaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 145:3451-62. 2004

Research Grants

Collaborators

Detail Information

Publications132 found, 100 shown here

  1. ncbi request reprint G protein-coupled, extracellular Ca2+ (Ca2+(o))-sensing receptor enables Ca2+(o) to function as a versatile extracellular first messenger
    E M Brown
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cell Biochem Biophys 33:63-95. 2000
    ....
  2. ncbi request reprint The extracellular Ca2+-sensing receptor: central mediator of systemic calcium homeostasis
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Nutr 20:507-33. 2000
    ....
  3. ncbi request reprint Calcium sensing by endocrine cells
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Endocr Pathol 15:187-219. 2004
    ....
  4. ncbi request reprint Calcium-sensing receptors in bone cells
    E M Brown
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Musculoskelet Neuronal Interact 4:412-3. 2004
  5. ncbi request reprint Calcium receptor and regulation of parathyroid hormone secretion
    E M Brown
    Endocrine Hypertension Division, Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Rev Endocr Metab Disord 1:307-15. 2000
    ..Finally, CaR activators offer promise as the first truly effective mode of medical therapy for these latter two conditions...
  6. ncbi request reprint Extracellular calcium sensing and extracellular calcium signaling
    E M Brown
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Physiol Rev 81:239-297. 2001
    ..In any event, the CaR and other receptors/sensors for Ca(o)(2+) and probably for other extracellular ions represent versatile regulators of numerous cellular functions and may serve as important therapeutic targets...
  7. ncbi request reprint Familial hypocalciuric hypercalcemia and other disorders with resistance to extracellular calcium
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Endocrinol Metab Clin North Am 29:503-22. 2000
    ....
  8. ncbi request reprint Clinical lessons from the calcium-sensing receptor
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension at Brigham and Women s Hospital in Boston, MA, USA
    Nat Clin Pract Endocrinol Metab 3:122-33. 2007
    ..Finally, calcimimetics-allosteric activators of the CaR-treat secondary hyperparathyroidism effectively in end-stage renal failure...
  9. ncbi request reprint Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas
    Olga Kifor
    Endocrine Hypertension Division and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:4455-64. 2003
    ..Thus, CaR and caveolin-1 colocalize in PT cells, and reduced levels of caveolin-1 could participate in the abnormal cellular function and proliferation of cultured bovine PT cells and PT adenomas...
  10. ncbi request reprint Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Beth Israel Seaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 145:3451-62. 2004
    ..Our data, therefore, show that the parathyroid/kidney CaR expressed in rat calvarial OBs exerts a mitogenic effect that involves activation of the JNK pathway and up-regulation of several mitogenic genes...
  11. ncbi request reprint High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Growth Factors 23:117-23. 2005
    ..In conclusion, the calcium activates the EGFR, possibly through the CaR, to regulate downstream signaling events and important biological functions in a model of HHM...
  12. ncbi request reprint Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism
    Olga Kifor
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 89:548-56. 2004
    ....
  13. pmc The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion
    Lakshmi Kantham
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 297:E915-23. 2009
    ....
  14. ncbi request reprint 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells
    Naibedya Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 284:E219-27. 2003
    ..The known antiproliferative effect of 1,25(OH)(2)D(3) on MG-63 cells can be accounted for by the concomitant 1,25(OH)(2)D(3)-induced inhibition of HGF production...
  15. ncbi request reprint Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:4222-31. 2004
    ..Finally, regulation of its expression has glioma-specific features and is selectively regulated by promalignant cytokines including EGFR ligands and HGF...
  16. ncbi request reprint PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation
    R John Macleod
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 284:E435-42. 2003
    ..We conclude that CaR specifically mediates the effect of increasing [Ca(2+)](o) on PTHrP synthesis and secretion and that activated MEK1/2 and p38 MAP kinases are determinants of the CaR's stimulation of PTHrP secretion...
  17. ncbi request reprint m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR
    Olga Kifor
    Endocrine Hypertension Division, Membrane Biology Program and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:31167-76. 2003
    ..Our data suggest that localization of m-calpain within caveolae may contribute to maintenance of the enzyme in an inactive state and that m-calpain may also contribute to the regulation of CaR levels...
  18. ncbi request reprint The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, United States
    Biochem Pharmacol 74:438-47. 2007
    ..In conclusion, Sr(2+) is a full CaR agonist in HEK-CaR and POB, and, therefore, the anabolic effect of Sr(2+) on bone in vivo could be mediated, in part, by the CaR...
  19. ncbi request reprint Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Nature 366:575-80. 1993
    ....
  20. ncbi request reprint Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 292:E523-32. 2007
    ..We conclude that the CaR may be a novel regulator of GnRH neuronal migration likely involving, in part, MCP-1...
  21. ncbi request reprint Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons
    Sanghamitra Bandyopadhyay
    Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02115, USA
    J Neurosci Res 85:882-95. 2007
    ..These results implicate CaR as an important regulator of GnRH neuron function in vivo by stimulating secretion of heretofore unsuspected cytokines, i.e., CXCL10 and MCP-3...
  22. ncbi request reprint Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells
    Jacob Tfelt-Hansen
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Endocrinol Metab 288:E1206-13. 2005
    ..In conclusion, high calcium upregulates the levels of iNOS mRNA and protein as well as NO production in H-500 cells, and the effect of Cao2+ on iNOS expression is mediated by the CaR...
  23. ncbi request reprint Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 322:1384-91. 2004
    ....
  24. ncbi request reprint Lysosomal exocytosis is impaired in mucolipidosis type IV
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Mol Genet Metab 89:339-48. 2006
    ..Further, we show that transfection with wild type MLN1 cDNA rescues exocytosis, suggesting the possibility of treatments based on the restoration of this crucial cellular function...
  25. pmc Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
    D Riccardi
    Laboratory of Molecular Physiology and Biophysics, Brigham and Women s Hospital, Boston, MA
    Proc Natl Acad Sci U S A 92:131-5. 1995
    ....
  26. pmc Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations
    Conall M O'Seaghdha
    National Heart, Lung, and Blood Institute s Framingham Heart Study and Center for Population Studies, Framingham, Massachusetts, United States of America Renal Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 9:e1003796. 2013
    ..We characterized the expression of these genes in gut, kidney, and bone, and demonstrate modulation of gene expression in bone in response to dietary calcium in mice. Our results shed new light on the genetics of calcium homeostasis...
  27. pmc Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium-sensing receptor gene deletion
    Jose R Romero
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Eur J Haematol 91:37-45. 2013
    ..Our results demonstrate that Ca2+ -sensing receptor and parathyroid hormone are functionally coupled to maintain erythrocyte homeostasis...
  28. pmc CaSR-mediated interactions between calcium and magnesium homeostasis in mice
    Stephen J Quinn
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 304:E724-33. 2013
    ..These hormonal responses to Mg loading and the CaSR's role in regulating renal function may help to explain changes in serum Mg and Ca found during Mg loading...
  29. pmc Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor
    J Carl Pallais
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:672-80. 2011
    ..Previously, glucocorticoid treatment has been shown to decrease the CaSR autoantibody titers and normalize the hypercalcemia in a patient with autoimmune hypocalciuric hypercalcemia (AHH)...
  30. ncbi request reprint Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy
    J Tfelt-Hansen
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 145:1211-7. 2004
    ..These effects are likely direct without the involvement of PTHrP in an autocrine mode...
  31. ncbi request reprint Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation
    Shozo Yano
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Bone 35:664-72. 2004
    ..This transactivation is most likely mediated by activation of MMP and cleavage of proheparin-binding EGF (proHB-EGF) to HB-EGF...
  32. doi request reprint Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice
    Naibedya Chattopadhyay
    Department of Medicine and Membrane Biology Program, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 86:2159-67. 2008
    ..We conclude that the CaR may be a novel regulator of oligodendroglial development and function...
  33. ncbi request reprint A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor
    Olga Kifor
    Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 88:60-72. 2003
    ..Autoimmune hypocalciuric hypercalcemic is an acquired disorder of Ca(2+)(o) sensing that should be differentiated from that caused by inactivating mutations of the CaR...
  34. pmc Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo
    Stephen J Quinn
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 304:E310-20. 2013
    ....
  35. ncbi request reprint Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor
    J Carl Pallais
    Department of Endocrinology, Massachusetts General Hospital, Boston, MA 02114, USA
    N Engl J Med 351:362-9. 2004
  36. ncbi request reprint Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2
    P M Vassilev
    Endocrine Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    J Membr Biol 184:113-20. 2001
    ....
  37. ncbi request reprint Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
    O Kifor
    Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
    Am J Physiol Renal Physiol 280:F291-302. 2001
    ....
  38. ncbi request reprint Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Nat Genet 8:303-7. 1994
    ..We conclude that this extracellular domain mutation increases the receptor's activity at low Ca2+ concentrations, causing hypocalcaemia in patients heterozygous for such a mutation...
  39. ncbi request reprint Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 271:19537-45. 1996
    ..Conversely, one activating mutation, which causes a form of autosomal dominant hypocalcemia, appears to increase the affinity of the receptor for its agonists...
  40. ncbi request reprint Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells
    J L Sanders
    Endocrine-Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Endocrinol Metab 281:E1267-74. 2001
    ....
  41. pmc Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria
    Hakan R Toka
    Division of Nephrology, Beth Israel Medical Center, 330 Brookline Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 23:1879-90. 2012
    ..Taken together, these data suggest that renal Casr regulates calcium reabsorption in the thick ascending limb, independent of any change in PTH, by increasing the lumen-positive driving force for paracellular Ca(2+) transport...
  42. ncbi request reprint Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase
    Chian Ping Ye
    Division of Endocrinology, Hypertension and Diabetes and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 75:491-8. 2004
    ..Large-conductance CAKCs play an important role in the regulation of cellular volume, so our results have important implications for glioma cell volume regulation...
  43. pmc The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Exp Cell Res 317:691-705. 2011
    ..MLN1 is absent or mutated in patients with mucolipidosis IV (MLIV), a lysosomal disorder with devastating neurological and other consequences. This study provides potential insight into the pathophysiology of MLIV...
  44. ncbi request reprint Role of the cytoskeleton in extracellular calcium-regulated PTH release
    Stephen J Quinn
    Division of Endocrinology, Diabetes and Hypertension and the Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biochem Biophys Res Commun 354:8-13. 2007
    ..We have demonstrated that in polarized PT cells, the F-actin cytoskeleton is involved in the regulation of PTH secretion and is critical for inhibition of PTH secretion by high calcium...
  45. ncbi request reprint Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    Surya M Nauli
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    Nat Genet 33:129-37. 2003
    ..Loss or dysfunction of PC1 or PC2 may therefore lead to PKD owing to the inability of cells to sense mechanical cues that normally regulate tissue morphogenesis...
  46. ncbi request reprint Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts
    Shozo Yano
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 146:2324-35. 2005
    ..Furthermore, RANTES secreted from osteoclasts induces osteoblast chemotaxis. Therefore, expression of RANTES and its receptors in both osteoblasts and osteoclasts could enable this chemokine to act in autocrine/paracrine modes...
  47. ncbi request reprint Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    M R Pollak
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell 75:1297-303. 1993
    ..We conclude that the mammalian Ca(2+)-sensing receptor "sets" the extracellular Ca2+ level and is defective in individuals with FHH and NSHPT...
  48. ncbi request reprint A rat kidney-specific calcium transporter in the distal nephron
    J B Peng
    Membrane Biology Program and Renal and Endocrine Hypertension Divisions, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:28186-94. 2000
    ..The high sensitivity of CaT2 to Cd(2+) also provides a potential explanation for Cd(2+)-induced hypercalciuria and resultant renal stone formation...
  49. ncbi request reprint Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
    T Yamaguchi
    Endocrine-Hypertension Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 280:C382-93. 2001
    ..5 microM), but not its less active stereoisomer NPS S-467 (0.5 microM), activate an outward K+ channel in MG-63 cells, strongly suggesting that the CaR in MG-63 cells is not only expressed but is functionally active...
  50. ncbi request reprint Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
    J B Peng
    Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:22739-46. 1999
    ..Our studies strongly suggest that CaT1 provides the principal mechanism for Ca(2+) entry into enterocytes as part of the transcellular pathway of calcium absorption in the intestine...
  51. ncbi request reprint Role of the calcium-sensing receptor in extracellular calcium homeostasis
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, EBRC 223A, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Best Pract Res Clin Endocrinol Metab 27:333-43. 2013
    ..These actions tend to mobilize skeletal Ca(2+) during [Formula: see text] deficiency and retain it when Ca(2+) is plentiful. ..
  52. ncbi request reprint The pathophysiology of primary hyperparathyroidism
    Edward M Brown
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 17:N24-9. 2002
    ..Thus, PTH-dependent hypercalcemia can occur in the setting of either inherited, generalized resistance to Ca(o)2+ (i.e., FHH and NSHPT) or acquired tissue selective resistance of pathological parathyroid glands to Ca(o)2+ (e.g., PHPT)...
  53. ncbi request reprint Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells
    Naibedya Chattopadhyay
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Rm 205, Boston, MA 02115, USA
    Brain Res Mol Brain Res 121:146-50. 2004
    ..Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy...
  54. pmc Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations
    Ogo I Egbuna
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Best Pract Res Clin Rheumatol 22:129-48. 2008
    ..Calcimimetic CaSR activators and calcilytic CaSR antagonists have also been developed with potential for use in the treatment of these disorders...
  55. ncbi request reprint Expression of extracellular calcium (Ca2 + o)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biochem Biophys Res Commun 243:753-7. 1998
    ..Therefore, taken together, our data strongly suggest that the osteoblast-like cell lines, UMR-106 and SAOS-2, possess both CaR protein and mRNA very similar if not identical to those in parathyroid and kidney...
  56. ncbi request reprint Polycystin-L is a calcium-regulated cation channel permeable to calcium ions
    X Z Chen
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 401:383-6. 1999
    ..Its large single-channel conductance and regulation by calcium ions distinguish it from other structurally related cation channels...
  57. ncbi request reprint Identification and functional assay of an extracellular calcium-sensing receptor in Necturus gastric mucosa
    R R Cima
    Department of Surgery, West Roxbury Veterans Affairs Medical Center, Massachusetts, USA
    Am J Physiol 273:G1051-60. 1997
    ..Inhibition of prostaglandin synthesis using indomethacin significantly attenuated these effects. We conclude that the CaR is present and functioning in Necturus gastric antrum...
  58. ncbi request reprint A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    C Ho
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 11:389-94. 1995
    ..Our findings suggest that Casr mutations cause these human disorders by reducing the number of functional receptor molecules on the cell surface...
  59. ncbi request reprint Protein kinase C phosphorylation of threonine at position 888 in Ca2+o-sensing receptor (CaR) inhibits coupling to Ca2+ store release
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:21267-75. 1998
    ..Our results suggest that phosphorylation of the CaR is the molecular basis for the previously described effect of PKC activation on Ca2+o-evoked changes in Ca2+i dynamics in parathyroid cells...
  60. ncbi request reprint Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene
    Suzy D C Bianco
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Bone Miner Res 22:274-85. 2007
    ..Although our Trpv6 KO affects the closely adjacent EphB6 gene, the phenotype reported here is not related to EphB6 dysfunction...
  61. ncbi request reprint New insights in bone biology: unmasking skeletal effects of the extracellular calcium-sensing receptor
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 20115, USA
    Sci Signal 1:pe40. 2008
    ....
  62. pmc Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Endocrinol Metab Clin North Am 38:437-45, x. 2009
    ..Other novel parathyroid autoantigens are starting to be elucidated, suggesting that new approaches to treatment, such as CaSR antagonists or agonists (calcilytics/calcimimetics), may be worthwhile...
  63. ncbi request reprint pH Sensing by the calcium-sensing receptor
    Stephen J Quinn
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:37241-9. 2004
    ..Several CaR-expressing tissues, including regions of the stomach, the kidney, bone, and the brain, could potentially use the CaR as a sensor for pH and acid-base status...
  64. ncbi request reprint Expression of an extracellular calcium-sensing receptor in human and mouse bone marrow cells
    M G House
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Bone Miner Res 12:1959-70. 1997
    ....
  65. pmc L-amino acid sensing by the extracellular Ca2+-sensing receptor
    A D Conigrave
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:4814-9. 2000
    ..The actions of l-amino acids on the CaR may provide explanations for several long recognized but poorly understood actions of dietary protein on calcium metabolism...
  66. ncbi request reprint CaT1 expression correlates with tumor grade in prostate cancer
    J B Peng
    Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 282:729-34. 2001
    ..These findings are the first to implicate a Ca(2+) channel in PCa progression and suggest that CaT1 may be a novel target for therapy...
  67. ncbi request reprint Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:23605-10. 1998
    ..Taken together, we conclude from these results that the functional CaR resides on the cell surface of transfected HEK293 cells in the form of a dimer...
  68. ncbi request reprint The calcium-sensing receptor in human disease
    Jacob Tfelt-Hansen
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC room 205, Boston, MA 02115, USA
    Front Biosci 8:s377-90. 2003
    ..In renal secondary hyperparathyroidism, a drug that stimulates the receptor (calcimimetic) shows great promise as a medical treatment for this condition...
  69. ncbi request reprint Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer
    Jacob Tfelt-Hansen
    Endocrine Hypertension Division, Department of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    Endocrinology 144:5188-93. 2003
    ..22-fold. In conclusion, we show for the first time that a GPCR, the CaR, stimulates the synthesis of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy and, in the process, might induce angiogenesis via VEGF...
  70. ncbi request reprint Apical entry channels in calcium-transporting epithelia
    Ji Bin Peng
    Membrane Biology Program and Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    News Physiol Sci 18:158-63. 2003
    ..These channels are regulated directly or indirectly by vitamin D and dietary calcium and undergo feedback control by intracellular calcium, suggesting their rate-limiting roles in transcellular calcium transport...
  71. ncbi request reprint Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells
    T Yamaguchi
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 139:3561-8. 1998
    ....
  72. ncbi request reprint Deficient cation channel regulation in neurons from mice with targeted disruption of the extracellular Ca2+-sensing receptor gene
    C Ye
    Howard Hughes Medical Institute and Department of Genetics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Brain Res Bull 44:75-84. 1997
    ..Thus the CaR regulates the activity of Ca2+-permeable NCC in hippocampal neurons and could potentially modulate key neuronal functions, including neurotransmission and neuronal excitability, via membrane depolarization...
  73. ncbi request reprint Is the calcium receptor a molecular target for the actions of strontium on bone?
    Edward M Brown
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    Osteoporos Int 14:S25-34. 2003
    ....
  74. ncbi request reprint Signal transduction in the parathyroid
    Olga Kifor
    Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 11:397-402. 2002
    ..To review recent developments regarding the mechanisms underlying the regulation of various aspects of parathyroid function...
  75. ncbi request reprint Calcium-sensing receptor in the brain
    Shozo Yano
    Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    Cell Calcium 35:257-64. 2004
    ..e. water homeostasis). Furthermore, the expression of the CaR in all three types of glial cells indicates potential roles in the maintenance of local ionic homeostasis as well as in disease processes such as glioma...
  76. ncbi request reprint Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR)
    Edward M Brown
    Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, EBRC 223A, 221 Longwood Ave, Boston, MA 02115, United States
    Biochem Pharmacol 80:297-307. 2010
    ..In the future, the drug could conceivably be utilized to modulate the activity of the CaSR in other tissues (i.e., kidney, colon) in therapeutically desirable ways...
  77. ncbi request reprint Extracellular calcium sensing and signalling
    Aldebaran M Hofer
    West Roxbury Veterans Affairs Medical Center and Brigham and Women s Hospital, Department of Surgery, Harvard Medical School, Room 2B111, 1400 VFW Parkway, West Roxbury, Massachusetts 02132, USA
    Nat Rev Mol Cell Biol 4:530-8. 2003
    ..Here, we describe new emerging concepts concerning the signalling function of extracellular Ca2+, with particular emphasis on the extracellular calcium-sensing receptor...
  78. ncbi request reprint Intercellular communication mediated by the extracellular calcium-sensing receptor
    A M Hofer
    Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massahusetts 02115, USA
    Nat Cell Biol 2:392-8. 2000
    ..The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours...
  79. ncbi request reprint The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis
    R Mentaverri
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 20:2562-4. 2006
    ....
  80. ncbi request reprint Expression of peroxisome proliferator-activated receptors (PPARS) in human astrocytic cells: PPARgamma agonists as inducers of apoptosis
    N Chattopadhyay
    Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci Res 61:67-74. 2000
    ..These data show that modulation of the process of apoptosis is one function of PPARgamma in cells derived from the human astrocytic lineage...
  81. ncbi request reprint Retinoic acid receptors are expressed in human primary astrocytes and their agonists inhibit parathyroid hormone-related peptide expression and secretion
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Brain Res Mol Brain Res 92:172-6. 2001
    ....
  82. ncbi request reprint Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy
    J L Sanders
    Endocrine Hypertension Division, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 269:427-32. 2000
    ..Thus in HHM caused by H-500 cells, the CaR could participate in a vicious cycle whereby PTHrP-induced increases in Ca(2+)(o) further stimulate PTHrP release and exacerbate hypercalcemia...
  83. ncbi request reprint Extracellular calcium-sensing receptor in rat oligodendrocytes: expression and potential role in regulation of cellular proliferation and an outward K+ channel
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
    Glia 24:449-58. 1998
    ....
  84. ncbi request reprint Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Brain Res 851:116-24. 1999
    ..Thus our study strongly suggests that elevated levels of Ca2+o, acting via the CaR, activate an NCC that could contribute to the associated CaR-induced stimulation of proliferation...
  85. pmc Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function
    M Bai
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:2834-9. 1999
    ..Our study suggests that intermolecular interactions within the dimeric CaR are important for the receptor's function...
  86. ncbi request reprint The extracellular calcium-sensing receptor: its role in health and disease
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Annu Rev Med 49:15-29. 1998
    ..Thus the discovery of the CaR and its associated diseases has documented that Ca2+o plays an essential role as an extracellular first messenger, in addition to serving its better recognized role as an intracellular second messenger...
  87. ncbi request reprint Evidence for extracellular calcium-sensing receptor mediated opening of an outward K+ channel in a human astrocytoma cell line (U87)
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Glia 26:64-72. 1999
    ..Thus U87 astrocytoma cells express both CaR mRNA and protein, and the receptor activates an outward K+ channel previously suggested to be involved in membrane polarization and cellular excitability...
  88. ncbi request reprint Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines
    J L Sanders
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Endocrinology 141:4357-64. 2000
    ....
  89. ncbi request reprint Regulation of secretion of PTHrP by Ca(2+)-sensing receptor in human astrocytes, astrocytomas, and meningiomas
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Physiol Cell Physiol 279:C691-9. 2000
    ..5-fold higher in HPA than in the glial tumors studied here. Therefore, our results show that HPA, astrocytomas, and meningiomas express both the CaR and PTHrP and that CaR agonists stimulate PTHrP secretion...
  90. ncbi request reprint Role of the Ca(2+)-sensing receptor in divalent mineral ion homeostasis
    S C Hebert
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Biol 200:295-302. 1997
    ..This mechanism can explain hypercalcemia-mediated polyuria (diabetes insipidus)...
  91. ncbi request reprint Structural conservation of the genes encoding CaT1, CaT2, and related cation channels
    J B Peng
    Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA
    Genomics 76:99-109. 2001
    ..We conclude that ECAC2 and ECAC1, which encode calcium selective channels, share a common ancestral gene with the genes encoding the related nonselective cation channels...
  92. ncbi request reprint Expression of extracellular calcium-sensing receptor by human lens epithelial cells
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 233:801-5. 1997
    ..Therefore, our data suggest that human lens-epithelial cells express the CaR, which may be functionally linked to Ca(2+)-activated K+ channels and, perhaps, to other ion channels involved in ionic homeostasis in the lens...
  93. ncbi request reprint Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase
    G Hjälm
    Calcium Section, Endocrine Hypertension Division and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:34880-7. 2001
    ..Therefore, the binding of the CaR's COOH-terminal tail to filamin-A may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CaR-mediated activation of MAPK...
  94. ncbi request reprint Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
    J Tfelt-Hansen
    Endocrine Hypertension Division, Dept of Medicine and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Am J Physiol Endocrinol Metab 285:E329-37. 2003
    ..We conclude that CaR regulation of PTHrP release in H-500 cells involves activation of PKC as well as the ERK1/2, p38 MAPK, and JNK pathways...
  95. ncbi request reprint Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease
    P M Vassilev
    Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 282:341-50. 2001
    ..The dysfunction of such mutants may result in defective coupling of PC2 to intracellular Ca(2+) homeostasis associated with the pathogenesis of ADPKD...
  96. ncbi request reprint Cellular "sensing" of extracellular calcium (Ca(2+)(o)): emerging roles in regulating diverse physiological functions
    N Chattopadhyay
    Endocrine Hypertension Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Signal 12:361-6. 2000
    ....
  97. ncbi request reprint Mutations in the calcium-sensing receptor and their clinical implications
    E M Brown
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Horm Res 48:199-208. 1997
    ..Drugs that activate the CaR ('calcimimetics') are currently undergoing clinical trials and will permit pharmacological manipulation of the receptor when it functions abnormally (e.g., in primary hyperparathyroidism)...
  98. ncbi request reprint Human calcium transport protein CaT1
    J B Peng
    Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochem Biophys Res Commun 278:326-32. 2000
    ..25 mM. Our studies suggest a role for hCaT1 in cellular calcium uptake in a variety of tissues, including the transcellular calcium transport pathway in intestine...
  99. ncbi request reprint Calcium-sensing receptor in the rat hippocampus: a developmental study
    N Chattopadhyay
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Brain Res Dev Brain Res 100:13-21. 1997
    ..Further studies are needed to determine the role of the CaR in the development of important aspects of the function of hippocampus and other regions of brain, including LTP...
  100. ncbi request reprint Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells
    N Chattopadhyay
    Endocrine Hypertension Division and Membrane Biology Program, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, MA 02115, Boston, USA
    Brain Res Mol Brain Res 87:100-8. 2001
    ....
  101. ncbi request reprint Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway
    Janice M LaPlante
    Division of Endocrinology, Diabetes and Hypertension and Membrane Biology Program, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    FEBS Lett 532:183-7. 2002
    ..With its Ca(2+) permeability and modulation by [Ca(2+)], MLN1 could play a major role in Ca(2+) transport regulating lysosomal exocytosis and potentially other phenomena related to the trafficking of late endosomes and lysosomes...

Research Grants1

  1. Ca2+-Sensing Receptor: Novel Roles in Calcium Homeostasis
    Edward M Brown; Fiscal Year: 2008
    ..These studies should clarify important mechanisms by which the body regulates calcium in bodily fluids under normal circumstances and how these processes can go awry in disease states. ..