Research Topics
Genomes and Genes
| Dennis BrownSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Bypassing vasopressin receptor signaling pathways in nephrogenic diabetes insipidusRichard Bouley
Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Semin Nephrol 28:266-78. 2008....
Phosphorylation events and the modulation of aquaporin 2 cell surface expressionDennis Brown
MGH Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Curr Opin Nephrol Hypertens 17:491-8. 2008....
Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient miceTeodor G Paunescu
Div of Nephrology, Massachusetts General Hospital, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
Am J Physiol Renal Physiol 293:F1915-26. 2007..However, our results show no increase in cell surface V-ATPase activity in response to metabolic acidosis in ICs from these animals, consistent with their inability to appropriately acidify their urine under these conditions...- cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cellsTeodor G Paunescu
MGH Center for Systems Biology, Program in Membrane Biology, and Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 298:F643-54. 2010.... - Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunitNicolas Da Silva
Massachusetts General Hospital, Harvard Medical School, Program in Membrane Biology, Nephrology Div, 185 Cambridge St, CPZN 8150, Boston, MA 02114 2790, USA
Am J Physiol Cell Physiol 293:C199-210. 2007..This relocation compensates for the absence of functional B1 and maintains the luminal pH in an acidic range that is compatible with fertility... - Acute hypertonicity alters aquaporin-2 trafficking and induces a MAPK-dependent accumulation at the plasma membrane of renal epithelial cellsUdo Hasler
Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114 2790, USA
J Biol Chem 283:26643-61. 2008..This may have important implications on adaptational processes governing transcellular water flux and/or cell survival under extreme conditions of hypertonicity... - Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cellsTeodor G Paunescu
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Physiol Renal Physiol 294:F130-8. 2008..This suggests that these enzymes have a close association and could be part of a protein complex that is involved in regulating renal distal proton secretion... - Calcitonin has a vasopressin-like effect on aquaporin-2 trafficking and urinary concentrationRichard Bouley
Massachusetts General Hospital, Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Simches Research Center, Room 8202, 185 Cambridge Street, Boston, MA 02114, USA
J Am Soc Nephrol 22:59-72. 2011..This suggests that calcitonin has a potential therapeutic use in nephrogenic diabetes insipidus... - Role of purinergic signaling pathways in V-ATPase recruitment to apical membrane of acidifying epididymal clear cellsClémence Belleannee
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Physiol Cell Physiol 298:C817-30. 2010.... - Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cellsWilliam L Rice
Program in Membrane Biology, Division of Nephrology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e32843. 2012..Overall, our data provide evidence supporting the role of S256 and S269 in the maintenance of AQP2 at the cell surface and reveal the dynamics of internalization and recycling of differentially phosphorylated AQP2 in cell culture... - Heat shock protein 70 interacts with aquaporin-2 and regulates its traffickingHua A J Lu
Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Biol Chem 282:28721-32. 2007..To summarize, we have identified the 70-kDa heat shock proteins as a AQP2 interactors and have shown for hsc70 that this interaction is involved in AQP2 trafficking... - Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cellsWinnie Waichi Shum
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Cell Physiol 301:C31-43. 2011..We propose that inhibition of RhoA-ROCKII might be part of the intracellular signaling cascade that is triggered upon agonist-induced apical membrane V-ATPase accumulation... - Simvastatin enhances aquaporin-2 surface expression and urinary concentration in vasopressin-deficient Brattleboro rats through modulation of Rho GTPaseWei Li
Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Dept of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Physiol Renal Physiol 301:F309-18. 2011..Our study provides an alternative mechanism to regulate AQP2 trafficking, bypassing the VP-vasopressin receptor signaling pathway... - Inhibition of endocytosis causes phosphorylation (S256)-independent plasma membrane accumulation of AQP2Hua Lu
Program in Membrane Biology, Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 286:F233-43. 2004.... - Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9Christine Pietrement
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
J Biol Chem 283:2986-96. 2008..We propose that CFTR is an important regulator of AQP9 and that the interaction between AQP9, NHERF1, and CFTR may facilitate the activation of AQP9 by cAMP... - Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cellsClaudia Silberstein
Renal Unit and Program in Membrane Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 287:F501-11. 2004.... - Proteomic analysis of V-ATPase-rich cells harvested from the kidney and epididymis by fluorescence-activated cell sortingNicolas Da Silva
Harvard Medical School, Boston, MA, USA
Am J Physiol Cell Physiol 298:C1326-42. 2010..These proteomic databases provide a framework for comprehensive future analysis of the common and distinct functions of V-ATPase-B1-expressing cells in the kidney and epididymis... - A fluorimetry-based ssYFP secretion assay to monitor vasopressin-induced exocytosis in LLC-PK1 cells expressing aquaporin-2Paula Nunes
Massachusetts General Hospital, Boston, MA 02114, USA
Am J Physiol Cell Physiol 295:C1476-87. 2008..These results support the idea that, in addition to its role in reducing AQP2 endocytosis, VP increases AQP2 exocytosis... - Effects of the renal medullary pH and ionic environment on vasopressin binding and signalingElena A Zalyapin
Program in Membrane Biology and Nephrology Division, MGH Center for Systems Biology, Boston, Massachusetts 02114, USA
Kidney Int 74:1557-67. 2008..While the gradient is important for urinary concentration, it may also play a substantial role in fine-tuning of the vasopressin response through the V2R... - Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distributionMaria Merkulova
Program in Membrane Biology and Nephrology Division, Center for Systems Biology, Simches Research Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA
Am J Physiol Cell Physiol 300:C1442-55. 2011.... - A dense network of dendritic cells populates the murine epididymisNicolas Da Silva
Program in Membrane Biology and Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, CPZN 8 206, Boston, Massachusetts 02114 2790, USA
Reproduction 141:653-63. 2011..eDCs are, therefore, strategically positioned to regulate the complex interplay between immune tolerance and activation, a balance that is fundamental to male fertility... - Transepithelial projections from basal cells are luminal sensors in pseudostratified epitheliaWinnie Wai Chi Shum
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
Cell 135:1108-17. 2008..We propose a paradigm in which basal cells scan and sense the luminal environment of pseudostratified epithelia and modulate epithelial function by a mechanism involving crosstalk with other epithelial cells... - Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormonesNURIA M PASTOR-SOLER
Program in Membrane Biology and Nephrology Division, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Reproduction 139:613-21. 2010..Our data show that expression of AQP9 in the developing rat epididymis is downregulated by neonatal DES, GNRHa, EE, and flutamide, and that the effects mediated by estrogens can be prevented by testosterone administration... - Vasopressin-induced differential stimulation of AQP4 splice variants regulates the in-membrane assembly of orthogonal arraysAlfred N Van Hoek
Simches Research Center, 8 208, 185 Cambridge St, Boston, MA 02114, USA
Am J Physiol Renal Physiol 296:F1396-404. 2009.... - Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligandSylvia Chen
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 152:3893-904. 2011..We conclude that the new VP(TMR) ligand is suitable for dissecting V2R and VP internalization and trafficking in cells, and that V2R trafficking and down-regulation is an MT-dependent mechanism... - Aquaporin 2 promotes cell migration and epithelial morphogenesisYing Chen
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
J Am Soc Nephrol 23:1506-17. 2012..In summary, these data suggest that the water channel AQP2 interacts with integrins to promote renal epithelial cell migration, contributing to the structural and functional integrity of the mammalian kidney... - New insights into the dynamic regulation of water and acid-base balance by renal epithelial cellsDennis Brown
MGH Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Simches Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Physiol Cell Physiol 302:C1421-33. 2012..This review summarizes recent advances in our understanding of these fundamental processes... - Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidneyLeileata M Russo
Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge St, Rm 8100, Boston, MA 02114, USA
Am J Physiol Renal Physiol 291:F246-53. 2006.... - Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle traffickingDennis Brown
Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
J Exp Biol 212:1762-72. 2009..Recent information about these pH-sensing mechanisms, which include the role of the V-ATPase itself as a pH sensor and the soluble adenylyl cyclase as a bicarbonate sensor, will be addressed in this review... - Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cellsRichard Bouley
Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Am J Physiol Cell Physiol 285:C750-62. 2003..However, this motif is not essential for the apical/basolateral sorting and polarized distribution of the V2R in LLC-PK1a cells or for adenylyl cyclase-mediated signal transduction... - The phosphorylation state of serine 256 is dominant over that of serine 261 in the regulation of AQP2 trafficking in renal epithelial cellsHua Jenny Lu
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Physiol Renal Physiol 295:F290-4. 2008..The potential role of S261 phosphorylation/dephosphorylation in vasopressin action remains to be determined... - V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathwayAndres Hurtado-Lorenzo
Program in Membrane Biology and Nephrology Division, Richard Simches Research Center, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
Nat Cell Biol 8:124-36. 2006.... - Differential expression and targeting of endogenous Arf1 and Arf6 small GTPases in kidney epithelial cells in situJaafar El-Annan
Program in Membrane Biology and Renal Unit, Massachusetts General Hospital, Boston, MA 02129 2020, USA
Am J Physiol Cell Physiol 286:C768-78. 2004..The results provide a framework on which to base and interpret future studies on the role of Arf GTPases in the multitude of cellular trafficking events that occur in renal tubular epithelial cells... - Postnatal expression of aquaporins in epithelial cells of the rat epididymisNicolas Da Silva
Massachusetts General Hospital, Program in Membrane Biology Nephrology Division, Boston, Massachusetts 02114, USA
Biol Reprod 74:427-38. 2006..AQPs may be involved not only in the transepithelial transport of water in the epididymis but also in the postnatal development of this organ, as suggested by the differential expression of AQP2... - Sensing, signaling and sorting events in kidney epithelial cell physiologyDennis Brown
Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Traffic 10:275-84. 2009.... - Impaired tubular uptake explains albuminuria in early diabetic nephropathyLeileata M Russo
Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospital Harvard Medical School, Simches Research Center, Boston, MA 02114, USA
J Am Soc Nephrol 20:489-94. 2009..In conclusion, in the early stages of diabetic nephropathy, the PT plays a major role in the development of albuminuria, which may be preceded by peptideuria... - Angiotensin II and hypertonicity modulate proximal tubular aquaporin 1 expressionRichard Bouley
Center for Systems Biology, Program in Membrane Biology, Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Physiol Renal Physiol 297:F1575-86. 2009.... - V-ATPase expression in the mouse olfactory epitheliumTeodor G Paunescu
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Massachusetts 02114, USA
Am J Physiol Cell Physiol 295:C923-30. 2008..These findings suggest that V-ATPase may be involved in proton secretion in the OE and, as such, may be important for the pH homeostasis of the neuroepithelial mucous layer and/or for signal transduction in CO(2) detection... - Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal diseaseKevin C Miranda
Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Kidney Int 78:191-9. 2010..Our study provides an experimental strategy for the routine isolation and use of urinary microvesicles as a novel and non-invasive source of nucleic acids to further renal disease biomarker discovery... - Regulation of luminal acidification in the male reproductive tract via cell-cell crosstalkWinnie W C Shum
Center for Systems Biology, Program in Membrane Biology, Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
J Exp Biol 212:1753-61. 2009..Thus, a complex interplay between the different cell types present in the epithelium leads to activation of the luminal acidifying capacity of the epididymis, a process that is crucial for sperm maturation and storage... - Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intoleranceLibin Liu
Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Cell Metab 8:310-7. 2008..Our results underscore the multiorgan role of caveolae in metabolic regulation and the obligate presence of Cavin for caveolae formation... - Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgensNuria Pastor-Soler
Renal Unit and Program in Membrane Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Reprod 66:1716-22. 2002..These data indicate that the expression of AQP9, a likely candidate for apical transepithelial fluid and solute transport in several regions of the male reproductive tract, is modulated by androgens in the adult rat epididymis... - Molecular mechanisms of acid-base sensing by the kidneyDennis Brown
MGH Center for Systems Biology, Program in Membrane Biology, Boston, MA, USA
J Am Soc Nephrol 23:774-80. 2012..This review collates current knowledge on renal acid-base sensing in the context of a whole organ sensing and response process... - Is caveolin involved in normal proximal tubule function? Presence in model PT systems but absence in situZhenjie Zhuang
Massachusetts General Hospital, Center for Systems Biology, Simches Research Bldg, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
Am J Physiol Renal Physiol 300:F199-206. 2011.... - Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynaminTian-Xiao Sun
Program in Membrane Biology and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 282:F998-1011. 2002..We propose that the IMP clusters previously associated with vasopressin action represent sites of dynamin-dependent, clathrin-mediated endocytosis in which AQP2 is concentrated before internalization... - Segmental and cellular expression of aquaporins in the male excurrent ductNicolas Da Silva
Program in Membrane Biology-Nephrology Division, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114-2790, USA
Biochim Biophys Acta 1758:1025-33. 2006..The present article reviews our current knowledge regarding the distribution and function of aquaporins in the male excurrent duct... - The soluble transforming growth factor-beta receptor: advantages and applicationsLeileata M Russo
Program in Membrane Biology, Center for Systems Biology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Biochem Cell Biol 41:472-6. 2009..Here we discuss the design, use and advantages of the highly specific TGF-beta binding molecule, the soluble human TGF-beta receptor (sTbetaR.Fc) as a TGF-beta sequestering agent... - Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory functionTeodor G Paunescu
MGH Center for Systems Biology, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS ONE 7:e45395. 2012..We conclude that V-ATPase-mediated H(+) secretion in the olfactory epithelium is required for optimal olfactory function... - Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cellsYin Xia
Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Soc Nephrol 21:666-77. 2010..Taken together, these results suggest that Dragon may enhance BMP signaling in renal tubular epithelial cells and maintain normal renal physiology... - Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptorLeileata M Russo
Program in Membrane Biology, Division of Nephrology, Department of Medicine, Massachusetts General Hospital Harvard Medical School, Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
Diabetes 56:380-8. 2007..Fc is a potential new agent for the treatment of fibrosis and albuminuria in diabetic nephropathy and may reduce albuminuria by reducing TGF-beta1-induced disruptions of renal proximal tubule cell uptake of albumin... - New insights into the regulation of V-ATPase-dependent proton secretionSylvie Breton
Program in Membrane Biology, Nephrology Division, Massachusetts General Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114 2790, USA
Am J Physiol Renal Physiol 292:F1-10. 2007..Modulation of the V-ATPase-rich cell phenotype and the pathophysiology of the V-ATPase in humans and experimental animals are also discussed... - Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipidsLei Lu
Developmental Gastroenterology Laboratory, Massachusetts General Hospital for Children, Boston, Massachusetts, USA
Gastroenterology 135:185-193.e1. 2008..Our aim was to characterize the developmental difference in cholera toxin (CT)-GM1-mediated endocytosis... - AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cellsNaofumi Yui
Massachusetts General Hospital Center for Systems Biology, Program in Membrane Biology and Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Open 1:101-8. 2012..This is the first report showing that VP/FK mediated F-actin depolymerization is dependent on AQP2 protein expression in renal epithelial cells, and that this is not dependent on the polarity of AQP2 membrane insertion... - Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathyHuaiping Yuan
Renal Section and Department of Medicine, Evans Biomedical Research Center, Boston University Medical Center, 650 Albany Street, Boston, MA 02118, USA
J Am Soc Nephrol 13:946-56. 2002..These events may underlie the loss of podocyte barrier function in membranous nephropathy... - In vivo molecular probing of cellular compartments with gold nanoparticles and nanoaggregatesJanina Kneipp
Wellman Center for Photomedicine, Harvard University, Medical School, Boston, Massachusetts 02114, USA
Nano Lett 6:2225-31. 2006..The results have implications for medical and biotechnology applications of SERS nanosensors in cells... - Antigen retrieval reveals widespread basolateral expression of syntaxin 3 in renal epitheliaSylvie Breton
Program in Membrane Biology and Renal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Physiol Renal Physiol 282:F523-9. 2002..The exclusive basolateral location of syntaxin 3 in situ, however, contrasts with the apical location of this SNARE protein in some kidney epithelial cells in culture... - Imaging protein traffickingDennis Brown
Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Nephron Exp Nephrol 103:e55-61. 2006..This review briefly introduces and discusses some of the systems and methodologies that are available from several manufacturers, including laser scanning and spinning disk confocal microscopy, and total internal reflectance microscopy... - TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal functionJochen Reiser
Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Nat Genet 37:739-44. 2005..Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function... - Identification of cytoskeletal regulatory proteins required for efficient phagocytosis in DrosophilaAlan M Pearson
Department of Pediatrics, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Microbes Infect 5:815-24. 2003..This study demonstrates that Drosophila provides a viable model system in which to dissect the complex interactions that regulate phagocytosis...