Kevin G Broadbelt
Affiliation: Harvard University
- Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell Proteomics 11:M111.009530. 2012..These data suggest a potential molecular defect in SIDS related to TPH2 regulation, as 14-3-3 is critical in this process...
- Serotonin-related FEV gene variant in the sudden infant death syndrome is a common polymorphism in the African-American populationKevin G Broadbelt
Department of Pathology, Enders Building Room 1111, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Pediatr Res 66:631-5. 2009..128-(191_192)dupA). The polymorphism seems to be a common, likely nonpathogenic, variant in the African-American population...
- Neuroanatomic relationships between the GABAergic and serotonergic systems in the developing human medullaKevin G Broadbelt
Department of Pathology, Children s Hospital Boston, Boston, MA 02115, USA
Auton Neurosci 154:30-41. 2010..The developmental profile of GABAergic markers changed dramatically relative to the 5-HT markers. These data provide baseline information for medullary studies of human pediatric disorders, such as sudden infant death syndrome...
- Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndromeKevin G Broadbelt
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
J Neuropathol Exp Neurol 70:799-810. 2011..026). These data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems...
- Lack of association of the serotonin transporter polymorphism with the sudden infant death syndrome in the San Diego DatasetDavid S Paterson
Department of Pathology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Res 68:409-13. 2010..These observations do not support previous findings that the L allele and/or LL genotype of the 5-HTTLPR are associated with SIDS...
- Late development of the GABAergic system in the human cerebral cortex and white matterGang Xu
Department of Pathology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Neuropathol Exp Neurol 70:841-58. 2011..This period corresponds to the peak window of vulnerability to perinatal hypoxia-ischemia in which GABAergic neurons are potentially developmentally susceptible, including in the preterm infant...
- Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infantsBradley B Randall
Department of Pathology, Enders Building Room 1112, Boston Children s Hospital, 61 Binney St, Boston, MA 02115
Pediatrics 132:e1616-25. 2013..g., supine), whereas infants with intermediate or borderline brainstem deficiencies require asphyxial stressors to precipitate death...
- The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasisHannah C Kinney
Department of Pathology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, United States
J Chem Neuroanat 41:182-99. 2011..The delineation of the development and organization of the human caudal 5-HT system provides the critical foundation for the neuropathologic elucidation of its disorders directly in the human brain...