Manfred Brigl

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens
    Manfred Brigl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Semin Immunol 22:79-86. 2010
  2. ncbi request reprint CD1: antigen presentation and T cell function
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 22:817-90. 2004
  3. pmc Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection
    Manfred Brigl
    Department of Pathology, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:1163-77. 2011
  4. pmc NK T cells provide lipid antigen-specific cognate help for B cells
    Elizabeth A Leadbetter
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8339-44. 2008
  5. ncbi request reprint GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
  6. pmc Rapid and reliable generation of invariant natural killer T-cell lines in vitro
    Asako Chiba
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 128:324-33. 2009
  7. pmc Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
    Patrick J Brennan
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:1202-11. 2011
  8. ncbi request reprint Apolipoprotein-mediated pathways of lipid antigen presentation
    Peter van den Elzen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 437:906-10. 2005
  9. pmc Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs
    Raju V V Tatituri
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1827-32. 2013
  10. pmc Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:90-9. 2013

Collaborators

Detail Information

Publications16

  1. doi request reprint How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens
    Manfred Brigl
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Semin Immunol 22:79-86. 2010
    ..The different pathways of activation endow iNKT cells with the ability to respond rapidly to a wide variety of infectious agents and to contribute effectively to the early immune response during infection...
  2. ncbi request reprint CD1: antigen presentation and T cell function
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 22:817-90. 2004
    ..This review describes the function of CD1-restricted T cells in antimicrobial responses, antitumor immunity, and in regulating the balance between tolerance and autoimmunity...
  3. pmc Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection
    Manfred Brigl
    Department of Pathology, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 208:1163-77. 2011
    ..These findings reveal that innate and cytokine-driven signals, rather than cognate microbial antigen, dominate in iNKT cell activation during microbial infections...
  4. pmc NK T cells provide lipid antigen-specific cognate help for B cells
    Elizabeth A Leadbetter
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8339-44. 2008
    ....
  5. ncbi request reprint GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  6. pmc Rapid and reliable generation of invariant natural killer T-cell lines in vitro
    Asako Chiba
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunology 128:324-33. 2009
    ..Given the desire to study primary iNKT cells for many purposes, these iNKT cell lines should provide an important tool for the study of iNKT cell subsets, antigen and TCR specificity, activation, inactivation and effector functions...
  7. pmc Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
    Patrick J Brennan
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:1202-11. 2011
    ..Thus, we propose that recognition of β-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation...
  8. ncbi request reprint Apolipoprotein-mediated pathways of lipid antigen presentation
    Peter van den Elzen
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 437:906-10. 2005
    ..Thus, the immune system has co-opted a component of lipid metabolism to develop immunological responses to lipid antigens...
  9. pmc Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs
    Raju V V Tatituri
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:1827-32. 2013
    ....
  10. pmc Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 14:90-9. 2013
    ..Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes...
  11. ncbi request reprint CD1 assembly and the formation of CD1-antigen complexes
    David L Hava
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Curr Opin Immunol 17:88-94. 2005
    ....
  12. doi request reprint Innate recognition of cell wall β-glucans drives invariant natural killer T cell responses against fungi
    Nadia R Cohen
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Host Microbe 10:437-50. 2011
    ..Innate recognition of β-1,3 glucans also drives iNKT cell responses against Candida, Histoplasma, and Alternaria, suggesting that this mechanism may broadly define the basis for antifungal iNKT cell responses...
  13. pmc CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium
    Lynn Bry
    4226 EBRC, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Infect Immun 74:673-81. 2006
    ..These findings have important implications for understanding the role of T-helper-cell responses during infections involving mucosal surfaces...
  14. doi request reprint Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions
    Patrick J Brennan
    Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 13:101-17. 2013
    ....
  15. ncbi request reprint Mechanism of CD1d-restricted natural killer T cell activation during microbial infection
    Manfred Brigl
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1230-7. 2003
    ..We propose this mechanism of activation as a major pathway responsible for the rapid activation of NKT cells in different microbial infections...
  16. ncbi request reprint Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors
    Manfred Brigl
    Department of Medical Microbiology and Immunology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706, USA
    J Immunol 176:3625-34. 2006
    ....