C Brander

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level
    Xu G Yu
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
    AIDS 19:1449-56. 2005
  2. pmc Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction
    Diana M Brainard
    Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:8439-50. 2007
  3. pmc HLA class I supertypes: a revised and updated classification
    John Sidney
    Division of Vaccine Discovery, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    BMC Immunol 9:1. 2008
  4. ncbi request reprint T lymphocyte responses in HIV-1 infection: implications for vaccine development
    C Brander
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, 5th Floor, 149 13th Street, Charlestown, MA 02129, USA
    Curr Opin Immunol 11:451-9. 1999
  5. ncbi request reprint Early and late cytotoxic T lymphocyte responses in HIV infection
    Christian Brander
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    AIDS 16:S97-103. 2002
  6. pmc Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences
    C Brander
    AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:10191-8. 1999
  7. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
  8. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
  9. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
  10. pmc Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 193:169-80. 2001

Detail Information

Publications80

  1. ncbi request reprint High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level
    Xu G Yu
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, 149 13th Street, Boston, MA 02129, USA
    AIDS 19:1449-56. 2005
    ....
  2. pmc Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction
    Diana M Brainard
    Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Virol 81:8439-50. 2007
    ..These data suggest that both CXCR3(+) CD8 T cells and LN CXCR3 ligands decrease as HIV infection progresses, resulting in reduced homing of CTL into LNs and contributing to immune dysfunction...
  3. pmc HLA class I supertypes: a revised and updated classification
    John Sidney
    Division of Vaccine Discovery, The La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    BMC Immunol 9:1. 2008
    ..The utility of this original supertype classification, as well several other subsequent arrangements derived by others, has been demonstrated in a large number of epitope identification studies...
  4. ncbi request reprint T lymphocyte responses in HIV-1 infection: implications for vaccine development
    C Brander
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, MGH East, 5th Floor, 149 13th Street, Charlestown, MA 02129, USA
    Curr Opin Immunol 11:451-9. 1999
    ..Together, these new data provide important insights to refocus efforts aimed at immunotherapeutic interventions and vaccine development...
  5. ncbi request reprint Early and late cytotoxic T lymphocyte responses in HIV infection
    Christian Brander
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    AIDS 16:S97-103. 2002
  6. pmc Efficient processing of the immunodominant, HLA-A*0201-restricted human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitope despite multiple variations in the epitope flanking sequences
    C Brander
    AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 73:10191-8. 1999
    ..These data suggest that escape from this immunodominant CTL response is not frequently accomplished by changes in the epitope flanking sequences...
  7. pmc Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 193:181-94. 2001
    ..This finding is an important consideration in vaccine design and in the evaluation of vaccine candidates...
  8. pmc Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Exp Med 192:1819-32. 2000
    ..These data together show that functionally inert CTLs do not play a significant role in chronic pediatric or adult HIV infection...
  9. pmc Differential narrow focusing of immunodominant human immunodeficiency virus gag-specific cytotoxic T-lymphocyte responses in infected African and caucasoid adults and children
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Virol 74:5679-90. 2000
    ..The fine focusing of dominant CTL responses to these few regions of high immunogenicity is of significance to vaccine design...
  10. pmc Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 193:169-80. 2001
    ..These data also provide rationale for therapeutic immunization aimed at broadening CTL responses in treated primary HIV infection...
  11. pmc The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals
    M M Addo
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 98:1781-6. 2001
    ..Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines...
  12. ncbi request reprint Evolution and transmission of stable CTL escape mutations in HIV infection
    P J Goulder
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 412:334-8. 2001
    ..These data suggest that CTL escape mutations in epitopes associated with suppression of viraemia will accumulate as the epidemic progresses, and therefore have important implications for vaccine design...
  13. ncbi request reprint Vpr is preferentially targeted by CTL during HIV-1 infection
    M Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    J Immunol 167:2743-52. 2001
    ..These findings will be important in evaluating the specificity and breadth of immune responses during acute and chronic infection, and in the design and testing of candidate HIV vaccines...
  14. doi request reprint Expansion of interferon-γ-secreting HIV-specific T cells during successful antiretroviral therapy
    O Gasser
    Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA
    HIV Med 14:241-6. 2013
    ..Accordingly, selected HIV-specific T-cell responses have been described to contract within weeks of ART initiation. Here, we sought to investigate whether these findings apply to the entire repertoire of HIV-specific T cells...
  15. pmc Treatment-dependent loss of polyfunctional CD8+ T-cell responses in HIV-infected kidney transplant recipients is associated with herpesvirus reactivation
    O Gasser
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Am J Transplant 9:794-803. 2009
    ..Long-term studies will be needed to assess the clinical risk associated with thymoglobulin treatment, in particular with regards to EBV-associated lymphoproliferative diseases...
  16. pmc Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities
    Nicole Frahm
    Partners AIDS Research Center, Endocrine Unit, Massachusetts General Hospital, Charlestown, Massachusetts 02129 2000, USA
    J Virol 78:2187-200. 2004
    ..The present study thus identifies factors that contribute to the immunogenicity of these highly targeted and relatively conserved sequences in HIV that may represent promising vaccine candidates for ethnically heterogeneous populations...
  17. ncbi request reprint Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein
    C Brander
    AIDS Research Center and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Infect Dis 184:119-26. 2001
    ..The optimal CTL epitope was identified by HLA restriction analysis and peptide titration assays. These data describe a latent phase viral gene product targeted by CTL that may be relevant for KSHV immunopathogenesis...
  18. pmc Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif
    M A Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Virol 75:1301-11. 2001
    ....
  19. ncbi request reprint Inhibition of human NK cell-mediated cytotoxicity by exposure to ammonium chloride
    C Brander
    AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol Methods 252:1-14. 2001
    ..Therefore, AC represents a powerful tool to study different mechanisms of cell-mediated cytotoxicity and may be helpful in assessing antigen-specific CTL cytotoxicity without the influence of NK cell-mediated background killing...
  20. pmc Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones
    P J Norris
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 75:9771-9. 2001
    ..These data indicate that T helper cells can target multiple regions of the p24 Gag protein and suggest that cytolytic activity may be a component of the antiviral effect of these cells...
  21. pmc Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load
    M M Addo
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School Fenway Community Health Center Lemuel Shattuck Hospital, Boston, Massachusetts 02129, USA
    J Virol 77:2081-92. 2003
    ....
  22. ncbi request reprint Characterization of full-length hepatitis C virus genotype 4 sequences
    J Timm
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA
    J Viral Hepat 14:330-7. 2007
    ..Here we describe seven unique HCV genotype 4a full genomes, in addition to a single genotype 4d genome, and characterize their sequence diversity in relation to other more closely characterized HCV genotypes...
  23. ncbi request reprint Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 7:173-8. 2006
    ..These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations...
  24. pmc Expansion of HIV-specific CD4+ and CD8+ T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef
    Daniel G Kavanagh
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, 149 13 St, Charlestown, MA 02129, USA
    Blood 107:1963-9. 2006
    ..Thus human dendritic cells transfected with mRNA encoding lysosome-targeted HIV antigen can expand a broad, polyclonal repertoire of antiviral T cells, offering a promising approach to HIV immunotherapy...
  25. pmc Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, and Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Virol 79:13239-49. 2005
    ..The stereotypic nature of acquired mutations provides support for biochemical constraints limiting HIV-1 evolution and for the impact of CD8 escape mutations on viral fitness...
  26. pmc The leukotriene B4 lipid chemoattractant receptor BLT1 defines antigen-primed T cells in humans
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 107:444-53. 2006
    ..Our studies provide novel insights into the LTB(4)-BLT1 lipid chemoattractant pathway in human T-cell responses, and how it may link innate and adaptive immunity...
  27. ncbi request reprint Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses
    Danni Ramduth
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa
    J Infect Dis 192:1588-96. 2005
    ..The relative immunogenicity of human immunodeficiency virus type 1 (HIV-1) proteins for CD8+ and CD4+ cell responses has not been defined...
  28. ncbi request reprint Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection
    Tonia Woodberry
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Infect Dis 192:1513-24. 2005
    ..These data provide an assessment of immunodominance patterns and guidance for developing immunotherapeutic interventions for EBV-associated disorders...
  29. ncbi request reprint Increased sequence diversity coverage improves detection of HIV-specific T cell responses
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 179:6638-50. 2007
    ..Toggled peptides therefore afford a cost-effective and significantly more complete view of the host immune response to HIV and are directly applicable to other variable pathogens...
  30. pmc Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control
    Rosario Zuniga
    Asociacion Civil Impacta Salud y Educacion, Lima, Peru
    J Virol 80:3122-5. 2006
    ..Analyses in a second cohort in the United States confirm these findings and point towards a dominant role of Gag-specific immunity in effective control of HIV infection, providing important guidance for HIV vaccine development...
  31. ncbi request reprint Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses
    Florian Bihl
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, 02129, USA
    J Immunol 176:4094-101. 2006
    ..The data support the important role of HLA-B alleles in antiviral immunity and afford a better understanding of the factors contributing to inter- and intraindividual immunodominance...
  32. ncbi request reprint HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Virology 353:366-73. 2006
    ..These results indicate impaired HIV-specific memory CD8 T cell differentiation, regardless of level of control of viremia, epitopes targeted or restricting HLA alleles...
  33. ncbi request reprint Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
    Alasdair Leslie
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Immunol 177:4699-708. 2006
    ..These findings are of relevance to vaccine approaches that seek to exploit HLA supertypes to overcome the problem of HLA diversity...
  34. pmc Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes
    Xu G Yu
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th Street, Room 5212, Charlestown, MA 02129, USA
    J Virol 81:1619-31. 2007
    ..These data show the influence of HLA allele subtypes on TCR selection and indicate that extensive TCR diversity is not a prerequisite to prevention of allowable viral mutations...
  35. pmc Availability of a diversely avid CD8+ T cell repertoire specific for the subdominant HLA-A2-restricted HIV-1 Gag p2419-27 epitope
    Keri L Schaubert
    Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Immunol 178:7756-66. 2007
    ....
  36. pmc Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication
    Arne Schneidewind
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Virol 81:12382-93. 2007
    ....
  37. doi request reprint Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection
    Zabrina L Brumme
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, Harvard Medical School, Massachusetts 02129, USA
    AIDS 22:1277-86. 2008
    ..Here we undertake a population-based identification of HLA-associated polymorphisms in Gag and investigate their relationship with plasma viral load...
  38. pmc Immune-driven recombination and loss of control after HIV superinfection
    Hendrik Streeck
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:1789-96. 2008
    ..These data also support a role for cellular immune pressures in driving the selection of new recombinant forms of HIV...
  39. pmc HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts
    Olivier Gasser
    Immunobiology Laboratory, Department of Research, University Hospital Basel, Basel, Switzerland
    PLoS Med 4:e96. 2007
    ....
  40. ncbi request reprint Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population
    Tonia Woodberry
    Partners AIDS Research Center, Massachusetts General Hospital, Boston 02129, USA
    J Immunol 175:4355-62. 2005
    ....
  41. pmc Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection
    Todd M Allen
    Howard Hughes Medical Institute, Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
    J Virol 78:7069-78. 2004
    ..Moreover, reversion of these mutations in the absence of the original immune pressure reveals the potential plasticity of immunologically selected evolutionary changes...
  42. ncbi request reprint Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responses
    Rika Draenert
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Immunol Methods 275:19-29. 2003
    ..We conclude that peptides ranging from 15 to 20 amino acids yield similar results in IFN-gamma-based Elispot and ICS assays, and that all are likely to underestimate the true breadth of responses to a given reference strain of virus...
  43. ncbi request reprint Clonotype tracking of TCR repertoires during chronic virus infections
    George B Cohen
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    Virology 304:474-84. 2002
    ....
  44. pmc De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection
    Todd M Allen
    Partners AIDS Research Center, Massachusetts General Hospital, Boston, 02129, USA
    J Virol 79:12952-60. 2005
    ....
  45. pmc Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides
    Daniel E Kaufmann
    Partners AIDS Research Center and Infectious Disease Unit, Howard Hughes Medical Institute, Massachusetts General Hospital, and Division of AIDS, Boston, Massachusetts 02114, USA
    J Virol 78:4463-77. 2004
    ..These findings have implications for the design of immunotherapeutic strategies and for testing candidate HIV vaccines...
  46. ncbi request reprint HIV-1 over time: fitness loss or robustness gain?
    Morgane Rolland
    Nat Rev Microbiol 5:C1. 2007
  47. ncbi request reprint A quantitative analysis of the variables affecting the repertoire of T cell specificities recognized after vaccinia virus infection
    Erika Assarsson
    Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
    J Immunol 178:7890-901. 2007
    ..This suggested that additional factors, including immunoregulatory mechanisms, restrict the repertoire of T cell specificities after vaccinia infection by a factor of at least 10...
  48. pmc Enhanced detection of human immunodeficiency virus type 1-specific T-cell responses to highly variable regions by using peptides based on autologous virus sequences
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital, and Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 77:7330-40. 2003
    ..They also demonstrate that CD8 T-cell responses to the variable HIV-1 proteins are more common than previously reported...
  49. pmc Extensive HLA class I allele promiscuity among viral CTL epitopes
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Immunol 37:2419-33. 2007
    ..These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development...
  50. ncbi request reprint Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma
    Florian Bihl
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, 13th Street, Charlestown, MA 02129, USA
    AIDS 21:1245-52. 2007
    ..Whereas the positive effects of HAART on the regression of KS have been well established, less is known about the role of herpesvirus-specific cellular immunity in disease improvement...
  51. ncbi request reprint IL-8 responsiveness defines a subset of CD8 T cells poised to kill
    Christoph Hess
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Blood 104:3463-71. 2004
    ..Thus, CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation...
  52. pmc Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Galit Alter
    Partners AIDS Research Center and Infectious Disease Unit, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 204:3027-36. 2007
    ..These data provide the first functional evidence that variation at the KIR locus influences the effectiveness of NK cell activity in the containment of viral replication...
  53. ncbi request reprint Important contribution of p15 Gag-specific responses to the total Gag-specific CTL responses
    Xu G Yu
    Partners AIDS Research Center, Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    AIDS 16:321-8. 2002
    ..However, the extent to which p15 Gag is targeted by the host immune system in natural infection as well as precise cytotoxic T lymphocyte (CTL) epitopes within this protein remains to be defined...
  54. ncbi request reprint Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma
    Christian Brander
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Blood 100:698-700. 2002
    ..These data therefore do not show a biologically important association between ongoing KSHV infection and MM...
  55. ncbi request reprint Cytotoxic HIV-1 p55gag-specific CD4+ T cells produce HIV-inhibitory cytokines and chemokines
    Barbara Lotti
    Clinic for Rheumatology and Clinical Immunology Allergology, University Hospital Bern, Switzerland
    J Clin Immunol 22:253-62. 2002
    ..These diverse functional features of HIV-specific CD4+ T cells suggest that they may exert direct antiviral activity...
  56. pmc Central role of reverting mutations in HLA associations with human immunodeficiency virus set point
    Philippa C Matthews
    Department of Paediatrics, Peter Medawar Building for Pathogen Research, United Kingdom
    J Virol 82:8548-59. 2008
    ..The significance of these results is in highlighting the rationale for an HIV vaccine that can induce these broad responses...
  57. ncbi request reprint HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nature 420:434-9. 2002
    ..The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development...
  58. pmc HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 82:6434-46. 2008
    ....
  59. pmc Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity
    Aviva Joseph
    Albert Einstein College of Medicine, Forchheimer Building, Room 408, 1300 Morris Park Ave, Bronx, NY 10461, USA
    J Virol 82:3078-89. 2008
    ....
  60. pmc Increased cytotoxic T-lymphocyte epitope variant cross-recognition and functional avidity are associated with hepatitis C virus clearance
    Daniel Yerly
    Massachusetts General Hospital and Harvard Medical School, Partners AIDS Research Center, MGH East no 5239, 149 13th St, Charlestown, MA 02143, USA
    J Virol 82:3147-53. 2008
    ..These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo...
  61. pmc Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection
    Hayley Crawford
    Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd, Oxford OX1 3SY, United Kingdom
    J Virol 81:8346-51. 2007
    ..These data may help explain the observed association between HLA-B*5703 and long-term control of viremia...
  62. ncbi request reprint Gradual adaptation of HIV to human host populations: good or bad news?
    Christian Brander
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Med 9:1359-62. 2003
    ..Here we discuss some potential scenarios of viral and host coevolution...
  63. ncbi request reprint Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels
    Rika Draenert
    Howard Hughes Medical Institute and Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School Division of AIDS, Boston, MA, USA
    AIDS 18:871-6. 2004
    ..The effect of epitope location within such peptides is not known but may influence recognition...
  64. ncbi request reprint Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins
    Tonia Woodberry
    Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Infect Dis 192:622-9. 2005
    ..These data have implications for the reliable identification of KSHV infection and may help guide the design of immune-based therapeutic and prophylactic interventions...
  65. pmc The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design
    Marcus Altfeld
    Partners AIDS Research Center, Massachusetts General Hospital, 149 13th St, Boston, MA 02129, USA
    J Virol 79:5000-5. 2005
    ....
  66. ncbi request reprint Discovery and characterization of highly immunogenic and broadly recognized mimics of the HIV-1 CTL epitope Gag77-85
    Cesar Boggiano
    Torrey Pines Institute for Molecular Studies, San Diego, USA
    Eur J Immunol 35:1428-37. 2005
    ..This approach may lead to vaccine candidates with higher in vivo immunogenicity and increased potential for cross-recognition of naturally occurring SL9 variants...
  67. pmc Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA
    Alasdair Leslie
    Peter Medawar Building, University of Oxford, Oxford OX13SY, UK
    J Exp Med 201:891-902. 2005
    ..These data help to explain how HIV is evolving at a population level. Understanding the direction of HIV evolution has important implications for vaccine development...
  68. ncbi request reprint Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA
    Photini Kiepiela
    HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZuluNatal, 719 Umbilo Road, Durban 4015, South Africa
    Nature 432:769-75. 2004
    ..The dominant involvement of HLA-B in influencing HIV disease outcome is of specific relevance to the direction of HIV research and to vaccine design...
  69. ncbi request reprint Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II
    Devi SenGupta
    Partners AIDS Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 173:1987-93. 2004
    ....
  70. pmc Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1
    Javier Martinez-Picado
    IrsiCaixa Foundation, University Hospital Germans Trias i Pujol, Barcelona, Spain
    J Virol 80:3617-23. 2006
    ....
  71. ncbi request reprint Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa
    Isobella Honeyborne
    Department of Paediatrics, Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    J Immunol 176:4699-705. 2006
    ..These data indicate that the previously anomalous position of HLA-A*2902 among HLA-A alleles, outside any recognized HLA-A supertype, is artifactual, and the true position of the A*2902 motif overlaps those of the A1 and A24 supertypes...
  72. ncbi request reprint T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily
    Mathias Lichterfeld
    Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, MA, USA
    Int Immunol 18:1179-88. 2006
    ..Thus, despite distinct TCR recognition of HLA-A3 or HLA-A11 presented HIV-1 peptides in the vast majority of cases, specific TCRs can cross-recognize their antigen in the context of both HLA-A3 and HLA-A11...
  73. ncbi request reprint The challenges of host and viral diversity in HIV vaccine design
    Christian Brander
    Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School Charlestown, 02192, USA
    Curr Opin Immunol 18:430-7. 2006
    ....
  74. pmc Fine specificity and cross-clade reactivity of HIV type 1 Gag-specific CD4+ T cells
    Philip J Norris
    Partners AIDS Research Center and Infectious Disease Unit, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    AIDS Res Hum Retroviruses 20:315-25. 2004
    ..Abrogated recognition of variant CD4(+) T cell epitopes presents a potential obstacle to vaccine development...
  75. pmc Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection
    Rika Draenert
    Howard Hughes Medical Institute, Charlestown, MA 02129, USA
    J Exp Med 199:905-15. 2004
    ..These results demonstrate that allele-associated sequence variation within the flanking region of CTL epitopes can alter antigen processing. Identifying such mutations is of major relevance in the construction of vaccine sequences...
  76. ncbi request reprint CD8+ T-cell responses to different HIV proteins have discordant associations with viral load
    Photini Kiepiela
    HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban 4013, South Africa
    Nat Med 13:46-53. 2007
    ..These population-based data, suggesting the existence of both effective immune responses and responses lacking demonstrable biological impact in chronic HIV infection, are of relevance to HIV vaccine design and evaluation...
  77. pmc Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections
    Christine M Rousseau
    Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 81:4492-500. 2007
    ..Thus, intrasubtype recombinants are common within the subtype C epidemic and these impact analyses of HIV-1 evolution...
  78. pmc Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes
    Florian Bihl
    Partners AIDS Research Center, Massachusetts General Hospital East, 149 13th Street, Charlestown, MA 02129 2000, USA
    J Virol 81:4904-8. 2007
    ....
  79. ncbi request reprint Founder effects in the assessment of HIV polymorphisms and HLA allele associations
    Tanmoy Bhattacharya
    Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Science 315:1583-6. 2007
    ..This approach has practical implications for understanding the impact of host immunity on pathogen evolution and for defining relevant variants for inclusion in vaccine antigens...
  80. pmc HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load
    Nicole Frahm
    Partners AIDS Research Center, Massachusetts General Hospital, No 5214, 149 13th Street, Charlestown, MA 02129, USA
    J Virol 79:10218-25. 2005
    ..The data support an important role of the presented epitope in mediating relative control of HIV replication and help to better define immune correlates of controlled HIV infection...