D Cristopher Bragg
Affiliation: Harvard University
- Molecular pathways in dystoniaD Cristopher Bragg
Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
Neurobiol Dis 42:136-47. 2011..This review focuses on these molecular pathways, highlighting potential common themes among these dystonias which may serve as areas for future research. This article is part of a Special Issue entitled "Advances in dystonia"...
- Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinAD Cristopher Bragg
Departments of Neurology and Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
Mol Cell Neurosci 27:417-26. 2004..These results thus indicate that torsinADeltaE must achieve a specific conformation to induce formation of intracellular membrane inclusions...
- Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domainCem Sengel
Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurochem 118:1087-100. 2011..These observations offer additional insight into the role of the coiled-coil domain in THAP1, which may facilitate future analyses of DYT6 mutations in this region...
- TorsinA and early-onset torsion dystoniaD Cristopher Bragg
Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
Adv Neurol 94:87-93. 2004
- Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutationNutan Sharma
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 25:5351-5. 2005..Together, these data suggest that these transgenic mice provide a useful model of the DeltaGAG carrier state that can be used to probe genetic and environmental factors that can trigger the dystonic state...
- Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamicsJeffrey W Hewett
Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
Neurobiol Dis 22:98-111. 2006....
- Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5Lianna R Orlando
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA
J Neurochem 110:557-69. 2009..Phosphorylation of the mGluR homer-binding domain, in contrast to homer 1a induction, provides a novel mechanism for potentially regulating a subset of homer interactions...
- Update on treatments for dystoniaD Cristopher Bragg
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Curr Neurol Neurosci Rep 14:454. 2014..We will also review the current treatment approaches and suggest ways in which these therapies can be applied to individuals with dystonia. ..