D Cristopher Bragg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Molecular pathways in dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Neurobiol Dis 42:136-47. 2011
  2. ncbi request reprint Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA
    D Cristopher Bragg
    Departments of Neurology and Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell Neurosci 27:417-26. 2004
  3. pmc Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain
    Cem Sengel
    Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 118:1087-100. 2011
  4. ncbi request reprint TorsinA and early-onset torsion dystonia
    D Cristopher Bragg
    Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
    Adv Neurol 94:87-93. 2004
  5. ncbi request reprint Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation
    Nutan Sharma
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:5351-5. 2005
  6. ncbi request reprint Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
    Jeffrey W Hewett
    Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neurobiol Dis 22:98-111. 2006
  7. doi request reprint Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5
    Lianna R Orlando
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA
    J Neurochem 110:557-69. 2009
  8. ncbi request reprint Update on treatments for dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Curr Neurol Neurosci Rep 14:454. 2014

Collaborators

Detail Information

Publications9

  1. pmc Molecular pathways in dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Neurobiol Dis 42:136-47. 2011
    ..This review focuses on these molecular pathways, highlighting potential common themes among these dystonias which may serve as areas for future research. This article is part of a Special Issue entitled "Advances in dystonia"...
  2. ncbi request reprint Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA
    D Cristopher Bragg
    Departments of Neurology and Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell Neurosci 27:417-26. 2004
    ..These results thus indicate that torsinADeltaE must achieve a specific conformation to induce formation of intracellular membrane inclusions...
  3. pmc Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain
    Cem Sengel
    Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 118:1087-100. 2011
    ..These observations offer additional insight into the role of the coiled-coil domain in THAP1, which may facilitate future analyses of DYT6 mutations in this region...
  4. ncbi request reprint TorsinA and early-onset torsion dystonia
    D Cristopher Bragg
    Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
    Adv Neurol 94:87-93. 2004
  5. ncbi request reprint Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation
    Nutan Sharma
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:5351-5. 2005
    ..Together, these data suggest that these transgenic mice provide a useful model of the DeltaGAG carrier state that can be used to probe genetic and environmental factors that can trigger the dystonic state...
  6. ncbi request reprint Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
    Jeffrey W Hewett
    Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neurobiol Dis 22:98-111. 2006
    ....
  7. doi request reprint Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5
    Lianna R Orlando
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA
    J Neurochem 110:557-69. 2009
    ..Phosphorylation of the mGluR homer-binding domain, in contrast to homer 1a induction, provides a novel mechanism for potentially regulating a subset of homer interactions...
  8. ncbi request reprint Update on treatments for dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Curr Neurol Neurosci Rep 14:454. 2014
    ..We will also review the current treatment approaches and suggest ways in which these therapies can be applied to individuals with dystonia. ..