D Cristopher Bragg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Molecular pathways in dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Neurobiol Dis 42:136-47. 2011
  2. ncbi Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA
    D Cristopher Bragg
    Departments of Neurology and Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell Neurosci 27:417-26. 2004
  3. pmc Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain
    Cem Sengel
    Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 118:1087-100. 2011
  4. ncbi Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
    Jeffrey W Hewett
    Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neurobiol Dis 22:98-111. 2006
  5. ncbi TorsinA and early-onset torsion dystonia
    D Cristopher Bragg
    Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
    Adv Neurol 94:87-93. 2004
  6. ncbi Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation
    Nutan Sharma
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:5351-5. 2005
  7. doi Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5
    Lianna R Orlando
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA
    J Neurochem 110:557-69. 2009
  8. pmc Update on treatments for dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Curr Neurol Neurosci Rep 14:454. 2014

Collaborators

Detail Information

Publications9

  1. pmc Molecular pathways in dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA
    Neurobiol Dis 42:136-47. 2011
    ..This review focuses on these molecular pathways, highlighting potential common themes among these dystonias which may serve as areas for future research. This article is part of a Special Issue entitled "Advances in dystonia"...
  2. ncbi Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA
    D Cristopher Bragg
    Departments of Neurology and Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Cell Neurosci 27:417-26. 2004
    ..These results thus indicate that torsinADeltaE must achieve a specific conformation to induce formation of intracellular membrane inclusions...
  3. pmc Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain
    Cem Sengel
    Neuroscience Center, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 118:1087-100. 2011
    ..These observations offer additional insight into the role of the coiled-coil domain in THAP1, which may facilitate future analyses of DYT6 mutations in this region...
  4. ncbi Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics
    Jeffrey W Hewett
    Molecular Neurogenetics Unit, Departments of Neurology and Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Neurobiol Dis 22:98-111. 2006
    ....
  5. ncbi TorsinA and early-onset torsion dystonia
    D Cristopher Bragg
    Molecular Neurogenetics Unit, Department of Neurology, Massachusetts General Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, USA
    Adv Neurol 94:87-93. 2004
  6. ncbi Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation
    Nutan Sharma
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:5351-5. 2005
    ..Together, these data suggest that these transgenic mice provide a useful model of the DeltaGAG carrier state that can be used to probe genetic and environmental factors that can trigger the dystonic state...
  7. doi Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5
    Lianna R Orlando
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, 02129, USA
    J Neurochem 110:557-69. 2009
    ..Phosphorylation of the mGluR homer-binding domain, in contrast to homer 1a induction, provides a novel mechanism for potentially regulating a subset of homer interactions...
  8. pmc Update on treatments for dystonia
    D Cristopher Bragg
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Curr Neurol Neurosci Rep 14:454. 2014
    ..We will also review the current treatment approaches and suggest ways in which these therapies can be applied to individuals with dystonia. ..