Research Topics
| Joshua BoyceSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Publications
Advances in mechanisms of asthma, allergy, and immunology in 2011Joshua A Boyce
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Allergy Clin Immunol 129:335-41. 2012..Finally, new therapeutic applications of anti-IgE were identified. The highlights of these studies and their potential clinical implications are summarized in this review...
T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4F H Hsieh
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
J Exp Med 193:123-33. 2001....
The role of mast cells in asthmaJoshua A Boyce
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, USA
Prostaglandins Leukot Essent Fatty Acids 69:195-205. 2003....- Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulationJoshua A Boyce
Department of Pediatrics, Harvard Medical School, Boston, MA, USA
Immunol Rev 217:168-85. 2007..This review focuses on the biologic functions for MC-associated eicosanoids, the regulation of their production, and the mechanisms by which eicosanoids may regulate MC function in host defense and disease... - No audible wheezing: nuggets and conundrums from mouse asthma modelsJoshua A Boyce
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 201:1869-73. 2005..We suggest that these discordances, reflecting methodological and genetic differences, may be informative for understanding heterogeneity of human asthma... - Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgEJoshua A Boyce
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 117:1415-8. 2006..These findings should prompt a reexamination of the potential pathogenetic role played by IgE and its high-affinity receptor on mast cells in idiopathic cold urticaria... - Eicosanoid mediators of mast cells: receptors, regulation of synthesis, and pathobiologic implicationsJoshua A Boyce
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Chem Immunol Allergy 87:59-79. 2005.... - Eicosanoids in asthma, allergic inflammation, and host defenseJoshua A Boyce
Department of Pediatrics and Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Curr Mol Med 8:335-49. 2008..This review summarizes these findings and reviews the data from both mouse and human studies pertinent to the pathobiologic role of each mediator... - Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonistsElizabeth A Mellor
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
J Exp Med 195:583-92. 2002.... - P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cellsYongfeng Jiang
Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
J Immunol 182:1129-37. 2009..Thus, CysLT1R and P2Y6 receptors, which are coexpressed on many cell types of innate immunity, reciprocally amplify one another's function in mast cells through endogenous ligands... - FcepsilonRI-dependent gene expression in human mast cells is differentially controlled by T helper type 2 cytokinesJose M Lora
Department of Immunobiology and Inflammation, Cambridge, MA, USA
J Allergy Clin Immunol 112:1119-26. 2003..Mast cells (MCs) proliferate in response to T(H)2 cytokines and express genes de novo after activation. Limited information is available concerning the interplay between these events... - CysLT2 receptors interact with CysLT1 receptors and down-modulate cysteinyl leukotriene dependent mitogenic responses of mast cellsYongfeng Jiang
Department of Medicine, Harvard Medical School, Boston, MA, USA
Blood 110:3263-70. 2007..Negative regulation of CysLT(1)-induced mitogenic signaling responses of MCs by CysLT(2) demonstrates physiologically relevant functions for GPCR heterodimers on primary cells central to inflammation... - Mast cells: ontogeny, homing, and recruitment of a unique innate effector cellMichael F Gurish
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, MA 02115 6007, USA
J Allergy Clin Immunol 117:1285-91. 2006..These findings in mice await confirmation in human subjects... - Cutting edge: Interleukin 4-dependent mast cell proliferation requires autocrine/intracrine cysteinyl leukotriene-induced signalingYongfeng Jiang
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 177:2755-9. 2006..Mouse MCs lacking LTC4S or CysLT1 showed substantially diminished IL-4-induced comitogenesis. Thus, IL-4 induces proliferation in part by inducing LTC4S and cys-LT generation, which causes CysLT1 to transactivate c-kit in RM... - Adenine nucleotides inhibit cytokine generation by human mast cells through a Gs-coupled receptorChunli Feng
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
J Immunol 173:7539-47. 2004.... - The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implicationsK Frank Austen
Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Allergy Clin Immunol 124:406-14; quiz 415-6. 2009..These findings prompt a renewed focus on LTE(4) receptors as therapeutic targets that are not currently addressed by available receptor antagonists... - Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptorSailaja Paruchuri
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 206:2543-55. 2009..Thus, the P2Y12 receptor is required for proinflammatory actions of the stable abundant mediator LTE4 and is a novel potential therapeutic target for asthma... - CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralisMichael F Gurish
Division of Rheumatology, Allergy and Immunology, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 168:5730-6. 2002..spiralis, and defines the essential requirement for CCR3 in eosinophil, but not MC recruitment to tissues... - The biology of the mast cellJoshua A Boyce
Division of Rheumatology, Immunology, and Allergy, Allergy and Inflammation Research, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Allergy Asthma Proc 25:27-30. 2004..This review focuses on the mechanisms of mast cell development, the cytokine control of this process, and the amplification of mast cell effector systems as an important determinant of disease... - Advances in mechanisms of asthma, allergy, and immunology in 2008Joshua A Boyce
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass, USA
J Allergy Clin Immunol 123:569-74. 2009..Articles from other journals have been included to supplement the topics presented... - Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cellsSailaja Paruchuri
Department of Medicine, Division of Rheumatology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 283:16477-87. 2008..This LTE(4)-selective receptor-mediated pathway may explain the unique physiologic responses of human airways to LTE(4) in vivo... - Biochemical and functional characterization of human transmembrane tryptase (TMT)/tryptase gamma. TMT is an exocytosed mast cell protease that induces airway hyperresponsiveness in vivo via an interleukin-13/interleukin-4 receptor alpha/signal transducer Guang W Wong
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 277:41906-15. 2002..Based on these data, we conclude that TMT is an exocytosed MC neutral protease that induces AHR in lungs primarily by activating an IL-13/IL-4Ralpha/STAT6-dependent pathway... - Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responsesYoshihide Kanaoka
Department of Medicine, Harvard University Medical School and Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston MA 02115, USA
J Immunol 173:1503-10. 2004.... - Mast cell growth, differentiation, and deathMichael F Gurish
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA
Clin Rev Allergy Immunol 22:107-18. 2002.... - Mast cells: beyond IgEJoshua A Boyce
Division of Rheumatology, Immunology, and Allergy, Harvard Medical School, Brigham and Women's Hospital, Boston 02199, USA
J Allergy Clin Immunol 111:24-32; quiz 33. 2003..Drug development must take these nonclassical mast cell activation pathways into account without compromising the beneficial and protective functions of mast cells... - CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13Kursteen S Price
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 28:420-7. 2003..Thus, hMCs may store CCR3 and rapidly mobilize it to their surface with IgE-dependent activation, providing a novel potential mechanism for enhanced hMC effector function, including IL-13 production... - Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1RElizabeth A Mellor
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, and Departments of Medicine and Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:11589-93. 2003.... - Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammationAnders Lundequist
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 184:433-41. 2010..Thus, mPGES-1 and its product, PGE(2), protect the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation, and these effects may be mediated by more than one EP receptor... - Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditionsJoshua A Boyce
Department of Medicine, Harvard Medical School, Boston, MA, USA
Blood 99:2890-6. 2002..These observations may explain the abundance of MCs at sites of mucosal inflammation, where VCAM-1 and E-selectin are important inducible receptors... - Human mast cells express multiple EP receptors for prostaglandin E2 that differentially modulate activation responsesChunli Feng
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
Blood 107:3243-50. 2006..These functions explain the potency of PGE2 as a suppressor of early- and late-phase allergic responses... - Asthma 2005-2006: bench to bedsideJoshua A Boyce
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 118:582-6. 2006..This review highlights some of the latest insights into the pathogenesis of asthma that might ultimately bear on the development or choice of treatment modalities... - Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lungJ Pablo Abonia
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith Building, Room 624, 1 Jimmy Fund Way, Boston, MA 02115, USA
Blood 108:1588-94. 2006..Furthermore, the MCp is currently unique among inflammatory cells in its partial dependence on alpha4beta7 integrins for lung recruitment... - The idiopathic hypereosinophilic syndromeDebby A Lin
Harvard Medical School, Departments of Medicine and Pediatrics, Brigham and Women's Hospital, Boston, Massachusetts, USA
Allergy Asthma Proc 24:417-20. 2003..The prognosis for patients with IHES has improved with targeted therapies and aggressive management of complications. We report a case of IHES and review the clinical features, evaluation, and options for treatment... - Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell functionGiorgio Giannattasio
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 185:4430-8. 2010..farinae, and whose function is also regulated by group V sPLA(2)... - Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromesJennifer K Garrett
Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA
J Allergy Clin Immunol 113:115-9. 2004..As such, anti-IL-5 may have significant therapeutic potential for hypereosinophilic syndromes... - Lysophosphatidic acid accelerates the development of human mast cellsSavita Bagga
Department of Medicine, Harvard Medical School, Boston, MA, USA
Blood 104:4080-7. 2004..LPA could facilitate MC hyperplasia in inflammation associated with either innate or adaptive immunity... - STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infectionMartin L Moore
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN37232, USA
J Immunol 183:2016-26. 2009..Basophils were the primary source of IL-4 in the lung in RSV infection, and STAT1 was a negative regulator of virus-induced basophil IL-4 expression... - IL-4 regulates MEK expression required for lysophosphatidic acid-mediated chemokine generation by human mast cellsDebby A Lin
Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
J Immunol 175:5430-8. 2005..Moreover, the regulation of MEK-dependent signaling is a mechanism by which IL-4 could amplify inflammation in mucosal immune responses through receptor systems for endogenous ligands such as LPA... - Coordinated involvement of mast cells and T cells in allergic mucosal inflammation: critical role of the CC chemokine ligand 1:CCR8 axisJose Angel Gonzalo
Department of Mucosal Immunology and Pharmacology, Millennium Pharmaceuticals, Inc, Cambridge, MA 02139, USA
J Immunol 179:1740-50. 2007..Thus, mast cell-derived CCL1- and CCR8-expressing CD4(+) effector T lymphocytes play an essential role in orchestrating lung mucosal inflammatory responses... - Mast cell biology in evolutionDean D Metcalfe
J Allergy Clin Immunol 117:1227-9. 2006
Research Grants
- Role of PGE2 in Human Mast Cell BiologyJoshua Boyce; Fiscal Year: 2007..abstract_text> ..
- CysLt and P2Y Receptors and Lung InflammationJoshua Boyce; Fiscal Year: 2007..abstract_text> ..
- CysLT and P2Y Receptors in Lung InflammationJoshua Boyce; Fiscal Year: 2009....
- CysLT and P2Y Receptors in Lung InflammationJoshua A Boyce; Fiscal Year: 2010....
- Regulation of Pulmonary Prostaglandins by Leukotriene E4Joshua A Boyce; Fiscal Year: 2010..The findings are expected to have immediate implications for asthma pathophysiology and treatment. ..
- The Role of Mast Cells in Lung InflammationJoshua Boyce; Fiscal Year: 2006..These studies, carried out in non-transformed hPrMC and hMC, have potential implications for the control of hMC distribution and effector function in asthma. ..
- CystLT and P2Y Receptors and Lung InflammationJoshua Boyce; Fiscal Year: 2006..Specific Aim 3 will explore the functional role of the GPCRs for cys-LT and UDP in mediating MC-dependent inflammatory responses in vivo using targeted deletion of their respective genes. ..
- CysLT and P2Y Receptors in Lung InflammationJoshua Boyce; Fiscal Year: 2009....