Mary L Bouxsein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fractures
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Osteoporos Int 13:358-65. 2002
  2. pmc Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 151:3502-13. 2010
  3. doi request reprint A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Bone 46:1082-8. 2010
  4. pmc Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:1923-9. 2013
  5. pmc Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 168:457-64. 2013
  6. doi request reprint High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties
    Samantha Pozzi
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Clin Cancer Res 15:5829-39. 2009
  7. pmc Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis
    Blaine A Christiansen
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Bone Miner Res 26:974-83. 2011
  8. pmc Variations of CT-based trunk muscle attenuation by age, sex, and specific muscle
    Dennis E Anderson
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, RN115, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 68:317-23. 2013
  9. pmc QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Bone Miner Res 27:654-63. 2012
  10. ncbi request reprint Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture
    Mary L Bouxsein
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Acad Orthop Surg 12:385-95. 2004

Detail Information

Publications90

  1. ncbi request reprint Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fractures
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Osteoporos Int 13:358-65. 2002
    ..Therefore, DXR-BMD may be useful for prediction of fracture risk in clinical settings where hip BMD is not available...
  2. pmc Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Endocrinology 151:3502-13. 2010
    ..Furthermore, PTH stimulated proliferation and increased mRNAs encoding cyclin D1 in primary osteoblasts derived from Wt but not from DSEL mice. Our data indicate that PLC signaling through the PTHR is required for skeletal homeostasis...
  3. doi request reprint A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Bone 46:1082-8. 2010
    ..Thus, soluble ActRIIA fusion protein may be useful in the prevention and/or treatment of osteoporosis and other diseases involving accelerated bone loss...
  4. pmc Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius
    Alexander T Faje
    Neuroendocrine Unit, Massachusetts General Hospital for Children, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 98:1923-9. 2013
    ..Because microarchitectural abnormalities and FEA may predict fracture risk independent of aBMD, these data are important to obtain...
  5. pmc Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters
    Elizabeth A Lawson
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 168:457-64. 2013
    ..We therefore investigated oxytocin secretion and its association with bone microarchitecture and strength in young female athletes...
  6. doi request reprint High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties
    Samantha Pozzi
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Clin Cancer Res 15:5829-39. 2009
    ..The increasing incidence of osteonecrosis of the jaw and its possible association with high cumulative doses of bisphosphonate led us to study the effects of high doses of zoledronic acid (ZA) on bone remodeling...
  7. pmc Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis
    Blaine A Christiansen
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Bone Miner Res 26:974-83. 2011
    ..This differential bone loss explains, in part, a greater decline in bone strength in women and may contribute to the higher incidence of vertebral fractures among women than men...
  8. pmc Variations of CT-based trunk muscle attenuation by age, sex, and specific muscle
    Dennis E Anderson
    Beth Israel Deaconess Medical Center, 330 Brookline Ave, RN115, Boston, MA 02215, USA
    J Gerontol A Biol Sci Med Sci 68:317-23. 2013
    ..However, variations in trunk muscle attenuation with age, sex and between specific muscles have not been investigated...
  9. pmc QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study
    Elizabeth J Samelson
    Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
    J Bone Miner Res 27:654-63. 2012
    ..Our study confirms the importance of evaluating determinants of vertebral strength in both the thoracic and lumbar spine and in both women and men to understand mechanisms underlying the structural failure of vertebral bodies with aging...
  10. ncbi request reprint Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture
    Mary L Bouxsein
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Acad Orthop Surg 12:385-95. 2004
    ..Thus, they have the unique opportunity to serve as primary advocates to ensure that appropriate action is taken to reduce the risk of future fracture...
  11. pmc Premenopausal women with a distal radial fracture have deteriorated trabecular bone density and morphology compared with controls without a fracture
    Tamara D Rozental
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA
    J Bone Joint Surg Am 95:633-42. 2013
    ..We hypothesized that premenopausal women with a fracture of the distal end of the radius have similar bone mineral density but altered bone microarchitecture compared with control subjects without a fracture...
  12. pmc Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study
    Ching Ti Liu
    Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
    J Bone Miner Res 27:954-8. 2012
    ....
  13. pmc Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3123-33. 2011
    ..Abnormal bone microarchitecture is an independent determinant of fracture risk and has not been assessed in young athletes and nonathletes...
  14. doi request reprint Comparison of hip fracture risk prediction by femoral aBMD to experimentally measured factor of risk
    Benjamin J Roberts
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Bone 46:742-6. 2010
    ..These findings strongly support the investigation of new biomechanically-based methods of fracture risk prediction...
  15. pmc Determinants of bone microarchitecture and mechanical properties in obese men
    Miriam A Bredella
    Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:4115-22. 2012
    ..Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis...
  16. pmc Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development
    Steven W Lane
    Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 119:736-44. 2012
    ..These data have implications for therapeutic strategies to target Rac signaling in HSC mobilization and in the treatment of leukemia and provide clarification to our evolving concepts of HSC-HM interactions...
  17. ncbi request reprint Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 22:825-31. 2007
    ..Reduced trochanteric soft tissue thickness, low femoral aBMD, and increased ratio of fall force to femoral strength (i.e., factor of risk) were associated with increased risk of hip fracture...
  18. ncbi request reprint Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships
    Yi Hsiang Hsu
    Harvard School of Public Health, Boston, Massachusetts, USA
    J Bone Miner Res 22:184-94. 2007
    ..Our results indicated four genome-wide significant QTLs for BMD. In comparison with 12 previous reported linkage studies, we reveal novel linkage regions that have reaching global significance...
  19. doi request reprint Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapy
    Tamara D Rozental
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Hand Surg Am 34:595-602. 2009
    ..To compare healing rates of distal radius fractures in patients on bisphosphonate therapy at the time of injury to rates in those not on bisphosphonate therapy...
  20. ncbi request reprint Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose
    Volker M Betz
    Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Gene Ther 18:907-15. 2007
    ..However, the newly formed bone lacked the structural organization of native bone, suggesting that further maturation is necessary...
  21. pmc Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 11:161-71. 2010
    ..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1...
  22. ncbi request reprint Mechanisms of osteoporosis therapy: a bone strength perspective
    Mary L Bouxsein
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Clin Cornerstone . 2003
    ..This observation suggests that the size, shape, distribution, and composition of bone may have important effects on bone strength and, therefore, the risk of fracture...
  23. ncbi request reprint Direct percutaneous gene delivery to enhance healing of segmental bone defects
    Oliver B Betz
    Center for Molecular Orthopaedics, 221 Longwood Avenue, BLI 152, Boston, MA 02115, USA
    J Bone Joint Surg Am 88:355-65. 2006
    ..Direct transfer of osteogenic genes offers an alternative, clinically expeditious, cost-effective approach. We evaluated its potential in a well-established, critical-size, rat femoral defect model...
  24. doi request reprint Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    Mary L Bouxsein
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:1468-86. 2010
    ..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results...
  25. pmc An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis
    Anyonya R Guntur
    Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, Maine, USA
    Ann N Y Acad Sci 1237:58-63. 2011
    ..The circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate...
  26. doi request reprint Quantifying the material and structural determinants of bone strength
    Mary L Bouxsein
    Orthopaedic Surgery, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Department of Orthopaedic Surgery, Harvard Medical School, RN115, 330 Brookline Ave, Boston, MA 02215, USA
    Best Pract Res Clin Rheumatol 23:741-53. 2009
    ....
  27. ncbi request reprint Age-related changes in trabecular architecture differ in female and male C57BL/6J mice
    Vaida Glatt
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 22:1197-207. 2007
    ..Deterioration in vertebral and femoral trabecular microarchitecture begins early, continues throughout life, is more pronounced at the femoral metaphysis than in the vertebrae, and is greater in females than males...
  28. pmc In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 283:21002-10. 2008
    ..Collectively, our findings provide the first in vivo demonstration that the calpain small subunit is essential for proper osteoblast activity and bone remodeling...
  29. doi request reprint Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trials
    Mary L Bouxsein
    Eli Lilly and Company, Indianapolis, Indiana, USA
    J Bone Joint Surg Am 91:1329-38. 2009
    ....
  30. pmc beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 20:635-43. 2005
    ..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces...
  31. ncbi request reprint Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 19:587-99. 2004
    ..Ultimately, identification of genes that regulate trabecular bone traits may yield important information regarding mechanisms that regulate mechanical integrity of the skeleton...
  32. ncbi request reprint Ovariectomy-induced bone loss varies among inbred strains of mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 20:1085-92. 2005
    ..We show that patterns of bone loss after ovariectomy vary among inbred strains of mice, providing evidence that there may be genetic regulation of bone loss induced by estrogen deficiency...
  33. pmc Regressions for estimating muscle parameters in the thoracic and lumbar trunk for use in musculoskeletal modeling
    Dennis E Anderson
    Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Biomech 45:66-75. 2012
    ..This work thus provides a resource for estimating muscle parameters in the general population for musculoskeletal modeling of the thoraco-lumbar trunk...
  34. doi request reprint Technology insight: noninvasive assessment of bone strength in osteoporosis
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Clin Pract Rheumatol 4:310-8. 2008
    ..Although they show strong potential, further development and validation of these techniques is needed to define their role in the clinical management of individuals with osteoporosis...
  35. ncbi request reprint Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 21:1475-82. 2006
    ..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence...
  36. pmc Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health
    Douglas P Kiel
    Institute for Aging Research, Boston, MA, USA
    Clin Trials 7:354-67. 2010
    ..Alternatives to pharmacologic treatment are needed for older adults. Nonpharmacologic treatment with low magnitude, high frequency mechanical stimulation has been shown to prevent bone loss in animal and human studies...
  37. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010
    ..These results support the hypothesis that caloric restriction during rapid skeletal growth is deleterious to cortical and trabecular bone mass and architecture, in contrast to potential skeletal benefits of CR in aging animals...
  38. doi request reprint Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized intervention
    Tamara D Rozental
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA
    J Bone Joint Surg Am 90:953-61. 2008
    ..The purpose of this study was to determine the rates of evaluation and treatment of osteoporosis following distal radial fractures and to test two interventions in the outpatient clinic to improve evaluation and treatment rates...
  39. ncbi request reprint Familial aggregation of bone mineral density and bone mineral content in a Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Osteoporos Int 16:1917-23. 2005
    ..39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults...
  40. ncbi request reprint Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 83:146-54. 2006
    ..Higher fat mass may be an independent risk factor for osteoporosis and osteoporotic fractures...
  41. doi request reprint Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading
    Jordan M Spatz
    Harvard Massachusetts Institute of Technology MIT Division of Health Sciences and Technology HST, Bioastronautics Program, Cambridge, MA, USA
    J Bone Miner Res 28:865-74. 2013
    ....
  42. doi request reprint Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
    Rachel Ellman
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, USA
    J Bone Miner Res 28:875-85. 2013
    ..These data confirm that the PWS model is highly effective in applying controllable, reduced, long-term loading that produces predictable, discrete adaptive changes in muscle and bone of the hindlimb...
  43. pmc Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation
    Makoto Okazaki
    Endocrine Unit and Center for Systems Biology, Massachusetts General Hospital, and Orthopedic Biomechanic Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:16525-30. 2008
    ..Controlling, via ligand analog design, the selectivity with which a PTH ligand binds to R(0), versus RG, may be a strategy for optimizing signaling duration time, and hence therapeutic efficacy, of PTHR agonist ligands...
  44. ncbi request reprint Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing
    Eleftherios Tsiridis
    Department of Orthopaedic Surgery, Boston University Medical Center, Laboratory of Orthopaedic Research, 715 Albany Street, R 205, Boston, Massachusetts 02118, USA
    J Orthop Res 25:1193-203. 2007
    ..In addition, differences in systemic versus local effects of PTH and OP-1 in accelerating metaphyseal fracture healing were found...
  45. pmc Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspective
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 23:1155-67. 2008
    ..To ensure optimal development and best use of biomarkers to accelerate drug development, continuous dialog among the health professionals, industry, and regulators is of paramount importance...
  46. pmc Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    Siddhartha Mukherjee
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:491-504. 2008
    ..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals...
  47. doi request reprint Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)
    Roberto José Fajardo
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Bone 46:64-71. 2010
    ....
  48. ncbi request reprint Determinants of skeletal fragility
    Mary L Bouxsein
    Department of Orthopaedic Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Best Pract Res Clin Rheumatol 19:897-911. 2005
    ..Finally, several current and future methodologies for improving assessment of bone strength in patients are evaluated...
  49. doi request reprint Specimen size and porosity can introduce error into microCT-based tissue mineral density measurements
    Roberto J Fajardo
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Bone 44:176-84. 2009
    ..Measurements of rho(m) of specimens of unequal size or quantities of bone mineral must be interpreted with caution unless appropriate steps are taken to minimize these potential artifacts...
  50. ncbi request reprint Bone geometry and skeletal fragility
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Curr Osteoporos Rep 4:49-56. 2006
    ..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements...
  51. ncbi request reprint Impact of seafood and fruit consumption on bone mineral density
    Pierre A Zalloua
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Maturitas 56:1-11. 2007
    ..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population...
  52. ncbi request reprint Bone marrow influences quantitative ultrasound measurements in human cancellous bone
    Patrick H F Nicholson
    Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 28:369-75. 2002
    ..Understanding and exploiting these effects could lead to novel approaches for ultrasonic characterisation of both bone and marrow...
  53. ncbi request reprint Bone quality: where do we go from here?
    Mary L Bouxsein
    Osteoporos Int 14:S118-27. 2003
    ....
  54. pmc Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
    Seth D Berman
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:11851-6. 2008
    ..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo...
  55. pmc A soluble activin type IIA receptor induces bone formation and improves skeletal integrity
    R Scott Pearsall
    Acceleron Pharma, Inc, 149 Sidney Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:7082-7. 2008
    ..These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility...
  56. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  57. ncbi request reprint Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
    ..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model...
  58. ncbi request reprint Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005
    ..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
  59. ncbi request reprint Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo
    Mary L Bouxsein
    The The Jackson Laboratory, Bar Harbor, Maine, USA
    J Bone Miner Res 17:570-9. 2002
    ..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone...
  60. ncbi request reprint Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, ME, USA
    Bone 35:1046-58. 2004
    ..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome...
  61. ncbi request reprint Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, USA
    J Bone Miner Res 19:2033-40. 2004
    ..We found that compound mutants had dose-dependent deficits in BMD and limb formation, suggesting functional redundancy between these two genes in bone and limb development...
  62. ncbi request reprint Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Bone Miner Res 19:1945-54. 2004
    ..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men...
  63. ncbi request reprint Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand
    James D Johnston
    Department of Mechanical Engineering, Human Mobility Research Centre, McLaughlin Hall, Room 319, Queen s University and Kingston General Hospital, Kingston, Ont, Canada K7L 3N6
    J Orthop Res 22:867-71. 2004
    ..The results provide a comprehensive understanding of scapholunate ligament biomechanics and demonstrate a relationship between bone and ligament properties...
  64. ncbi request reprint Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    Melissa A Kacena
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Miner Res 19:652-60. 2004
    ..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice...
  65. pmc Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
    J Clin Invest 113:96-105. 2004
    ..These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism...
  66. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  67. ncbi request reprint A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair
    Thomas A Einhorn
    Boston University Medical Center, Massachusetts 02118 2393, USA
    J Bone Joint Surg Am 85:1425-35. 2003
    ..The purpose of this investigation was to test the hypothesis that a single, local, percutaneous injection of rhBMP-2 would accelerate fracture-healing in a standard rat femoral fracture model...
  68. ncbi request reprint High bone mass in mice expressing a mutant LRP5 gene
    Philip Babij
    Genomics, Wyeth Research, Andover, Massachusetts, USA
    J Bone Miner Res 18:960-74. 2003
    ..Together, these findings establish the importance of this novel and unexpected role of a lipoprotein receptor in regulating bone mass and afford a new model to explore LRP5 and its recent association with Wnt signaling in bone biology...
  69. ncbi request reprint Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density
    Kathryn L Shultz
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:175-85. 2003
    ....
  70. ncbi request reprint Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  71. ncbi request reprint In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography
    Stephanie Boutroy
    INSERM Unit 403, and Claude Bernard University of Lyon, France
    J Clin Endocrinol Metab 90:6508-15. 2005
    ....
  72. ncbi request reprint Cortical stability of the femoral neck and hip fracture risk
    Mary L Bouxsein
    Lancet 366:1523-4; author reply 1524-5. 2005
  73. ncbi request reprint Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone
    Patrick Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
    Bone 38:300-9. 2006
    ..We conclude that the extent and nature of collagen cross-linking contribute to the mechanical properties of fetal bovine cortical bone independently of bone mineral density...
  74. doi request reprint Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats
    Julie F McManus
    Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia
    Bone 42:1164-74. 2008
    ..fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent...
  75. pmc Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 93:2166-72. 2008
    ..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use...
  76. pmc Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice
    Laura E Wright
    Department of Physiology, The University of Arizona, Tucson, Arizona, USA
    J Bone Miner Res 23:1296-303. 2008
    ....
  77. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  78. ncbi request reprint Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women
    Stephanie Boutroy
    INSERM Research Unit 831 and Université de Lyon, Lyon, France
    J Bone Miner Res 23:392-9. 2008
    ..BMD, bone microarchitecture, and bone mechanical properties assessed in vivo by finite element analysis were associated with wrist fracture in postmenopausal women...
  79. ncbi request reprint Structural determinants of vertebral fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 22:1885-92. 2007
    ..Vertebral fractures are more strongly associated with specific bone density, structure, and strength parameters than with areal BMD, but all of these variables are correlated...
  80. doi request reprint Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions
    Klaus Engelke
    Institute of Medical Physics, University of Erlangen, Germany Synarc, Hamburg, Germany
    J Clin Densitom 11:123-62. 2008
    ..Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge...
  81. ncbi request reprint Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women
    L Joseph Melton
    Division of Epidemology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 22:1442-8. 2007
    ..Bone structure, strength and load-strength ratios contribute to forearm fracture risk independently of areal BMD...
  82. pmc Lifelong accumulation of bone in mice lacking Pten in osteoblasts
    Ximeng Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:2259-64. 2007
    ..These findings support a critical role for this tumor-suppressor gene in regulating osteoblast lifespan and likely explain the skeletal abnormalities in patients carrying germ-line mutations of PTEN...
  83. ncbi request reprint Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  84. ncbi request reprint The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone
    Shoshana Yakar
    National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
    J Endocrinol 189:289-99. 2006
    ..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)...
  85. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...
  86. ncbi request reprint Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice
    Dominique D Pierroz
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Bone 39:260-7. 2006
    ..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis...
  87. ncbi request reprint Predicting the failure load of the distal radius
    Monique E Muller
    Department of Nuclear Medicine Hamilton Health Sciences McMaster Site, HSC 1P10, L8N 3Z5, Hamilton, Ontario, Canada
    Osteoporos Int 14:345-52. 2003
    ..04), whereas the men would have likely withstood the impact without fracturing their wrist (Phi wrist= 0.79)...
  88. ncbi request reprint Health professional's guide to rehabilitation of the patient with osteoporosis
    Francis J Bonner
    Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
    Osteoporos Int 14:S1-22. 2003
  89. ncbi request reprint Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...
  90. pmc The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development
    Ying Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Clin Invest 117:1616-26. 2007
    ..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...