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Genomes and Genes | Mary L BouxseinSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fracturesM L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Osteoporos Int 13:358-65. 2002..Therefore, DXR-BMD may be useful for prediction of fracture risk in clinical settings where hip BMD is not available...
Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTHJun Guo
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Endocrinology 151:3502-13. 2010..Furthermore, PTH stimulated proliferation and increased mRNAs encoding cyclin D1 in primary osteoblasts derived from Wt but not from DSEL mice. Our data indicate that PLC signaling through the PTHR is required for skeletal homeostasis...
A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeysSutada Lotinun
Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
Bone 46:1082-8. 2010..Thus, soluble ActRIIA fusion protein may be useful in the prevention and/or treatment of osteoporosis and other diseases involving accelerated bone loss...- Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parametersElizabeth A Lawson
Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Eur J Endocrinol 168:457-64. 2013..We therefore investigated oxytocin secretion and its association with bone microarchitecture and strength in young female athletes... - High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical propertiesSamantha Pozzi
Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
Clin Cancer Res 15:5829-39. 2009..The increasing incidence of osteonecrosis of the jaw and its possible association with high cumulative doses of bisphosphonate led us to study the effects of high doses of zoledronic acid (ZA) on bone remodeling... - Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysisBlaine A Christiansen
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Bone Miner Res 26:974-83. 2011..This differential bone loss explains, in part, a greater decline in bone strength in women and may contribute to the higher incidence of vertebral fractures among women than men... - Variations of CT-Based Trunk Muscle Attenuation by Age, Sex, and Specific MuscleDennis E Anderson
Beth Israel Deaconess Medical Center, 330 Brookline Ave, RN115, Boston, MA 02215
J Gerontol A Biol Sci Med Sci 68:317-23. 2013..However, variations in trunk muscle attenuation with age, sex and between specific muscles have not been investigated... - QCT measures of bone strength at the thoracic and lumbar spine: the Framingham StudyElizabeth J Samelson
Institute for Aging Research, Hebrew SeniorLife, Boston, MA 02131, USA
J Bone Miner Res 27:654-63. 2012..Our study confirms the importance of evaluating determinants of vertebral strength in both the thoracic and lumbar spine and in both women and men to understand mechanisms underlying the structural failure of vertebral bodies with aging... - Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fractureMary L Bouxsein
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Am Acad Orthop Surg 12:385-95. 2004..Thus, they have the unique opportunity to serve as primary advocates to ensure that appropriate action is taken to reduce the risk of future fracture... - Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham studyChing Ti Liu
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
J Bone Miner Res 27:954-8. 2012.... - Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controlsKathryn E Ackerman
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 96:3123-33. 2011..Abnormal bone microarchitecture is an independent determinant of fracture risk and has not been assessed in young athletes and nonathletes... - Comparison of hip fracture risk prediction by femoral aBMD to experimentally measured factor of riskBenjamin J Roberts
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Bone 46:742-6. 2010..These findings strongly support the investigation of new biomechanically-based methods of fracture risk prediction... - Determinants of bone microarchitecture and mechanical properties in obese menMiriam A Bredella
Massachusetts General Hospital, Yawkey 6E, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 97:4115-22. 2012..Recent studies have suggested that obesity in men is associated with increased fracture risk. Obesity in men is also associated with dysregulation of the GH/IGF-I and gonadal steroid axes, important regulators of bone homeostasis... - Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic developmentSteven W Lane
Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Blood 119:736-44. 2012..These data have implications for therapeutic strategies to target Rac signaling in HSC mobilization and in the treatment of leukemia and provide clarification to our evolving concepts of HSC-HM interactions... - Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibshipsYi Hsiang Hsu
Harvard School of Public Health, Boston, Massachusetts, USA
J Bone Miner Res 22:184-94. 2007..Our results indicated four genome-wide significant QTLs for BMD. In comparison with 12 previous reported linkage studies, we reveal novel linkage regions that have reaching global significance... - Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector doseVolker M Betz
Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Gene Ther 18:907-15. 2007..However, the newly formed bone lacked the structural organization of native bone, suggesting that further maturation is necessary... - Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formationJun Guo
Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Cell Metab 11:161-71. 2010..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1... - Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture riskMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 22:825-31. 2007..Reduced trochanteric soft tissue thickness, low femoral aBMD, and increased ratio of fall force to femoral strength (i.e., factor of risk) were associated with increased risk of hip fracture... - Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapyTamara D Rozental
Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
J Hand Surg Am 34:595-602. 2009..To compare healing rates of distal radius fractures in patients on bisphosphonate therapy at the time of injury to rates in those not on bisphosphonate therapy... - Direct percutaneous gene delivery to enhance healing of segmental bone defectsOliver B Betz
Center for Molecular Orthopaedics, 221 Longwood Avenue, BLI-152, Boston, MA 02115, USA
J Bone Joint Surg Am 88:355-65. 2006..BMP-2 induces healing of critical-size femoral bone defects in rats within eight weeks. At this time, the repair tissue is predominantly trabecular bone, has normal bone mineral content, and has gained mechanical strength... - Mechanisms of osteoporosis therapy: a bone strength perspectiveMary L Bouxsein
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Clin Cornerstone . 2003..This observation suggests that the size, shape, distribution, and composition of bone may have important effects on bone strength and, therefore, the risk of fracture... - Age-related changes in trabecular architecture differ in female and male C57BL/6J miceVaida Glatt
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 22:1197-207. 2007..Deterioration in vertebral and femoral trabecular microarchitecture begins early, continues throughout life, is more pronounced at the femoral metaphysis than in the vertebrae, and is greater in females than males... - In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formationMasako Shimada
Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
J Biol Chem 283:21002-10. 2008..Collectively, our findings provide the first in vivo demonstration that the calpain small subunit is essential for proper osteoblast activity and bone remodeling... - Quantifying the material and structural determinants of bone strengthMary L Bouxsein
Orthopaedic Surgery, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Department of Orthopaedic Surgery, Harvard Medical School, RN115, 330 Brookline Ave, Boston, MA 02215, USA
Best Pract Res Clin Rheumatol 23:741-53. 2009.... - An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasisAnyonya R Guntur
Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, Maine, USA
Ann N Y Acad Sci 1237:58-63. 2011..The circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate... - Guidelines for assessment of bone microstructure in rodents using micro-computed tomographyMary L Bouxsein
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Bone Miner Res 25:1468-86. 2010..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results... - Ovariectomy-induced bone loss varies among inbred strains of miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Bone Miner Res 20:1085-92. 2005..We show that patterns of bone loss after ovariectomy vary among inbred strains of mice, providing evidence that there may be genetic regulation of bone loss induced by estrogen deficiency... - Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trialsMary L Bouxsein
Eli Lilly and Company, Indianapolis, Indiana, USA
J Bone Joint Surg Am 91:1329-38. 2009.... - beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 20:635-43. 2005..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces... - Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 19:587-99. 2004..Ultimately, identification of genes that regulate trabecular bone traits may yield important information regarding mechanisms that regulate mechanical integrity of the skeleton... - Regressions for estimating muscle parameters in the thoracic and lumbar trunk for use in musculoskeletal modelingDennis E Anderson
Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Biomech 45:66-75. 2012..This work thus provides a resource for estimating muscle parameters in the general population for musculoskeletal modeling of the thoraco-lumbar trunk... - Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal healthDouglas P Kiel
Institute for Aging Research, Boston, MA, USA
Clin Trials 7:354-67. 2010..Alternatives to pharmacologic treatment are needed for older adults. Nonpharmacologic treatment with low magnitude, high frequency mechanical stimulation has been shown to prevent bone loss in animal and human studies... - Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized interventionTamara D Rozental
Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA
J Bone Joint Surg Am 90:953-61. 2008..The purpose of this study was to determine the rates of evaluation and treatment of osteoporosis following distal radial fractures and to test two interventions in the outpatient clinic to improve evaluation and treatment rates... - Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCTMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 21:1475-82. 2006..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence... - Technology insight: noninvasive assessment of bone strength in osteoporosisMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Nat Clin Pract Rheumatol 4:310-8. 2008..Although they show strong potential, further development and validation of these techniques is needed to define their role in the clinical management of individuals with osteoporosis... - Caloric restriction leads to high marrow adiposity and low bone mass in growing miceMaureen J Devlin
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Bone Miner Res 25:2078-88. 2010..These results support the hypothesis that caloric restriction during rapid skeletal growth is deleterious to cortical and trabecular bone mass and architecture, in contrast to potential skeletal benefits of CR in aging animals... - Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and womenYi-Hsiang Hsu
Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 83:146-54. 2006..Thus, fat mass has a negative effect on bone mass in contrast with the positive effect of weight-bearing itself... - Familial aggregation of bone mineral density and bone mineral content in a Chinese populationYan Feng
Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
Osteoporos Int 16:1917-23. 2005..39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults... - Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loadingJordan M Spatz
Harvard Massachusetts Institute of Technology MIT Division of Health Sciences and Technology HST, Bioastronautics Program, Cambridge, MA, USA
J Bone Miner Res 28:865-74. 2013.... - Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle massRachel Ellman
Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, MA, USA
J Bone Miner Res 28:875-85. 2013..These data confirm that the PWS model is highly effective in applying controllable, reduced, long-term loading that produces predictable, discrete adaptive changes in muscle and bone of the hindlimb... - Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspectiveMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 23:1155-67. 2008..To ensure optimal development and best use of biomarkers to accelerate drug development, continuous dialog among the health professionals, industry, and regulators is of paramount importance... - Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in miceSiddhartha Mukherjee
Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:491-504. 2008..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals... - Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis)Roberto José Fajardo
Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Bone 46:64-71. 2010.... - Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healingEleftherios Tsiridis
Department of Orthopaedic Surgery, Boston University Medical Center, Laboratory of Orthopaedic Research, 715 Albany Street, R 205, Boston, Massachusetts 02118, USA
J Orthop Res 25:1193-203. 2007..In addition, differences in systemic versus local effects of PTH and OP-1 in accelerating metaphyseal fracture healing were found... - Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformationMakoto Okazaki
Endocrine Unit and Center for Systems Biology, Massachusetts General Hospital, and Orthopedic Biomechanic Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 105:16525-30. 2008..Controlling, via ligand analog design, the selectivity with which a PTH ligand binds to R(0), versus RG, may be a strategy for optimizing signaling duration time, and hence therapeutic efficacy, of PTHR agonist ligands... - Determinants of skeletal fragilityMary L Bouxsein
Department of Orthopaedic Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Best Pract Res Clin Rheumatol 19:897-911. 2005..Finally, several current and future methodologies for improving assessment of bone strength in patients are evaluated... - Impact of seafood and fruit consumption on bone mineral densityPierre A Zalloua
Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
Maturitas 56:1-11. 2007..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population... - Bone geometry and skeletal fragilityMary L Bouxsein
Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Curr Osteoporos Rep 4:49-56. 2006..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements... - Specimen size and porosity can introduce error into microCT-based tissue mineral density measurementsRoberto J Fajardo
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Bone 44:176-84. 2009..Measurements of rho(m) of specimens of unequal size or quantities of bone mineral must be interpreted with caution unless appropriate steps are taken to minimize these potential artifacts... - Bone marrow influences quantitative ultrasound measurements in human cancellous bonePatrick H F Nicholson
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Ultrasound Med Biol 28:369-75. 2002..Understanding and exploiting these effects could lead to novel approaches for ultrasonic characterisation of both bone and marrow... - A soluble activin type IIA receptor induces bone formation and improves skeletal integrityR Scott Pearsall
Acceleron Pharma, Inc, 149 Sidney Street, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:7082-7. 2008..These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility... - Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineageSeth D Berman
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:11851-6. 2008..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo... - Bone quality: where do we go from here?Mary L Bouxsein
Osteoporos Int 14:S118-27. 2003.... - PPARG by dietary fat interaction influences bone mass in mice and humansCheryl L Ackert-Bicknell
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Bone Miner Res 23:1398-408. 2008..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene... - Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official PositionsKlaus Engelke
Institute of Medical Physics, University of Erlangen, Germany Synarc, Hamburg, Germany
J Clin Densitom 11:123-62. 2008..Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge... - Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized miceDominique D Pierroz
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Bone 39:260-7. 2006..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis... - Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized ratsJulie F McManus
Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia
Bone 42:1164-74. 2008..fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent... - Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivoMary L Bouxsein
The The Jackson Laboratory, Bar Harbor, Maine, USA
J Bone Miner Res 17:570-9. 2002..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone... - Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation programClifford J Rosen
The Jackson Laboratory, Bar Harbor, ME, USA
Bone 35:1046-58. 2004..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome... - Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6Sheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, USA
J Bone Miner Res 19:2033-40. 2004..We found that compound mutants had dose-dependent deficits in BMD and limb formation, suggesting functional redundancy between these two genes in bone and limb development... - Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sitesB Lawrence Riggs
Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
J Bone Miner Res 19:1945-54. 2004..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men... - Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the handJames D Johnston
Department of Mechanical Engineering, Human Mobility Research Centre, McLaughlin Hall, Room 319, Queen's University and Kingston General Hospital, Kingston, Ont, Canada K7L 3N6
J Orthop Res 22:867-71. 2004..The results provide a comprehensive understanding of scapholunate ligament biomechanics and demonstrate a relationship between bone and ligament properties... - Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2Melissa A Kacena
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
J Bone Miner Res 19:652-60. 2004..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice... - Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient miceShoshana Yakar
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
J Clin Invest 113:96-105. 2004..These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism... - The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
N Engl J Med 349:1207-15. 2003..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone... - A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repairThomas A Einhorn
Boston University Medical Center, Massachusetts 02118 2393, USA
J Bone Joint Surg Am 85:1425-35. 2003..The purpose of this investigation was to test the hypothesis that a single, local, percutaneous injection of rhBMP-2 would accelerate fracture-healing in a standard rat femoral fracture model... - High bone mass in mice expressing a mutant LRP5 genePhilip Babij
Genomics, Wyeth Research, Andover, Massachusetts, USA
J Bone Miner Res 18:960-74. 2003..Together, these findings establish the importance of this novel and unexpected role of a lipoprotein receptor in regulating bone mass and afford a new model to explore LRP5 and its recent association with Wnt signaling in bone biology... - Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral densityKathryn L Shultz
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Bone Miner Res 18:175-85. 2003.... - Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationMei Zhang
Department of Medicine, University of Cincinnati, Ohio 45267, USA
J Biol Chem 277:44005-12. 2002..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required... - Essential role of beta-catenin in postnatal bone acquisitionSheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
J Biol Chem 280:21162-8. 2005..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts... - In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomographyStephanie Boutroy
INSERM Unit 403, and Claude Bernard University of Lyon, France
J Clin Endocrinol Metab 90:6508-15. 2005..CONCLUSION: HR-pQCT appears promising to assess bone density and microarchitecture at peripheral sites in terms of reproducibility and ability to detect age- and disease-related changes... - Cortical stability of the femoral neck and hip fracture riskMary L Bouxsein
Lancet 366:1523-4; author reply 1524-5. 2005 - Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodelingDennis M Black
Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
J Clin Endocrinol Metab 93:2166-72. 2008..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use... - Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in miceLaura E Wright
Department of Physiology, The University of Arizona, Tucson, Arizona, USA
J Bone Miner Res 23:1296-303. 2008.... - Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCTDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
J Bone Miner Res 23:1326-33. 2008.... - Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal womenStephanie Boutroy
INSERM Research Unit 831 and Université de Lyon, Lyon, France
J Bone Miner Res 23:392-9. 2008..BMD, bone microarchitecture, and bone mechanical properties assessed in vivo by finite element analysis were associated with wrist fracture in postmenopausal women... - Structural determinants of vertebral fracture riskL Joseph Melton
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Bone Miner Res 22:1885-92. 2007..Vertebral fractures are more strongly associated with specific bone density, structure, and strength parameters than with areal BMD, but all of these variables are correlated... - Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesisGang Li
The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
J Orthop Res 20:779-88. 2002..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model... - Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal womenL Joseph Melton
Division of Epidemology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Bone Miner Res 22:1442-8. 2007..Bone structure, strength and load-strength ratios contribute to forearm fracture risk independently of areal BMD... - Lifelong accumulation of bone in mice lacking Pten in osteoblastsXimeng Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:2259-64. 2007..These findings support a critical role for this tumor-suppressor gene in regulating osteoblast lifespan and likely explain the skeletal abnormalities in patients carrying germ-line mutations of PTEN... - Mechanisms of disease: is osteoporosis the obesity of bone?Clifford J Rosen
The Jackson Laboratory in Bar Harbor, ME 04401, USA
Nat Clin Pract Rheumatol 2:35-43. 2006.... - The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormoneShoshana Yakar
National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
J Endocrinol 189:289-99. 2006..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)... - Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fracturesB Lawrence Riggs
Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Bone Miner Res 21:315-23. 2006..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD... - Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bonePatrick Garnero
INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
Bone 38:300-9. 2006..We conclude that the extent and nature of collagen cross-linking contribute to the mechanical properties of fetal bovine cortical bone independently of bone mineral density... - Health professional's guide to rehabilitation of the patient with osteoporosisFrancis J Bonner
Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
Osteoporos Int 14:S1-22. 2003 - Predicting the failure load of the distal radiusMonique E Muller
Department of Nuclear Medicine Hamilton Health Sciences McMaster Site, HSC-1P10, L8N 3Z5, Hamilton, Ontario, Canada
Osteoporos Int 14:345-52. 2003..04), whereas the men would have likely withstood the impact without fracturing their wrist (Phi wrist= 0.79)... - Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body compositionClifford J Rosen
The Jackson Laboratory, Bar Harbor, Maine, USA
Pediatr Nephrol 20:255-60. 2005..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure... - The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal developmentYing Wang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Clin Invest 117:1616-26. 2007..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...