Mary Bouxsein

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis
    Blaine A Christiansen
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Bone Miner Res 26:974-83. 2011
  2. pmc Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats
    J E M Brouwers
    Eindhoven University of Technology, Eindhoven, The Netherlands
    Osteoporos Int 20:1377-84. 2009
  3. doi request reprint Quantifying the material and structural determinants of bone strength
    Mary L Bouxsein
    Orthopaedic Surgery, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Department of Orthopaedic Surgery, Harvard Medical School, RN115, 330 Brookline Ave, Boston, MA 02215, USA
    Best Pract Res Clin Rheumatol 23:741-53. 2009
  4. ncbi request reprint Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 19:587-99. 2004
  5. ncbi request reprint Non-invasive measurements of bone strength: promise and peril
    M L Bouxsein
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Musculoskelet Neuronal Interact 4:404-5. 2004
  6. pmc Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspective
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 23:1155-67. 2008
  7. pmc beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 20:635-43. 2005
  8. pmc Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 150:144-52. 2009
  9. doi request reprint Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trials
    Mary L Bouxsein
    Eli Lilly and Company, Indianapolis, Indiana, USA
    J Bone Joint Surg Am 91:1329-38. 2009
  10. ncbi request reprint Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 22:825-31. 2007

Detail Information

Publications79

  1. pmc Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis
    Blaine A Christiansen
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Bone Miner Res 26:974-83. 2011
    ..This differential bone loss explains, in part, a greater decline in bone strength in women and may contribute to the higher incidence of vertebral fractures among women than men...
  2. pmc Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats
    J E M Brouwers
    Eindhoven University of Technology, Eindhoven, The Netherlands
    Osteoporos Int 20:1377-84. 2009
    ..Typical fatigue behavior was found and was similar to that seen in other species. Fatigue properties were comparable between both groups...
  3. doi request reprint Quantifying the material and structural determinants of bone strength
    Mary L Bouxsein
    Orthopaedic Surgery, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Department of Orthopaedic Surgery, Harvard Medical School, RN115, 330 Brookline Ave, Boston, MA 02215, USA
    Best Pract Res Clin Rheumatol 23:741-53. 2009
    ....
  4. ncbi request reprint Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 19:587-99. 2004
    ..Ultimately, identification of genes that regulate trabecular bone traits may yield important information regarding mechanisms that regulate mechanical integrity of the skeleton...
  5. ncbi request reprint Non-invasive measurements of bone strength: promise and peril
    M L Bouxsein
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Musculoskelet Neuronal Interact 4:404-5. 2004
  6. pmc Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspective
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 23:1155-67. 2008
    ..To ensure optimal development and best use of biomarkers to accelerate drug development, continuous dialog among the health professionals, industry, and regulators is of paramount importance...
  7. pmc beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 20:635-43. 2005
    ..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces...
  8. pmc Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 150:144-52. 2009
    ..Our findings also suggest direct positive effects of weight and/or leptin on bone turnover and cortical bone structure, independent of adrenergic signaling...
  9. doi request reprint Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trials
    Mary L Bouxsein
    Eli Lilly and Company, Indianapolis, Indiana, USA
    J Bone Joint Surg Am 91:1329-38. 2009
    ....
  10. ncbi request reprint Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 22:825-31. 2007
    ..Reduced trochanteric soft tissue thickness, low femoral aBMD, and increased ratio of fall force to femoral strength (i.e., factor of risk) were associated with increased risk of hip fracture...
  11. doi request reprint Technology insight: noninvasive assessment of bone strength in osteoporosis
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nat Clin Pract Rheumatol 4:310-8. 2008
    ..Although they show strong potential, further development and validation of these techniques is needed to define their role in the clinical management of individuals with osteoporosis...
  12. ncbi request reprint Ovariectomy-induced bone loss varies among inbred strains of mice
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Bone Miner Res 20:1085-92. 2005
    ..We show that patterns of bone loss after ovariectomy vary among inbred strains of mice, providing evidence that there may be genetic regulation of bone loss induced by estrogen deficiency...
  13. doi request reprint Guidelines for assessment of bone microstructure in rodents using micro-computed tomography
    Mary L Bouxsein
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:1468-86. 2010
    ..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results...
  14. ncbi request reprint Bone geometry and skeletal fragility
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Curr Osteoporos Rep 4:49-56. 2006
    ..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements...
  15. ncbi request reprint Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT
    Mary L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 21:1475-82. 2006
    ..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence...
  16. ncbi request reprint Prediction of the strength of the elderly proximal femur by bone mineral density and quantitative ultrasound measurements of the heel and tibia
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Bone 25:49-54. 1999
    ..These findings imply that tibial SOS may be of limited use for assessing hip fracture risk. Prospective fracture risk data are needed to define further the clinical utility of tibia ultrasound measurements...
  17. ncbi request reprint Precision and accuracy of computed digital absorptiometry for assessment of bone density of the hand
    M L Bouxsein
    Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Osteoporos Int 7:444-9. 1997
    ..Thus, with further clinical verification, this technique may prove to be a useful tool for the widespread testing and assessment of osteoporotic fracture risk...
  18. ncbi request reprint Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fractures
    M L Bouxsein
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Osteoporos Int 13:358-65. 2002
    ..Therefore, DXR-BMD may be useful for prediction of fracture risk in clinical settings where hip BMD is not available...
  19. pmc Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis Study
    E J Samelson
    Hebrew SeniorLife, Institute for Aging Research Boston, Boston, MA, USA
    Osteoporos Int 22:1123-31. 2011
    ..Agreement was fair to good for mild fractures, and agreement was good to excellent for more severe fractures. CT scout views are useful to assess vertebral fracture...
  20. ncbi request reprint Congenic mice reveal sex-specific genetic regulation of femoral structure and strength
    C H Turner
    Indiana University School of Medicine, Biomechanics and Biomaterials Research Center, 541 Clinical Drive, Room 600, Indianapolis, IN 46202, USA
    Calcif Tissue Int 73:297-303. 2003
    ....
  21. pmc Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes
    Kathryn E Ackerman
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Bone 51:680-7. 2012
    ..Finite element analysis (FEA) is a unique tool to estimate bone strength in vivo, and the contribution of cortical microstructure to bone strength in young athletes is not well understood...
  22. pmc Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone
    D Yang
    Endocrine Unit, Thier 11, Massachusetts General Hospital, Boston, MA 02114, USA
    Bone 40:1453-61. 2007
    ..PTH1R PLC signaling pathway is not required for an anabolic effect of intermittent PTH(1-34) on bone...
  23. ncbi request reprint Effect of local density changes on the failure load of the proximal femur
    Z M Oden
    Department of Orthopedic Surgery, Charles A Dana Research Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    J Orthop Res 17:661-7. 1999
    ..4%. These findings suggest that agents capable of inducing increased bone density in small regions of the proximal femur have the potential to reduce the risk of hip fracture...
  24. ncbi request reprint Effect of temperature on ultrasonic properties of the calcaneus in situ
    P H F Nicholson
    Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Osteoporos Int 13:888-92. 2002
    ..Given the magnitude of the thermal coefficients observed, the clinical impact of temperature-related QUS errors is likely to be modest for diagnostic purposes but of greater significance in follow-up studies...
  25. ncbi request reprint Three-dimensional distribution of bone density in the proximal humerus
    M J Tingart
    Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Calcif Tissue Int 73:531-6. 2003
    ..In one. These results point to bone sites that may provide stronger fixation for implants, reduce the risk of implant loosening, and therefore improve patient outcome...
  26. ncbi request reprint Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects
    O B Betz
    Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Gene Ther 14:1039-44. 2007
    ..BMP-2 until 5 or 10 days after surgery enables a greater percentage of critical-sized, segmental defects to achieve radiological union, producing a repair tissue with enhanced mineralization and greater mechanical strength...
  27. ncbi request reprint Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women
    L Joseph Melton
    Division of Epidemology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 22:1442-8. 2007
    ..Bone structure, strength and load-strength ratios contribute to forearm fracture risk independently of areal BMD...
  28. ncbi request reprint Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing
    Eleftherios Tsiridis
    Department of Orthopaedic Surgery, Boston University Medical Center, Laboratory of Orthopaedic Research, 715 Albany Street, R 205, Boston, Massachusetts 02118, USA
    J Orthop Res 25:1193-203. 2007
    ..In addition, differences in systemic versus local effects of PTH and OP-1 in accelerating metaphyseal fracture healing were found...
  29. ncbi request reprint Age-related changes in trabecular architecture differ in female and male C57BL/6J mice
    Vaida Glatt
    Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Bone Miner Res 22:1197-207. 2007
    ..Deterioration in vertebral and femoral trabecular microarchitecture begins early, continues throughout life, is more pronounced at the femoral metaphysis than in the vertebrae, and is greater in females than males...
  30. doi request reprint Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions
    Klaus Engelke
    Institute of Medical Physics, University of Erlangen, Germany Synarc, Hamburg, Germany
    J Clin Densitom 11:123-62. 2008
    ..Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge...
  31. doi request reprint Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats
    Julie F McManus
    Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia
    Bone 42:1164-74. 2008
    ..fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent...
  32. ncbi request reprint Essential role of beta-catenin in postnatal bone acquisition
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    J Biol Chem 280:21162-8. 2005
    ..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts...
  33. pmc Lifelong accumulation of bone in mice lacking Pten in osteoblasts
    Ximeng Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:2259-64. 2007
    ..These findings support a critical role for this tumor-suppressor gene in regulating osteoblast lifespan and likely explain the skeletal abnormalities in patients carrying germ-line mutations of PTEN...
  34. ncbi request reprint Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships
    Yi Hsiang Hsu
    Harvard School of Public Health, Boston, Massachusetts, USA
    J Bone Miner Res 22:184-94. 2007
    ..Our results indicated four genome-wide significant QTLs for BMD. In comparison with 12 previous reported linkage studies, we reveal novel linkage regions that have reaching global significance...
  35. pmc Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
    J Bone Miner Res 23:1326-33. 2008
    ....
  36. ncbi request reprint Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose
    Volker M Betz
    Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Gene Ther 18:907-15. 2007
    ..However, the newly formed bone lacked the structural organization of native bone, suggesting that further maturation is necessary...
  37. doi request reprint Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized intervention
    Tamara D Rozental
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA
    J Bone Joint Surg Am 90:953-61. 2008
    ..The purpose of this study was to determine the rates of evaluation and treatment of osteoporosis following distal radial fractures and to test two interventions in the outpatient clinic to improve evaluation and treatment rates...
  38. pmc Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    J Clin Endocrinol Metab 93:2166-72. 2008
    ..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use...
  39. pmc Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice
    Laura E Wright
    Department of Physiology, The University of Arizona, Tucson, Arizona, USA
    J Bone Miner Res 23:1296-303. 2008
    ....
  40. pmc In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation
    Masako Shimada
    Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
    J Biol Chem 283:21002-10. 2008
    ..Collectively, our findings provide the first in vivo demonstration that the calpain small subunit is essential for proper osteoblast activity and bone remodeling...
  41. pmc Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage
    Seth D Berman
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:11851-6. 2008
    ..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo...
  42. pmc A soluble activin type IIA receptor induces bone formation and improves skeletal integrity
    R Scott Pearsall
    Acceleron Pharma, Inc, 149 Sidney Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:7082-7. 2008
    ..These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility...
  43. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  44. pmc Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    Siddhartha Mukherjee
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:491-504. 2008
    ..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals...
  45. ncbi request reprint Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women
    Stephanie Boutroy
    INSERM Research Unit 831 and Université de Lyon, Lyon, France
    J Bone Miner Res 23:392-9. 2008
    ..BMD, bone microarchitecture, and bone mechanical properties assessed in vivo by finite element analysis were associated with wrist fracture in postmenopausal women...
  46. ncbi request reprint Structural determinants of vertebral fracture risk
    L Joseph Melton
    Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Bone Miner Res 22:1885-92. 2007
    ..Vertebral fractures are more strongly associated with specific bone density, structure, and strength parameters than with areal BMD, but all of these variables are correlated...
  47. ncbi request reprint Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  48. ncbi request reprint Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6
    Sheri L Holmen
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, USA
    J Bone Miner Res 19:2033-40. 2004
    ..We found that compound mutants had dose-dependent deficits in BMD and limb formation, suggesting functional redundancy between these two genes in bone and limb development...
  49. ncbi request reprint Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    J Bone Miner Res 19:1945-54. 2004
    ..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men...
  50. ncbi request reprint Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand
    James D Johnston
    Department of Mechanical Engineering, Human Mobility Research Centre, McLaughlin Hall, Room 319, Queen s University and Kingston General Hospital, Kingston, Ont, Canada K7L 3N6
    J Orthop Res 22:867-71. 2004
    ..The results provide a comprehensive understanding of scapholunate ligament biomechanics and demonstrate a relationship between bone and ligament properties...
  51. ncbi request reprint Mechanisms of osteoporosis therapy: a bone strength perspective
    Mary L Bouxsein
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Clin Cornerstone . 2003
    ..This observation suggests that the size, shape, distribution, and composition of bone may have important effects on bone strength and, therefore, the risk of fracture...
  52. ncbi request reprint Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2
    Melissa A Kacena
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
    J Bone Miner Res 19:652-60. 2004
    ..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice...
  53. ncbi request reprint Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density
    Kathryn L Shultz
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:175-85. 2003
    ....
  54. pmc Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice
    Shoshana Yakar
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
    J Clin Invest 113:96-105. 2004
    ..These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism...
  55. ncbi request reprint Bone quality: where do we go from here?
    Mary L Bouxsein
    Osteoporos Int 14:S118-27. 2003
    ....
  56. ncbi request reprint The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
    Dennis M Black
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
    N Engl J Med 349:1207-15. 2003
    ..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone...
  57. ncbi request reprint A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair
    Thomas A Einhorn
    Boston University Medical Center, Massachusetts 02118 2393, USA
    J Bone Joint Surg Am 85:1425-35. 2003
    ..The purpose of this investigation was to test the hypothesis that a single, local, percutaneous injection of rhBMP-2 would accelerate fracture-healing in a standard rat femoral fracture model...
  58. ncbi request reprint High bone mass in mice expressing a mutant LRP5 gene
    Philip Babij
    Genomics, Wyeth Research, Andover, Massachusetts, USA
    J Bone Miner Res 18:960-74. 2003
    ..Together, these findings establish the importance of this novel and unexpected role of a lipoprotein receptor in regulating bone mass and afford a new model to explore LRP5 and its recent association with Wnt signaling in bone biology...
  59. ncbi request reprint Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization
    Mei Zhang
    Department of Medicine, University of Cincinnati, Ohio 45267, USA
    J Biol Chem 277:44005-12. 2002
    ..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required...
  60. ncbi request reprint Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis
    Gang Li
    The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
    J Orthop Res 20:779-88. 2002
    ..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model...
  61. ncbi request reprint Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, ME, USA
    Bone 35:1046-58. 2004
    ..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome...
  62. ncbi request reprint Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo
    Mary L Bouxsein
    The The Jackson Laboratory, Bar Harbor, Maine, USA
    J Bone Miner Res 17:570-9. 2002
    ..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone...
  63. ncbi request reprint Impact of seafood and fruit consumption on bone mineral density
    Pierre A Zalloua
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Maturitas 56:1-11. 2007
    ..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population...
  64. ncbi request reprint The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone
    Shoshana Yakar
    National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
    J Endocrinol 189:289-99. 2006
    ..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)...
  65. ncbi request reprint Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice
    Dominique D Pierroz
    Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
    Bone 39:260-7. 2006
    ..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis...
  66. ncbi request reprint Direct percutaneous gene delivery to enhance healing of segmental bone defects
    Oliver B Betz
    Center for Molecular Orthopaedics, 221 Longwood Avenue, BLI 152, Boston, MA 02115, USA
    J Bone Joint Surg Am 88:355-65. 2006
    ..Direct transfer of osteogenic genes offers an alternative, clinically expeditious, cost-effective approach. We evaluated its potential in a well-established, critical-size, rat femoral defect model...
  67. ncbi request reprint Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures
    B Lawrence Riggs
    Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Bone Miner Res 21:315-23. 2006
    ..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD...
  68. ncbi request reprint Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
    Yi Hsiang Hsu
    Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 83:146-54. 2006
    ..Higher fat mass may be an independent risk factor for osteoporosis and osteoporotic fractures...
  69. ncbi request reprint Determinants of skeletal fragility
    Mary L Bouxsein
    Department of Orthopaedic Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Best Pract Res Clin Rheumatol 19:897-911. 2005
    ..Finally, several current and future methodologies for improving assessment of bone strength in patients are evaluated...
  70. ncbi request reprint Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone
    Patrick Garnero
    INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
    Bone 38:300-9. 2006
    ..We conclude that the extent and nature of collagen cross-linking contribute to the mechanical properties of fetal bovine cortical bone independently of bone mineral density...
  71. ncbi request reprint Cortical stability of the femoral neck and hip fracture risk
    Mary L Bouxsein
    Lancet 366:1523-4; author reply 1524-5. 2005
  72. ncbi request reprint In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography
    Stephanie Boutroy
    INSERM Unit 403, and Claude Bernard University of Lyon, France
    J Clin Endocrinol Metab 90:6508-15. 2005
    ....
  73. ncbi request reprint Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture
    Mary L Bouxsein
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Am Acad Orthop Surg 12:385-95. 2004
    ..Thus, they have the unique opportunity to serve as primary advocates to ensure that appropriate action is taken to reduce the risk of future fracture...
  74. ncbi request reprint Familial aggregation of bone mineral density and bone mineral content in a Chinese population
    Yan Feng
    Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Osteoporos Int 16:1917-23. 2005
    ..39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults...
  75. pmc The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development
    Ying Wang
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    J Clin Invest 117:1616-26. 2007
    ..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone...
  76. ncbi request reprint Bone marrow influences quantitative ultrasound measurements in human cancellous bone
    Patrick H F Nicholson
    Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Ultrasound Med Biol 28:369-75. 2002
    ..Understanding and exploiting these effects could lead to novel approaches for ultrasonic characterisation of both bone and marrow...
  77. ncbi request reprint Predicting the failure load of the distal radius
    Monique E Muller
    Department of Nuclear Medicine Hamilton Health Sciences McMaster Site, HSC 1P10, L8N 3Z5, Hamilton, Ontario, Canada
    Osteoporos Int 14:345-52. 2003
    ..04), whereas the men would have likely withstood the impact without fracturing their wrist (Phi wrist= 0.79)...
  78. ncbi request reprint Health professional's guide to rehabilitation of the patient with osteoporosis
    Francis J Bonner
    Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
    Osteoporos Int 14:S1-22. 2003
  79. ncbi request reprint Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...

Research Grants11

  1. Microcomputed Tomography Device (Scanco UCT40)
    Mary Bouxsein; Fiscal Year: 2004
    ..abstract_text> ..
  2. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary Bouxsein; Fiscal Year: 2009
    ....
  3. CORE--Skeletal Phenotyping Core
    Mary Bouxsein; Fiscal Year: 2007
    ..abstract_text> ..
  4. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary Bouxsein; Fiscal Year: 2007
    ....
  5. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2007
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  6. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2006
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  7. REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTIN
    Mary Bouxsein; Fiscal Year: 2005
    ..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
  8. Biomechanics of Vertebral Fracture: The Framingham QCT Study
    Mary L Bouxsein; Fiscal Year: 2010
    ....