Research Topics
Species | Mary BouxseinSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized ratsJ E M Brouwers
Eindhoven University of Technology, Eindhoven, The Netherlands
Osteoporos Int 20:1377-84. 2009..Typical fatigue behavior was found and was similar to that seen in other species. Fatigue properties were comparable between both groups...
Technology insight: noninvasive assessment of bone strength in osteoporosisMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Nat Clin Pract Rheumatol 4:310-8. 2008..Although they show strong potential, further development and validation of these techniques is needed to define their role in the clinical management of individuals with osteoporosis...- Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomyM L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
Endocrinology 150:144-52. 2009..Our findings also suggest direct positive effects of weight and/or leptin on bone turnover and cortical bone structure, independent of adrenergic signaling... - Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspectiveMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 23:1155-67. 2008..To ensure optimal development and best use of biomarkers to accelerate drug development, continuous dialog among the health professionals, industry, and regulators is of paramount importance... - Guidelines for assessment of bone microstructure in rodents using micro-computed tomographyMary L Bouxsein
Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Bone Miner Res 25:1468-86. 2010..Other variables also may be appropriate depending on the research question and technical quality of the scan. Standard nomenclature, outlined in this article, should be followed for reporting of results... 
Non-invasive measurements of bone strength: promise and perilM L Bouxsein
Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Musculoskelet Neuronal Interact 4:404-5. 2004- Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trialsMary L Bouxsein
Eli Lilly and Company, Indianapolis, Indiana, USA
J Bone Joint Surg Am 91:1329-38. 2009.... - Quantifying the material and structural determinants of bone strengthMary L Bouxsein
Orthopaedic Surgery, Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Department of Orthopaedic Surgery, Harvard Medical School, RN115, 330 Brookline Ave, Boston, MA 02215, USA
Best Pract Res Clin Rheumatol 23:741-53. 2009.... - Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture riskMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 22:825-31. 2007..Reduced trochanteric soft tissue thickness, low femoral aBMD, and increased ratio of fall force to femoral strength (i.e., factor of risk) were associated with increased risk of hip fracture... - beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 20:635-43. 2005..These data indicate that arrestin-mediated regulation of intracellular signaling contributes to the differential effects of PTH at endosteal and periosteal bone surfaces... - Ovariectomy-induced bone loss varies among inbred strains of miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
J Bone Miner Res 20:1085-92. 2005..We show that patterns of bone loss after ovariectomy vary among inbred strains of mice, providing evidence that there may be genetic regulation of bone loss induced by estrogen deficiency... - Bone geometry and skeletal fragilityMary L Bouxsein
Orthopedic Biomechanics Laboratory, RN115, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Curr Osteoporos Rep 4:49-56. 2006..Additional studies that incorporate three-dimensional imaging are needed to better define the relationship between bone geometry and skeletal fragility, and to establish the clinical utility of bone geometry measurements... - Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCTMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 21:1475-82. 2006..With age, vertebral strength declined and Phi(vert) increased significantly more in women than men. Age- and sex-specific differences in Phi(vert) closely resembled previously reported vertebral fracture incidence... - Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in miceMary L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 19:587-99. 2004..Ultimately, identification of genes that regulate trabecular bone traits may yield important information regarding mechanisms that regulate mechanical integrity of the skeleton... - Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fracturesM L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Osteoporos Int 13:358-65. 2002..Therefore, DXR-BMD may be useful for prediction of fracture risk in clinical settings where hip BMD is not available... - Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis StudyE J Samelson
Hebrew SeniorLife, Institute for Aging Research Boston, Boston, MA, USA
Osteoporos Int 22:1123-31. 2011..Agreement was fair to good for mild fractures, and agreement was good to excellent for more severe fractures. CT scout views are useful to assess vertebral fracture... - Prediction of the strength of the elderly proximal femur by bone mineral density and quantitative ultrasound measurements of the heel and tibiaM L Bouxsein
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Bone 25:49-54. 1999..These findings imply that tibial SOS may be of limited use for assessing hip fracture risk. Prospective fracture risk data are needed to define further the clinical utility of tibia ultrasound measurements... - Precision and accuracy of computed digital absorptiometry for assessment of bone density of the handM L Bouxsein
Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Osteoporos Int 7:444-9. 1997..Thus, with further clinical verification, this technique may prove to be a useful tool for the widespread testing and assessment of osteoporotic fracture risk... - Congenic mice reveal sex-specific genetic regulation of femoral structure and strengthC H Turner
Indiana University School of Medicine, Biomechanics and Biomaterials Research Center, 541 Clinical Drive, Room 600, Indianapolis, IN 46202, USA
Calcif Tissue Int 73:297-303. 2003.... - Effect of local density changes on the failure load of the proximal femurZ M Oden
Department of Orthopedic Surgery, Charles A Dana Research Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Orthop Res 17:661-7. 1999..4%. These findings suggest that agents capable of inducing increased bone density in small regions of the proximal femur have the potential to reduce the risk of hip fracture... - Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on boneD Yang
Endocrine Unit, Thier 11, Massachusetts General Hospital, Boston, MA 02114, USA
Bone 40:1453-61. 2007..PTH1R PLC signaling pathway is not required for an anabolic effect of intermittent PTH(1-34) on bone... - Effect of temperature on ultrasonic properties of the calcaneus in situP H F Nicholson
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Osteoporos Int 13:888-92. 2002..Given the magnitude of the thermal coefficients observed, the clinical impact of temperature-related QUS errors is likely to be modest for diagnostic purposes but of greater significance in follow-up studies... - Three-dimensional distribution of bone density in the proximal humerusM J Tingart
Orthopaedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Calcif Tissue Int 73:531-6. 2003..In one. These results point to bone sites that may provide stronger fixation for implants, reduce the risk of implant loosening, and therefore improve patient outcome... - Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defectsO B Betz
Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Gene Ther 14:1039-44. 2007..BMP-2 until 5 or 10 days after surgery enables a greater percentage of critical-sized, segmental defects to achieve radiological union, producing a repair tissue with enhanced mineralization and greater mechanical strength... - Age-related changes in trabecular architecture differ in female and male C57BL/6J miceVaida Glatt
Orthopedic Biomechanics Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Bone Miner Res 22:1197-207. 2007..Deterioration in vertebral and femoral trabecular microarchitecture begins early, continues throughout life, is more pronounced at the femoral metaphysis than in the vertebrae, and is greater in females than males... - Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodelingDennis M Black
Department of Epidemiology and Biostatistics, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
J Clin Endocrinol Metab 93:2166-72. 2008..Daily PTH administration increases bone mineral density (BMD) and reduces fracture risk. However, cost and compliance significantly limit clinical use... - Lifelong accumulation of bone in mice lacking Pten in osteoblastsXimeng Liu
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 104:2259-64. 2007..These findings support a critical role for this tumor-suppressor gene in regulating osteoblast lifespan and likely explain the skeletal abnormalities in patients carrying germ-line mutations of PTEN... - Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healingEleftherios Tsiridis
Department of Orthopaedic Surgery, Boston University Medical Center, Laboratory of Orthopaedic Research, 715 Albany Street, R 205, Boston, Massachusetts 02118, USA
J Orthop Res 25:1193-203. 2007..In addition, differences in systemic versus local effects of PTH and OP-1 in accelerating metaphyseal fracture healing were found... - Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibshipsYi Hsiang Hsu
Harvard School of Public Health, Boston, Massachusetts, USA
J Bone Miner Res 22:184-94. 2007..Our results indicated four genome-wide significant QTLs for BMD. In comparison with 12 previous reported linkage studies, we reveal novel linkage regions that have reaching global significance... - Mechanisms of disease: is osteoporosis the obesity of bone?Clifford J Rosen
The Jackson Laboratory in Bar Harbor, ME 04401, USA
Nat Clin Pract Rheumatol 2:35-43. 2006.... - Structural determinants of vertebral fracture riskL Joseph Melton
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Bone Miner Res 22:1885-92. 2007..Vertebral fractures are more strongly associated with specific bone density, structure, and strength parameters than with areal BMD, but all of these variables are correlated... - Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in miceSiddhartha Mukherjee
Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:491-504. 2008..Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals... - Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector doseVolker M Betz
Center for Molecular Orthopaedics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Gene Ther 18:907-15. 2007..However, the newly formed bone lacked the structural organization of native bone, suggesting that further maturation is necessary... - Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized interventionTamara D Rozental
Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Stoneman 10, Boston, MA 02215, USA
J Bone Joint Surg Am 90:953-61. 2008..The purpose of this study was to determine the rates of evaluation and treatment of osteoporosis following distal radial fractures and to test two interventions in the outpatient clinic to improve evaluation and treatment rates... - Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official PositionsKlaus Engelke
Institute of Medical Physics, University of Erlangen, Germany Synarc, Hamburg, Germany
J Clin Densitom 11:123-62. 2008..Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge... - In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formationMasako Shimada
Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA
J Biol Chem 283:21002-10. 2008..Collectively, our findings provide the first in vivo demonstration that the calpain small subunit is essential for proper osteoblast activity and bone remodeling... - Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineageSeth D Berman
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:11851-6. 2008..Finally, we show that loss of Rb and p53 in Sca-1-positive mesenchymal stem/progenitor cells is sufficient to yield transformed cells that can initiate osteosarcoma formation in vivo... - Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized ratsJulie F McManus
Department of Medicine, University of Melbourne, Austin Health, Studley Road, Heidelberg, Vic, Australia
Bone 42:1164-74. 2008..fPth1 was similarly effective in SHAM rats. Notwithstanding the low amino acid sequence homology with hPTH (1-34), we have clearly established the efficacy of fPth1 (1-34) as an anabolic bone agent... - PPARG by dietary fat interaction influences bone mass in mice and humansCheryl L Ackert-Bicknell
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Bone Miner Res 23:1398-408. 2008..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene... - Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in miceLaura E Wright
Department of Physiology, The University of Arizona, Tucson, Arizona, USA
J Bone Miner Res 23:1296-303. 2008.... - Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCTDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107, USA
J Bone Miner Res 23:1326-33. 2008.... - Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal womenStephanie Boutroy
INSERM Research Unit 831 and Université de Lyon, Lyon, France
J Bone Miner Res 23:392-9. 2008..BMD, bone microarchitecture, and bone mechanical properties assessed in vivo by finite element analysis were associated with wrist fracture in postmenopausal women... - A soluble activin type IIA receptor induces bone formation and improves skeletal integrityR Scott Pearsall
Acceleron Pharma, Inc, 149 Sidney Street, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 105:7082-7. 2008..These observations support the development of this pharmacological strategy for the treatment of diseases with skeletal fragility... - Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal womenL Joseph Melton
Division of Epidemology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Bone Miner Res 22:1442-8. 2007..Bone structure, strength and load-strength ratios contribute to forearm fracture risk independently of areal BMD... - Impact of seafood and fruit consumption on bone mineral densityPierre A Zalloua
Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
Maturitas 56:1-11. 2007..We investigated environmental determinants, specifically dietary habits, of BMD by using multiple regression models in a rural Chinese population... - Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6Sheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan, USA
J Bone Miner Res 19:2033-40. 2004..We found that compound mutants had dose-dependent deficits in BMD and limb formation, suggesting functional redundancy between these two genes in bone and limb development... - Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sitesB Lawrence Riggs
Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
J Bone Miner Res 19:1945-54. 2004..Over life, the cross-sectional area of the vertebrae and proximal femur increased by approximately 15% in both sexes, whereas vBMD at these sites decreased by 39-55% and 34-46%, respectively, with greater decreases in women than in men... - Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the handJames D Johnston
Department of Mechanical Engineering, Human Mobility Research Centre, McLaughlin Hall, Room 319, Queen's University and Kingston General Hospital, Kingston, Ont, Canada K7L 3N6
J Orthop Res 22:867-71. 2004..The results provide a comprehensive understanding of scapholunate ligament biomechanics and demonstrate a relationship between bone and ligament properties... - Mechanisms of osteoporosis therapy: a bone strength perspectiveMary L Bouxsein
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Clin Cornerstone . 2003..This observation suggests that the size, shape, distribution, and composition of bone may have important effects on bone strength and, therefore, the risk of fracture... - Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2Melissa A Kacena
Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06520 8071, USA
J Bone Miner Res 19:652-60. 2004..Osteoblast proliferation increased up to 6-fold when cultured with megakaryocytes. A megakaryocyte-osteoblast interaction plays a role in the increased bone formation in these mice... - Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral densityKathryn L Shultz
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Bone Miner Res 18:175-85. 2003.... - Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient miceShoshana Yakar
Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda Maryland 20892 1758, USA
J Clin Invest 113:96-105. 2004..These results suggest that IGF-1 plays a role in maintaining a fine balance between GH and insulin to promote normal carbohydrate and lipid metabolism... - Bone quality: where do we go from here?Mary L Bouxsein
Osteoporos Int 14:S118-27. 2003.... - The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosisDennis M Black
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94105, USA
N Engl J Med 349:1207-15. 2003..We conducted a randomized, double-blind clinical study of parathyroid hormone and alendronate to test the hypothesis that the concurrent administration of the two agents would increase bone density more than the use of either one alone... - A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repairThomas A Einhorn
Boston University Medical Center, Massachusetts 02118 2393, USA
J Bone Joint Surg Am 85:1425-35. 2003..The purpose of this investigation was to test the hypothesis that a single, local, percutaneous injection of rhBMP-2 would accelerate fracture-healing in a standard rat femoral fracture model... - High bone mass in mice expressing a mutant LRP5 genePhilip Babij
Genomics, Wyeth Research, Andover, Massachusetts, USA
J Bone Miner Res 18:960-74. 2003..Together, these findings establish the importance of this novel and unexpected role of a lipoprotein receptor in regulating bone mass and afford a new model to explore LRP5 and its recent association with Wnt signaling in bone biology... - Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralizationMei Zhang
Department of Medicine, University of Cincinnati, Ohio 45267, USA
J Biol Chem 277:44005-12. 2002..This action is likely to be particularly important during the pubertal growth spurt when rapid bone formation and consolidation are required... - Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesisGang Li
The Department of Trauma and Orthopaedic Surgery, Queen s University of Belfast, Musgrave Park Hospital, UK
J Orthop Res 20:779-88. 2002..In Summary, both injection of rhBMP-2/buffer and implantation of rhBMP-2/ACS enhanced the consolidation stage of distraction osteogenesis in this rabbit model... - Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation programClifford J Rosen
The Jackson Laboratory, Bar Harbor, ME, USA
Bone 35:1046-58. 2004..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome... - Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivoMary L Bouxsein
The The Jackson Laboratory, Bar Harbor, Maine, USA
J Bone Miner Res 17:570-9. 2002..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone... - The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormoneShoshana Yakar
National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA
J Endocrinol 189:289-99. 2006..We postulate that the ternary complex itself, rather than IGF-I alone, influences bone acquisition in a compartment-specific manner (i.e. cortical vs trabecular bone)... - Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized miceDominique D Pierroz
Service of Bone Diseases, WHO Collaborating Center for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, Geneva University Hospital, HUGs, 24, rue Micheli-du-Crest, 1211 Geneva 14, Switzerland
Bone 39:260-7. 2006..In turn, PRO exerted synergistic effects with intermittent PTH on bone mass and cancellous bone architecture. As such, combined therapy of beta-blockers and PTH may be of interest in the treatment of postmenopausal osteoporosis... - Direct percutaneous gene delivery to enhance healing of segmental bone defectsOliver B Betz
Center for Molecular Orthopaedics, 221 Longwood Avenue, BLI-152, Boston, MA 02115, USA
J Bone Joint Surg Am 88:355-65. 2006..BMP-2 induces healing of critical-size femoral bone defects in rats within eight weeks. At this time, the repair tissue is predominantly trabecular bone, has normal bone mineral content, and has gained mechanical strength... - Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fracturesB Lawrence Riggs
Endocrine Research Unit, Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Bone Miner Res 21:315-23. 2006..These load/strength ratios more closely simulated patterns of wrist and hip fractures occurring in the same population than did measurement of vBMD... - Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and womenYi-Hsiang Hsu
Program for Population Genetics, Harvard School of Public Health, Boston, MA, USA
Am J Clin Nutr 83:146-54. 2006..Thus, fat mass has a negative effect on bone mass in contrast with the positive effect of weight-bearing itself... - Determinants of skeletal fragilityMary L Bouxsein
Department of Orthopaedic Surgery, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Best Pract Res Clin Rheumatol 19:897-911. 2005..Finally, several current and future methodologies for improving assessment of bone strength in patients are evaluated... - Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bonePatrick Garnero
INSERM Unit 403, Hopital E Herriot, Pav F, 69437 Lyon Cedex 03, France
Bone 38:300-9. 2006..We conclude that the extent and nature of collagen cross-linking contribute to the mechanical properties of fetal bovine cortical bone independently of bone mineral density... - Cortical stability of the femoral neck and hip fracture riskMary L Bouxsein
Lancet 366:1523-4; author reply 1524-5. 2005 - In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomographyStephanie Boutroy
INSERM Unit 403, and Claude Bernard University of Lyon, France
J Clin Endocrinol Metab 90:6508-15. 2005..CONCLUSION: HR-pQCT appears promising to assess bone density and microarchitecture at peripheral sites in terms of reproducibility and ability to detect age- and disease-related changes... - Familial aggregation of bone mineral density and bone mineral content in a Chinese populationYan Feng
Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
Osteoporos Int 16:1917-23. 2005..39)], 8.71 (95% CI 5.74-13.22) and 5.90 (95% CI 3.57-9.76) for total body, total hip and lumbar spine, respectively. This study demonstrates a significant familial aggregation of BMD and BMC in a large sample of rural Chinese adults... - Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fractureMary L Bouxsein
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Am Acad Orthop Surg 12:385-95. 2004..Thus, they have the unique opportunity to serve as primary advocates to ensure that appropriate action is taken to reduce the risk of future fracture... - Essential role of beta-catenin in postnatal bone acquisitionSheri L Holmen
Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
J Biol Chem 280:21162-8. 2005..These findings suggest that Wnt/beta-catenin signaling in osteoblasts coordinates postnatal bone acquisition by controlling the differentiation and activity of both osteoblasts and osteoclasts... - Bone marrow influences quantitative ultrasound measurements in human cancellous bonePatrick H F Nicholson
Orthopedic Biomechanics Laboratory, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Ultrasound Med Biol 28:369-75. 2002..Understanding and exploiting these effects could lead to novel approaches for ultrasonic characterisation of both bone and marrow... - Predicting the failure load of the distal radiusMonique E Muller
Department of Nuclear Medicine Hamilton Health Sciences McMaster Site, HSC-1P10, L8N 3Z5, Hamilton, Ontario, Canada
Osteoporos Int 14:345-52. 2003..04), whereas the men would have likely withstood the impact without fracturing their wrist (Phi wrist= 0.79)... - Health professional's guide to rehabilitation of the patient with osteoporosisFrancis J Bonner
Medical Director, Rehabilitation Hospital of South Jersey, Vineland, NJ, USA
Osteoporos Int 14:S1-22. 2003 - The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal developmentYing Wang
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
J Clin Invest 117:1616-26. 2007..These studies suggest that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone... - Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body compositionClifford J Rosen
The Jackson Laboratory, Bar Harbor, Maine, USA
Pediatr Nephrol 20:255-60. 2005..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...
Research Grants
- Microcomputed Tomography Device (Scanco UCT40)Mary Bouxsein; Fiscal Year: 2004..abstract_text> ..
- CORE--Skeletal Phenotyping CoreMary Bouxsein; Fiscal Year: 2007..abstract_text> ..
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary Bouxsein; Fiscal Year: 2007....
- REGULATION OF PTH ACTIVITY IN BONE BY BETA-ARRESTINMary Bouxsein; Fiscal Year: 2007..Information gained from the proposed studies will be instrumental for developing new PTH1R ligands with improved signaling and biologic activity profiles for treatment of osteoporosis and other metabolic bone disorders. ..
- Biomechanics of Vertebral Fracture: The Framingham QCT StudyMary L Bouxsein; Fiscal Year: 2010....