A Bousvaros

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Medical therapy for refractory pediatric Crohn's disease
    William A Faubion
    Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 4:1199-213. 2006
  2. pmc Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease
    Eliseo Papa
    Harvard MIT Health Science and Technology Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e39242. 2012
  3. pmc Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    Xochitl C Morgan
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genome Biol 13:R79. 2012
  4. ncbi request reprint Mucosal healing in children with Crohn's disease: appropriate therapeutic goal or medical overkill?
    Athos Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital, Boston, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 10:481-3. 2004
  5. ncbi request reprint Research and clinical challenges in paediatric inflammatory bowel disease
    A Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital Boston, Harvard Medical School, MA 02115, United States
    Dig Liver Dis 40:32-8. 2008
  6. doi request reprint Use of immunomodulators and biologic therapies in children with inflammatory bowel disease
    Athos Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital Boston, MA 02115, USA
    Expert Rev Clin Immunol 6:659-66. 2010
  7. ncbi request reprint Challenges in pediatric inflammatory bowel disease
    Athos Bousvaros
    Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Inflamm Bowel Dis 12:885-913. 2006
  8. ncbi request reprint A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease
    Athos Bousvaros
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 11:833-9. 2005
  9. ncbi request reprint Challenges and progress in pediatric inflammatory bowel disease
    Paul A Rufo
    Children s Hospital Boston, Inflammatory Bowel Disease Center, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 23:406-12. 2007
  10. ncbi request reprint Intercenter variation in initial management of children with Crohn's disease
    Michael D Kappelman
    Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 13:890-5. 2007

Detail Information

Publications47

  1. ncbi request reprint Medical therapy for refractory pediatric Crohn's disease
    William A Faubion
    Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 4:1199-213. 2006
    ..This review discusses the data existing in both the adult and pediatric literature for medical therapy of refractory pediatric Crohn's disease...
  2. pmc Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease
    Eliseo Papa
    Harvard MIT Health Science and Technology Institute, Cambridge, Massachusetts, United States of America
    PLoS ONE 7:e39242. 2012
    ..We investigated the use of 16S rRNA sequencing of fecal samples and new analytical methods to assess differences in the microbiota of children with IBD and other gastrointestinal disorders...
  3. pmc Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
    Xochitl C Morgan
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Genome Biol 13:R79. 2012
    ..Gene and pathway composition were assessed, based on 16S data from phylogenetically-related reference genomes, and associated using sparse multivariate linear modeling with medications, environmental factors, and IBD status...
  4. ncbi request reprint Mucosal healing in children with Crohn's disease: appropriate therapeutic goal or medical overkill?
    Athos Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital, Boston, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 10:481-3. 2004
  5. ncbi request reprint Research and clinical challenges in paediatric inflammatory bowel disease
    A Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital Boston, Harvard Medical School, MA 02115, United States
    Dig Liver Dis 40:32-8. 2008
    ..Particular emphasis is given to the link between the improvement of the research in the pathogenetic mechanisms and the development of novel therapeutic strategies able to promote a change in the natural course of the disorder...
  6. doi request reprint Use of immunomodulators and biologic therapies in children with inflammatory bowel disease
    Athos Bousvaros
    Inflammatory Bowel Disease Center, Children s Hospital Boston, MA 02115, USA
    Expert Rev Clin Immunol 6:659-66. 2010
    ..This article provides information about the safety and efficacy of these medications in the treatment of children with Crohn's disease and ulcerative colitis...
  7. ncbi request reprint Challenges in pediatric inflammatory bowel disease
    Athos Bousvaros
    Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Inflamm Bowel Dis 12:885-913. 2006
    ..At the conclusion of the meeting, investigators discussed the formation of a multicenter collaborative network to advance clinical and basic research in the field...
  8. ncbi request reprint A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's disease
    Athos Bousvaros
    Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 11:833-9. 2005
    ..18). The LGG was well tolerated, with a side effect profile comparable with placebo. This study suggests that LGG does not prolong time to relapse in children with CD when given as an adjunct to standard therapy...
  9. ncbi request reprint Challenges and progress in pediatric inflammatory bowel disease
    Paul A Rufo
    Children s Hospital Boston, Inflammatory Bowel Disease Center, Boston, Massachusetts 02115, USA
    Curr Opin Gastroenterol 23:406-12. 2007
    ....
  10. ncbi request reprint Intercenter variation in initial management of children with Crohn's disease
    Michael D Kappelman
    Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
    Inflamm Bowel Dis 13:890-5. 2007
    ..We undertook this study to determine the extent of intercenter variation in the initial management of children newly diagnosed with Crohn's disease...
  11. ncbi request reprint Current therapy of inflammatory bowel disease in children
    Paul A Rufo
    Center for Inflammatory Bowel Diseases, Combined Program in Gastroenterology and Nutrition, Children s Hospital, Boston, Massachusetts 02115, USA
    Paediatr Drugs 8:279-302. 2006
    ..In addition, patients with UC and CD involving the colon are at increased risk of developing colon cancer, and should be enrolled into a colonoscopy surveillance program after 8-10 years of disease duration...
  12. doi request reprint Restorative proctocolectomy and ileal pouch-anal anastomosis in children
    Craig W Lillehei
    Department of Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Dis Colon Rectum 52:1645-9. 2009
    ..This study was designed to evaluate the results of restorative proctocolectomy with distal rectal mucosectomy and ileal pouch-anal anastomosis in children...
  13. ncbi request reprint 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprine
    Scott Hande
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Inflamm Bowel Dis 12:251-7. 2006
    ..We tested the theory that coadministration of 5-ASA agents with AZA/6-MP results in higher 6-TGn levels in a large cohort of children and adults with CD or ulcerative colitis (UC)...
  14. ncbi request reprint Depressive symptoms and inflammatory bowel disease in children and adolescents: a cross-sectional study
    Eva Szigethy
    Department of Psychiatry, Children s Hospital, Boston, Massachusetts 02115, USA
    J Pediatr Gastroenterol Nutr 39:395-403. 2004
    ..This study assessed the rates of depressive symptoms in older children and adolescents with inflammatory bowel disease (IBD) and the associations between depressive symptoms and IBD disease characteristics...
  15. ncbi request reprint Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis
    A Bitton
    Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Gastroenterology 120:13-20. 2001
    ..Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. We aimed to assess whether clinical, biological, and histologic parameters in quiescent UC predict time to clinical relapse...
  16. ncbi request reprint Pouch outcomes among children with ulcerative colitis treated with calcineurin inhibitors before ileal pouch anal anastomosis surgery
    Elizabeth J Hait
    The Center for Inflammatory Bowel Disease, Children s Hospital Boston, Harvard University, Boston, MA 02115, USA
    J Pediatr Surg 42:31-4; discussion 34-5. 2007
    ..The purpose of this article is to describe the outcomes of the pouches of 14 children with ulcerative colitis (UC) who were pretreated with calcineurin inhibitors before they underwent their ileal pouch anal anastomosis (IPAA) surgery...
  17. ncbi request reprint Elevated serum hepatocyte growth factor in children and young adults with inflammatory bowel disease
    M Srivastava
    Combined Program in Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115
    J Pediatr Gastroenterol Nutr 33:548-53. 2001
    ..The raised serum HGF suggests that HGF may mediate angiogenesis and vascular permeability in the mucosa of children with inflammatory bowel disease. Alternatively, the raised serum HGF may be an epiphenomenon of inflammation...
  18. ncbi request reprint Thalidomide in gastrointestinal disorders
    A Bousvaros
    Division of Gastroenterology, Boston Children s Hospital Harvard Medical School, Massachusetts 02115, USA
    Drugs 61:777-87. 2001
    ..Given the potential toxicity, thalidomide use should generally be limited to clinical protocols with institutional review board oversight...
  19. ncbi request reprint Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn disease
    Rachel Rosen
    Division of Pediatric Gastroenterology and Inflammatory Bowel Disease Center, Boston Children s Hospital, Boston, Massachusetts, USA
    J Pediatr Gastroenterol Nutr 35:695-9. 2002
  20. ncbi request reprint The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States
    Michael D Kappelman
    Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Clin Gastroenterol Hepatol 5:1424-9. 2007
    ..This study sought to determine the prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in a large national sample and to compare the prevalence across geographic regions and other sociodemographic characteristics...
  21. ncbi request reprint Inflammatory bowel disease associated with immune thrombocytopenic purpura in children
    L M Higuchi
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 33:582-7. 2001
    ..To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP...
  22. pmc Immune response to influenza vaccine in children with inflammatory bowel disease
    Ying Lu
    Division of Gastroenterology, Hepatology, and Nutrition, Inflammatory Bowel Disease Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 104:444-53. 2009
    ..The immune response in these patients to vaccines has not been well studied. We conducted a prospective, open label study to evaluate the serologic response to influenza vaccine in children with IBD...
  23. ncbi request reprint Risk of early surgery for Crohn's disease: implications for early treatment strategies
    Bruce E Sands
    Gastrointestinal Unit and Center for the Study of IBD, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRJ 7, Boston, MA 02114, USA
    Am J Gastroenterol 98:2712-8. 2003
    ..In this study we aimed to define the rate of early surgery for Crohn's disease and to identify risk factors associated with early surgery as a basis for subsequent studies of early intervention in Crohn's disease...
  24. ncbi request reprint Nutritional concerns in pediatric inflammatory bowel disease patients
    Michael D Kappelman
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Mol Nutr Food Res 52:867-74. 2008
    ..This article provides an overview of the epidemiology, pathophysiology, evaluation, and management of selected nutritional complications in pediatric IBD...
  25. ncbi request reprint Workshop report: prevention of postoperative recurrence in Crohn's disease
    James Markowitz
    Division of Pediatric Gastroenterology, Schneider Chidren s Hospital, North Shore LIJ Health System, New Hyde Park, NY 11040, and University of Chicago, Chicago, IL, USA
    J Pediatr Gastroenterol Nutr 41:145-51. 2005
  26. ncbi request reprint Efficacy of probiotic use in acute diarrhea in children: a meta-analysis
    Jeannie S Huang
    Children s Hospital, Boston, Massachusetts, USA
    Dig Dis Sci 47:2625-34. 2002
    ..6 to -1.2 days, P < 0.001). In conclusion, bacterial probiotic therapy shortens the duration of acute diarrheal illness in children by approximately one day...
  27. ncbi request reprint Blocking lymphocyte adhesion: new treatment for sticky cases of Crohn disease?
    Sue J Rhee
    The Children s Hospital, Department of Gastroenterology and Nutrition, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr Gastroenterol Nutr 37:211-3. 2003
  28. ncbi request reprint Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype
    Anna Zholudev
    Inflammatory Bowel Disease Center, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Gastroenterol 99:2235-41. 2004
    ..We also wished to determine whether antibody levels correlated with disease activity, and whether a specific antibody pattern correlated with location and outcome of disease in children...
  29. pmc Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation
    Gaith Semrin
    Center for Inflammatory Bowel Disease and Divisions of Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Inflamm Bowel Dis 12:1101-6. 2006
    ..We sought to elucidate alterations in iron absorption in pediatric patients with active and inactive CD...
  30. ncbi request reprint Isolated neonatal swallowing dysfunction: a case series and review of the literature
    Robert B Heuschkel
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Boston, Massachusetts 02115, USA
    Dig Dis Sci 48:30-5. 2003
    ..Nasogastric feeding followed by a gastrostomy is recommended in those without gastroesophageal reflux. Jejunal feedings are necessary in some. While most improve over time, they may need nutritional support for 3 years or more...
  31. doi request reprint Immunizations in patients with inflammatory bowel disease
    Ying Lu
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Inflamm Bowel Dis 15:1417-23. 2009
    ..While some studies in immune compromised hosts suggest the live attenuated varicella vaccine can be given without adverse events, administration of this vaccine in patients on immunosuppression remains controversial...
  32. ncbi request reprint Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findings
    Jonathan N Glickman
    Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 28:190-7. 2004
    ..Therefore, the objectives of this study were to determine the clinical and pathologic features of new-onset UC in children and to compare the initial presentation of UC in this group with a control group of adults...
  33. ncbi request reprint A review of activity indices and end points for clinical trials in children with Crohn's disease
    Anne M Griffiths
    Hospital for Sick Children, Toronto, Ontario, Canada
    Inflamm Bowel Dis 11:185-96. 2005
    ....
  34. ncbi request reprint Effect of early immunomodulator use in moderate to severe pediatric Crohn disease
    Jaya Punati
    Nationwide Children s Hospital, Ohio State University, Columbus, Ohio 43210, USA
    Inflamm Bowel Dis 14:949-54. 2008
    ..We describe IM use in newly diagnosed pediatric CD, comparing outcomes of "early" versus "late" initiation of therapy...
  35. ncbi request reprint Complementary medicine use in children and young adults with inflammatory bowel disease
    Robert Heuschkel
    Center for Pediatric Gastroenterology, Royal Free Hospital, London, United Kingdom
    Am J Gastroenterol 97:382-8. 2002
    ..We examined the use of complementary alternative medicine (CAM) in children and young adults with inflammatory bowel disease...
  36. ncbi request reprint Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel disease
    Anthony R Otley
    FRCPC, Division of Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada
    Inflamm Bowel Dis 12:684-91. 2006
    ..The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis...
  37. ncbi request reprint Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America
    Athos Bousvaros
    J Pediatr Gastroenterol Nutr 44:653-74. 2007
    ....
  38. ncbi request reprint The natural history of corticosteroid therapy for ulcerative colitis in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut, USA
    Clin Gastroenterol Hepatol 4:1118-23. 2006
    ..The aim of this study was to determine the clinical outcome after corticosteroid therapy in children who are newly diagnosed with ulcerative colitis (UC)...
  39. ncbi request reprint Corticosteroid therapy in the age of infliximab: acute and 1-year outcomes in newly diagnosed children with Crohn's disease
    James Markowitz
    North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
    Clin Gastroenterol Hepatol 4:1124-9. 2006
    ..We also aimed to determine whether there are clinical or laboratory characteristics associated with corticosteroid therapy outcomes...
  40. ncbi request reprint Pediatric inflammatory bowel disease: what children can teach adults
    Elizabeth Hait
    Inflamm Bowel Dis 11:519-27. 2005
  41. ncbi request reprint Effective advocacy for patients with inflammatory bowel disease: communication with insurance companies, school administrators, employers, and other health care overseers
    Jennifer C Jaff
    Advocacy for Patients with Chronic Illness, Inc, Farmington, Connecticut, USA
    Inflamm Bowel Dis 12:814-23. 2006
    ..Although this article has a pediatric focus, adults have similar advocacy needs. Case examples and sample letters to third-party payors, schools, and employers are included in this article...
  42. ncbi request reprint Research agenda for pediatric gastroenterology, hepatology and nutrition: chronic inflammatory bowel disease. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition F
    Menno Verhave
    Children s Digestive Health and Nutrition Foundation, PO Box 6, Flourtown, PA 19031, USA
    J Pediatr Gastroenterol Nutr 35:S286-90. 2002
  43. ncbi request reprint Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut, USA
    J Pediatr Gastroenterol Nutr 41:416-21. 2005
    ....
  44. ncbi request reprint Normal homocysteine levels in a population of children with inflammatory bowel disease
    Anna Zholudev
    Inflamm Bowel Dis 11:620-1. 2005
  45. ncbi request reprint Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohorts
    Subra Kugathasan
    Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pediatr 151:523-7. 2007
    ..To conduct a systematic review of children with newly diagnosed inflammatory bowel disease (IBD) from 2 prospective inception cohorts to examine body mass index (BMI) status at presentation...
  46. ncbi request reprint Laboratory values for children with newly diagnosed inflammatory bowel disease
    David R Mack
    Department of Pediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
    Pediatrics 119:1113-9. 2007
    ..The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease...
  47. ncbi request reprint Cognitive-behavioral therapy for adolescents with inflammatory bowel disease and subsyndromal depression
    Eva Szigethy
    Children s Hospital of Pittsburgh University of Pittsburgh Medical Center, Department of Psychiatry, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 46:1290-8. 2007
    ....