Research Topics
| A BousvarosSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Medical therapy for refractory pediatric Crohn's diseaseWilliam A Faubion
Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 4:1199-213. 2006..This review discusses the data existing in both the adult and pediatric literature for medical therapy of refractory pediatric Crohn's disease...
Use of immunomodulators and biologic therapies in children with inflammatory bowel diseaseAthos Bousvaros
Inflammatory Bowel Disease Center, Children s Hospital Boston, MA 02115, USA
Expert Rev Clin Immunol 6:659-66. 2010..This article provides information about the safety and efficacy of these medications in the treatment of children with Crohn's disease and ulcerative colitis...- A randomized, double-blind trial of Lactobacillus GG versus placebo in addition to standard maintenance therapy for children with Crohn's diseaseAthos Bousvaros
Division of Pediatric Gastroenterology, Children s Hospital, Boston, Massachusetts 02115, USA
Inflamm Bowel Dis 11:833-9. 2005..18). The LGG was well tolerated, with a side effect profile comparable with placebo. This study suggests that LGG does not prolong time to relapse in children with CD when given as an adjunct to standard therapy... - Challenges in pediatric inflammatory bowel diseaseAthos Bousvaros
Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
Inflamm Bowel Dis 12:885-913. 2006..At the conclusion of the meeting, investigators discussed the formation of a multicenter collaborative network to advance clinical and basic research in the field... - Research and clinical challenges in paediatric inflammatory bowel diseaseA Bousvaros
Inflammatory Bowel Disease Center, Children s Hospital Boston, Harvard Medical School, MA 02115, United States
Dig Liver Dis 40:32-8. 2008..Particular emphasis is given to the link between the improvement of the research in the pathogenetic mechanisms and the development of novel therapeutic strategies able to promote a change in the natural course of the disorder... - Mucosal healing in children with Crohn's disease: appropriate therapeutic goal or medical overkill?Athos Bousvaros
Inflammatory Bowel Disease Center, Children s Hospital, Boston, Boston, Massachusetts 02115, USA
Inflamm Bowel Dis 10:481-3. 2004 - Depressive symptoms and inflammatory bowel disease in children and adolescents: a cross-sectional studyEva Szigethy
Department of Psychiatry, Children s Hospital, Boston, Massachusetts 02115, USA
J Pediatr Gastroenterol Nutr 39:395-403. 2004..This study assessed the rates of depressive symptoms in older children and adolescents with inflammatory bowel disease (IBD) and the associations between depressive symptoms and IBD disease characteristics... - Intercenter variation in initial management of children with Crohn's diseaseMichael D Kappelman
Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts 02115, USA
Inflamm Bowel Dis 13:890-5. 2007..We undertook this study to determine the extent of intercenter variation in the initial management of children newly diagnosed with Crohn's disease... - Challenges and progress in pediatric inflammatory bowel diseasePaul A Rufo
Children s Hospital Boston, Inflammatory Bowel Disease Center, Boston, Massachusetts 02115, USA
Curr Opin Gastroenterol 23:406-12. 2007.... - Restorative proctocolectomy and ileal pouch-anal anastomosis in childrenCraig W Lillehei
Department of Surgery, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Dis Colon Rectum 52:1645-9. 2009..This study was designed to evaluate the results of restorative proctocolectomy with distal rectal mucosectomy and ileal pouch-anal anastomosis in children... - Current therapy of inflammatory bowel disease in childrenPaul A Rufo
Center for Inflammatory Bowel Diseases, Combined Program in Gastroenterology and Nutrition, Children s Hospital, Boston, Massachusetts 02115, USA
Paediatr Drugs 8:279-302. 2006..In addition, patients with UC and CD involving the colon are at increased risk of developing colon cancer, and should be enrolled into a colonoscopy surveillance program after 8-10 years of disease duration... - 5-aminosalicylate therapy is associated with higher 6-thioguanine levels in adults and children with inflammatory bowel disease in remission on 6-mercaptopurine or azathioprineScott Hande
Brigham and Women s Hospital, Boston, Massachusetts, USA
Inflamm Bowel Dis 12:251-7. 2006..We tested the theory that coadministration of 5-ASA agents with AZA/6-MP results in higher 6-TGn levels in a large cohort of children and adults with CD or ulcerative colitis (UC)... - Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitisA Bitton
Gastroenterology Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Gastroenterology 120:13-20. 2001..Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel disease. We aimed to assess whether clinical, biological, and histologic parameters in quiescent UC predict time to clinical relapse... - Pouch outcomes among children with ulcerative colitis treated with calcineurin inhibitors before ileal pouch anal anastomosis surgeryElizabeth J Hait
The Center for Inflammatory Bowel Disease, Children s Hospital Boston, Harvard University, Boston, MA 02115, USA
J Pediatr Surg 42:31-4; discussion 34-5. 2007..The purpose of this article is to describe the outcomes of the pouches of 14 children with ulcerative colitis (UC) who were pretreated with calcineurin inhibitors before they underwent their ileal pouch anal anastomosis (IPAA) surgery... - Thalidomide in gastrointestinal disordersA Bousvaros
Division of Gastroenterology, Boston Children s Hospital Harvard Medical School, Massachusetts 02115, USA
Drugs 61:777-87. 2001..Given the potential toxicity, thalidomide use should generally be limited to clinical protocols with institutional review board oversight... - The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United StatesMichael D Kappelman
Center for Inflammatory Bowel Disease, Division of Gastroenterology and Nutrition, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
Clin Gastroenterol Hepatol 5:1424-9. 2007..This study sought to determine the prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in a large national sample and to compare the prevalence across geographic regions and other sociodemographic characteristics... - Severe pancytopenia from thiopurine methyltransferase deficiency: a preventable complication of 6-mercaptopurine therapy in children with Crohn diseaseRachel Rosen
Division of Pediatric Gastroenterology and Inflammatory Bowel Disease Center, Boston Children's Hospital, Boston, Massachusetts, USA
J Pediatr Gastroenterol Nutr 35:695-9. 2002 - Elevated serum hepatocyte growth factor in children and young adults with inflammatory bowel diseaseM Srivastava
Combined Program in Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115
J Pediatr Gastroenterol Nutr 33:548-53. 2001..The raised serum HGF suggests that HGF may mediate angiogenesis and vascular permeability in the mucosa of children with inflammatory bowel disease. Alternatively, the raised serum HGF may be an epiphenomenon of inflammation... - Inflammatory bowel disease associated with immune thrombocytopenic purpura in childrenL M Higuchi
Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
J Pediatr Gastroenterol Nutr 33:582-7. 2001..To date, only five children with both diseases have been described. The aim of the study was to describe the characteristics of children with IBD and ITP... - Immune response to influenza vaccine in children with inflammatory bowel diseaseYing Lu
Division of Gastroenterology, Hepatology, and Nutrition, Inflammatory Bowel Disease Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Am J Gastroenterol 104:444-53. 2009..The immune response in these patients to vaccines has not been well studied. We conducted a prospective, open label study to evaluate the serologic response to influenza vaccine in children with IBD... - Risk of early surgery for Crohn's disease: implications for early treatment strategiesBruce E Sands
Gastrointestinal Unit and Center for the Study of IBD, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRJ 7, Boston, MA 02114, USA
Am J Gastroenterol 98:2712-8. 2003..These results suggest that improved risk stratification and potent therapies with rapid onset of action are needed to modify the natural history of Crohn's disease... - Nutritional concerns in pediatric inflammatory bowel disease patientsMichael D Kappelman
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Mol Nutr Food Res 52:867-74. 2008..This article provides an overview of the epidemiology, pathophysiology, evaluation, and management of selected nutritional complications in pediatric IBD... - Blocking lymphocyte adhesion: new treatment for sticky cases of Crohn disease?Sue J Rhee
The Children s Hospital, Department of Gastroenterology and Nutrition, Harvard Medical School, Boston, Massachusetts, USA
J Pediatr Gastroenterol Nutr 37:211-3. 2003 - Workshop report: prevention of postoperative recurrence in Crohn's diseaseJames Markowitz
Division of Pediatric Gastroenterology, Schneider Chidren's Hospital, North Shore-LIJ Health System, New Hyde Park, NY 11040, and University of Chicago, Chicago, IL, USA
J Pediatr Gastroenterol Nutr 41:145-51. 2005 - Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotypeAnna Zholudev
Inflammatory Bowel Disease Center, Division of Gastroenterology and Nutrition, Children's Hospital Boston, Boston, Massachusetts 02115, USA
Am J Gastroenterol 99:2235-41. 2004..The ASCA antibodies, while highly specific for CD, identify predominantly the subset of children with disease of the ileum and ascending colon who may be at increased risk of surgery... - Efficacy of probiotic use in acute diarrhea in children: a meta-analysisJeannie S Huang
Children's Hospital, Boston, Massachusetts, USA
Dig Dis Sci 47:2625-34. 2002..6 to -1.2 days, P < 0.001). In conclusion, bacterial probiotic therapy shortens the duration of acute diarrheal illness in children by approximately one day... - Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findingsJonathan N Glickman
Department of Pathology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Surg Pathol 28:190-7. 2004..Therefore, the objectives of this study were to determine the clinical and pathologic features of new-onset UC in children and to compare the initial presentation of UC in this group with a control group of adults... - Isolated neonatal swallowing dysfunction: a case series and review of the literatureRobert B Heuschkel
Combined Program in Pediatric Gastroenterology and Nutrition, Children's Hospital, Boston, Massachusetts 02115, USA
Dig Dis Sci 48:30-5. 2003..Nasogastric feeding followed by a gastrostomy is recommended in those without gastroesophageal reflux. Jejunal feedings are necessary in some. While most improve over time, they may need nutritional support for 3 years or more... 
Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammationGaith Semrin
Center for Inflammatory Bowel Disease and Divisions of Gastroenterology and Nutrition, Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
Inflamm Bowel Dis 12:1101-6. 2006..These findings suggest that oral iron may be of limited benefit to these patients. Future study is needed to define the molecular basis for impaired iron absorption...- Immunizations in patients with inflammatory bowel diseaseYing Lu
Inflammatory Bowel Disease Center, Division of Gastroenterology, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
Inflamm Bowel Dis 15:1417-23. 2009..While some studies in immune compromised hosts suggest the live attenuated varicella vaccine can be given without adverse events, administration of this vaccine in patients on immunosuppression remains controversial... - Complementary medicine use in children and young adults with inflammatory bowel diseaseRobert Heuschkel
Center for Pediatric Gastroenterology, Royal Free Hospital, London, United Kingdom
Am J Gastroenterol 97:382-8. 2002..Some complementary therapies have potential for adverse effects and for drug interactions with conventional treatments. Physicians should take a thorough history of CAM use in children with chronic inflammatory bowel disease... - A review of activity indices and end points for clinical trials in children with Crohn's diseaseAnne M Griffiths
Hospital for Sick Children, Toronto, Ontario, Canada
Inflamm Bowel Dis 11:185-96. 2005.... - Health-related quality of life in the first year after a diagnosis of pediatric inflammatory bowel diseaseAnthony R Otley
FRCPC, Division of Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada
Inflamm Bowel Dis 12:684-91. 2006..The aim of this study was to describe HRQOL and influential factors in newly diagnosed pediatric patients with Crohn's disease and ulcerative colitis during the first 12 months after diagnosis... - Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of AmericaAthos Bousvaros
J Pediatr Gastroenterol Nutr 44:653-74. 2007..quot; The authors hope that progress being made in genetic, serological, and imaging studies leads to more reliable phenotyping... - Corticosteroid therapy in the age of infliximab: acute and 1-year outcomes in newly diagnosed children with Crohn's diseaseJames Markowitz
North Shore Long Island Jewish Health System, New Hyde Park, New York, USA
Clin Gastroenterol Hepatol 4:1124-9. 2006..We also aimed to determine whether there are clinical or laboratory characteristics associated with corticosteroid therapy outcomes... - The natural history of corticosteroid therapy for ulcerative colitis in childrenJeffrey Hyams
Connecticut Children s Medical Center, Hartford, Connecticut, USA
Clin Gastroenterol Hepatol 4:1118-23. 2006..The aim of this study was to determine the clinical outcome after corticosteroid therapy in children who are newly diagnosed with ulcerative colitis (UC)... - Effect of early immunomodulator use in moderate to severe pediatric Crohn diseaseJaya Punati
Nationwide Children s Hospital, Ohio State University, Columbus, Ohio 43210, USA
Inflamm Bowel Dis 14:949-54. 2008..We describe IM use in newly diagnosed pediatric CD, comparing outcomes of "early" versus "late" initiation of therapy... - Body mass index in children with newly diagnosed inflammatory bowel disease: observations from two multicenter North American inception cohortsSubra Kugathasan
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
J Pediatr 151:523-7. 2007..To conduct a systematic review of children with newly diagnosed inflammatory bowel disease (IBD) from 2 prospective inception cohorts to examine body mass index (BMI) status at presentation... - Research agenda for pediatric gastroenterology, hepatology and nutrition: chronic inflammatory bowel disease. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition FMenno Verhave
Children's Digestive Health and Nutrition Foundation, PO Box 6, Flourtown, PA 19031, USA
J Pediatr Gastroenterol Nutr 35:S286-90. 2002 - Cognitive-behavioral therapy for adolescents with inflammatory bowel disease and subsyndromal depressionEva Szigethy
Children s Hospital of Pittsburgh University of Pittsburgh Medical Center, Department of Psychiatry, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 46:1290-8. 2007.... - Laboratory values for children with newly diagnosed inflammatory bowel diseaseDavid R Mack
Department of Pediatrics, Children s Hospital of Eastern Ontario, 401 Smyth Rd, Ottawa, Ontario, Canada K1H 8L1
Pediatrics 119:1113-9. 2007..The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease... - Pediatric inflammatory bowel disease: what children can teach adultsElizabeth Hait
Inflamm Bowel Dis 11:519-27. 2005 - Normal homocysteine levels in a population of children with inflammatory bowel diseaseAnna Zholudev
Inflamm Bowel Dis 11:620-1. 2005 - Effective advocacy for patients with inflammatory bowel disease: communication with insurance companies, school administrators, employers, and other health care overseersJennifer C Jaff
Advocacy for Patients with Chronic Illness, Inc, Farmington, Connecticut, USA
Inflamm Bowel Dis 12:814-23. 2006..Although this article has a pediatric focus, adults have similar advocacy needs. Case examples and sample letters to third-party payors, schools, and employers are included in this article... - Evaluation of the pediatric crohn disease activity index: a prospective multicenter experienceJeffrey Hyams
Connecticut Children s Medical Center, Hartford, Connecticut, USA
J Pediatr Gastroenterol Nutr 41:416-21. 2005....