Sylvain Bouix

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Increased gray matter diffusion anisotropy in patients with persistent post-concussive symptoms following mild traumatic brain injury
    Sylvain Bouix
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e66205. 2013
  2. ncbi request reprint Hippocampal shape analysis using medial surfaces
    Sylvain Bouix
    Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 25:1077-89. 2005
  3. ncbi request reprint Flux driven automatic centerline extraction
    Sylvain Bouix
    Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, USA
    Med Image Anal 9:209-21. 2005
  4. pmc On evaluating brain tissue classifiers without a ground truth
    Sylvain Bouix
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
    Neuroimage 36:1207-24. 2007
  5. pmc Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study
    Jungsu S Oh
    Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 30:3812-25. 2009
  6. pmc A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia
    Takeshi Yoshida
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 113:84-94. 2009
  7. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
  8. pmc Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging study
    Toshiro Kawashima
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 110:119-26. 2009
  9. pmc A hierarchical algorithm for MR brain image parcellation
    Kilian M Pohl
    Surgical Planning Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Med Imaging 26:1201-12. 2007
  10. pmc Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study
    KangUk Lee
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Schizophr Res 108:33-40. 2009

Research Grants

Collaborators

Detail Information

Publications43

  1. pmc Increased gray matter diffusion anisotropy in patients with persistent post-concussive symptoms following mild traumatic brain injury
    Sylvain Bouix
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e66205. 2013
    ..In addition, the individualized analysis shows promise for enhancing the clinical care of PPCS patients as it could play a role in the diagnosis of brain injury not revealed using conventional imaging...
  2. ncbi request reprint Hippocampal shape analysis using medial surfaces
    Sylvain Bouix
    Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, MA 02115, USA
    Neuroimage 25:1077-89. 2005
    ..We suggest that the analysis of HC shape using medial surfaces might thus serve as a complimentary technique to investigate group differences to the established segmentation protocols for volume quantification in MRI...
  3. ncbi request reprint Flux driven automatic centerline extraction
    Sylvain Bouix
    Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, USA
    Med Image Anal 9:209-21. 2005
    ..We validate the method quantitatively on a number of synthetic data sets with known centerlines and qualitatively on colon and vessel data segmented from CT and CRA images...
  4. pmc On evaluating brain tissue classifiers without a ground truth
    Sylvain Bouix
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
    Neuroimage 36:1207-24. 2007
    ....
  5. pmc Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography study
    Jungsu S Oh
    Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Hum Brain Mapp 30:3812-25. 2009
    ..These findings suggest that our method can enhance the regional and functional specificity of DTI group studies, thus improving our understanding of brain function...
  6. pmc A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophrenia
    Takeshi Yoshida
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 113:84-94. 2009
    ..These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia...
  7. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
    ..Here, we use a new shape measure which importantly permits local in addition to global shape analysis, as well as local correlations with behavioral measures...
  8. pmc Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging study
    Toshiro Kawashima
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Schizophr Res 110:119-26. 2009
    ..The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease...
  9. pmc A hierarchical algorithm for MR brain image parcellation
    Kilian M Pohl
    Surgical Planning Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
    IEEE Trans Med Imaging 26:1201-12. 2007
    ..The results of our analysis are similar to the original findings, except for one structure (the left superior temporal gyrus) in which a trend-level statistical significance (p = 0.07) was observed instead of statistical significance...
  10. pmc Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging study
    KangUk Lee
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Schizophr Res 108:33-40. 2009
    ..The goal of this study was to conduct the first Diffusion Tensor Imaging (DTI) study to investigate altered structural integrity in STG gray and white matter in patients with chronic schizophrenia compared with healthy controls...
  11. pmc Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI study
    Motoaki Nakamura
    Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Boston, USA
    Biol Psychiatry 62:773-83. 2007
    ....
  12. pmc Characterizing the shape of anatomical structures with Poisson's equation
    Haissam Haidar
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Med Imaging 25:1249-57. 2006
    ..In the second study, we present a data set of caudate nuclei of premature infants with asymmetric white matter injury. Our method shows structural shape differences that volumetric measurements were unable to detect...
  13. pmc Local white matter geometry indices from diffusion tensor gradients
    Peter Savadjiev
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 12:345-52. 2009
    ..We define two new scalar measures of (1) fibre dispersion and (2) fibre curving, and we demonstrate them on synthetic and in-vivo datasets. Finally, we illustrate their applicability in a group study on schizophrenia...
  14. pmc Global medical shape analysis using the Laplace-Beltrami spectrum
    Marc Niethammer
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Med Image Comput Comput Assist Interv 10:850-7. 2007
    ..The discriminatory power of the method is tested on a population of female caudate shapes of normal control subjects and of subjects with schizotypal personality disorder...
  15. pmc On diffusion tensor estimation
    Marc Niethammer
    Dept of Psychiatry, Harvard Med Sch, and Brigham and Women s Hospital, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2622-5. 2006
    ..A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense, removing the need for optimization-based tensor estimation...
  16. doi request reprint Globally and locally reduced MRI gray matter volumes in neuroleptic-naive men with schizotypal personality disorder: association with negative symptoms
    Takeshi Asami
    Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Brockton, MA 02301, USA
    JAMA Psychiatry 70:361-72. 2013
    ..Thus, there is need for a whole-brain comparison to resolve inconsistencies and provide hitherto generally absent data on the association between GMV and symptoms...
  17. pmc Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validation
    Takeshi Asami
    Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, Massachusetts, USA
    Neuroimage 59:986-96. 2012
    ..Importantly, these reductions are directly associated with a worse clinical course. Congruence with ROI analyses suggests the promise of this longitudinal VBM methodology...
  18. pmc Fiber geometry in the corpus callosum in schizophrenia: evidence for transcallosal misconnection
    Thomas J Whitford
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Schizophr Res 132:69-74. 2011
    ..Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia...
  19. doi request reprint A filtered approach to neural tractography using the Watson directional function
    James G Malcolm
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Med Image Anal 14:58-69. 2010
    ..In vivo experiments examine the corpus callosum and internal capsule and confirm the ability to trace through regions known to contain such crossing and branching while providing inherent path regularization...
  20. pmc Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophrenia
    Marek Kubicki
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Neuroimage 55:1657-64. 2011
    ..However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied...
  21. pmc White matter bundle registration and population analysis based on Gaussian processes
    Demian Wassermann
    Laboratory of Mathematics in Imaging, Brigham and Women s Hospital, Boston, MA, USA
    Inf Process Med Imaging 22:320-32. 2011
    ..Finally we test our results in several different bundles obtained from in-vivo data...
  22. pmc Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophrenia
    Yogesh Rathi
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Magn Reson Imaging 29:507-15. 2011
    ..Thus, the changes affecting first-episode patients seem to be global in nature (spread throughout the brain)...
  23. pmc Two methods for validating brain tissue classifiers
    Marcos Martin-Fernandez
    Laboratory of Mathematics in Imaging, Brigham and Women s Hospital, Boston, MA, USA
    Med Image Comput Comput Assist Interv 8:515-22. 2005
    ..We provide an interpretation of the results and show how similar the output of the STAPLE analysis and Williams' index are. When no ground truth is required, we recommend the use of Williams' index as it is easy and fast to compute...
  24. pmc Outlier rejection for diffusion weighted imaging
    Marc Niethammer
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 10:161-8. 2007
    ..The approach is based on the thresholding of Laplacian measurements over the sphere of the apparent diffusion coefficient profiles defined for a given set of gradient directions. Exemplary results are presented...
  25. pmc Directional functions for orientation distribution estimation
    Yogesh Rathi
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Anal 13:432-44. 2009
    ..In particular, we discuss a complete Euclidean as well as a "hybrid" framework, comprising of the Riemannian as well as Euclidean spaces, to perform interpolation and compute geodesic distances between two ODF's...
  26. pmc Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset
    Ofer Pasternak
    Department of Psychiatry, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:17365-72. 2012
    ..These findings promote anti-inflammatory treatment for early diagnosed schizophrenia patients...
  27. pmc A 3D interactive multi-object segmentation tool using local robust statistics driven active contours
    Yi Gao
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Med Image Anal 16:1216-27. 2012
    ....
  28. pmc Voxel-based morphometry (VBM) studies in schizophrenia-can white matter changes be reliably detected with VBM?
    Eric D Melonakos
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Psychiatry Res 193:65-70. 2011
    ..This poor replication rate suggests that the application of VBM to DTI data may not be the optimal way for finding the subtle microstructural abnormalities suggested in schizophrenia...
  29. ncbi request reprint On diffusion tensor estimation
    Marc Niethammer
    Department of Psychiatry, Brigham Women s Hospital, Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc . 2006
    ..A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense,removing the need for optimization-based tensor estimation...
  30. doi request reprint Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography study
    Gudrun Rosenberger
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Brain Imaging Behav 6:417-25. 2012
    ....
  31. pmc Fiber bundle estimation and parameterization
    Marc Niethammer
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Med Image Comput Comput Assist Interv 9:252-9. 2006
    ..It further introduces a coordinate system warped to the fiber bundle geometry, allowing for the definition of geometrically meaningful fiber bundle measures...
  32. pmc Local white matter geometry from diffusion tensor gradients
    Peter Savadjiev
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neuroimage 49:3175-86. 2010
    ..We derive new scalar indices of (1) fiber dispersion and (2) fiber curving, and we demonstrate them on synthetic and in vivo data. Finally, we illustrate their applicability to a group study on schizophrenia...
  33. pmc Tensor kernels for simultaneous fiber model estimation and tractography
    Yogesh Rathi
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Magn Reson Med 64:138-48. 2010
    ..In vivo experiments using two and three components examine the corpus callosum and corticospinal tract and confirm the ability to trace through regions known to contain such crossing and branching...
  34. pmc Multi-scale characterization of white matter tract geometry
    Peter Savadjiev
    Laboratory for Mathematics in Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Med Image Comput Comput Assist Interv 15:34-41. 2012
    ..We illustrate our method on different fibre tracts and apply it to a population study on hemispheric lateralization in healthy controls. We conclude with directions for future work...
  35. doi request reprint A prospective study of physician-observed concussion during a varsity university hockey season: white matter integrity in ice hockey players. Part 3 of 4
    Inga K Koerte
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard University, Boston, Massachusetts, USA
    Neurosurg Focus 33:E3: 1-7. 2012
    ..The aim of this study was to investigate the effect of repetitive head impacts on white matter integrity that were sustained during 1 Canadian Interuniversity Sports (CIS) ice hockey season, using advanced diffusion tensor imaging (DTI)...
  36. ncbi request reprint Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorder
    Min Seong Koo
    Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Arch Gen Psychiatry 63:1090-100. 2006
    ..Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD)...
  37. pmc Filtering in the diffeomorphism group and the registration of point sets
    Yi Gao
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    IEEE Trans Image Process 21:4383-96. 2012
    ....
  38. pmc Atlas-guided segmentation of vervet monkey brain MRI
    Andriy Fedorov
    Surgical Planning Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Open Neuroimag J 5:186-97. 2011
    ..Second, we develop a digital atlas of vervet monkey brain MRIs to enable similar studies that rely on the vervet model...
  39. doi request reprint Sparse texture active contour
    Yi Gao
    Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    IEEE Trans Image Process 22:3866-78. 2013
    ....
  40. pmc Genetic contributions to changes of fiber tracts of ventral visual stream in 22q11.2 deletion syndrome
    Zora Kikinis
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA, 02115, USA
    Brain Imaging Behav 7:316-25. 2013
    ..We conclude that reduced axonal changes may be key to understanding the underlying pathology of WM leading to the visuo-spatial phenotype in 22q11.2DS. ..
  41. pmc Automated dispersion and orientation analysis for carbon nanotube reinforced polymer composites
    Yi Gao
    Psychiatry Neuroimaging Laboratory, Harvard Medical School, Boston, MA 02115, USA
    Nanotechnology 23:435706. 2012
    ..Moreover, these indices help to explain the electrical properties of CNT/silicone composite, which is used as a model compound. This method can also be extended to other polymer composites with high-aspect-ratio fillers...
  42. pmc An in vivo MRI study of prefrontal cortical complexity in first-episode psychosis
    Laura C Wiegand
    Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
    Am J Psychiatry 162:65-70. 2005
    ..The purpose of this study was to investigate abnormalities in the surface complexity of the prefrontal cortex and in the hemispheric asymmetry of cortical complexity in first-episode patients with schizophrenia...
  43. pmc Using the logarithm of odds to define a vector space on probabilistic atlases
    Kilian M Pohl
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Med Image Anal 11:465-77. 2007
    ..On this data set, the Bayesian classification model with our new representation outperformed the other approaches in segmenting subcortical structures...

Research Grants2

  1. Computational Morphometry in Schizophrenia and Related Disorders
    Sylvain Bouix; Fiscal Year: 2010
    ..We believe that our proposed study, to design and to evaluate computational morphometric tools, will provide us with invaluable information about normal and abnormal neurodevelopment and its correlation with mental illnesses. ..