Research Topics
| Sylvain BouixSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Hippocampal shape analysis using medial surfacesSylvain Bouix
Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, MA 02115, USA
Neuroimage 25:1077-89. 2005..We suggest that the analysis of HC shape using medial surfaces might thus serve as a complimentary technique to investigate group differences to the established segmentation protocols for volume quantification in MRI...- Flux driven automatic centerline extractionSylvain Bouix
Department of Psychiatry, Boston VA Healthcare System, Harvard Medical School, Boston, USA
Med Image Anal 9:209-21. 2005..We validate the method quantitatively on a number of synthetic data sets with known centerlines and qualitatively on colon and vessel data segmented from CT and CRA images... - On evaluating brain tissue classifiers without a ground truthSylvain Bouix
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Boston, MA, USA
Neuroimage 36:1207-24. 2007.... - Thalamo-frontal white matter alterations in chronic schizophrenia: a quantitative diffusion tractography studyJungsu S Oh
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Hum Brain Mapp 30:3812-25. 2009..These findings suggest that our method can enhance the regional and functional specificity of DTI group studies, thus improving our understanding of brain function... - Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: a cross-sectional and longitudinal MRI studyMotoaki Nakamura
Clinical Neuroscience Division, Laboratory of Neuroscience, Veterans Affairs Boston Healthcare System, Brockton Division, Boston, USA
Biol Psychiatry 62:773-83. 2007.... - Shape abnormalities of caudate nucleus in schizotypal personality disorderJames J Levitt
Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
Schizophr Res 110:127-39. 2009..Here, we use a new shape measure which importantly permits local in addition to global shape analysis, as well as local correlations with behavioral measures... - A prospective longitudinal volumetric MRI study of superior temporal gyrus gray matter and amygdala-hippocampal complex in chronic schizophreniaTakeshi Yoshida
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston VA Healthcare System, Brockton Division and Harvard Medical School, Brockton, MA 02301, USA
Schizophr Res 113:84-94. 2009..These data, and separately reported first episode data from our laboratory, suggest marked progression at the initial stage of schizophrenia, but less in chronic schizophrenia... - A hierarchical algorithm for MR brain image parcellationKilian M Pohl
Surgical Planning Laboratory, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
IEEE Trans Med Imaging 26:1201-12. 2007..The results of our analysis are similar to the original findings, except for one structure (the left superior temporal gyrus) in which a trend-level statistical significance (p = 0.07) was observed instead of statistical significance... - Uncinate fasciculus abnormalities in recent onset schizophrenia and affective psychosis: a diffusion tensor imaging studyToshiro Kawashima
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Schizophr Res 110:119-26. 2009..The CB abnormalities reported in chronic schizophrenia may develop during the later course of the disease... - Increased diffusivity in superior temporal gyrus in patients with schizophrenia: a Diffusion Tensor Imaging studyKangUk Lee
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
Schizophr Res 108:33-40. 2009..The goal of this study was to conduct the first Diffusion Tensor Imaging (DTI) study to investigate altered structural integrity in STG gray and white matter in patients with chronic schizophrenia compared with healthy controls... - Characterizing the shape of anatomical structures with Poisson's equationHaissam Haidar
Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
IEEE Trans Med Imaging 25:1249-57. 2006..In the second study, we present a data set of caudate nuclei of premature infants with asymmetric white matter injury. Our method shows structural shape differences that volumetric measurements were unable to detect... - Global medical shape analysis using the Laplace-Beltrami spectrumMarc Niethammer
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
Med Image Comput Comput Assist Interv 10:850-7. 2007..The discriminatory power of the method is tested on a population of female caudate shapes of normal control subjects and of subjects with schizotypal personality disorder... - Local white matter geometry indices from diffusion tensor gradientsPeter Savadjiev
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Med Image Comput Comput Assist Interv 12:345-52. 2009..We define two new scalar measures of (1) fibre dispersion and (2) fibre curving, and we demonstrate them on synthetic and in-vivo datasets. Finally, we illustrate their applicability in a group study on schizophrenia... - On diffusion tensor estimationMarc Niethammer
Dept of Psychiatry, Harvard Med Sch, and Brigham and Women s Hospital, Boston, MA, USA
Conf Proc IEEE Eng Med Biol Soc 1:2622-5. 2006..A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense, removing the need for optimization-based tensor estimation... - Longitudinal loss of gray matter volume in patients with first-episode schizophrenia: DARTEL automated analysis and ROI validationTakeshi Asami
Laboratory of Neuroscience, Clinical Neuroscience Division, Department of Psychiatry, Boston Veterans Affairs Healthcare System, Brockton Division, Harvard Medical School, Brockton, Massachusetts, USA
Neuroimage 59:986-96. 2012..Importantly, these reductions are directly associated with a worse clinical course. Congruence with ROI analyses suggests the promise of this longitudinal VBM methodology... - Fiber geometry in the corpus callosum in schizophrenia: evidence for transcallosal misconnectionThomas J Whitford
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Schizophr Res 132:69-74. 2011..Structural abnormalities in the callosal fibers connecting the heteromodal association areas of the prefrontal and temporoparietal cortices bilaterally have been suggested to play a role in the etiology of schizophrenia... - Outlier rejection for diffusion weighted imagingMarc Niethammer
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Med Image Comput Comput Assist Interv 10:161-8. 2007..The approach is based on the thresholding of Laplacian measurements over the sphere of the apparent diffusion coefficient profiles defined for a given set of gradient directions. Exemplary results are presented... - A filtered approach to neural tractography using the Watson directional functionJames G Malcolm
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Med Image Anal 14:58-69. 2010..In vivo experiments examine the corpus callosum and internal capsule and confirm the ability to trace through regions known to contain such crossing and branching while providing inherent path regularization... - Stochastic tractography study of Inferior Frontal Gyrus anatomical connectivity in schizophreniaMarek Kubicki
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Neuroimage 55:1657-64. 2011..However, due to technical challenges, anatomical connectivity abnormalities within this network and their involvement in clinical and cognitive deficits have not been studied... - Two methods for validating brain tissue classifiersMarcos Martin-Fernandez
Laboratory of Mathematics in Imaging, Brigham and Women's Hospital, Boston, MA, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:515-22. 2005..We provide an interpretation of the results and show how similar the output of the STAPLE analysis and Williams' index are. When no ground truth is required, we recommend the use of Williams' index as it is easy and fast to compute... - Statistical analysis of fiber bundles using multi-tensor tractography: application to first-episode schizophreniaYogesh Rathi
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Magn Reson Imaging 29:507-15. 2011..Thus, the changes affecting first-episode patients seem to be global in nature (spread throughout the brain)... - White matter bundle registration and population analysis based on Gaussian processesDemian Wassermann
Laboratory of Mathematics in Imaging, Brigham and Women s Hospital, Boston, MA, USA
Inf Process Med Imaging 22:320-32. 2011..Finally we test our results in several different bundles obtained from in-vivo data... - Smaller neocortical gray matter and larger sulcal cerebrospinal fluid volumes in neuroleptic-naive women with schizotypal personality disorderMin-Seong Koo
Clinical Neuroscience Division, Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Arch Gen Psychiatry 63:1090-100. 2006..CONCLUSIONS: The smaller neocortical gray matter volume and larger sulcal CSF volume provide evidence of the brain basis of this personality disorder and emphasize the communality of brain abnormalities in the schizophrenia spectrum... - Voxel-based morphometry (VBM) studies in schizophrenia-can white matter changes be reliably detected with VBM?Eric D Melonakos
Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Psychiatry Res 193:65-70. 2011..This poor replication rate suggests that the application of VBM to DTI data may not be the optimal way for finding the subtle microstructural abnormalities suggested in schizophrenia... - Anterior limb of the internal capsule in schizophrenia: a diffusion tensor tractography studyGudrun Rosenberger
Psychiatry Neuroimaging Laboratory, Department of Psychiatry and Radiology, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
Brain Imaging Behav 6:417-25. 2012.... - Tensor kernels for simultaneous fiber model estimation and tractographyYogesh Rathi
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Magn Reson Med 64:138-48. 2010..In vivo experiments using two and three components examine the corpus callosum and corticospinal tract and confirm the ability to trace through regions known to contain such crossing and branching... - Local white matter geometry from diffusion tensor gradientsPeter Savadjiev
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Neuroimage 49:3175-86. 2010..We derive new scalar indices of (1) fiber dispersion and (2) fiber curving, and we demonstrate them on synthetic and in vivo data. Finally, we illustrate their applicability to a group study on schizophrenia... - On diffusion tensor estimationMarc Niethammer
Department of Psychiatry, Brigham Women s Hospital, Harvard Medical School, Boston, MA, USA
Conf Proc IEEE Eng Med Biol Soc . 2006..A closed-form solution is derived that is the optimal data-fit in the matrix 2-norm sense,removing the need for optimization-based tensor estimation... - Fiber bundle estimation and parameterizationMarc Niethammer
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
Med Image Comput Comput Assist Interv 9:252-9. 2006..It further introduces a coordinate system warped to the fiber bundle geometry, allowing for the definition of geometrically meaningful fiber bundle measures... - Directional functions for orientation distribution estimationYogesh Rathi
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Med Image Anal 13:432-44. 2009..In particular, we discuss a complete Euclidean as well as a "hybrid" framework, comprising of the Riemannian as well as Euclidean spaces, to perform interpolation and compute geodesic distances between two ODF's... - Atlas-guided segmentation of vervet monkey brain MRIAndriy Fedorov
Surgical Planning Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
Open Neuroimag J 5:186-97. 2011..Second, we develop a digital atlas of vervet monkey brain MRIs to enable similar studies that rely on the vervet model... - Filtering in the diffeomorphism group and the registration of point setsYi Gao
Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
IEEE Trans Image Process 21:4383-96. 2012.... - A 3D interactive multi-object segmentation tool using local robust statistics driven active contoursYi Gao
Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
Med Image Anal 16:1216-27. 2012.... - Automated dispersion and orientation analysis for carbon nanotube reinforced polymer compositesYi Gao
Psychiatry Neuroimaging Laboratory, Harvard Medical School, Boston, MA 02115, USA
Nanotechnology 23:435706. 2012..Moreover, these indices help to explain the electrical properties of CNT/silicone composite, which is used as a model compound. This method can also be extended to other polymer composites with high-aspect-ratio fillers... - An in vivo MRI study of prefrontal cortical complexity in first-episode psychosisLaura C Wiegand
Clinical Neuroscience Division, Laboratory of Neuroscience, VA Boston Healthcare System-Brockton Division, Harvard Medical School, Brockton, MA 02301, USA
Am J Psychiatry 162:65-70. 2005..CONCLUSIONS: An abnormal pattern of asymmetry in the prefrontal cortex of first-episode patients with schizophrenia provides evidence for a neurodevelopmental mechanism in the etiology of schizophrenia... - Using the logarithm of odds to define a vector space on probabilistic atlasesKilian M Pohl
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Med Image Anal 11:465-77. 2007..On this data set, the Bayesian classification model with our new representation outperformed the other approaches in segmenting subcortical structures...
Research Grants
- Computational Morphometry in Schizophrenia and Related DisordersSylvain Bouix; Fiscal Year: 2010..We believe that our proposed study, to design and to evaluate computational morphometric tools, will provide us with invaluable information about normal and abnormal neurodevelopment and its correlation with mental illnesses. ..