JOSEPH VINCENT BONVENTRE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Kidney injury molecule-1
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Crit Care 16:556-61. 2010
  2. pmc Can we target tubular damage to prevent renal function decline in diabetes?
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Semin Nephrol 32:452-62. 2012
  3. pmc Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2
    Shiro Kurusu
    Department of Medicine, Massachusetts GeneralHospital, Boston, Massachusetts, USA
    FASEB J 26:3800-10. 2012
  4. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
  5. pmc TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors
    Jit Kong Cheong
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Transl Med 7:8. 2009
  6. pmc High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry
    Claude Lechene
    National Resource for Imaging Mass Spectrometry, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    J Biol 5:20. 2006
  7. ncbi request reprint Recent advances in the pathophysiology of ischemic acute renal failure
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
    J Am Soc Nephrol 14:2199-210. 2003
  8. ncbi request reprint Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital and Department of Medicine, Harvard Stem Cell Institute, Harvard Medical School and Harvard Massachusetts Institute of Technology, Boston, MA 02115, USA
    Contrib Nephrol 156:39-46. 2007
  9. ncbi request reprint Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
    Joseph V Bonventre
    Brigham and Women s Hospital, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Massachusetts, USA
    J Am Soc Nephrol 14:S55-61. 2003
  10. ncbi request reprint Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004

Research Grants

  1. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    Joseph Bonventre; Fiscal Year: 2009
  2. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
  3. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
  4. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
  5. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 2007
  6. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2007
  7. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 1992
  8. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 2006
  9. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    Joseph Bonventre; Fiscal Year: 2007
  10. Training Grant in Academic Nephrology
    Joseph Bonventre; Fiscal Year: 2007

Detail Information

Publications91

  1. doi request reprint Kidney injury molecule-1
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Crit Care 16:556-61. 2010
    ....
  2. pmc Can we target tubular damage to prevent renal function decline in diabetes?
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA
    Semin Nephrol 32:452-62. 2012
    ..Local ischemia ensues with further injury to the tubules, more profibrogenic mediators, matrix protein deposition, fibrosis, and glomerulosclerosis...
  3. pmc Group IVA phospholipase A₂ optimizes ovulation and fertilization in rodents through induction of and metabolic coupling with prostaglandin endoperoxide synthase 2
    Shiro Kurusu
    Department of Medicine, Massachusetts GeneralHospital, Boston, Massachusetts, USA
    FASEB J 26:3800-10. 2012
    ..Our data strongly suggest that PLA(2)G4A amplifies hCG induction of PTGS2 and colocalizes with the induced PTGS2, thus contributing to robust PG production required for optimal ovulation and fertilization in rodents...
  4. pmc Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
    Youren Tong
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Mol Neurodegener 7:2. 2012
    ..We previously reported that loss of LRRK2 causes impairment of protein degradation pathways as well as increases of apoptotic cell death and inflammatory responses in the kidney of aged mice...
  5. pmc TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors
    Jit Kong Cheong
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Transl Med 7:8. 2009
    ..We, herein, focus on the detailed functional characterization of the least understood member of the TRIP-Br/SERTAD protein family, TRIP-Br2 (SERTAD2)...
  6. pmc High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry
    Claude Lechene
    National Resource for Imaging Mass Spectrometry, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    J Biol 5:20. 2006
    ....
  7. ncbi request reprint Recent advances in the pathophysiology of ischemic acute renal failure
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, and the Harvard MIT, Division of Health Sciences and Technology, Charlestown, Massachusetts, USA
    J Am Soc Nephrol 14:2199-210. 2003
  8. ncbi request reprint Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital and Department of Medicine, Harvard Stem Cell Institute, Harvard Medical School and Harvard Massachusetts Institute of Technology, Boston, MA 02115, USA
    Contrib Nephrol 156:39-46. 2007
    ..Understanding how these anti-inflammatory processes are regulated may provide insight into how we might intervene to facilitate and enhance them so that we might prevent or mitigate the devastating consequences of AKI...
  9. ncbi request reprint Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
    Joseph V Bonventre
    Brigham and Women s Hospital, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Massachusetts, USA
    J Am Soc Nephrol 14:S55-61. 2003
    ....
  10. ncbi request reprint Ischemic acute renal failure: an inflammatory disease?
    Joseph V Bonventre
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Charlestown, USA
    Kidney Int 66:480-5. 2004
    ..Understanding the inflammatory response prevalent in ischemic kidney injury will facilitate identification of molecular targets for therapeutic intervention...
  11. ncbi request reprint Diagnosis of acute kidney injury: from classic parameters to new biomarkers
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital and Department of Medicine, Harvard Stem Cell Institute, Harvard Medical School and Harvard Massachusetts Institute of Technology, Boston, MA 02115, USA
    Contrib Nephrol 156:213-9. 2007
    ....
  12. ncbi request reprint Urine neutrophil gelatinase-associated lipocalin as a marker of acute kidney injury in critically ill children
    Joseph V Bonventre
    Brigham and Women s Hospital, Renal Division, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    Nat Clin Pract Nephrol 4:78-9. 2008
  13. ncbi request reprint Pathophysiology of ischemic acute renal failure. Inflammation, lung-kidney cross-talk, and biomarkers
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Contrib Nephrol 144:19-30. 2004
  14. ncbi request reprint The 85-kD cytosolic phospholipase A2 knockout mouse: a new tool for physiology and cell biology
    J V Bonventre
    Medical Services, Massachusetts General Hospital, Charlestown 02129, USA
    J Am Soc Nephrol 10:404-12. 1999
  15. doi request reprint Kidney Injury Molecule-1 (KIM-1): a specific and sensitive biomarker of kidney injury
    Joseph V Bonventre
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Scand J Clin Lab Invest Suppl 241:78-83. 2008
    ..Studies in man indicate that tissue expression and urinary excretion of the ectodomain of KIM-1 are sensitive and specific markers of injury as well as predictors of outcome...
  16. ncbi request reprint Kidney ischemic preconditioning
    Joseph V Bonventre
    Medical Services, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Curr Opin Nephrol Hypertens 11:43-8. 2002
    ..Armed with this understanding we can then attempt to mimic these processes and thereby prevent and treat ischemic acute renal failure...
  17. pmc Cellular pathophysiology of ischemic acute kidney injury
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 121:4210-21. 2011
    ....
  18. doi request reprint Pathophysiology of AKI: injury and normal and abnormal repair
    Joseph V Bonventre
    Renal Division, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, Mass 02115, USA
    Contrib Nephrol 165:9-17. 2010
    ..The epithelium plays an important role in abnormal repair through a recently defined link between cell cycle arrest of the epithelial cell and profibrogenic cytokine production...
  19. pmc Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    Jeremy S Duffield
    Renal Division and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 115:1743-55. 2005
    ..It is likely that intrinsic tubular cell proliferation accounts for functionally significant replenishment of the tubular epithelium after ischemia...
  20. pmc Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    Biomarkers 14:423-31. 2009
    ..006). In this small pilot cohort, KIM-1 performed best as an early biomarker for AKI. Larger studies are needed to explore further the role of biomarkers for early detection of AKI following cardiac surgery...
  21. ncbi request reprint Biologic markers for the early detection of acute kidney injury
    Won K Han
    Medical Services, Renal Division, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Crit Care 10:476-82. 2004
    ..This review discusses the current status of several biomarkers as potential diagnostic tools in patients with acute kidney disease...
  22. ncbi request reprint Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury
    Won Il Choi
    Department of Medicine, Pulmonary Critical Care Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Respir Crit Care Med 167:1627-32. 2003
    ..Endothelial NOS may mediate the systemic microvascular leak of the present model of VILI...
  23. ncbi request reprint Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury
    Kwon Moo Park
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:52282-92. 2004
    ....
  24. pmc A rapid urine test for early detection of kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 76:108-14. 2009
    ....
  25. ncbi request reprint Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    J Am Soc Nephrol 18:904-12. 2007
    ..78 (95% CI 0.71 to 0.84) in predicting the composite outcome. Urinary markers of kidney injury such as NAG and KIM-1 can predict adverse clinical outcomes in patients with ARF...
  26. ncbi request reprint Renal ischemia/reperfusion and ATP depletion/repletion in LLC-PK(1) cells result in phosphorylation of FKHR and FKHRL1
    Michele Andreucci
    Massachusetts General Hospital East, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 64:1189-98. 2003
    ..Cell death and survival pathways are critical determinants of epithelial cell fate after ischemia. Forkhead proteins have been implicated in the regulation of cellular survival. METHODS and..
  27. pmc Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 176:85-97. 2010
    ..These data indicate that therapeutic strategies directly targeting pericyte differentiation in vivo may productively impact fibrotic kidney disease...
  28. doi request reprint Intrinsic epithelial cells repair the kidney after injury
    Benjamin D Humphreys
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Cell Stem Cell 2:284-91. 2008
    ..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney...
  29. ncbi request reprint Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation
    Cheng Chieh Hung
    Medical Services, Massachusetts General Hospital and Brigham and Women s Hospital, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:29317-26. 2003
    ..Furthermore, ERK activation is an important downstream effector mechanism for cellular protection by ER stress...
  30. ncbi request reprint Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney
    Kwon Moo Park
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:27256-66. 2003
    ....
  31. pmc Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
    Rene O Sanchez-Mejia
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    Nat Neurosci 11:1311-8. 2008
    ..Inhibition of GIVA-PLA(2) may be beneficial in the treatment and prevention of Alzheimer's disease...
  32. pmc Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis
    Barbara Balestrieri
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 281:6691-8. 2006
    ..These data demonstrate that group V sPLA2 contributes to the innate immune response both through regulation of eicosanoid generation in response to a phagocytic stimulus and also as a component of the phagocytic machinery...
  33. pmc Conditional ablation of macrophages halts progression of crescentic glomerulonephritis
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 167:1207-19. 2005
    ..This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis...
  34. pmc Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury
    Jeremy S Duffield
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Kidney Int 68:1956-61. 2005
    ..Analysis of the phenotype of interstitial and vascular cells following I/R injury revealed small numbers of peritubular endothelial cells to be derived from bone marrow cells that may serve in the repair process...
  35. ncbi request reprint Resolvin D series and protectin D1 mitigate acute kidney injury
    Jeremy S Duffield
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5902-11. 2006
    ..These data may also have therapeutic implications for potentiation of recovery from acute kidney injury...
  36. ncbi request reprint Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury
    Vishal S Vaidya
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, 4 Blackfan Circle, Harvard Institutes of Medicine, Rm 550, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 290:F517-29. 2006
    ....
  37. ncbi request reprint Shedding of the urinary biomarker kidney injury molecule-1 (KIM-1) is regulated by MAP kinases and juxtamembrane region
    Zhiwei Zhang
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, and Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Boston, Massachusetts, USA
    J Am Soc Nephrol 18:2704-14. 2007
    ..Mutagenesis studies demonstrated that the juxtamembrane secondary structure, not the primary amino acid sequence, was critical to the cleavage of KIM-1...
  38. ncbi request reprint Molecular response to cytotoxic injury: role of inflammation, MAP kinases, and endoplasmic reticulum stress response
    Joseph V Bonventre
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Semin Nephrol 23:439-48. 2003
    ..Particular attention is paid to the vascular and inflammatory aspects of nephrotoxicity as well as the activation of the MAP kinase families and the endoplasmic reticulum stress response by the tubular epithelial cell...
  39. doi request reprint Biomarkers of nephrotoxic acute kidney injury
    Michael A Ferguson
    Division of Nephrology, Children s Hospital Boston, Hunnewell 319, Boston, MA 02115, United States
    Toxicology 245:182-93. 2008
    ....
  40. doi request reprint Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury
    Li Yang
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:535-43, 1p following 143. 2010
    ..Hence, epithelial cell cycle arrest at G2/M and its subsequent downstream signaling are hitherto unrecognized therapeutic targets for the prevention of fibrosis and interruption of the accelerated progression of kidney disease...
  41. pmc The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair
    Bing Li
    Laboratory of Inflammation Research, Brigham and Womens Hospital and Harvard Medical School, Boston, MA 02115, USA
    FASEB J 24:4767-81. 2010
    ..Therefore, Gpnmb is a novel prorepair gene that is necessary for crosstalk between the macroautophagic degradation pathway and phagocytosis...
  42. pmc Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2alpha activation
    Eriya Kikawada
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 110:561-7. 2007
    ..The findings support the suggestion that group V sPLA(2) regulates innate immune responses...
  43. pmc Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction
    Fumito Ichinose
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Invest 109:1493-500. 2002
    ..These results indicate that cPLA(2) contributes to the murine pulmonary vasoconstrictor response to hypoxia. Augmenting pulmonary vascular tone restores HPV in the absence of cPLA(2) activity...
  44. ncbi request reprint NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure
    Mary C Perianayagam
    Division of Nephrology, Kidney and Dialysis Research Laboratory, Caritas St Elizabeth s Medical Center, Boston, MA 02135, USA
    J Am Soc Nephrol 18:255-63. 2007
    ..02). The polymorphism in the gene that encodes the NADPH oxidase p22phox subunit at position +242 is associated with dialysis requirement or hospital death among patients with ARF. Larger studies are needed to confirm these relationships...
  45. ncbi request reprint Participation of cytosolic phospholipase A2 in eicosanoid generation by mouse bone marrow-derived mast cells
    Bruno L Diaz
    Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Adv Exp Med Biol 507:41-6. 2002
  46. ncbi request reprint Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction
    Kwon Moo Park
    Medical Services, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 277:2040-9. 2002
    ..The persistent increase in HSP-25 that occurs as a result of UO may contribute to the reduction in phosphorylation of MAPKs that have been implicated in adhesion molecule up-regulation and cell death...
  47. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..This should enable early identification and elimination of compounds that are potentially nephrotoxic...
  48. ncbi request reprint Kidney injury molecule-1 expression in murine polycystic kidney disease
    E Wolfgang Kuehn
    Renal Unit and Department of Medicine, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Physiol Renal Physiol 283:F1326-36. 2002
    ..Although the functional role of the protein in cysts remains unknown, Kim-1 expression in tubules is strongly associated with partial dedifferentiation of epithelial cells and may play a role in the development of interstitial fibrosis...
  49. pmc Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nephron Clin Pract 109:c192-7. 2008
    ..Once adopted, more sensitive biomarkers of acute kidney injury hold the potential to transform the care of patients with renal disease...
  50. ncbi request reprint Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
    Won K Han
    Medical Services, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Kidney Int 62:237-44. 2002
    ..The ectodomain of KIM-1 is shed from cells. The current studies were carried out to evaluate whether KIM-1 is present in human acute renal failure and might serve as a urinary marker of acute renal tubular injury...
  51. ncbi request reprint Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice
    Nilda M Munoz
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    J Immunol 179:4800-7. 2007
    ..Our data demonstrate that gVPLA2 is a critical messenger enzyme in the development of AHR and regulation of cell migration during immunosensitization by a pathway that is independent of group IVa phospholipase A2...
  52. pmc Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma
    Won K Han
    Renal Division, Brigham and Women s Hospital, Medical Service, Massachusetts General Hospital, Boston, USA
    J Am Soc Nephrol 16:1126-34. 2005
    ..In conclusion, the cleaved ectodomain of hKIM-1 can be detected in the urine of patients with RCC and may serve as a new biomarker for early detection of RCC...
  53. pmc Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
    Ayumi Takakura
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 4 Blackfan Circle, Boston, MA 02115, USA
    Hum Mol Genet 18:2523-31. 2009
    ..These data demonstrate, for the first time, a role for polycystin-1 in kidney injury and repair and indicate that renal injury constitutes a 'third hit' resulting in rapid cyst formation in adulthood...
  54. ncbi request reprint Human group V phospholipase A2 induces group IVA phospholipase A2-independent cysteinyl leukotriene synthesis in human eosinophils
    Nilda M Munoz
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:38813-20. 2003
    ..As such, this study represents a unique example in which a secretory phospholipase induces the eicosanoid formation in inflammatory cells, completely independent of cPLA2 activation...
  55. ncbi request reprint Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachido
    Won K Han
    Medical Services, Massachusetts General Hospital, Department of Medicine and Anesthesia, Harvard Medical School, Massachusetts, USA
    J Biol Chem 278:24153-63. 2003
    ..Group IIa and V PLA2s are regulatory and cPLA2alpha is responsible for AA release...
  56. doi request reprint HIF in kidney disease and development
    Lakshman Gunaratnam
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:1877-87. 2009
    ..In this review, we discuss the mechanisms of oxygen sensing in renal cells and highlight the role of hypoxia and HIF activation under physiologic conditions and in renal development as well as in acute and chronic kidney diseases...
  57. ncbi request reprint Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
    Glenn M Chertow
    Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
    J Am Soc Nephrol 16:3365-70. 2005
    ..Moreover, outcomes are related directly to the severity of acute kidney injury, whether characterized by nominal or percentage changes in serum creatinine...
  58. ncbi request reprint Novel non-rodent models of kidney disease
    Dirk M Hentschel
    Brigham and Women s Hospital, Department of Medicine, Renal Division, and Harvard Medical School, Boston, MA 02115, USA
    Curr Mol Med 5:537-46. 2005
    ....
  59. pmc Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells
    Takaharu Ichimura
    Renal Division, Brigham and Women s Hospital, Harvard Institutes of Medicine, Room 550, 4 Blackfan Circle, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1657-68. 2008
    ..Thus, KIM-1 is the first nonmyeloid phosphatidylserine receptor identified to our knowledge that transforms epithelial cells into semiprofessional phagocytes...
  60. ncbi request reprint Deletion of cytosolic phospholipase A2 promotes striated muscle growth
    Syed Haq
    Molecular Cardiology Research Institute, Tufts New England Medical Center and Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Nat Med 9:944-51. 2003
    ..These results indicate that cytosolic PLA2 and arachidonic acid regulate striated muscle growth by modulating multiple growth-regulatory pathways...
  61. ncbi request reprint Acute renal failure in zebrafish: a novel system to study a complex disease
    Dirk M Hentschel
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 288:F923-9. 2005
    ..Therefore, zebrafish provides a unique model system, amenable to genetic manipulation and drug screening, to explore the pathophysiology of ARF and establish novel therapies with potential use in mammals...
  62. ncbi request reprint Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury
    Takaharu Ichimura
    Medical Services, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 286:F552-63. 2004
    ..The upregulation of expression of Kim-1 and its presence in the urine in response to exposure to various types of nephrotoxicants suggest that this protein may serve as a general biomarker for tubular injury and repair processes...
  63. ncbi request reprint The contribution of adult stem cells to renal repair
    Benjamin D Humphreys
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Harvard Stem Cell Institute and Harvard MIT Division of Health Sciences and Technology, Boston, MA 02115, USA
    Nephrol Ther 3:3-10. 2007
    ..The identification of adult renal epithelial progenitor cells will ultimately determine the future direction of renal regenerative medicine...
  64. ncbi request reprint Group IV cytosolic phospholipase A2 (PLA2) function: insights from the knockout mouse
    Joseph V Bonventre
    Department of Medicine, Harvard Medical School, Medical Service, Massachusetts General Hospital, Harvard Massachusetts Institute of Technology, Division of Health Sciences, Boston, MA, USA
    Adv Exp Med Biol 507:25-31. 2002
  65. ncbi request reprint Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases
    Li Fu Li
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 285:L464-75. 2003
    ..We conclude that stretch-induced transcriptional regulation of IL-8 mRNA and IL-8 production was via activation of AP-1 and NF-kappaB and was dependent on JNK and NIK activation, respectively...
  66. pmc Creatinine kinetics and the definition of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:672-9. 2009
    ..5-mg/dl increase in SCr was virtually identical after moderate to severe AKI (>50% reduction in creatinine clearance). We propose an alternative definition of AKI that incorporates absolute changes in SCr over a 24- to 48-h time period...
  67. pmc Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Kidney Int 78:486-94. 2010
    ..This ideal must be balanced, however, against practical considerations...
  68. ncbi request reprint Polymorphism of host response genes: implications in the pathogenesis and treatment of acute renal failure
    Bertrand L Jaber
    Division of Nephrology, Caritas St Elizabeth s Medical Center, Boston, Massachusetts 02135, USA
    Kidney Int 67:14-33. 2005
    ..Conclusions are drawn on the application of genetic epidemiology to the field of ARF and the rationale for further research on the role of genetic markers in ARF...
  69. doi request reprint A framework and key research questions in AKI diagnosis and staging in different environments
    Patrick T Murray
    Department of Medicine, Section of Nephrology, MC 5100, Room S 511, University of Chicago Hospitals, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Clin J Am Soc Nephrol 3:864-8. 2008
    ....
  70. ncbi request reprint Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:557-64. 2007
    ..This review summarizes clinical studies of newer biomarkers that may permit earlier and more accurate identification of acute kidney injury...
  71. ncbi request reprint Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2
    Amy M Meyer
    Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    Carcinogenesis 25:1517-24. 2004
    ..These results demonstrate a role for cPLA2 in mouse lung tumorigenesis that may be mediated by decreased prostaglandin synthesis...
  72. ncbi request reprint Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration
    Veronique Bailly
    Biogen Inc, Cambridge, Massachusetts 02142, USA
    J Biol Chem 277:39739-48. 2002
    ....
  73. ncbi request reprint Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation
    Adam Sapirstein
    Anesthesiology and Critical Care Medicine, Johns Hopkins School of Medicine, 600 N Wolfe St Meyer 297 A, Baltimore, MD 21287 7294, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1774-82. 2005
    ..These results indicate that cPLA(2)alpha inhibition is a novel anti-inflammatory strategy that modulates, but does not completely prevent, eicosanoid responses...
  74. ncbi request reprint Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development
    Haengseok Song
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160 7336, USA
    Development 129:2879-89. 2002
    ....
  75. ncbi request reprint Animal models of acute tubular necrosis
    Samuel N Heyman
    Department of Medicine, Hadassah Hospital, Mount Scopus, and Hebrew University Medical School, Jerusalem, Israel
    Curr Opin Crit Care 8:526-34. 2002
    ..In this report, we summarize some concepts of acute tubular necrosis that have evolved as a result of these studies, evaluate available animal models, and underscore controversies regarding experimental acute tubular necrosis...
  76. ncbi request reprint Orchiectomy reduces susceptibility to renal ischemic injury: a role for heat shock proteins
    Kwon Moo Park
    Department of Anatomy and Pain and Neural Injury Research Center, MRC, School of Medicine, Kyungpook National University, Daegu 700 422, Republic of Korea
    Biochem Biophys Res Commun 328:312-7. 2005
    ..These findings indicate that testosterone inhibits the heat shock response and may provide a new paradigm for design of therapies for I/R injury...
  77. ncbi request reprint Brain lipid metabolism in the cPLA2 knockout mouse
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Lipid Res 44:109-17. 2003
    ....
  78. ncbi request reprint Can we rely on blood urea nitrogen as a biomarker to determine when to initiate dialysis?
    Sushrut S Waikar
    Clin J Am Soc Nephrol 1:903-4. 2006
  79. pmc Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts
    Moumita Ghosh
    Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 282:11676-86. 2007
    ....
  80. ncbi request reprint M1 muscarinic receptors inhibit L-type Ca2+ current and M-current by divergent signal transduction cascades
    Liwang Liu
    Program in Neuroscience and Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Neurosci 26:11588-98. 2006
    ..Our findings support a model of M(1)R-meditated channel modulation that broadens rather than restricts the roles of phospholipids and fatty acids in regulating ion channel activity...
  81. ncbi request reprint Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2
    Shahid Noor
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    J Biol Chem 283:4744-55. 2008
    ..Therefore activation of cPLA2alpha in macrophages may impact immune responses to L. monocytogenes...
  82. pmc High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
    ..Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria...
  83. ncbi request reprint T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation
    Paul D Rennert
    Biogen Idec, 12 Cambridge Center, Cambridge, MA 01746, USA
    J Immunol 177:4311-21. 2006
    ..These studies show that TIM-2 is a novel and critical regulator of effector T cell activity...
  84. ncbi request reprint Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase
    Martin H de Borst
    Dept of Pathology and Laboratory Medicine, Univ Medical Center Groningen and Univ of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 292:F313-20. 2007
    ..01). Kim-1 is associated with development of RAS-mediated renal damage. Antifibrotic treatment through RAS blockade or p38 MAP kinase inhibition reduced Kim-1 in the homozygous Ren2 model...
  85. pmc Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 36:397-409. 2008
    ..It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants...
  86. ncbi request reprint Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts
    Moumita Ghosh
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:91-100. 2004
    ..The results demonstrate a primary role for cPLA2 alpha in providing arachidonic acid for PGE2 production in mouse lung fibroblasts and support a role for this pathway in regulating collagen production...
  87. ncbi request reprint Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity
    Jazmin Pérez-Rojas
    Molecular Physiology Unit, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico
    Am J Physiol Renal Physiol 292:F131-9. 2007
    ..In conclusion, MR blockade with Sp prevented the progression of renal injury in preexisting chronic CsA nephropathy. These results suggest that Sp may reduce CsA-induced established nephrotoxicity in patients...
  88. pmc Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge
    Frederic Chagnon
    Groupe de Recherche en Physiopathologie Respiratoire, Centre de Recherche Clinique, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada
    Crit Care Med 36:3054-61. 2008
    ....
  89. ncbi request reprint Tubular kidney injury molecule-1 in protein-overload nephropathy
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Am J Physiol Renal Physiol 291:F456-64. 2006
    ..These results implicate involvement of Kim-1 in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage...
  90. ncbi request reprint Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice
    Amy M Meyer
    University of Colorado Health Sciences Center, School of Pharmacy, Box C238, 4200 E 9th Avenue, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1260-6. 2006
    ....
  91. ncbi request reprint Methylmercury-induced toxicity is mediated by enhanced intracellular calcium through activation of phosphatidylcholine-specific phospholipase C
    Mi Sun Kang
    Department of Environmental and Health Chemistry, College of Pharmacy, Chung Ang University, Seoul, 221 Huksuk Dong, Dongjak Ku, Seoul 156 756, South Korea
    Toxicol Appl Pharmacol 216:206-15. 2006
    ..Our results demonstrated that MeHg-induced toxicity was linked to elevation of [Ca(2+)](i) through activation of PC-PLC, but not attributable to the signaling pathways such as cPLA(2), A-SMase, and PKC, or to the generation of ROS...

Research Grants33

  1. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    Joseph Bonventre; Fiscal Year: 2009
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  2. TWO NOVEL CPLA2 BINDING PROTEINS AND CELL DEATH
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..Given the large number of patients that are initiated on dialysis each year, this addresses a critical public health problem. ..
  3. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..In addition the use of novel genetic approaches to target injury to the kidney will help in the determination of the factors important for "good" vs "bad" repair short term and long term. ..
  4. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..The work hopefully will lead to new understandings that can be used to develop new therapeutic drugs that can enhance recovery of the kidney when it is injured and prevent progression of kidney disease. ..
  5. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 2007
    ..In addition the use of novel genetic approaches to target injury to the kidney will help in the determination of the factors important for "good" vs "bad" repair short term and long term. ..
  6. Biomarkers in Acute Kidney Injury
    Joseph Bonventre; Fiscal Year: 2007
    ..The identification of early biomarkers of AKI will be a major step forward in the clinical care of patients at risk for AKI and will tremendously aid research on novel strategies for its prevention and treatment. ..
  7. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 1992
    ....
  8. MECHANISMS OF ISCHEMIC INJURY AND REPAIR
    Joseph Bonventre; Fiscal Year: 2006
    ....
  9. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    Joseph Bonventre; Fiscal Year: 2007
    ..abstract_text> ..
  10. Training Grant in Academic Nephrology
    Joseph Bonventre; Fiscal Year: 2007
    ..Techniques represented include protein and nucleic acid.. ..
  11. KIDNEY INJURY MOLECULE-1 IN EPITHELIAL REPAIR
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    ..abstract_text> ..