Research Topics
Genomes and Genes
| Susan Bonner-WeirSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Transdifferentiation of pancreatic ductal cells to endocrine beta-cellsSusan Bonner-Weir
Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, MA 02215 USA
Biochem Soc Trans 36:353-6. 2008....
How can we get more beta cells?Akari Inada
Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Curr Diab Rep 6:96-101. 2006..Major questions still remain: whether there are true pancreatic stem cells, what are the pancreatic progenitor cells after birth, and whether expanded beta cells themselves could serve as the source...- GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ductsGang Xu
Diabetes Res Clin Pract 73:107-10. 2006 - In vivo imaging of islet transplantationNatalia V Evgenov
Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Room 2301, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
Nat Med 12:144-8. 2006..We anticipate that the information obtained in this study would ultimately result in the ability to detect and monitor islet engraftment in humans, which would greatly aid the clinical management of this disease... - New sources of pancreatic beta-cellsSusan Bonner-Weir
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
Nat Biotechnol 23:857-61. 2005..Recent progress in the search for new sources of beta-cells has opened promising new opportunities and spawned clinical trials... 
In vitro cultivation of human islets from expanded ductal tissueS Bonner-Weir
Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 97:7999-8004. 2000..This approach may provide a potential new source of pancreatic islet cells for transplantation...- Stem cells in diabetes: what has been achievedSusan Bonner-Weir
Department of Medicine, Harvard Medical School, and Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Mass 02215, USA
Horm Res 60:10. 2003..Each new report has been met with a mixture of excitement and skepticism. With continued efforts and rigorous assessments, hopefully the potential of generating enough new beta-cells from stem cells will be realized... - The pancreatic ductal epithelium serves as a potential pool of progenitor cellsSusan Bonner-Weir
Department of Medicine, Research Division, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Pediatr Diabetes 5:16-22. 2004..We will develop our case for this hypothesis in this perspective... - Assessment of human islet preparations to be used for islet expansion, survival, or transplantSusan Bonner-Weir
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes Technol Ther 6:493-4. 2004 - Are there pancreatic progenitor cells from which new islets form after birth?Susan Bonner-Weir
Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
Nat Clin Pract Endocrinol Metab 2:240-1. 2006 - Pancreatic stem cellsSusan Bonner-Weir
Section of Islet Transplantation and Cellular Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Pathol 197:519-26. 2002..However, no clearly identifiable adult pancreatic stem cell has been found as yet. The putative pancreatic stem cells will be the focus of this review... - Life and death of the pancreatic beta cellsS Bonner-Weir
Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Trends Endocrinol Metab 11:375-8. 2000..The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation... - beta-cell turnover: its assessment and implicationsS Bonner-Weir
Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 50:S20-4. 2001..Two major implications of beta-cell turnover are that 1) at any time, the beta-cells would be at different ages and 2) any limitation on replacement could have dire consequences for glucose homeostasis... - A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cellsWataru Nishimura
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
Dev Biol 293:526-39. 2006..Thus, this redundancy in the function and expression of the large-Maf factors may explain the normal islet morphology observed in the MafA knockout mice at birth... - Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cellsHideaki Kaneto
Section on Islet Transplantation and Cell Biology and Section on Vascular Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Biol Chem 277:3680-5. 2002..These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression... - Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetesD Ross Laybutt
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes 51:1793-804. 2002.... - NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytesShigeru Yatoh
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Diabetes Metab Res Rev 23:239-49. 2007..Our goal was to convert adult mouse hepatocytes to pancreatic beta-cells... - Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activationHideaki Kaneto
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
J Biol Chem 277:12998-3006. 2002..This mechanism may explain some of the beta-cell dysfunction found in diabetes... - Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectorsJustin R Fernandes
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Room 535, Boston, MA 02215, USA
Transpl Immunol 13:191-200. 2004.... - Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expressionHideaki Kaneto
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Biol Chem 277:30010-8. 2002..In conclusion, activation of JNK is involved in the reduction of insulin gene expression by oxidative stress, and suppression of the JNK pathway protects beta-cells from oxidative stress... - Modification of adverse inflammation is required to cure new-onset type 1 diabetic hostsMaria Koulmanda
Department of Surgery, Harvard Medical School, and Islet Transplantation Research Laboratory, Massachusetts General Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:13074-9. 2007..Thus, this triple-therapy regimen, possessing both tolerance-inducing and select antiinflammatory properties, may represent a prototype for therapies able to restore euglycemia and self-tolerance in T1DM... - Lack of evidence for recipient precursor cells replenishing β-cells in transplanted isletsYoshiyuki Hamamoto
Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Cell Transplant 19:1563-72. 2010..This study provides further support for the concept that recipient precursor cells do not produce new β-cells in grafts of transplanted islets... - Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetesLorella Marselli
Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
PLoS ONE 5:e11499. 2010..Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D) should provide insights into their abnormal insulin secretion and turnover... - Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult ratsWan Chun Li
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Sci 123:2792-802. 2010..This mechanism of regeneration relies mainly on the plasticity of the differentiated cells within the pancreas... - Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetesGang Xu
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Diabetes 56:1551-8. 2007..Taken together, GLP-1 and GIP receptor expression is decreased with chronic hyperglycemia, and this decrease likely contributes to the impaired incretin effects found in diabetes... - Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birthAkari Inada
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 105:19915-9. 2008..This identification of a differentiated pancreatic cell type as an in vivo progenitor of all differentiated pancreatic cell types has implications for a potential expandable source for new islets for replenishment therapy for diabetes... - Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cellsMasaki Nagaya
Research Division, Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Endocrinol 201:37-47. 2009..This approach may lead to a new source of beta-cells that can be used for transplantation in diabetes... - Evidence for a role of the ubiquitin-proteasome pathway in pancreatic isletsMaria D Lopez-Avalos
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
Diabetes 55:1223-31. 2006.... - Normal relationship of beta- and non-beta-cells not needed for successful islet transplantationAileen J F King
Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
Diabetes 56:2312-8. 2007..It is therefore likely that islet non-beta-cells are not essential for successful islet transplantation... - Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic miceAbdulkadir Omer
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 52:69-75. 2003..In conclusion, NPCCs encapsulated with simple barium alginate can differentiate into beta-cells and reverse high blood glucose levels in immunocompetent mice without immunosuppression for >20 weeks... - Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissectionLorella Marselli
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Clin Endocrinol Metab 93:1046-53. 2008..Assessment is complicated when isolated islets are studied because of contamination by non-beta-cells and the trauma of the isolation procedure... - Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient miceWataru Nishimura
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
Dev Biol 314:443-56. 2008..Thus, Pax6 acts upstream of MafB, which in turn may trigger the expression of insulin and regulate the PDX-1 and MafA expression required for beta-cell maturation... - Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into ratsAbdulkadir Omer
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Xenotransplantation 10:240-51. 2003..CONCLUSION: We conclude that depletion of peritoneal macrophages with clodronate liposomes improve the survival of macroencapsulated NPCCs... - Developmental pathways during in vitro progression of human islet neogenesisRikke Dodge
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Differentiation 77:135-47. 2009..We suggest that appropriate manipulation of these differentiation-associated pathways will enhance the efficiency of differentiation of insulin-producing beta-cells in this in vitro model... - Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesisKirstine Juhl
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
Curr Opin Organ Transplant 15:79-85. 2010..This review will summarize recent advances in in-vivo generation of beta-cells from cells that are not beta-cells (neogenesis) and discuss ways to overcome the limitations of this process... - Differentiation of affinity-purified human pancreatic duct cells to beta-cellsShigeru Yatoh
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Diabetes 56:1802-9. 2007..Thus, purified duct cells from adult human pancreas can differentiate to insulin-producing cells... - Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistanceBingzhong Xue
Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Biol Chem 282:23829-40. 2007..Thus, even in the setting of high genetic risk for diabetes, reducing PTP1B is partially protective, further demonstrating its attractiveness as a target for prevention and treatment of type 2 diabetes... - Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemiaD Ross Laybutt
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes 51:413-23. 2002..In conclusion, beta-cell adaptation to chronic hyperglycemia and, hence, increased insulin demand is accompanied by the induction of protective stress genes that may contribute to the survival of hypertrophied beta-cells... - Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetesD Ross Laybutt
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Biol Chem 278:2997-3005. 2003..Thus, both the severity and duration of hyperglycemia appear to contribute to the deterioration of the beta-cell phenotype found in diabetes... - p38 MAPK is a major regulator of MafA protein stability under oxidative stressTakuma Kondo
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Endocrinol 23:1281-90. 2009..Therefore, preventing p38 MAPK-mediated degradation of MafA represents a novel approach to improve beta-cell function... - Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita miceTomoyuki Akashi
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Diabetes Metab Res Rev 24:585-90. 2008..In this study, we carried out bone marrow and foetal liver cell transplantation to determine if these cells could differentiate into pancreatic beta-cells or promote regeneration... - Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer cultureKrystyna Tatarkiewicz
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
Dev Growth Differ 45:39-50. 2003..Furthermore, in such a culture setting, precursor duct cells have a high rate of proliferation and are more efficiently transduced with a retrovirus-based reporter gene than are beta cells... - Suppression of beta cell energy metabolism and insulin release by PGC-1alphaJ Cliff Yoon
Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
Dev Cell 5:73-83. 2003..These results strongly suggest that PGC-1alpha plays a key functional role in the beta cell and is involved in the pathogenesis of the diabetic phenotype... - Protective unfolded protein response in human pancreatic beta cells transplanted into miceJeffrey Kennedy
Section on Islet Cell Biology and Regenerative Medicine, Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:e11211. 2010..There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation... - Expression of MafA in pancreatic progenitors is detrimental for pancreatic developmentWataru Nishimura
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Dev Biol 333:108-20. 2009..These findings imply that MafA should be used to enhance maturation, rather than specification, of beta-cells from stem/progenitor cells... - Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD miceMaria Koulmanda
Departments of Surgery and Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:16242-7. 2008..Indeed, the functional mass of beta cells expands in AAT-treated diabetic NOD mice... - Five stages of evolving beta-cell dysfunction during progression to diabetesGordon C Weir
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Diabetes 53:S16-21. 2004..For type 1 diabetes, as remission develops, progression from stage 4 to stage 2 is typically found. Delineation of these stages provides insight into the pathophysiology of both progression and remission of diabetes... - PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cellsHirofumi Noguchi
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Diabetes 52:1732-7. 2003.... - Subpopulations of GFP-Marked Mouse Pancreatic β-Cells Differ in Size, Granularity, and Insulin SecretionHitoshi Katsuta
Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215
Endocrinology 153:5180-7. 2012..The three populations from the youngest had larger cells (forward scatter) and less granularity (side scatter) than those from the adults. This approach opens up new ways to advance knowledge about β-cell heterogeneity... - Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturityTandy Aye
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Histochem Cytochem 58:369-76. 2010.... - Importance of hyperglycemia on the primary function of allogeneic islet transplantsLeila Makhlouf
Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA
Transplantation 76:657-64. 2003..CONCLUSIONS: This study demonstrates that severe hyperglycemia impairs islet allograft function in BALB/c and NOD mice and that successful islet allotransplantation depends on the degree of hyperglycemia in the recipient... - Timing and expression pattern of carbonic anhydrase II in pancreasAkari Inada
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Dev Dyn 235:1571-7. 2006..Thus, we believe that the CAII gene could serve as a useful pancreatic duct cell marker... - Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cellsAkari Inada
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Biochem Biophys Res Commun 329:925-9. 2005..Since ICER Igamma is greatly increased in diabetes as well as in FFA- or high glucose-treated islets, this effect may in part exacerbate diabetes by limiting beta-cell proliferation... - Mechanism of PDX-1 protein transductionHirofumi Noguchi
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
Biochem Biophys Res Commun 332:68-74. 2005.... - Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profilingLorella Marselli
Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
Methods Mol Biol 560:87-98. 2009..We have developed a protocol of rapid tissue dehydration followed by identification of human beta-cells by their intrinsic autofluorescence, which allows laser microdissection for gene-profiling studies... - Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist StudyHillary A Keenan
Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
Diabetes 59:2846-53. 2010..To evaluate the extent of pancreatic β-cell function in a large number of insulin-dependent diabetic patients with a disease duration of 50 years or longer (Medalists)... - Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemiaD Ross Laybutt
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
J Biol Chem 277:10912-21. 2002..This global maladaptation in gene expression at the time of increased secretory demand may contribute to the beta-cell dysfunction found in diabetes... - Stem cell therapy for type 1 diabetes mellitusCristina Aguayo-Mazzucato
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Nat Rev Endocrinol 6:139-48. 2010.... - A dominant role for glucose in beta cell compensation of insulin resistanceGordon C Weir
Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 117:81-3. 2007..The study also provides strong evidence that insulin receptor substrate 2 (Irs2), which is known to have major effects on beta cell growth and survival, is a key downstream mediator of the effects of glucose found in this study... - p16INK4a induces an age-dependent decline in islet regenerative potentialJanakiraman Krishnamurthy
Department of Medicine, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Nature 443:453-7. 2006..These genetic data support the view that an age-induced increase of p16INK4a expression limits the regenerative capacity of beta-cells with ageing... - Finally! A human pancreatic β cell lineGordon C Weir
Section on Islet Cell Biology and Regenerative Medicine, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Clin Invest 121:3395-7. 2011.... - Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetesKevin Larade
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 283:29285-91. 2008.... - In vivo multimodal imaging of transplanted pancreatic isletsZdravka Medarova
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Nat Protoc 1:429-35. 2006..This information would be essential not only for the long-term monitoring of graft function but also for the design of improved transplantation and immunomodulatory methods... - Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunctionMaciej Borowiec
Research Division, Department of Medicine, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 106:14460-5. 2009..1. These actions are greatly attenuated by the Ala71Thr mutation. These findings point to BLK as a previously unrecognized modulator of beta-cell function, the deficit of which may lead to the development of diabetes... - Stem cell approaches for diabetes: towards beta cell replacementGordon C Weir
Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA, and the Department of Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
Genome Med 3:61. 2011..Herein, we review recent advances in our understanding of diabetes and beta cell biology at the genomic level, and we discuss how stem-cell-based approaches might be used for replacing beta cells and for treating diabetes... - Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in KoreaKun Ho Yoon
Department of Endocrinology and Metabolism, Immunology, and Cell Biology Core Laboratory, Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea 137 701
J Clin Endocrinol Metab 88:2300-8. 2003..Moreover, decreased beta-cell but increased alpha-cell proportion in the islets suggests for a selective beta-cell loss in the pathogenesis of Korean type 2 diabetes... - Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesAlexandra E Butler
Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
Diabetes 52:102-10. 2003.... - Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cellsAkari Inada
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Mol Cell Biol 24:2831-41. 2004..These results suggest that CRE and CRE-binding factors have an important role in pancreatic beta-cell physiology not only directly by regulation of gene trans-activation but also indirectly by regulation of beta-cell mass... - Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technologyHirofumi Noguchi
Diabetes Research Institute Japan, Toyoake, Aichi 470 1192, Japan
Cell Transplant 15:929-38. 2006..These data suggest that the overexpression of transcription factors, especially NeuroD, facilitates pancreatic stem/progenitor cell differentiation into insulin-producing cells... - Beta-cell precursors--a work in progressGordon C Weir
Nat Biotechnol 22:1095-6. 2004 - Imaging beta-cell death with a near-infrared probeZdravka Medarova
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA
Diabetes 54:1780-8. 2005.... - In vivo imaging of immune rejection in transplanted pancreatic isletsNatalia V Evgenov
Molecular Imaging Laboratory, Department of Radiology, Massachusetts General Hospital/Massachusetts Institute of Technology/Harvard Medical School, Charlestown, MA 02129, USA
Diabetes 55:2419-28. 2006..We believe that this agent, in combination with our preclinical model of islet transplantation, will facilitate the transition of imaging immune rejection to clinical trials... - Toward development of imaging modalities for islets after transplantation: insights from the National Institutes of Health Workshop on Beta Cell ImagingBreay W Paty
Department of Medicine, University of Alberta, Edmonton, Canada
Transplantation 77:1133-7. 2004..To better understand the fate of transplanted islets and the relationship between transplanted islet mass, graft function, and overall glucose homeostasis, an accurate and reproducible method of imaging islets in vivo is needed... - BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequenceHirofumi Noguchi
Dept of Transplantation and Immunology, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
Diabetes 54:2859-66. 2005..These data suggest that BETA2/NeuroD protein transduction could be a safe and valuable strategy for enhancing insulin gene transcription without requiring gene transfer technology... - Metabolic decompensation in pump users due to lispro insulin precipitationHoward A Wolpert
Joslin Diabetes Center, Boston, MA 02215, USA
BMJ 324:1253. 2002 - Preservation of beta-cell function by targeting beta-cell massEelco J P de Koning
Department of Nephrology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Trends Pharmacol Sci 29:218-27. 2008..In this review, we address the mechanisms involved in beta-cell dysfunction and beta-cell loss, and provide a rationale for pharmacological intervention for the preservation and/or expansion of beta-cell mass in type 2 diabetes... - Establishment of a diabetic mouse model with progressive diabetic nephropathyAkari Inada
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
Am J Pathol 167:327-36. 2005..Thus, similar to human diabetic nephropathy, ICER Igamma transgenic mice exhibit a stable and progressive phenotype of diabetic kidney disease due solely to chronic hyperglycemia without other modulating factors... - Photo-acceleration of protein release from endosome in the protein transduction systemMasayuki Matsushita
Department of Physiology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
FEBS Lett 572:221-6. 2004..Moreover, FITC-11R-p53 protein was released from endosomes following stimulation with light. These data suggest that photo-acceleration is a more efficient strategy in terms of the protein transduction system...
Research Grants
- Phenotypic Analysis of Young and Old Beta CellsSusan Bonner Weir; Fiscal Year: 2007..Another important outcome of this research should be valuable information about such practical questions as what will lead to successful long-term islet transplantation. ..
- Strategies to Identify In Vitro Islet ProgenitorsSusan Bonner Weir; Fiscal Year: 2007..Identifying such cell(s) would then direct focus on the expansion and differentiation of that cell type to a sustainable source of new beta cells. ..
- MECHANISMS OF ISLET GROWTH AND DIFFERENTIATIONSusan Bonner Weir; Fiscal Year: 1993..This project should contribute to the understanding of the presumably complex orchestration of factors regulating the growth and differentiation of the pancreatic B-cell...