Valentina Bollati

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study
    C Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Landmark Center West, Suite 415, 401 Park Dr, Boston, MA 02215, USA
    J Epidemiol Community Health 64:49-56. 2010
  2. pmc Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma
    Andrea Baccarelli
    Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epigenomics 4:91-100. 2012
  3. pmc Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study
    Diddier Prada
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston 02115, MA, USA
    BMC Psychiatry 14:223. 2014
  4. pmc Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers
    Laura Cantone
    Department of Environmental and Occupational Health, Università di Milano and Istituto Di Ricovero e Cura a Carattere Scientifico, and Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Environ Health Perspect 119:964-9. 2011
  5. pmc DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments
    Andrea Bellavia
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Am Heart Assoc 2:e000212. 2013
  6. pmc Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA
    Part Fibre Toxicol 10:28. 2013
  7. pmc Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
    Lifang Hou
    Department of Preventive Medicine Feinberg, School of Medicine Northwestern University, Chicago, IL 60611, USA
    Part Fibre Toxicol 10:17. 2013
  8. pmc Effects of airborne pollutants on mitochondrial DNA methylation
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Part Fibre Toxicol 10:18. 2013
  9. pmc Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulation
    Letizia Tarantini
    Department of Clinical and Community Sciences, Università degli Studi di Milano and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Occup Environ Med 70:418-25. 2013
  10. pmc Environmental exposures, epigenetics and cardiovascular disease
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 15:323-9. 2012

Detail Information

Publications81

  1. pmc Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging Study
    C Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Landmark Center West, Suite 415, 401 Park Dr, Boston, MA 02215, USA
    J Epidemiol Community Health 64:49-56. 2010
    ..5 mum in aerodynamic diameter (PM(2.5)) on heart rate variability (HRV) were modified by gene polymorphisms related to those pathways were evaluated...
  2. pmc Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthma
    Andrea Baccarelli
    Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epigenomics 4:91-100. 2012
    ..However, epigenetic studies are constrained by uncertainties on whether samples that can be easily collected in human individuals can provide informative results...
  3. pmc Influence of multiple APOE genetic variants on cognitive function in a cohort of older men - results from the Normative Aging Study
    Diddier Prada
    Department of Environmental Health, Harvard School of Public Health, 665 Huntington Ave, Boston 02115, MA, USA
    BMC Psychiatry 14:223. 2014
    ..APOE is the biomarker with the greatest known influence on cognitive function; however, the effect of complex haplotypes involving polymorphisms rs449647, rs405509, rs440446, rs429358 and rs7412 has never been studied in older populations...
  4. pmc Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers
    Laura Cantone
    Department of Environmental and Occupational Health, Università di Milano and Istituto Di Ricovero e Cura a Carattere Scientifico, and Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Environ Health Perspect 119:964-9. 2011
    ..Whether inhalation of metal components of PM induces histone modifications in human subjects is undetermined...
  5. pmc DNA hypomethylation, ambient particulate matter, and increased blood pressure: findings from controlled human exposure experiments
    Andrea Bellavia
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Am Heart Assoc 2:e000212. 2013
    ..No experimental evidence is available to confirm those observational data and demonstrate the relations between PM, hypomethylation, and BP...
  6. pmc Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA, USA
    Part Fibre Toxicol 10:28. 2013
    ..The purpose of the study is to evaluate sensitivity of DNA methylation in differentially‒evolved LINE, Alu, and HERV subfamilies to different types of airborne pollutants...
  7. pmc Inhalable particulate matter and mitochondrial DNA copy number in highly exposed individuals in Beijing, China: a repeated-measure study
    Lifang Hou
    Department of Preventive Medicine Feinberg, School of Medicine Northwestern University, Chicago, IL 60611, USA
    Part Fibre Toxicol 10:17. 2013
    ..Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a highly-exposed population in Beijing, China...
  8. pmc Effects of airborne pollutants on mitochondrial DNA methylation
    Hyang Min Byun
    Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Part Fibre Toxicol 10:18. 2013
    ..However, no study has yet investigated whether mitochondrial DNA methylation is sensitive to pro-oxidant environmental exposures...
  9. pmc Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulation
    Letizia Tarantini
    Department of Clinical and Community Sciences, Università degli Studi di Milano and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Occup Environ Med 70:418-25. 2013
    ..DNA methylation is an environmentally sensitive mechanism of gene regulation that could potentially contribute to PM-induced hypercoagulability. We aimed to test whether altered methylation mediates environmental effects on coagulation...
  10. pmc Environmental exposures, epigenetics and cardiovascular disease
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 15:323-9. 2012
    ..The purpose of this review is to render an overview of the possible mechanisms of epigenetic regulation of gene expression in response to environmental pollutants leading to cardiovascular diseases (CVD)...
  11. pmc Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional study
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N, Lakeshore Drive, Chicago, 60611, USA
    Part Fibre Toxicol 8:25. 2011
    ....
  12. pmc Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study
    Susan M Wernimont
    Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
    BMC Med Genet 12:150. 2011
    ..Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease...
  13. pmc Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Environ Health 10:45. 2011
    ..We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations...
  14. pmc Cis sequence effects on gene expression
    Andrew W Bergen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
    BMC Genomics 8:296. 2007
    ....
  15. pmc Ischemic heart disease and stroke in relation to blood DNA methylation
    Andrea Baccarelli
    Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and IRCCS Ca, Granda Policlinico Maggiore Hospital Foundation, Milan, Italy
    Epidemiology 21:819-28. 2010
    ..We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke...
  16. ncbi Mannose-binding lectin-2 genetic variation and stomach cancer risk
    Andrea Baccarelli
    EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
    Int J Cancer 119:1970-5. 2006
    ..6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk...
  17. pmc Air pollution, smoking, and plasma homocysteine
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:176-81. 2007
    ..Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, particularly in the presence of a preexisting proinflammatory status such as that found in cigarette smokers...
  18. pmc Exposure to particulate air pollution and risk of deep vein thrombosis
    Andrea Baccarelli
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Arch Intern Med 168:920-7. 2008
    ..Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown...
  19. pmc Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    Circulation 117:1802-9. 2008
    ....
  20. pmc Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxin
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 5:e161. 2008
    ....
  21. ncbi Effects of exposure to air pollution on blood coagulation
    A Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    J Thromb Haemost 5:252-60. 2007
    ..Consistent evidence has indicated that air pollution increases the risk of cardiovascular diseases. The underlying mechanisms linking air pollutants to increased cardiovascular risk are unclear...
  22. pmc Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston MA 02215, USA
    Int J Epidemiol 42:270-80. 2013
    ..We examined the relation of BP to the methylation of retrotransposon sequences of DNA and of selected candidate genes...
  23. pmc Allergen sensitization is associated with increased DNA methylation in older men
    Joanne E Sordillo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Int Arch Allergy Immunol 161:37-43. 2013
    ..We examined the association of asthma and allergic phenotypes with DNA methylation levels of retrotransposon-derived elements...
  24. pmc Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysis
    Zhong zheng Zhu
    Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Int J Epidemiol 41:126-39. 2012
    ..The aim of this study was to examine whether age, gender, smoking habits, alcohol drinking and body mass index (BMI) are associated with Alu or LINE-1 methylation levels in blood leucocyte DNA of healthy individuals...
  25. pmc Biomarkers of lead exposure and DNA methylation within retrotransposons
    Robert O Wright
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 118:790-5. 2010
    ..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead...
  26. pmc Arsenic exposure and DNA methylation among elderly men
    Angeliki Lambrou
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 23:668-76. 2012
    ..This association has also been explored in highly exposed human populations, but studies among populations environmentally exposed to low arsenic levels are lacking...
  27. pmc Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes
    Valentina Bollati
    Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico, Center of Molecular and Genetic Epidemiology, Milan, Italy
    Environ Health Perspect 118:763-8. 2010
    ..MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate the expression of broad gene networks at the posttranscriptional level...
  28. pmc Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposure
    Michele Carugno
    Department of Occupational and Environmental Health, Universita degli Studi di Milano, Milan, Italy
    Environ Health Perspect 120:210-5. 2012
    ..Benzene is an established leukemogen at high exposure levels. Although low-level benzene exposure is widespread and may induce oxidative damage, no mechanistic biomarkers are available to detect biological dysfunction at low doses...
  29. ncbi Global DNA methylation and low-level exposure to benzene
    Silvia Fustinoni
    Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Med Lav 103:84-95. 2012
    ..Whether global genomic DNA methylation content is reduced in response to benzene exposure is still undetermined...
  30. pmc Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging Study
    Zhong zheng Zhu
    Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Cancer Causes Control 22:437-47. 2011
    ..Because samples in case-control studies are collected after disease development, whether DNA hypomethylation is causal or just associated with cancer development is still unclear...
  31. pmc Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation
    Letizia Tarantini
    Laboratory of Environmental Epigenetics, Department of Preventive Medicine, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
    Environ Health Perspect 117:217-22. 2009
    ..Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined...
  32. pmc Epigenetic effects of shiftwork on blood DNA methylation
    Valentina Bollati
    Dipartimento di Medicina del Lavoro, Universita degli Studi di Milano, Milan, Italy
    Chronobiol Int 27:1093-104. 2010
    ..Further studies are required to determine the role of such alterations in mediating the effects of shiftwork on human health...
  33. pmc Decline in genomic DNA methylation through aging in a cohort of elderly subjects
    Valentina Bollati
    Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Mech Ageing Dev 130:234-9. 2009
    ..089 %5mC/year, p<0.0001). In contrast, average LINE-1 methylation did not vary over time [p=0.51]. Our results demonstrate a progressive loss of DNA methylation in repetitive elements dispersed throughout the genome...
  34. pmc Rapid DNA methylation changes after exposure to traffic particles
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Am J Respir Crit Care Med 179:572-8. 2009
    ..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis...
  35. pmc Integrative Analysis of miRNA and inflammatory gene expression after acute particulate matter exposure
    Valeria Motta
    Exposure, Epidemiology and Risk Program, Department of Environmental Health, Laboratory of Environmental Epigenetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Toxicol Sci 132:307-16. 2013
    ..Acute PM exposure may affect gene regulation through PM-responsive miRNAs that directly or indirectly control inflammatory gene expression...
  36. ncbi Changes in DNA methylation patterns in subjects exposed to low-dose benzene
    Valentina Bollati
    Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
    Cancer Res 67:876-80. 2007
    ..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure...
  37. ncbi Relevance of telomere/telomerase system impairment in early stage chronic lymphocytic leukemia
    Mirjam Hoxha
    Department of Clinical Sciences and Community Health, Center of Molecular and Genetic Epidemiology, University of Milan, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Genes Chromosomes Cancer 53:612-21. 2014
    ..Moreover, the correlation between telomere shortening and global DNA hypomethylation supports the involvement of DNA hypomethylation to increase chromosome instability. © 2014 Wiley Periodicals, Inc. ..
  38. ncbi Does enhancement of oxidative stress markers mediate health effects of ambient air particles?
    Pier Alberto Bertazzi
    1 Department of Clinical Sciences and Community Health, Center of Molecular and Genetic Epidemiology, Università di Milano and Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy
    Antioxid Redox Signal 21:46-51. 2014
    ..g., cardiovascular) effects...
  39. pmc Urinary benzene biomarkers and DNA methylation in Bulgarian petrochemical workers: study findings and comparison of linear and beta regression models
    Wei Jie Seow
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 7:e50471. 2012
    ..We showed that beta-regression is more appropriate than OLS regression for fitting methylation data...
  40. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  41. ncbi Differential repetitive DNA methylation in multiple myeloma molecular subgroups
    Valentina Bollati
    Center of Molecular and Genetic Epidemiology, EPOCA, Epidemiology Research Center, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milan, Italy
    Carcinogenesis 30:1330-5. 2009
    ..001). Our results indicate that global hypomethylation of repetitive elements is significantly associated with tumor progression in MM and may contribute toward a more extensive stratification of the disease...
  42. pmc Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemia
    Sonia Fabris
    Medical Sciences Department, University of Milan and Hematology 1, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
    Epigenetics 6:188-94. 2011
    ..Our study extended previous limited evidences in methylation of repetitive sequences in CLL suggesting an important biological and clinical relevance in the disease...
  43. pmc DNA methylation in repetitive elements and Alzheimer disease
    V Bollati
    Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
    Brain Behav Immun 25:1078-83. 2011
    ..Further prospective investigations are warranted to evaluate the dynamics of DNA methylation from early-stage AD to advanced phases of the disease...
  44. ncbi Occupational and environmental agents as endocrine disruptors: experimental and human evidence
    A Baccarelli
    Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, and EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Italy
    J Endocrinol Invest 23:771-81. 2000
    ..This paper reviews the experimental and human evidence of the effects of occupational and environmental chemical agents on hypothalamus-pituitary unit, pineal gland, parathyroid and calcium metabolism and adrenal glands...
  45. pmc Epigenetics and environmental chemicals
    Andrea Baccarelli
    Laboratory of Environmental Epigenetics, Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, Milan, Italy
    Curr Opin Pediatr 21:243-51. 2009
    ..Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemicals...
  46. pmc Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter
    Elissa Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:935-40. 2009
    ..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
  47. pmc Correlation of global and gene-specific DNA methylation in maternal-infant pairs
    Molly L Kile
    Environmental Health Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 5:e13730. 2010
    ..Future studies should also use a multi-generational family-based design that would quantify both maternal and paternal contributions to DNA methylation in offspring across more than one generation...
  48. pmc Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 118:1564-70. 2010
    ..Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown...
  49. pmc Gene-air pollution interaction and cardiovascular disease: a review
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
    Prog Cardiovasc Dis 53:344-52. 2011
    ....
  50. pmc Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes
    Elissa H Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 118:943-8. 2010
    ..MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated...
  51. pmc Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:198-206. 2010
    ..nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature...
  52. ncbi Metals and neurotoxicology
    Robert O Wright
    Department of Pediatrics, Children s Hospital, Boston Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 137:2809-13. 2007
    ..Parallel work in metals demonstrates that epigenetics may be a critical pathway by which metals produce health effects...
  53. pmc Air pollution, obesity, genes and cellular adhesion molecules
    Jaime Madrigano
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 67:312-7. 2010
    ..We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association...
  54. pmc Environmental epigenetics
    V Bollati
    Department of Environmental and Occupational Health, Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Heredity (Edinb) 105:105-12. 2010
    ....
  55. pmc Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging study
    S E Alexeeff
    Stacey E Alexeeff, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, Massachusetts 02215, USA
    Occup Environ Med 65:736-42. 2008
    ..It then investigated whether genetic polymorphisms of antioxidant genes (heme oxygenase-1 (HMOX1) and glutathione S-transferase pi (GSTP1)) modified these associations...
  56. ncbi Health effects of dioxin exposure: a 20-year mortality study
    P A Bertazzi
    EPOCA, Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
    Am J Epidemiol 153:1031-44. 2001
    ..Results support evaluation of dioxin as carcinogenic to humans and corroborate the hypotheses of its association with other health outcomes, including cardiovascular- and endocrine-related effects...
  57. doi Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidism
    S Corbetta
    Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
    Eur J Endocrinol 160:283-8. 2009
    ..Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT as well as in idiopathic stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism...
  58. ncbi Quantitative analysis of methylation defects and correlation with clinical characteristics in patients with pseudohypoparathyroidism type I and GNAS epigenetic alterations
    Francesca M Elli
    Department of Clinical Sciences and Community Health F M E, M F, A M B, E P, P B P, A s, G M, Endocrinology and Diabetology Unit, University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Ca Granda Ospedale Maggiore Policlinico, and Center of Molecular and Genetic Epidemiology V B, L T, Department of Clinical Sciences and Community Health, Università di Milano and Fondazione Cà Granda Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore Policlinico, 20122 Milan, Italy and Department of Public Health and Pediatrics L d S, University of Turin, and Regina Margherita Children s Hospital, 10126 Turin, Italy
    J Clin Endocrinol Metab 99:E508-17. 2014
    ..Recently methylation defects have been detected also in patients with PHP and different degrees of AHO, indicating a molecular overlap between the two forms...
  59. ncbi Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident"
    Angela Cecilia Pesatori
    Department of Occupational and Environmental Medicine and EPOCA Epidemiology Research Center, Università degli Studi and Istituti Clinici di Perfezionamento, Milan, Italy
    Ind Health 41:127-38. 2003
    ..The mortality and cancer incidence follow-up of the Seveso cohort are continuing...
  60. ncbi Aryl hydrocarbon receptor-interacting protein and pituitary adenomas: a population-based study on subjects exposed to dioxin after the Seveso, Italy, accident
    Angela Cecilia Pesatori
    Department of Occupational and Environmental Health, EPOCA Research Center, Clinica L Devoto, University of Milan, Via San Barnaba 8, 20122 Milano, Italy
    Eur J Endocrinol 159:699-703. 2008
    ..AIP is a chaperone protein with multifunction properties, including modulation of the transcriptional activity of the aryl hydrocarbon receptor, which mediates toxicological and carcinogenic dioxin effects...
  61. pmc Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers
    Mirjam Hoxha
    Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Environ Health 8:41. 2009
    ..Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated...
  62. ncbi Dioxin effects on neonatal and infant thyroid function: routes of perinatal exposure, mechanisms of action and evidence from epidemiology studies
    Sara Mariasole Giacomini
    EPOCA Epidemiology Research Center, Department of Environmental and Occupational Health Clinica del Lavoro L Devoto, Maggiore Hospital Foundation IRCCS, University of Milan, Via San Barnaba 8, 20122, Milan, Italy
    Int Arch Occup Environ Health 79:396-404. 2006
    ..In the present review article, we appraise available evidence on the effects of perinatal exposure to dioxin on fetal and infant thyroid function...
  63. doi Antimicrobial-coated endotracheal tubes: an experimental study
    Lorenzo Berra
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Intensive Care Med 34:1020-9. 2008
    ..After 24 h of mechanical ventilation, standard microbiological studies were performed together with scanning electron microscopy and confocal microscopy...
  64. ncbi t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, Italy
    Andrea Baccarelli
    EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Carcinogenesis 27:2001-7. 2006
    ..Whether this change in t(14;18) frequency is an indicator of elevated lymphoma risk remains speculative and needs further investigation for its potential impact on public health...
  65. pmc Immunologic effects of dioxin: new results from Seveso and comparison with other studies
    Andrea Baccarelli
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
    Environ Health Perspect 110:1169-73. 2002
    ..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation...
  66. ncbi TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
    Carcinogenesis 24:673-80. 2003
    ....
  67. ncbi CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
    Toxicology 207:191-202. 2005
    ..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease...
  68. pmc Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population
    Rajeev Mahajan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
    Jpn J Clin Oncol 38:626-33. 2008
    ..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology...
  69. ncbi Correspondence re: K. Toide et al., Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. 12: 219
    Maria Teresa Landi
    Cancer Epidemiol Biomarkers Prev 12:1116-7; author reply 1118. 2003
  70. ncbi Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, Italy
    Andrea Baccarelli
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
    Toxicol Lett 149:287-93. 2004
    ..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident...
  71. pmc Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30306, USA
    Environ Health Perspect 112:1265-8. 2004
    ..There are also new data regarding how the AhR functions in mediating the carcinogenic response to TCDD. The new evidence generally supports the 1997 IARC classification...
  72. ncbi CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenoma
    Lifang Hou
    Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Carcinogenesis 26:1122-8. 2005
    ..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions...
  73. ncbi Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicology 229:101-13. 2007
    ..Further examination of the role of these genes in dioxin induced-toxicity is warranted...
  74. ncbi Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne study
    Andrea Baccarelli
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD 20852, USA
    Chemosphere 60:898-906. 2005
    ..6% of plasma TCDD measurements were non-detects. We suggest that distribution-based multiple imputation be the preferred method to analyze environmental data when substantial proportions of observations are non-detects...
  75. ncbi Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, Russia
    Andrea Baccarelli
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
    Am J Ind Med 49:460-7. 2006
    ..Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer...
  76. ncbi Risk of lung cancer and exposure to industrial acids, solvents, and metals in leningrad province, Russia
    Andrea Baccarelli
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Occup Environ Med 48:48-55. 2006
    ..We sought to investigate the association of occupational exposure to industrial acids, solvents, and metals with lung cancer in Leningrad Province, Russia, where an excess of occupationally related lung cancer was reported recently...
  77. ncbi COX1 and COX2 polymorphisms and gastric cancer risk in a Polish population
    Lifang Hou
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
    Anticancer Res 27:4243-7. 2007
    ..Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied...
  78. ncbi Plasma stromal cell-derived factor-1: host derived marker predictive of distant metastasis in breast cancer
    Saima Hassan
    Department of Oncology and Surgery, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
    Clin Cancer Res 14:446-54. 2008
    ..We investigated the value of SDF-1 as a predictive blood marker of distant metastasis in breast cancer, together with a common polymorphism of SDF-1, SDF-1-3'A...
  79. ncbi Pesticide exposure and lung cancer mortality in Leningrad province in Russia
    Won Jin Lee
    Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
    Environ Int 32:412-6. 2006
    ..Our findings suggest no associations between pesticide exposures and mortality of lung cancer in the population of the Leningrad province in Russia that deserves further evaluation...
  80. ncbi [Risk factors of malignant skin melanoma in Italian population: review of results of a case-control study]
    Andrea Baccarelli
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH 6120 Executive Blvd, EPS 7110, Bethesda, MD 20892 7236, USA
    Epidemiol Prev 26:293-9. 2002
    ..7; 95% CI: 2.4-18.6) than those lacking dysplastic nevi and with high DRC. These results may help identify high-risk subjects in the Mediterranean populations who would the benefit from preventive measures...
  81. ncbi DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanoma
    Maria Teresa Landi
    Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
    J Natl Cancer Inst 94:94-101. 2002
    ..We designed this case-control study to determine whether DNA repair capacity (DRC) is associated with the risk of CMM and to identify risk factors that may interact biologically with DRC in the development of melanoma...