Research Topics
Genomes and Genes
Species | Valentina BollatiSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Lipid and endothelium-related genes, ambient particulate matter, and heart rate variability--the VA Normative Aging StudyC Ren
Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Landmark Center West, Suite 415, 401 Park Dr, Boston, MA 02215, USA
J Epidemiol Community Health 64:49-56. 2010..5 mum in aerodynamic diameter (PM(2.5)) on heart rate variability (HRV) were modified by gene polymorphisms related to those pathways were evaluated...- Blood hypomethylation of inflammatory genes mediates the effects of metal-rich airborne pollutants on blood coagulationLetizia Tarantini
Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Office Landmark Center, Rm 415E West, PO Box 15677, 401 Park Dr, Boston, MA 02215, USA
Occup Environ Med 70:418-25. 2013..DNA methylation is an environmentally sensitive mechanism of gene regulation that could potentially contribute to PM-induced hypercoagulability. We aimed to test whether altered methylation mediates environmental effects on coagulation... - Environmental exposures, epigenetics and cardiovascular diseaseAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Curr Opin Clin Nutr Metab Care 15:323-9. 2012..The purpose of this review is to render an overview of the possible mechanisms of epigenetic regulation of gene expression in response to environmental pollutants leading to cardiovascular diseases (CVD)... 
Nasal cell DNA methylation, inflammation, lung function and wheezing in children with asthmaAndrea Baccarelli
Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
Epigenomics 4:91-100. 2012..However, epigenetic studies are constrained by uncertainties on whether samples that can be easily collected in human individuals can provide informative results...- Ambient PM exposure and DNA methylation in tumor suppressor genes: a cross-sectional studyLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N, Lakeshore Drive, Chicago, 60611, USA
Part Fibre Toxicol 8:25. 2011.... - Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association studySusan M Wernimont
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
BMC Med Genet 12:150. 2011..Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease... - Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging StudyElissa H Wilker
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
Environ Health 10:45. 2011..We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations... - Cis sequence effects on gene expressionAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA
BMC Genomics 8:296. 2007.... 
Effects of exposure to air pollution on blood coagulationA Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
J Thromb Haemost 5:252-60. 2007..Consistent evidence has indicated that air pollution increases the risk of cardiovascular diseases. The underlying mechanisms linking air pollutants to increased cardiovascular risk are unclear...- Air pollution, smoking, and plasma homocysteineAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:176-81. 2007..Air pollution exposure induces short-term inflammatory changes that may determine hyperhomocysteinemia, particularly in the presence of a preexisting proinflammatory status such as that found in cigarette smokers... - Mannose-binding lectin-2 genetic variation and stomach cancer riskAndrea Baccarelli
EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
Int J Cancer 119:1970-5. 2006..5, 95% CI 1.6-7.6; p = 0.001). Our findings suggest that the codon 52 D MBL2 variant causing a cysteine > arginine replacement, but not B and C variants producing glycine substitutions, is specifically associated with gastric cancer risk... - Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxinAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 5:e161. 2008.... - Exposure to particulate air pollution and risk of deep vein thrombosisAndrea Baccarelli
Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Arch Intern Med 168:920-7. 2008..Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown... - Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphismsAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
Circulation 117:1802-9. 2008.... - Ischemic heart disease and stroke in relation to blood DNA methylationAndrea Baccarelli
Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and IRCCS Ca, Granda Policlinico Maggiore Hospital Foundation, Milan, Italy
Epidemiology 21:819-28. 2010..We evaluated whether lower blood DNA methylation in heavily methylated repetitive sequences predicts the risk of ischemic heart disease and stroke... - Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workersLaura Cantone
Department of Environmental and Occupational Health, Università di Milano and Istituto Di Ricovero e Cura a Carattere Scientifico, and Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Environ Health Perspect 119:964-9. 2011..Whether inhalation of metal components of PM induces histone modifications in human subjects is undetermined... - Predictors of global methylation levels in blood DNA of healthy subjects: a combined analysisZhong zheng Zhu
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Int J Epidemiol 41:126-39. 2012..The aim of this study was to examine whether age, gender, smoking habits, alcohol drinking and body mass index (BMI) are associated with Alu or LINE-1 methylation levels in blood leucocyte DNA of healthy individuals... - Arsenic exposure and DNA methylation among elderly menAngeliki Lambrou
Exposure, Epidemiology and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Epidemiology 23:668-76. 2012..This association has also been explored in highly exposed human populations, but studies among populations environmentally exposed to low arsenic levels are lacking... - Global DNA methylation and low-level exposure to benzeneSilvia Fustinoni
Department of Occupational and Environmental Medicine, University of Milan and Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Med Lav 103:84-95. 2012..Whether global genomic DNA methylation content is reduced in response to benzene exposure is still undetermined... - Biomarkers of lead exposure and DNA methylation within retrotransposonsRobert O Wright
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 118:790-5. 2010..Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of cumulative exposure, may therefore better predict DNA methylation than does blood lead... - Repetitive element hypomethylation in blood leukocyte DNA and cancer incidence, prevalence, and mortality in elderly individuals: the Normative Aging StudyZhong zheng Zhu
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Maggiore Policlinico Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Cancer Causes Control 22:437-47. 2011..Because samples in case-control studies are collected after disease development, whether DNA hypomethylation is causal or just associated with cancer development is still unclear... - Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytesValentina Bollati
Department of Environmental and Occupational Health, Università degli Studi di Milano and IRCCS Fondazione Ca Granda Ospedale Maggiore Policlinico, Center of Molecular and Genetic Epidemiology, Milan, Italy
Environ Health Perspect 118:763-8. 2010..MicroRNAs (miRNAs) are highly conserved, noncoding small RNAs that regulate the expression of broad gene networks at the posttranscriptional level... - Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylationLetizia Tarantini
Laboratory of Environmental Epigenetics, Department of Preventive Medicine, University of Milan and IRCCS Maggiore Hospital, Milan, Italy
Environ Health Perspect 117:217-22. 2009..Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined... - Increased mitochondrial DNA copy number in occupations associated with low-dose benzene exposureMichele Carugno
Department of Occupational and Environmental Health, Universita degli Studi di Milano, Milan, Italy
Environ Health Perspect 120:210-5. 2012..Benzene is an established leukemogen at high exposure levels. Although low-level benzene exposure is widespread and may induce oxidative damage, no mechanistic biomarkers are available to detect biological dysfunction at low doses... - Decline in genomic DNA methylation through aging in a cohort of elderly subjectsValentina Bollati
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan and IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Mech Ageing Dev 130:234-9. 2009..089 %5mC/year, p<0.0001). In contrast, average LINE-1 methylation did not vary over time [p=0.51]. Our results demonstrate a progressive loss of DNA methylation in repetitive elements dispersed throughout the genome... - Rapid DNA methylation changes after exposure to traffic particlesAndrea Baccarelli
Laboratory of Environmental Epigenetics, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
Am J Respir Crit Care Med 179:572-8. 2009..Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis... - Epigenetic effects of shiftwork on blood DNA methylationValentina Bollati
Dipartimento di Medicina del Lavoro, Universita degli Studi di Milano, Milan, Italy
Chronobiol Int 27:1093-104. 2010..Further studies are required to determine the role of such alterations in mediating the effects of shiftwork on human health... - Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genesStacey E Alexeeff
Department of Environmental Health, Harvard School of Public Health, Boston MA 02215, USA
Int J Epidemiol 42:270-80. 2013..We examined the relation of BP to the methylation of retrotransposon sequences of DNA and of selected candidate genes... - Allergen sensitization is associated with increased DNA methylation in older menJoanne E Sordillo
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass, USA
Int Arch Allergy Immunol 161:37-43. 2013..Future work is needed to identify potential underlying mechanisms for these relationships... - Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohortTeresa Chahine
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:1617-22. 2007..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter... - Integrative Analysis of miRNA and inflammatory gene expression after acute particulate matter exposureValeria Motta
Exposure, Epidemiology and Risk Program, Department of Environmental Health, Laboratory of Environmental Epigenetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Toxicol Sci 132:307-16. 2013..Acute PM exposure may affect gene regulation through PM-responsive miRNAs that directly or indirectly control inflammatory gene expression... - Differential repetitive DNA methylation in multiple myeloma molecular subgroupsValentina Bollati
Center of Molecular and Genetic Epidemiology, EPOCA, Epidemiology Research Center, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, 20122 Milan, Italy
Carcinogenesis 30:1330-5. 2009..001). Our results indicate that global hypomethylation of repetitive elements is significantly associated with tumor progression in MM and may contribute toward a more extensive stratification of the disease... - Changes in DNA methylation patterns in subjects exposed to low-dose benzeneValentina Bollati
Molecular Epidemiology Laboratory, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, 20122 Milan, Italy
Cancer Res 67:876-80. 2007..20). This is the first human study to link altered DNA methylation, reproducing the aberrant epigenetic patterns found in malignant cells, to low-level carcinogen exposure... - Biological and clinical relevance of quantitative global methylation of repetitive DNA sequences in chronic lymphocytic leukemiaSonia Fabris
Medical Sciences Department, University of Milan and Hematology 1, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy
Epigenetics 6:188-94. 2011..Our study extended previous limited evidences in methylation of repetitive sequences in CLL suggesting an important biological and clinical relevance in the disease... - Occupational and environmental agents as endocrine disruptors: experimental and human evidenceA Baccarelli
Institute of Endocrine Sciences, Ospedale Maggiore, IRCCS, and EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, University of Milan, Italy
J Endocrinol Invest 23:771-81. 2000..This paper reviews the experimental and human evidence of the effects of occupational and environmental chemical agents on hypothalamus-pituitary unit, pineal gland, parathyroid and calcium metabolism and adrenal glands... - DNA methylation in repetitive elements and Alzheimer diseaseV Bollati
Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy
Brain Behav Immun 25:1078-83. 2011..Further prospective investigations are warranted to evaluate the dynamics of DNA methylation from early-stage AD to advanced phases of the disease... - Epigenetics and environmental chemicalsAndrea Baccarelli
Laboratory of Environmental Epigenetics, Center of Molecular and Genetic Epidemiology, Department of Environmental and Occupational Health, University of Milan, Via San Barnaba 8, Milan, Italy
Curr Opin Pediatr 21:243-51. 2009..Here, we review current evidence indicating that epigenetic alterations mediate toxicity from environmental chemicals... - Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollutionCizao Ren
Exposure, Epidemiology, and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
Epidemiology 21:198-206. 2010..nondeletion), and HMOX-1 (any short vs. both long). We attempted to replicate identified genes in an analysis of heart rate variability and in other outcomes reported in the literature... - Air pollution, obesity, genes and cellular adhesion moleculesJaime Madrigano
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Occup Environ Med 67:312-7. 2010..We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association... - Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genesElissa H Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 118:943-8. 2010..MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated... - Correlation of global and gene-specific DNA methylation in maternal-infant pairsMolly L Kile
Environmental Health Department, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 5:e13730. 2010..Future studies should also use a multi-generational family-based design that would quantify both maternal and paternal contributions to DNA methylation in offspring across more than one generation... - Gene-air pollution interaction and cardiovascular disease: a reviewAntonella Zanobetti
Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02115, USA
Prog Cardiovasc Dis 53:344-52. 2011.... - Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging StudyJohn McCracken
Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr, Boston, MA 02215, USA
Environ Health Perspect 118:1564-70. 2010..Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown... - Metals and neurotoxicologyRobert O Wright
Department of Pediatrics, Children s Hospital, Boston Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
J Nutr 137:2809-13. 2007..Parallel work in metals demonstrates that epigenetics may be a critical pathway by which metals produce health effects... - Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matterElissa Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:935-40. 2009..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation... - Health effects of dioxin exposure: a 20-year mortality studyP A Bertazzi
EPOCA, Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, Milan, Italy
Am J Epidemiol 153:1031-44. 2001..Results support evaluation of dioxin as carcinogenic to humans and corroborate the hypotheses of its association with other health outcomes, including cardiovascular- and endocrine-related effects... - Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging studyS E Alexeeff
Stacey E Alexeeff, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, Massachusetts 02215, USA
Occup Environ Med 65:736-42. 2008..It then investigated whether genetic polymorphisms of antioxidant genes (heme oxygenase-1 (HMOX1) and glutathione S-transferase pi (GSTP1)) modified these associations... - Environmental epigeneticsV Bollati
Department of Environmental and Occupational Health, Center of Molecular and Genetic Epidemiology, Università degli Studi di Milano and Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
Heredity (Edinb) 105:105-12. 2010.... - Analysis of the 206M polymorphic variant of the SLC26A6 gene encoding a Cl- oxalate transporter in patients with primary hyperparathyroidismS Corbetta
Endocrinology and Diabetology Unit, Department of Medical Surgical Sciences, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
Eur J Endocrinol 160:283-8. 2009..Hypercalciuria and urine oxalate excretion are considered risk factors for urolithiasis in PHPT as well as in idiopathic stone-formers. Recently, the anion-exchanger SLC26A6 has been involved in the oxalate metabolism... - Urinary benzene biomarkers and DNA methylation in Bulgarian petrochemical workers: study findings and comparison of linear and beta regression modelsWei Jie Seow
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 7:e50471. 2012..We showed that beta-regression is more appropriate than OLS regression for fitting methylation data... - Short- and long-term morbidity and mortality in the population exposed to dioxin after the "Seveso accident"Angela Cecilia Pesatori
Department of Occupational and Environmental Medicine and EPOCA Epidemiology Research Center, , Milan, Italy
Ind Health 41:127-38. 2003..The mortality and cancer incidence follow-up of the Seveso cohort are continuing... - Aryl hydrocarbon receptor-interacting protein and pituitary adenomas: a population-based study on subjects exposed to dioxin after the Seveso, Italy, accidentAngela Cecilia Pesatori
Department of Occupational and Environmental Health, EPOCA Research Center, Clinica L Devoto, University of Milan, Via San Barnaba 8, 20122 Milano, Italy
Eur J Endocrinol 159:699-703. 2008..AIP is a chaperone protein with multifunction properties, including modulation of the transcriptional activity of the aryl hydrocarbon receptor, which mediates toxicological and carcinogenic dioxin effects... - Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workersMirjam Hoxha
Center of Molecular and Genetic Epidemiology, Department of Preventive Medicine, IRCCS Maggiore Hospital, Mangiagalli and Regina Elena Foundation, Milan, Italy
Environ Health 8:41. 2009..Traffic pollution has been linked with both cardiovascular and cancer risks, particularly in older subjects. Whether exposure to traffic pollution is associated with telomere shortening has never been evaluated... - Dioxin effects on neonatal and infant thyroid function: routes of perinatal exposure, mechanisms of action and evidence from epidemiology studiesSara Mariasole Giacomini
EPOCA Epidemiology Research Center, Department of Environmental and Occupational Health Clinica del Lavoro L. Devoto, Maggiore Hospital Foundation IRCCS, University of Milan, Via San Barnaba 8, 20122, Milan, Italy
Int Arch Occup Environ Health 79:396-404. 2006.... - t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, ItalyAndrea Baccarelli
EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
Carcinogenesis 27:2001-7. 2006..Whether this change in t(14;18) frequency is an indicator of elevated lymphoma risk remains speculative and needs further investigation for its potential impact on public health... - Antimicrobial-coated endotracheal tubes: an experimental studyLorenzo Berra
Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Intensive Care Med 34:1020-9. 2008..After 24 h of mechanical ventilation, standard microbiological studies were performed together with scanning electron microscopy and confocal microscopy... - Immunologic effects of dioxin: new results from Seveso and comparison with other studiesAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Environ Health Perspect 110:1169-73. 2002..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation... - Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish populationRajeev Mahajan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA
Jpn J Clin Oncol 38:626-33. 2008..7-1.3) for C/T and 0.6 (95% CI, 0.3-1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology... - Correspondence re: K. Toide et al., Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. 12: 219Maria Teresa Landi
Cancer Epidemiol Biomarkers Prev 12:1116-7; author reply 1118. 2003 - TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accidentMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
Carcinogenesis 24:673-80. 2003.... - Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, ItalyAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
Toxicol Lett 149:287-93. 2004..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident... - CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, ItalyMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
Toxicology 207:191-202. 2005..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease... - COX1 and COX2 polymorphisms and gastric cancer risk in a Polish populationLifang Hou
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA
Anticancer Res 27:4243-7. 2007..Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied... - Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjectsCliona M McHale
School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Toxicology 229:101-13. 2007..Further examination of the role of these genes in dioxin induced-toxicity is warranted... - Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogenKyle Steenland
Rollins School of Public Health, Emory University, Atlanta, Georgia 30306, USA
Environ Health Perspect 112:1265-8. 2004..There are also new data regarding how the AhR functions in mediating the carcinogenic response to TCDD. The new evidence generally supports the 1997 IARC classification... - Risk of lung cancer from exposure to dusts and fibers in Leningrad Province, RussiaAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland, USA
Am J Ind Med 49:460-7. 2006..Exposures to several dusts and fibers (DFs) have been established or suggested as etiologic factors for lung cancer... - CYP1A1 Val462 and NQO1 Ser187 polymorphisms, cigarette use, and risk for colorectal adenomaLifang Hou
Department of Human and Health Services, Division of Cancer Epidemiology and Genetics, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Carcinogenesis 26:1122-8. 2005..002). In summary, joint carriage of CYP1A1 Val(462) and NQO1 Ser(187) alleles, particularly in smokers, was related to colorectal adenoma risk, with a propensity for formation of multiple lesions... - Risk of lung cancer and exposure to industrial acids, solvents, and metals in leningrad province, RussiaAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
J Occup Environ Med 48:48-55. 2006..We sought to investigate the association of occupational exposure to industrial acids, solvents, and metals with lung cancer in Leningrad Province, Russia, where an excess of occupationally related lung cancer was reported recently... - Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne studyAndrea Baccarelli
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, Bethesda, MD 20852, USA
Chemosphere 60:898-906. 2005..6% of plasma TCDD measurements were non-detects. We suggest that distribution-based multiple imputation be the preferred method to analyze environmental data when substantial proportions of observations are non-detects... - [Risk factors of malignant skin melanoma in Italian population: review of results of a case-control study]Andrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH 6120 Executive Blvd, EPS 7110, Bethesda, MD 20892 7236, USA
Epidemiol Prev 26:293-9. 2002..7; 95% CI: 2.4-18.6) than those lacking dysplastic nevi and with high DRC. These results may help identify high-risk subjects in the Mediterranean populations who would the benefit from preventive measures... - Pesticide exposure and lung cancer mortality in Leningrad province in RussiaWon Jin Lee
Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
Environ Int 32:412-6. 2006..Our findings suggest no associations between pesticide exposures and mortality of lung cancer in the population of the Leningrad province in Russia that deserves further evaluation... - Plasma stromal cell-derived factor-1: host derived marker predictive of distant metastasis in breast cancerSaima Hassan
Department of Oncology and Surgery, Lady Davis Institute, Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal, Quebec, Canada
Clin Cancer Res 14:446-54. 2008..We investigated the value of SDF-1 as a predictive blood marker of distant metastasis in breast cancer, together with a common polymorphism of SDF-1, SDF-1-3'A... - DNA repair, dysplastic nevi, and sunlight sensitivity in the development of cutaneous malignant melanomaMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
J Natl Cancer Inst 94:94-101. 2002..We designed this case-control study to determine whether DNA repair capacity (DRC) is associated with the risk of CMM and to identify risk factors that may interact biologically with DRC in the development of melanoma...