Affiliation: Harvard University
- Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probesM Bogyo
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Chem Biol 5:307-20. 1998..Although mutational studies in yeast have begun to define substrate specificities of individual catalytically active beta subunits, little is known about the principles that govern substrate hydrolysis by the proteasome...
- Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesienseC R Caffrey
Tropical Disease Research Unit, Department of Pathology, University of California San Francisco, VAMC, 4150 Clement Street-113B, San Francisco, CA 94121, USA
Mol Biochem Parasitol 118:61-73. 2001..S2 subsite mapping of rhodesain and cruzain with fluorogenic peptidyl substrates demonstrates that the presence of alanine rather than glutamate at S2 prevents rhodesain from cleaving substrates in which P2 is arginine...