Research Topics
| David BoasSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Haemoglobin oxygen saturation as a biomarker: the problem and a solutionDavid A Boas
Optics Division of the Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th St rm 2301, Charlestown, MA 02129, USA
Philos Transact A Math Phys Eng Sci 369:4407-24. 2011..Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism...
Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain functionDavid A Boas
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Appl Opt 44:1957-68. 2005..However, issues of depth resolution within the cortex remain to be resolved...- Laser speckle contrast imaging in biomedical opticsDavid A Boas
Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 15:011109. 2010..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology... - Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humansD A Boas
Anthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:1506-8. 2004.... - A vascular anatomical network model of the spatio-temporal response to brain activationDavid A Boas
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Neuroimage 40:1116-29. 2008.... - Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imagingShuai Yuan
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
Appl Opt 44:1823-30. 2005..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents... - Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortexCorey J Keller
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
J Neurosci Methods 179:208-18. 2009..This device can provide a new and robust means for obtaining detailed, quantitative data for defining neurovascular coupling in awake humans... - Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulationElizabeth M C Hillman
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
Neuroimage 35:89-104. 2007.... - Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisitionWanmei Ou
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
Neuroimage 46:624-32. 2009..This finding suggests that in addition to the initial evoked-response deflections related to the talamic afferent input, later cortical activity is needed to predict the hemodynamic response... - Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depressionSava Sakadzic
Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Appl Opt 48:D169-77. 2009..This new instrument will enable further study of neurovascular coupling in normal and diseased brain... - Depth-resolved microscopy of cortical hemodynamics with optical coherence tomographyVivek J Srinivasan
Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 34:3086-8. 2009..The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level... - Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapniaTheodore J Huppert
University of Pittsburgh, Department of Radiology, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
J Biomed Opt 14:044038. 2009..We conclude that evoked changes in blood flow and cerebral oxygen metabolism are more closely associated with underlying evoked neuronal responses... - Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortexCenk Ayata
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 24:744-55. 2004..In summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution... - Oxygen advection and diffusion in a three- dimensional vascular anatomical networkQianqian Fang
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Opt Express 16:17530-41. 2008..We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments... - Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemiaPhill B Jones
Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 13:044007. 2008.... - Optical monitoring of oxygen tension in cortical microvessels with confocal microscopyMohammad A Yaseen
Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Opt Express 17:22341-50. 2009..Here we present high-resolution phosphorescence images of cortical microvasculature and temporal pO(2) profiles from multiple locations in response to varied fraction of inspired oxygen and functional activation... - A haemodynamic response function model in spatio-temporal diffuse optical tomographyYiheng Zhang
Department of Radiology, University of Michigan Hospital, 1500 E Medical Center Drive, CGC B2109, Ann Arbor, MI 48109, USA
Phys Med Biol 50:4625-44. 2005..We also present an efficient algorithm for solving the associated large-scale systems. The expected improvements in spatial resolution and contrast-to-noise ratio are illustrated with simulations of human brain activation... - Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracyDavid A Boas
Anthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 23:S275-88. 2004.... - A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilationTheodore J Huppert
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
J Cereb Blood Flow Metab 27:1262-79. 2007..Finally, we compare this model to earlier work and find that the multicompartment model more accurately describes the observed oxygenation changes when compared with a single compartment version... - Diffuse optical imaging of the whole headMaria Angela Franceschini
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
J Biomed Opt 11:054007. 2006.... - A time domain fluorescence tomography system for small animal imagingAnand T N Kumar
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
IEEE Trans Med Imaging 27:1152-63. 2008..These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular imaging, particularly with the use of lifetime as a contrast mechanism... - Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imagingTheodore J Huppert
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 11:064018. 2006..73, p=5x10(-6) and R=0.71, p=9x10(-6), respectively) than the flow to deoxyhemoglobin spatial correlation (R=0.26, p=0.10)... - Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel modelTheodore J Huppert
Department of Radiology, University of Pittsburgh, UPMC Presbyterian, 200 Lothrop St, Pittsburgh, PA 15213, USA
Hum Brain Mapp 30:1548-67. 2009.... - Coupling between somatosensory evoked potentials and hemodynamic response in the ratMaria Angela Franceschini
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street Bldg 149 room 2301, Charlestown, MA 02129, USA
Neuroimage 41:189-203. 2008..The N1 and P2 components, and not P1, need to be considered to correctly interpret neurovascular coupling... - Assessment of infant brain development with frequency-domain near-infrared spectroscopyMaria Angela Franceschini
Athinoula A Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Pediatr Res 61:546-51. 2007..FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development... - Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillationsGeorge Themelis
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
J Biomed Opt 12:014033. 2007..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs... - Direct estimation of evoked hemoglobin changes by multimodality fusion imagingTheodore J Huppert
The Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 13:054031. 2008..Using this multimodal method, we estimate the calibration of the 3 tesla BOLD signal to be -0.55%+/-0.40% signal change per micromolar change of deoxyhemoglobin... - Rapid volumetric angiography of cortical microvasculature with optical coherence tomographyVivek J Srinivasan
Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 35:43-5. 2010..By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated... - The effect of different anesthetics on neurovascular couplingMaria Angela Franceschini
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 51:1367-77. 2010..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used... - Quantitative cerebral blood flow with optical coherence tomographyVivek J Srinivasan
Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Opt Express 18:2477-94. 2010..We show that OCT estimates of absolute CBF values in rats agree with prior measures by autoradiography, suggesting that Doppler OCT can perform absolute flow measurements in animal models... - Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic rangeInna Sukhotinsky
Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 30:1168-77. 2010.... - Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing unitsQianqian Fang
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts, 02129, USA
Opt Express 17:20178-90. 2009..These results render the GPU-based Monte Carlo simulation a practical solution for data analysis in a wide range of diffuse optical imaging applications, such as human brain or small-animal imaging... - Increased cerebral blood volume and oxygen consumption in neonatal brain injuryP Ellen Grant
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA
J Cereb Blood Flow Metab 29:1704-13. 2009.... - Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of lifeNadege Roche-Labarbe
Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, 02129, USA
Hum Brain Mapp 31:341-52. 2010..A stable CBV-CBF relationship may not be valid for premature neonates... - Feasibility of in vivo imaging of fluorescent proteins using lifetime contrastAnand T N Kumar
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Opt Lett 34:2066-8. 2009..These results suggest the potential for exploiting fluorescence lifetime for imaging FPs for a variety of whole-body small-animal imaging applications... - Fast optical signal not detected in awake behaving monkeysHarsha Radhakrishnan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
Neuroimage 45:410-9. 2009..Based on these negative results, despite the optimal experimental conditions, we doubt the usefulness of non-invasive fast optical signal measurements with NIRS... - Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortexAnna Devor
Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
J Neurosci 28:14347-57. 2008..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus... - Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compressionQianqian Fang
Massachusetts General Hospital, Charlestown, MA 02148 USA
IEEE Trans Med Imaging 28:30-42. 2009..The optical images from a subset of patients show composite features from both tissue structure and pressure distribution. We present mechanical simulations which further confirm this hypothesis... - Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laserSava Sakadzic
MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Express 16:20848-63. 2008..These studies demonstrate the potential of this laser source for use in a broad range of MPM applications... - Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imagingDanny K Joseph
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
Appl Opt 45:8142-51. 2006..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging... - Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activationAndrew K Dunn
Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
Opt Lett 28:28-30. 2003..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains... - Noninvasive measurement of neuronal activity with near-infrared optical imagingMaria Angela Franceschini
Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 21:372-86. 2004..The relative changes in intensity associated with the fast signal were approximately 0.07% and the latency of the signal was approximately 100 ms... - Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validationJuliette Selb
Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:11013. 2005..Finally, we use the time-gated measurements to resolve in depth the brain activation during the motor stimulus... - Optimal linear inverse solution with multiple priors in diffuse optical tomographyAng Li
Department of Physics Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 44:1948-56. 2005..Simulations are performed to demonstrate the significant improvement in image quality afforded by combining spatial and spectral priors... - Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activityAnna Devor
Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:3822-7. 2005..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data... - Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid mediaElizabeth M C Hillman
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:1650-2. 2004..System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution... - Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomographyAng Li
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 29:256-8. 2004..We demonstrate this improvement with simulations and a dynamic blood phantom experiment... - Volumetric diffuse optical tomography of brain activityJoseph P Culver
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 28:2061-3. 2003..A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance... - Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imagingMaria Angela Franceschini
NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 40:548-60. 2003..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging... - Tomographic optical breast imaging guided by three-dimensional mammographyAng Li
Department of Physics, Tufts University, Medford, Massachusetts 02155, USA
Appl Opt 42:5181-90. 2003..We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method... - Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortexAnna Devor
Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
Neuron 39:353-9. 2003.... - Optode positional calibration in diffuse optical tomographyJonathan J Stott
Harvard Medical School Massachusetts Institute of Technology Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3154-62. 2003..We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments... - Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imagingAlex H Bamett
Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Appl Opt 42:3095-108. 2003..We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging... - Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parametersGary Strangman
Neural Systems Group, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 18:865-79. 2003.... - Coregistered tomographic x-ray and optical breast imaging: initial resultsQuan Zhang
Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129, USA
J Biomed Opt 10:024033. 2005..This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging... - Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortexAndrew K Dunn
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 27:279-90. 2005..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes... - Pronounced hypoperfusion during spreading depression in mouse cortexCenk Ayata
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
J Cereb Blood Flow Metab 24:1172-82. 2004..The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+... - Comparison of frequency-domain and time-domain fluorescence lifetime tomographyAnand T N Kumar
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Opt Lett 33:470-2. 2008..We also demonstrate experimentally, using complex-shaped phantoms, the advantages of the asymptotic time-domain approach over a Fourier-based approach for analyzing time-domain fluorescence data... - Physiological system identification with the Kalman filter in diffuse optical tomographySolomon Gilbert Diamond
Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Med Image Comput Comput Assist Interv 8:649-56. 2005..Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT may be adapted for BOLD fMRI analysis and multimodal studies... - Time-gated optical system for depth-resolved functional brain imagingJuliette Selb
Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
J Biomed Opt 11:044008. 2006..The imaging probe was tested on dynamic phantoms and a preliminary result on an adult performing a motor task shows discrimination between superficial and cortical responses to the stimulus on both hemispheres... - Dynamic physiological modeling for functional diffuse optical tomographySolomon Gilbert Diamond
Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 30:88-101. 2006..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis... - Fluorescence-lifetime-based tomography for turbid mediaAnand T N Kumar
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 30:3347-9. 2005.... - Combined optical and X-ray tomosynthesis breast imagingQianqian Fang
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Radiology 258:89-97. 2011..To explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system... - Study of neurovascular coupling by modulating neuronal activity with GABAHarsha Radhakrishnan
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Brain Res 1372:1-12. 2011..These results suggest that the hemodynamic response is predominantly driven by cortico-cortical interactions and not by the initial thalamocortical activity in layer IV... - Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infantsDaniel C Hyde
Laboratory for Developmental Studies, Department of Psychology, Harvard University, Cambridge, MA, USA
Neuroimage 53:647-52. 2010.... - Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissueSava Sakadzic
Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
Nat Methods 7:755-9. 2010..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies... - Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurementsStefan A Carp
Harvard Medical School, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
J Biomed Opt 11:064016. 2006..Additionally, the dynamic characteristics of the changes in breast physiological parameters, together with the ability to probe the tissue metabolic state, may prove useful for breast cancer detection... - Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine modelHayrunnisa Bolay
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:136-42. 2002.... - A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activationGary Strangman
Harvard U, Cambridge
Neuroimage 17:719-31. 2002..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation... - Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imagingAnna Custo
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Appl Opt 45:4747-55. 2006..Our findings lead us to expect that the diffusion approximation will be valid even in the presence of the CSF, with consequences for faster solution of the inverse problem... - Non-invasive neuroimaging using near-infrared lightGary Strangman
Harvard U, Cambridge, MA
Biol Psychiatry 52:679-93. 2002..We find that, while diffuse optics can provide substantial advantages to the psychiatric researcher relative to the alternative brain imaging methods, the method remains substantially underutilized in this field... - Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulationAndrew M Siegel
Tufts University Bioengineering Center, Medford, MA 02155, USA
Phys Med Biol 48:1391-403. 2003.... - Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemiaHwa Kyoung Shin
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Brain 130:1631-42. 2007..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia... - Fluorescence optical diffusion tomographyAdam B Milstein
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 1285, USA
Appl Opt 42:3081-94. 2003..The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green... - Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural informationGregory Boverman
Department of Electrical and Computer Engineering, Northeastern University, 302 Stearns Hall, Boston, MA 02115, USA
Phys Med Biol 50:3941-56. 2005..In addition, we examine the consequences which errors in the breast segmentation have on estimating both the background and inhomogeneity chromophore concentrations... - Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemiaHwa Kyoung Shin
Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Stroke 39:1548-55. 2008..We, therefore, tested whether pharmacologically induced hypertension improves cerebral blood flow and metabolism and tissue outcome in acute stroke using optical imaging with high spatiotemporal resolution... - Optical imaging of phonological processing in two distinct orthographiesHsin Chin Chen
Department of Psychology, National Chung Cheng University, 168 University Rd, Ming Hsiung Chia Yi, Taiwan
Exp Brain Res 184:427-33. 2008..Results thus support previous findings using fMRI and suggest that different neural mappings arise depending on whether an individual has learned to process written language using an alphabetic or logographic script... - Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomographyGregory Boverman
Biomedical Engineering Department, Rensselaer Polytechnic Institute, Jonsson Engineering Center, Troy, NY 12180, USA
Phys Med Biol 52:3619-41. 2007..We are able to quantify the global return of blood to the breast following compression, and, in addition, localized changes are observed which correspond to the glandular region of the breast... - Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomographyGregory Boverman
Biomedical Engineering Department, Rensselaer Polytechnic Institute, 7046 Jonsson Engineering Center, Troy, NY 12180, USA
IEEE Trans Med Imaging 27:752-65. 2008..82 cm(3) with errors of less than 10% in object volume and absorption contrast. We also investigate the robustness of our shape-based reconstruction approach to a violation of the assumption that the medium is purely piecewise constant... - Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imagingYiheng Zhang
Northeastern University, Electrical and Computer Engineering Department, Boston, Massachusetts 02115, USA
J Biomed Opt 10:11014. 2005..By projecting the data onto the orthogonal nullspace of these eigenvectors, we can obtain more localized response, as reflected in improved contrast-to-noise ratio and correlation coefficient maps... - Using near-infrared spectroscopy to assess neural activation during object processing in infantsTeresa Wilcox
Texas A and M University, Psychology Department, MS 4235 TAMU, College Station, Texas 77843, USA
J Biomed Opt 10:11010. 2005..The outcome has important implications for research in cognitive development, developmental neuroscience, and optical imaging... - Image reconstruction in optical tomography in the presence of coupling errorsMartin Schweiger
Centre for Medical Image Computing, University College London, London, UK
Appl Opt 46:2743-56. 2007..Reconstructions from simulated and experimental phantom data are presented, which show that including the coupling coefficients in the reconstruction greatly improves the recovery of absorption and scattering images... - Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signalAnna Devor
Department of Neurosciences, University of California, San Diego, California 92093, USA
J Neurosci 27:4452-9. 2007.... - Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjectsMaria Angela Franceschini
Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford, Massachusetts 02155 6013, USA
J Appl Physiol 92:372-84. 2002..Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline... - Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobinJoseph P Culver
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 27:947-59. 2005..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms... - Fluorescence optical diffusion tomography using multiple-frequency dataAdam B Milstein
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907-2035, USA
J Opt Soc Am A Opt Image Sci Vis 21:1035-49. 2004..A broadly applicable mutual information performance metric is also presented and used to investigate the advantages of using multiple modulation frequencies compared with using only one... - Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical propertiesGuobin Ma
Advance Research Technologies, Incorporated ART, Canada
Appl Opt 46:1686-92. 2007..The difference in time characteristics of the signal is also examined... - Frontal lobe activation during object permanence: data from near-infrared spectroscopyAbigail A Baird
Laboratory of Infant Study, Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Neuroimage 16:1120-5. 2002..The evidence described in this report reveals that the emergence of object permanence is related to an increase in hemoglobin concentration in frontal cortex... - Assessing infants' cortical response to speech using near-infrared spectroscopyHeather Bortfeld
Department of Psychology, Texas A and M University, 4235 TAMU, College Station, TX 77843, USA
Neuroimage 34:407-15. 2007..In particular, these findings support the use of NIRS to study the neurobiology of language development in older infants, a task that is difficult to accomplish without the use of attention-getting visual stimuli... - Assessing the future of diffuse optical imaging technologies for breast cancer managementBruce J Tromberg
Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA
Med Phys 35:2443-51. 2008.... - Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological explorationTeresa Wilcox
Department of Psychology, Texas A and M University, College Station, TX 77843, USA
Dev Sci 11:361-70. 2008..These data were discussed in terms of (a) what they suggest about the neural basis of feature processing in infants and (b) the viability of using NIRS to study brain-behavior relations in infants...
Research Grants
- Imaging CMRO2 with combined DOT and MRIDavid Boas; Fiscal Year: 2007....
- IMAGING OF INTRACRANIAL HEMATOMAS BY DIFFUSE TOMOGRAPHYDavid Boas; Fiscal Year: 2002....
- Dynamic Inverse Solutions for Multimodal ImagingDavid Boas; Fiscal Year: 2007..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
- Multiscale Dynamic Measurements and Modeling of Cerebrovascular PhysiologyDavid Boas; Fiscal Year: 2009..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..
- Dynamic Inverse Solutions for Multimodal ImagingDavid Boas; Fiscal Year: 2009..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
- 3D Optical Imaging and Digital Xray of Breast LesionsDavid A Boas; Fiscal Year: 2010..The major public health benefits are expected to be the detection of more early stage cancers and a reduction in unnecessary biopsy procedures. ..
- Integrated 3D Xray and Dynamic Tomographic Optical Breast Imaging SystemDavid A Boas; Fiscal Year: 2010....
- Multiscale Dynamic Measurements and Modeling of Cerebrovascular PhysiologyDavid A Boas; Fiscal Year: 2010..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..
- Dynamic Inverse Solutions for Multimodal ImagingDavid A Boas; Fiscal Year: 2010..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
- Multiscale Dynamic Measurements and Modeling of Cerebrovascular PhysiologyDavid Boas; Fiscal Year: 2007..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..
- Multi-photon and fluorescence-lifetime microscope for in-vivo functional imagingDavid Boas; Fiscal Year: 2006..This system will be an invaluable resource for the many interdisciplinary research projects within the Martinos center, in the surrounding MGH community, and for many others in the greater Boston area. ..
- 3D Optical Imaging and Digital X-Ray of Breast LesionsDavid Boas; Fiscal Year: 2006..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
- 3D Optical Imaging and Digital Xray of Breast LesionsDavid A Boas; Fiscal Year: 2011..The major public health benefits are expected to be the detection of more early stage cancers and a reduction in unnecessary biopsy procedures. ..