David Boas

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot
    Meryem A Yucel
    Institute of Biomedical Engineering, Boğaziçi University Istanbul, Turkey
    Front Neuroenergetics 1:7. 2009
  2. pmc A systematic comparison of motion artifact correction techniques for functional near-infrared spectroscopy
    Robert J Cooper
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Charlestown, MA, USA
    Front Neurosci 6:147. 2012
  3. pmc In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH
    Mohammad A Yaseen
    Optics Division, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomed Opt Express 4:307-21. 2013
  4. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
  5. ncbi request reprint Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1957-68. 2005
  6. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
  7. ncbi request reprint Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans
    D A Boas
    Anthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:1506-8. 2004
  8. pmc Haemoglobin oxygen saturation as a biomarker: the problem and a solution
    David A Boas
    Optics Division of the Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th St rm 2301, Charlestown, MA 02129, USA
    Philos Trans A Math Phys Eng Sci 369:4407-24. 2011
  9. ncbi request reprint Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
    Shuai Yuan
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1823-30. 2005
  10. pmc Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex
    Corey J Keller
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 179:208-18. 2009

Detail Information

Publications94

  1. pmc The Possible Role of CO(2) in Producing A Post-Stimulus CBF and BOLD Undershoot
    Meryem A Yucel
    Institute of Biomedical Engineering, Boğaziçi University Istanbul, Turkey
    Front Neuroenergetics 1:7. 2009
    ..Our results suggest that increased cerebral blood flow during stimulation causes CO(2) washout which then results in a post-stimulus hypocapnia induced vasoconstrictive effect...
  2. pmc A systematic comparison of motion artifact correction techniques for functional near-infrared spectroscopy
    Robert J Cooper
    Department of Radiology, Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School Charlestown, MA, USA
    Front Neurosci 6:147. 2012
    ..On the basis of this analysis, we recommend the routine application of motion correction techniques (particularly spline interpolation or wavelet analysis) to minimize the impact of motion artifacts on functional NIRS data...
  3. pmc In vivo imaging of cerebral energy metabolism with two-photon fluorescence lifetime microscopy of NADH
    Mohammad A Yaseen
    Optics Division, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biomed Opt Express 4:307-21. 2013
    ..Individual components show potential as indicators of specific molecular pathways involved in oxidative metabolism...
  4. pmc A vascular anatomical network model of the spatio-temporal response to brain activation
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Neuroimage 40:1116-29. 2008
    ....
  5. ncbi request reprint Simulation study of magnetic resonance imaging-guided cortically constrained diffuse optical tomography of human brain function
    David A Boas
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1957-68. 2005
    ..However, issues of depth resolution within the cortex remain to be resolved...
  6. pmc Laser speckle contrast imaging in biomedical optics
    David A Boas
    Harvard Medical School, Massachusetts General Hospital, Anthinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 15:011109. 2010
    ..We also review applications of laser speckle contrast imaging in neuroscience, dermatology and ophthalmology...
  7. ncbi request reprint Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans
    D A Boas
    Anthinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:1506-8. 2004
    ....
  8. pmc Haemoglobin oxygen saturation as a biomarker: the problem and a solution
    David A Boas
    Optics Division of the Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 149 13th St rm 2301, Charlestown, MA 02129, USA
    Philos Trans A Math Phys Eng Sci 369:4407-24. 2011
    ..Finally, we discuss the solution to obtain more robust measures of tissue injury and cancer by combining oxygen saturation measurements with measures of blood flow and volume to more accurately estimate oxygen metabolism...
  9. ncbi request reprint Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging
    Shuai Yuan
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts 02129, USA
    Appl Opt 44:1823-30. 2005
    ..Our results suggests that approximately 5 ms is an optimal exposure time for imaging of stimulus-induced changes in cerebral blood flow in rodents...
  10. pmc Intracranial microprobe for evaluating neuro-hemodynamic coupling in unanesthetized human neocortex
    Corey J Keller
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neurosci Methods 179:208-18. 2009
    ..This device can provide a new and robust means for obtaining detailed, quantitative data for defining neurovascular coupling in awake humans...
  11. pmc Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition
    Wanmei Ou
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
    Neuroimage 46:624-32. 2009
    ..This finding suggests that in addition to the initial evoked-response deflections related to the talamic afferent input, later cortical activity is needed to predict the hemodynamic response...
  12. pmc Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression
    Sava Sakadzic
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 48:D169-77. 2009
    ..This new instrument will enable further study of neurovascular coupling in normal and diseased brain...
  13. pmc Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation
    Elizabeth M C Hillman
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149, 13th Street, Charlestown, MA 02129, USA
    Neuroimage 35:89-104. 2007
    ....
  14. pmc Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 34:3086-8. 2009
    ..The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level...
  15. pmc Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia
    Theodore J Huppert
    University of Pittsburgh, Department of Radiology, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 14:044038. 2009
    ..We conclude that evoked changes in blood flow and cerebral oxygen metabolism are more closely associated with underlying evoked neuronal responses...
  16. pmc Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia
    Phill B Jones
    Massachusetts General Hospital, Harvard Medical School, Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:044007. 2008
    ....
  17. ncbi request reprint Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy
    David A Boas
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 23:S275-88. 2004
    ....
  18. ncbi request reprint Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 24:744-55. 2004
    ..In summary, LSF has distinct advantages over LDF for CBF monitoring because of high spatial resolution...
  19. pmc Optical monitoring of oxygen tension in cortical microvessels with confocal microscopy
    Mohammad A Yaseen
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Opt Express 17:22341-50. 2009
    ..Here we present high-resolution phosphorescence images of cortical microvasculature and temporal pO(2) profiles from multiple locations in response to varied fraction of inspired oxygen and functional activation...
  20. pmc Oxygen advection and diffusion in a three- dimensional vascular anatomical network
    Qianqian Fang
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Express 16:17530-41. 2008
    ..We validated this algorithm for both static and dynamic conditions. We also applied it to a complex vascular network obtained from a rodent somatosensory cortex. Qualitative agreement was found with in-vivo experiments...
  21. ncbi request reprint A haemodynamic response function model in spatio-temporal diffuse optical tomography
    Yiheng Zhang
    Department of Radiology, University of Michigan Hospital, 1500 E Medical Center Drive, CGC B2109, Ann Arbor, MI 48109, USA
    Phys Med Biol 50:4625-44. 2005
    ..We also present an efficient algorithm for solving the associated large-scale systems. The expected improvements in spatial resolution and contrast-to-noise ratio are illustrated with simulations of human brain activation...
  22. pmc Study of neurovascular coupling by modulating neuronal activity with GABA
    Harsha Radhakrishnan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Brain Res 1372:1-12. 2011
    ..These results suggest that the hemodynamic response is predominantly driven by cortico-cortical interactions and not by the initial thalamocortical activity in layer IV...
  23. pmc A time domain fluorescence tomography system for small animal imaging
    Anand T N Kumar
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    IEEE Trans Med Imaging 27:1152-63. 2008
    ..These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular imaging, particularly with the use of lifetime as a contrast mechanism...
  24. pmc Estimating cerebral oxygen metabolism from fMRI with a dynamic multicompartment Windkessel model
    Theodore J Huppert
    Department of Radiology, University of Pittsburgh, UPMC Presbyterian, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Hum Brain Mapp 30:1548-67. 2009
    ....
  25. pmc Coupling between somatosensory evoked potentials and hemodynamic response in the rat
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street Bldg 149 room 2301, Charlestown, MA 02129, USA
    Neuroimage 41:189-203. 2008
    ..The N1 and P2 components, and not P1, need to be considered to correctly interpret neurovascular coupling...
  26. pmc Comparison of frequency-domain and time-domain fluorescence lifetime tomography
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 33:470-2. 2008
    ..We also demonstrate experimentally, using complex-shaped phantoms, the advantages of the asymptotic time-domain approach over a Fourier-based approach for analyzing time-domain fluorescence data...
  27. pmc Assessment of infant brain development with frequency-domain near-infrared spectroscopy
    Maria Angela Franceschini
    Athinoula A Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Pediatr Res 61:546-51. 2007
    ..FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development...
  28. pmc Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations
    George Themelis
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 12:014033. 2007
    ..Preliminary results show the potential of this NIRS method to measure pCBF and pCBV relative changes in neonatal pigs...
  29. pmc Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging
    Theodore J Huppert
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064018. 2006
    ..73, p=5x10(-6) and R=0.71, p=9x10(-6), respectively) than the flow to deoxyhemoglobin spatial correlation (R=0.26, p=0.10)...
  30. pmc Direct estimation of evoked hemoglobin changes by multimodality fusion imaging
    Theodore J Huppert
    The Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 13:054031. 2008
    ..Using this multimodal method, we estimate the calibration of the 3 tesla BOLD signal to be -0.55%+/-0.40% signal change per micromolar change of deoxyhemoglobin...
  31. pmc Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser
    Sava Sakadzic
    MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Express 16:20848-63. 2008
    ..These studies demonstrate the potential of this laser source for use in a broad range of MPM applications...
  32. pmc Quantitative cerebral blood flow with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Opt Express 18:2477-94. 2010
    ..We show that OCT estimates of absolute CBF values in rats agree with prior measures by autoradiography, suggesting that Doppler OCT can perform absolute flow measurements in animal models...
  33. ncbi request reprint Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Anna Devor
    Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 39:353-9. 2003
    ....
  34. pmc Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range
    Inna Sukhotinsky
    Department of Radiology, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 30:1168-77. 2010
    ....
  35. pmc Monte Carlo simulation of photon migration in 3D turbid media accelerated by graphics processing units
    Qianqian Fang
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, Massachusetts, 02129, USA
    Opt Express 17:20178-90. 2009
    ..These results render the GPU-based Monte Carlo simulation a practical solution for data analysis in a wide range of diffuse optical imaging applications, such as human brain or small-animal imaging...
  36. pmc Increased cerebral blood volume and oxygen consumption in neonatal brain injury
    P Ellen Grant
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 29:1704-13. 2009
    ....
  37. pmc Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Opt Lett 34:2066-8. 2009
    ..These results suggest the potential for exploiting fluorescence lifetime for imaging FPs for a variety of whole-body small-animal imaging applications...
  38. pmc The effect of different anesthetics on neurovascular coupling
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:1367-77. 2010
    ..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used...
  39. pmc Fast optical signal not detected in awake behaving monkeys
    Harsha Radhakrishnan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
    Neuroimage 45:410-9. 2009
    ..Based on these negative results, despite the optimal experimental conditions, we doubt the usefulness of non-invasive fast optical signal measurements with NIRS...
  40. pmc Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life
    Nadege Roche-Labarbe
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, 02129, USA
    Hum Brain Mapp 31:341-52. 2010
    ..A stable CBV-CBF relationship may not be valid for premature neonates...
  41. pmc Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex
    Anna Devor
    Martinos Center for Biomedical Imaging, Stroke and Neurovascular Regulation Laboratory, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14347-57. 2008
    ..We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus...
  42. pmc Combined optical imaging and mammography of the healthy breast: optical contrast derived from breast structure and compression
    Qianqian Fang
    Massachusetts General Hospital, Charlestown, MA 02148 USA
    IEEE Trans Med Imaging 28:30-42. 2009
    ..The optical images from a subset of patients show composite features from both tissue structure and pressure distribution. We present mechanical simulations which further confirm this hypothesis...
  43. pmc Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 35:43-5. 2010
    ..By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated...
  44. pmc A multicompartment vascular model for inferring baseline and functional changes in cerebral oxygen metabolism and arterial dilation
    Theodore J Huppert
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 27:1262-79. 2007
    ..Finally, we compare this model to earlier work and find that the multicompartment model more accurately describes the observed oxygenation changes when compared with a single compartment version...
  45. ncbi request reprint Physiological system identification with the Kalman filter in diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Med Image Comput Comput Assist Interv 8:649-56. 2005
    ..Cardiovascular dynamics also affect the blood oxygen dependent (BOLD) signal in functional magnetic resonance imaging (fMRI). This Kalman filter framework for DOT may be adapted for BOLD fMRI analysis and multimodal studies...
  46. ncbi request reprint Fluorescence-lifetime-based tomography for turbid media
    Anand T N Kumar
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 30:3347-9. 2005
    ....
  47. ncbi request reprint Volumetric diffuse optical tomography of brain activity
    Joseph P Culver
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:2061-3. 2003
    ..A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance...
  48. pmc Noninvasive measurement of neuronal activity with near-infrared optical imaging
    Maria Angela Franceschini
    Anthinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 21:372-86. 2004
    ..The relative changes in intensity associated with the fast signal were approximately 0.07% and the latency of the signal was approximately 100 ms...
  49. pmc Dynamic physiological modeling for functional diffuse optical tomography
    Solomon Gilbert Diamond
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 30:88-101. 2006
    ..This state-space approach to DOT analysis could be extended to BOLD fMRI analysis, multimodal studies and real-time analysis...
  50. ncbi request reprint Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media
    Elizabeth M C Hillman
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:1650-2. 2004
    ..System design and image reconstruction techniques are described, along with simulation and phantom results that demonstrate the characteristics and limitations of system accuracy and resolution...
  51. ncbi request reprint Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography
    Ang Li
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 29:256-8. 2004
    ..We demonstrate this improvement with simulations and a dynamic blood phantom experiment...
  52. pmc Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity
    Anna Devor
    Massachusetts General Hospital NMR Center and Program in Biophysics, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:3822-7. 2005
    ..The surround "negative" hemodynamic activity did not correspond to observable changes in neuronal activity. The complex spatial integration of the hemodynamic response should be considered when interpreting fMRI data...
  53. ncbi request reprint Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex
    Andrew K Dunn
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 27:279-90. 2005
    ..Multi-parameter full field imaging of the functional response provides a more complete picture of the hemodynamic response to functional activation including the spatial and temporal estimation of CMRO(2) changes...
  54. ncbi request reprint Coregistered tomographic x-ray and optical breast imaging: initial results
    Quan Zhang
    Harvard Medical School, Massachusetts General Hospital, The Martinos Center for Biomedical Imaging, 13th Street, Building 149, Room 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 10:024033. 2005
    ..This comparison will ultimately lead to a better understanding of the relationship between the functional contrast afforded by optical imaging and the structural contrast provided by x-ray imaging...
  55. ncbi request reprint Optimal linear inverse solution with multiple priors in diffuse optical tomography
    Ang Li
    Department of Physics Tufts University, Medford, Massachusetts 02155, USA
    Appl Opt 44:1948-56. 2005
    ..Simulations are performed to demonstrate the significant improvement in image quality afforded by combining spatial and spectral priors...
  56. pmc Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging
    Maria Angela Franceschini
    NMR Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 40:548-60. 2003
    ..Our findings based on optical imaging are in agreement with results in the literature obtained with positron emission tomography and functional magnetic resonance imaging...
  57. ncbi request reprint Tomographic optical breast imaging guided by three-dimensional mammography
    Ang Li
    Department of Physics, Tufts University, Medford, Massachusetts 02155, USA
    Appl Opt 42:5181-90. 2003
    ..We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method...
  58. ncbi request reprint Optode positional calibration in diffuse optical tomography
    Jonathan J Stott
    Harvard Medical School Massachusetts Institute of Technology Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Massachusetts 02129, USA
    Appl Opt 42:3154-62. 2003
    ..We present a technique for simultaneously calibrating optode positions and reconstructing images that significantly improves image quality, as we demonstrate with simulations and phantom experiments...
  59. pmc Diffuse optical imaging of the whole head
    Maria Angela Franceschini
    Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, 13th Street, Bldg 149 RM 2301, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:054007. 2006
    ....
  60. ncbi request reprint Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging
    Danny K Joseph
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, MA 02129, USA
    Appl Opt 45:8142-51. 2006
    ..Experimental results showing the application of this instrument for imaging human brain activation are also presented. The observed improvement in spatial resolution is confirmed by functional magnetic resonance imaging...
  61. ncbi request reprint Time-gated optical system for depth-resolved functional brain imaging
    Juliette Selb
    Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:044008. 2006
    ..The imaging probe was tested on dynamic phantoms and a preliminary result on an adult performing a motor task shows discrimination between superficial and cortical responses to the stimulus on both hemispheres...
  62. ncbi request reprint Pronounced hypoperfusion during spreading depression in mouse cortex
    Cenk Ayata
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    J Cereb Blood Flow Metab 24:1172-82. 2004
    ..The differences in CBF response between species may be in part caused by an increased sensitivity of mouse cerebral vessels to elevated extracellular K+...
  63. ncbi request reprint Simultaneous imaging of total cerebral hemoglobin concentration, oxygenation, and blood flow during functional activation
    Andrew K Dunn
    Athinoula A Martinos Center, Massachusetts General Hospital, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Opt Lett 28:28-30. 2003
    ..This is of significance to the neuroscience community and will lead to a better understanding of the interrelationship of neural, metabolic, and hemodynamic processes in normal and diseased brains...
  64. ncbi request reprint Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters
    Gary Strangman
    Neural Systems Group, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 18:865-79. 2003
    ....
  65. ncbi request reprint Robust inference of baseline optical properties of the human head with three-dimensional segmentation from magnetic resonance imaging
    Alex H Bamett
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Appl Opt 42:3095-108. 2003
    ..We sample from the exact posterior and show robustness to numerical model error. This opens up the possibility of simultaneous DOT and MR for quantitative cortically constrained functional neuroimaging...
  66. ncbi request reprint Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation
    Juliette Selb
    Massachusetts General Hospital, Athinoula A Martinos Center, Photon Migration Imaging Laboratory, Building 149, 13th Street, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 10:11013. 2005
    ..Finally, we use the time-gated measurements to resolve in depth the brain activation during the motor stimulus...
  67. pmc Combined optical and X-ray tomosynthesis breast imaging
    Qianqian Fang
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Radiology 258:89-97. 2011
    ..To explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system...
  68. pmc Near-infrared spectroscopy shows right parietal specialization for number in pre-verbal infants
    Daniel C Hyde
    Laboratory for Developmental Studies, Department of Psychology, Harvard University, Cambridge, MA, USA
    Neuroimage 53:647-52. 2010
    ....
  69. pmc Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue
    Sava Sakadzic
    Photon Migration Imaging Laboratory, Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Nat Methods 7:755-9. 2010
    ..The properties of the probe allowed for direct high-resolution measurement of cortical extravascular (tissue) pO(2), opening many possibilities for functional metabolic brain studies...
  70. ncbi request reprint Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements
    Stefan A Carp
    Harvard Medical School, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
    J Biomed Opt 11:064016. 2006
    ..Additionally, the dynamic characteristics of the changes in breast physiological parameters, together with the ability to probe the tissue metabolic state, may prove useful for breast cancer detection...
  71. ncbi request reprint Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging
    Yiheng Zhang
    Northeastern University, Electrical and Computer Engineering Department, Boston, Massachusetts 02115, USA
    J Biomed Opt 10:11014. 2005
    ..By projecting the data onto the orthogonal nullspace of these eigenvectors, we can obtain more localized response, as reflected in improved contrast-to-noise ratio and correlation coefficient maps...
  72. ncbi request reprint Fluorescence optical diffusion tomography
    Adam B Milstein
    School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 1285, USA
    Appl Opt 42:3081-94. 2003
    ..The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green...
  73. ncbi request reprint Spatio-temporal imaging of the hemoglobin in the compressed breast with diffuse optical tomography
    Gregory Boverman
    Biomedical Engineering Department, Rensselaer Polytechnic Institute, Jonsson Engineering Center, Troy, NY 12180, USA
    Phys Med Biol 52:3619-41. 2007
    ..We are able to quantify the global return of blood to the breast following compression, and, in addition, localized changes are observed which correspond to the glandular region of the breast...
  74. pmc Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Brain 130:1631-42. 2007
    ..Our data show that normobaric hyperoxia increases tissue O2 delivery, and that novel mechanisms such as CBF augmentation, and suppression of PIDs may afford neuroprotection during hyperoxia...
  75. ncbi request reprint Image reconstruction in optical tomography in the presence of coupling errors
    Martin Schweiger
    Centre for Medical Image Computing, University College London, London, UK
    Appl Opt 46:2743-56. 2007
    ..Reconstructions from simulated and experimental phantom data are presented, which show that including the coupling coefficients in the reconstruction greatly improves the recovery of absorption and scattering images...
  76. pmc Using near-infrared spectroscopy to assess neural activation during object processing in infants
    Teresa Wilcox
    Texas A and M University, Psychology Department, MS 4235 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 10:11010. 2005
    ..The outcome has important implications for research in cognitive development, developmental neuroscience, and optical imaging...
  77. ncbi request reprint Comparison of simplified Monte Carlo simulation and diffusion approximation for the fluorescence signal from phantoms with typical mouse tissue optical properties
    Guobin Ma
    Advance Research Technologies, Incorporated ART, Canada
    Appl Opt 46:1686-92. 2007
    ..The difference in time characteristics of the signal is also examined...
  78. ncbi request reprint Non-invasive neuroimaging using near-infrared light
    Gary Strangman
    Neural Systems Group, Massachusetts General Hospital, Harvard Medical School and Harvard MIT Division of Health Sciences and Technology, Charlestown, MA 02129, USA
    Biol Psychiatry 52:679-93. 2002
    ..We find that, while diffuse optics can provide substantial advantages to the psychiatric researcher relative to the alternative brain imaging methods, the method remains substantially underutilized in this field...
  79. ncbi request reprint Frontal lobe activation during object permanence: data from near-infrared spectroscopy
    Abigail A Baird
    Laboratory of Infant Study, Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuroimage 16:1120-5. 2002
    ..The evidence described in this report reveals that the emergence of object permanence is related to an increase in hemoglobin concentration in frontal cortex...
  80. ncbi request reprint Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    Hayrunnisa Bolay
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:136-42. 2002
    ....
  81. pmc Optical imaging of phonological processing in two distinct orthographies
    Hsin Chin Chen
    Department of Psychology, National Chung Cheng University, 168 University Rd, Ming Hsiung Chia Yi, Taiwan
    Exp Brain Res 184:427-33. 2008
    ..Results thus support previous findings using fMRI and suggest that different neural mappings arise depending on whether an individual has learned to process written language using an alphabetic or logographic script...
  82. ncbi request reprint Effective scattering coefficient of the cerebral spinal fluid in adult head models for diffuse optical imaging
    Anna Custo
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Appl Opt 45:4747-55. 2006
    ..Our findings lead us to expect that the diffusion approximation will be valid even in the presence of the CSF, with consequences for faster solution of the inverse problem...
  83. ncbi request reprint Temporal comparison of functional brain imaging with diffuse optical tomography and fMRI during rat forepaw stimulation
    Andrew M Siegel
    Tufts University Bioengineering Center, Medford, MA 02155, USA
    Phys Med Biol 48:1391-403. 2003
    ....
  84. ncbi request reprint Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin
    Joseph P Culver
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 27:947-59. 2005
    ..These results indicate that total hemoglobin and cerebral blood volume may have advantages as hemodynamic mapping contrasts, particularly for large amplitude, longer duration stimulus paradigms...
  85. pmc Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects
    Maria Angela Franceschini
    Bioengineering Center, Department of Electrical Engineering and Computer Science Tufts University, Medford, Massachusetts 02155 6013, USA
    J Appl Physiol (1985) 92:372-84. 2002
    ..Finally, in a preliminary test involving muscle exercise, Sv(O(2))-NIRS(resp) showed an expected postexercise decrease from the initial baseline value and a subsequent recovery to baseline...
  86. ncbi request reprint Fluorescence optical diffusion tomography using multiple-frequency data
    Adam B Milstein
    School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907 2035, USA
    J Opt Soc Am A Opt Image Sci Vis 21:1035-49. 2004
    ..A broadly applicable mutual information performance metric is also presented and used to investigate the advantages of using multiple modulation frequencies compared with using only one...
  87. ncbi request reprint Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information
    Gregory Boverman
    Department of Electrical and Computer Engineering, Northeastern University, 302 Stearns Hall, Boston, MA 02115, USA
    Phys Med Biol 50:3941-56. 2005
    ..In addition, we examine the consequences which errors in the breast segmentation have on estimating both the background and inhomogeneity chromophore concentrations...
  88. pmc Estimation and statistical bounds for three-dimensional polar shapes in diffuse optical tomography
    Gregory Boverman
    Biomedical Engineering Department, Rensselaer Polytechnic Institute, 7046 Jonsson Engineering Center, Troy, NY 12180, USA
    IEEE Trans Med Imaging 27:752-65. 2008
    ..82 cm(3) with errors of less than 10% in object volume and absorption contrast. We also investigate the robustness of our shape-based reconstruction approach to a violation of the assumption that the medium is purely piecewise constant...
  89. pmc Mild induced hypertension improves blood flow and oxygen metabolism in transient focal cerebral ischemia
    Hwa Kyoung Shin
    Stroke and Neurovascular Regulation Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Stroke 39:1548-55. 2008
    ..We, therefore, tested whether pharmacologically induced hypertension improves cerebral blood flow and metabolism and tissue outcome in acute stroke using optical imaging with high spatiotemporal resolution...
  90. pmc Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal
    Anna Devor
    Department of Neurosciences, University of California, San Diego, California 92093, USA
    J Neurosci 27:4452-9. 2007
    ....
  91. ncbi request reprint A quantitative comparison of simultaneous BOLD fMRI and NIRS recordings during functional brain activation
    Gary Strangman
    Neural Systems Group, NMR Center, Massachusetts General Hospital Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Charlestown 02129, USA
    Neuroimage 17:719-31. 2002
    ..This may reflect, at least in part, the superior contrast-to-noise ratio for oxyhemoglobin relative to deoxyhemoglobin (from optical measurements), rather than physiology related to BOLD signal interpretation...
  92. pmc Hemodynamic response to featural changes in the occipital and inferior temporal cortex in infants: a preliminary methodological exploration
    Teresa Wilcox
    Department of Psychology, Texas A and M University, College Station, TX 77843, USA
    Dev Sci 11:361-70. 2008
    ..These data were discussed in terms of (a) what they suggest about the neural basis of feature processing in infants and (b) the viability of using NIRS to study brain-behavior relations in infants...
  93. pmc Assessing infants' cortical response to speech using near-infrared spectroscopy
    Heather Bortfeld
    Department of Psychology, Texas A and M University, 4235 TAMU, College Station, TX 77843, USA
    Neuroimage 34:407-15. 2007
    ..In particular, these findings support the use of NIRS to study the neurobiology of language development in older infants, a task that is difficult to accomplish without the use of attention-getting visual stimuli...
  94. pmc Assessing the future of diffuse optical imaging technologies for breast cancer management
    Bruce J Tromberg
    Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California 92612, USA
    Med Phys 35:2443-51. 2008
    ....

Research Grants24

  1. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2007
    ....
  2. IMAGING OF INTRACRANIAL HEMATOMAS BY DIFFUSE TOMOGRAPHY
    David Boas; Fiscal Year: 2002
    ....
  3. Dynamic Inverse Solutions for Multimodal Imaging
    David Boas; Fiscal Year: 2007
    ..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
  4. 3D Optical Imaging and Digital Xray of Breast Lesions
    David Boas; Fiscal Year: 2009
    ..The major public health benefits are expected to be the detection of more early stage cancers and a reduction in unnecessary biopsy procedures. ..
  5. Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology
    David Boas; Fiscal Year: 2009
    ..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..
  6. Dynamic Inverse Solutions for Multimodal Imaging
    David Boas; Fiscal Year: 2009
    ..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
  7. 3D Optical Imaging and Digital Xray of Breast Lesions
    David A Boas; Fiscal Year: 2010
    ..The major public health benefits are expected to be the detection of more early stage cancers and a reduction in unnecessary biopsy procedures. ..
  8. Integrated 3D Xray and Dynamic Tomographic Optical Breast Imaging System
    David A Boas; Fiscal Year: 2010
    ....
  9. Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology
    David A Boas; Fiscal Year: 2010
    ..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..
  10. Dynamic Inverse Solutions for Multimodal Imaging
    David A Boas; Fiscal Year: 2010
    ..Collectively, they are experts in the multi-modal combination of fMRI (All), EEG and MEG (Bonmassar, Brown, and Hamalainen), and DOT (Boas), spannin experiments, analysis, and clinical application. ..
  11. 3D Optical Imaging and Digital Xray of Breast Lesions
    David A Boas; Fiscal Year: 2011
    ..The major public health benefits are expected to be the detection of more early stage cancers and a reduction in unnecessary biopsy procedures. ..
  12. 3D Optical Imaging and Digital X-Ray of Breast Lesions
    David Boas; Fiscal Year: 2003
    ..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
  13. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2003
    ....
  14. 3D Optical Imaging and Digital X-Ray of Breast Lesions
    David Boas; Fiscal Year: 2004
    ..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
  15. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2004
    ....
  16. 3D Optical Imaging and Digital X-Ray of Breast Lesions
    David Boas; Fiscal Year: 2005
    ..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
  17. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2005
    ....
  18. Multi-photon and fluorescence-lifetime microscope for in-vivo functional imaging
    David Boas; Fiscal Year: 2006
    ..This system will be an invaluable resource for the many interdisciplinary research projects within the Martinos center, in the surrounding MGH community, and for many others in the greater Boston area. ..
  19. Imaging CMRO2 with combined DOT and MRI
    David Boas; Fiscal Year: 2006
    ....
  20. 3D Optical Imaging and Digital X-Ray of Breast Lesions
    David Boas; Fiscal Year: 2006
    ..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
  21. 3D Optical Imaging and Digital X-Ray of Breast Lesions
    David Boas; Fiscal Year: 2002
    ..This research project would not be feasible without the clinical research expertise of the Breast Imaging Research Lab, headed by Dr. Kopans. ..
  22. Multiscale Dynamic Measurements and Modeling of Cerebrovascular Physiology
    David Boas; Fiscal Year: 2007
    ..We will then utilize this VAN model to determine the accuracy of the lumped parameter windkessel model, which is more conducive to routine analysis of human brain imaging data. ..