D Blacker

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Genetic and environmental contributions to the development of alcohol dependence in male twins
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    Arch Gen Psychiatry 61:897-903. 2004
  2. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
  3. ncbi request reprint New insights into genetic aspects of Alzheimer's disease. Does genetic information make a difference in clinical practice?
    D Blacker
    Harvard Medical School, Gerontology Research Unit, Massachusetts General Hospital East, Boston, USA
    Postgrad Med 108:119-22, 125-6, 129. 2000
  4. pmc Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease
    R S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    AJNR Am J Neuroradiol 30:532-8. 2009
  5. ncbi request reprint Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 290:2302-3. 2000
  6. pmc Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
  7. pmc Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families
    L Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases MIND, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    J Med Genet 42:857-62. 2005
  8. ncbi request reprint No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease
    L Bertram
    Genetics and Aging Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Ann Neurol 49:114-6. 2001
  9. pmc Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
    S L Miller
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 79:630-5. 2008
  10. pmc Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
    J L O'Brien
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Neurology 74:1969-76. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Genetic and environmental contributions to the development of alcohol dependence in male twins
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    Arch Gen Psychiatry 61:897-903. 2004
    ..Information on the heritability of the development of alcohol dependence could provide a better understanding of the importance of genetic components in disease transition...
  2. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
    ..We used genotype and phenotype data from the Framingham Heart Study to perform a full-genome scan for quantitative trait loci underlying the metabolic syndrome...
  3. ncbi request reprint New insights into genetic aspects of Alzheimer's disease. Does genetic information make a difference in clinical practice?
    D Blacker
    Harvard Medical School, Gerontology Research Unit, Massachusetts General Hospital East, Boston, USA
    Postgrad Med 108:119-22, 125-6, 129. 2000
    ..There is a broad consensus that APOE testing lacks sufficient predictive value to be suitable for predictive testing in asymptomatic persons...
  4. pmc Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease
    R S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    AJNR Am J Neuroradiol 30:532-8. 2009
    ..Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific temporoparietal regions can predict the time to progress from MCI to AD...
  5. ncbi request reprint Evidence for genetic linkage of Alzheimer's disease to chromosome 10q
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Science 290:2302-3. 2000
    ..Furthermore, we found evidence for allele-specific association between the putative disease locus and marker D10S583, which has recently been located within 195 kilobases of the IDE gene...
  6. pmc Family-based tests of association in the presence of linkage
    S L Lake
    Department of Biostatistics, Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Hum Genet 67:1515-25. 2000
    ..Since the A2M gene lies in a chromosomal region (chromosome 12p) that consistently has been linked to AD, association tests should be conducted under the null hypothesis that there is linkage but no association...
  7. pmc Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families
    L Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases MIND, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    J Med Genet 42:857-62. 2005
    ....
  8. ncbi request reprint No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease
    L Bertram
    Genetics and Aging Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Ann Neurol 49:114-6. 2001
    ..Thus, our analyses on more than 800 subjects suggest that if an association between the CTSD exon 2 polymorphism and AD exists, it is likely to be smaller than previously reported...
  9. pmc Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline
    S L Miller
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 79:630-5. 2008
    ..To use functional MRI (fMRI) to investigate whether hippocampal activation during a memory task can predict cognitive decline in individuals with mild cognitive impairment (MCI)...
  10. pmc Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline
    J L O'Brien
    Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Neurology 74:1969-76. 2010
    ..We have hypothesized that subjects in early phases of prodromal AD may experience a period of hippocampal hyperactivation, followed by loss of hippocampal activation as the disease progresses...
  11. pmc Disclosure of APOE genotype for risk of Alzheimer's disease
    Robert C Green
    Boston University School of Medicine, Boston, MA 02118, USA
    N Engl J Med 361:245-54. 2009
    ..We examined the effect of genotype disclosure in a prospective, randomized, controlled trial...
  12. ncbi request reprint Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    B C Dickerson
    Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:404-11. 2005
    ..To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)...
  13. ncbi request reprint Family-based tests of association in the presence and absence of known linkage
    L Bertram
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Genet Epidemiol 21:S292-7. 2001
    ..Our results indicate that both tests generally perform comparably in either setting...
  14. pmc Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults
    B C Dickerson
    Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
    Neurology 76:1395-402. 2011
    ....
  15. ncbi request reprint White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging
    David H Salat
    Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
    Stroke 37:1759-64. 2006
    ..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA...
  16. ncbi request reprint Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:1415-20. 2004
    ..We sought to determine whether hemorrhages detected at the time of lobar ICH predict the major clinical complications of CAA: recurrent ICH or decline in cognition and function...
  17. pmc MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD
    R S Desikan
    Dept of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 71:819-25. 2008
    ..The current study was designed to determine whether a broader set of temporoparietal regions show differential rates of atrophy during the evolution of AD...
  18. pmc Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 39:10-8. 2008
    ....
  19. ncbi request reprint Knowledge of and attitudes about Alzheimer disease genetics: report of a pilot survey and two focus groups
    T J Moscarillo
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Community Genet 10:97-102. 2007
    ....
  20. pmc Single photon emission computed tomography perfusion differences in mild cognitive impairment
    K A Johnson
    Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    J Neurol Neurosurg Psychiatry 78:240-7. 2007
    ..To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI)...
  21. pmc Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy
    Anand Viswanathan
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 39:1988-92. 2008
    ..We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment...
  22. ncbi request reprint Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients
    S Y Guenette
    Genetics and Aging Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurosci Lett 296:17-20. 2000
    ..We conclude that the association of the FE65 intron 13 polymorphism with AD, if any, is smaller than previously reported...
  23. pmc Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  24. ncbi request reprint A phase 2 study of tramiprosate for cerebral amyloid angiopathy
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Alzheimer Dis Assoc Disord 20:269-74. 2006
    ..Tramiprosate (3-amino-1-propanesulfonic acid) is a candidate molecule shown in preclinical studies to reduce CAA in a transgenic mouse model...
  25. ncbi request reprint Amyloid angiopathy-related vascular cognitive impairment
    Steven M Greenberg
    Neurology Clinical Trials Unit and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Stroke 35:2616-9. 2004
    ..These data highlight the importance of elucidating the effects of vascular amyloid on cerebrovascular function and of developing therapeutic strategies for this potentially widespread form of microvascular cognitive impairment...
  26. ncbi request reprint Cerebral amyloid angiopathy and lobar intracerebral hemorrhage
    Eric E Smith
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Neurol 63:148-51. 2006
  27. pmc Management of thrombolysis-associated symptomatic intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, STE 3B, Boston, MA 02114, USA
    Arch Neurol 67:965-9. 2010
    ..It is not clear whether patients with sICH continue to bleed after diagnosis, nor has the most appropriate treatment been determined...
  28. ncbi request reprint Hemorrhagic stroke
    Eric E Smith
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroimaging Clin N Am 15:259-72, ix. 2005
    ..New evidence suggests that MR imaging alone may be adequate to identify hemorrhagic stroke in the acute setting, and that MR imaging is superior to CT for identification of chronic microbleeds and hemorrhagic conversion of infarction...
  29. ncbi request reprint Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
    Eric E Smith
    Neurology Clinical Trials Unit, Wang 836, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Curr Atheroscler Rep 5:260-6. 2003
    ..These criteria will be crucial for disease classification for future clinical studies...
  30. pmc CT angiography for intracerebral hemorrhage does not increase risk of acute nephropathy
    Alexandra Oleinik
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Stroke 40:2393-7. 2009
    ..Its use is limited by the concern for contrast induced nephropathy (CIN); however, the magnitude of this risk is not known...
  31. pmc Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhage
    Pratik V Patel
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, 175 Cambridge St, Ste 300, Boston, MA 02114, USA
    Arch Neurol 66:79-84. 2009
    ..To determine the prevalence of subdural hematoma (SDH) in patients presenting with primary nontraumatic lobar intracerebral hemorrhage (ICH) and characteristics associated with the presence of SDH...
  32. pmc Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B
    Steven M Greenberg
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Ann Neurol 64:587-91. 2008
    ..These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions...
  33. doi request reprint Risk of thromboembolism following acute intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Massachusetts General Hospital, Zero Emerson Place, Suite 3B, Boston, MA 02114, USA
    Neurocrit Care 10:28-34. 2009
    ..We hypothesized that TEs are relatively common following ICH, and that anticoagulated patients are at higher risk for these complications...
  34. ncbi request reprint Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
    Jonathan Rosand
    Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 58:459-62. 2005
    ..These data suggest that regional differences within the brain play a role in the development of CAA-related hemorrhage...
  35. ncbi request reprint Risk factors for stroke after acute coronary syndromes in the Orbofiban in Patients with Unstable Coronary Syndromes--Thrombolysis In Myocardial Infarction (OPUS-TIMI) 16 study
    Eric E Smith
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Am Heart J 151:338-44. 2006
    ..Previous reports have associated acute coronary syndromes (ACSs) with cerebrovascular disease but in general have not included long-term patient follow-up or have not analyzed ischemic and hemorrhagic cerebrovascular events separately...
  36. ncbi request reprint Spontaneous hyperacute postischemic hemorrhage leading to death
    Eric E Smith
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Neuroimaging 14:361-4. 2004
    ..In patients with ischemic stroke, MRI findings such as hyperacute petechial hemorrhage or chronic cerebral microbleeds might predict subsequent parenchymal hemorrhage and thus have implications for tissue plasminogen activator use...
  37. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  38. ncbi request reprint Timing of fresh frozen plasma administration and rapid correction of coagulopathy in warfarin-related intracerebral hemorrhage
    Joshua N Goldstein
    Department of Emergency Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Stroke 37:151-5. 2006
    ..We sought to determine whether particular emergency department (ED) interventions are effective in reversing coagulopathy and improving outcome...
  39. doi request reprint MRI showing white matter lesions and multiple lobar microbleeds in a patient with reversible encephalopathy
    Roy N Alcalay
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Neuroimaging 19:89-91. 2009
    ..In steroid-responsive patients, clinical improvement can precede radiographic improvement...
  40. doi request reprint Prediction of functional outcome in patients with primary intracerebral hemorrhage: the FUNC score
    Natalia S Rost
    Massachusetts General Hospital, Center for Human Genetic Research, Boston, MA 02114, USA
    Stroke 39:2304-9. 2008
    ..We developed an acute clinical score to predict likelihood of functional independence...
  41. ncbi request reprint Genetic and environmental contributions to age of onset of alcohol dependence symptoms in male twins
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital, Taipei, Taiwan
    Addiction 99:1403-9. 2004
    ..To investigate genetic and environmental influences on the development of specific alcohol dependence symptoms...
  42. ncbi request reprint The application of a random effects model to censored twin data
    I Chao Liu
    Department of Psychiatry, Cardinal Tien Hospital and Fu Jen Medical School, Taipei, Taiwan
    Behav Genet 35:781-9. 2005
    ..Our results show genetic factors contribute about one third of twin similarity in the age of onset of alcohol abuse in male twins. The application of this model to twin data is discussed...

Research Grants4

  1. GENETIC KNOWLEDGE AND ATTITUDES IN ALZHEIMER'S DISEASE
    Deborah Blacker; Fiscal Year: 2001
    ..abstract_text> ..
  2. Small vessel disease and beta-amyloid deposition in mildly impaired cognition
    Eric E Smith; Fiscal Year: 2010
    ..Our results will aid the design of clinical trials to prevent dementia by defining imaging markers of small vessel disease and Alzheimer-type pathology and their effects on cognitive decline. ..