Gal Bitan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Acc Chem Res 37:357-64. 2004
  2. pmc Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:330-5. 2003
  3. ncbi request reprint Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:34882-9. 2003
  4. ncbi request reprint A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Chem Soc 125:15359-65. 2003
  5. ncbi request reprint Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice
    Timothy J Seabrook
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Neurobiol Aging 28:813-23. 2007
  6. ncbi request reprint Determination of Peptide oligomerization state using rapid photochemical crosslinking
    Sabrina S Vollers
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 299:11-8. 2005
  7. pmc Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    Alon Monsonego
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 112:415-22. 2003
  8. ncbi request reprint Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 299:3-9. 2005
  9. ncbi request reprint Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies
    Marina D Kirkitadze
    Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 69:567-77. 2002
  10. pmc Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins
    Gal Bitan
    UCLA, Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA
    Methods Enzymol 413:217-36. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Acc Chem Res 37:357-64. 2004
    ..The method provides essential insights into the factors that control the assembly of pathogenic protein oligomers, facilitating efforts toward the development of therapeutic agents...
  2. pmc Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:330-5. 2003
    ..The strong etiologic association of Abeta42 with AD may thus be a result of assemblies formed at the earliest stages of peptide oligomerization...
  3. ncbi request reprint Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, and Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:34882-9. 2003
    ..These results reveal how specific regions and residues control A beta oligomerization and show that these controlling elements differ between A beta 40 and A beta 42...
  4. ncbi request reprint A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Am Chem Soc 125:15359-65. 2003
    ..Preventing assembly of toxic Abeta42 paranuclei through selective oxidation of Met(35) thus represents a potential therapeutic approach for AD...
  5. ncbi request reprint Dendrimeric Abeta1-15 is an effective immunogen in wildtype and APP-tg mice
    Timothy J Seabrook
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Neurobiol Aging 28:813-23. 2007
    ..Anti-Abeta antibodies bound monomeric, oligomeric, and fibrillar Abeta. Our data suggest that dAbeta1-15 may be an effective and potentially safer immunogen for Alzheimer's disease (AD) vaccination...
  6. ncbi request reprint Determination of Peptide oligomerization state using rapid photochemical crosslinking
    Sabrina S Vollers
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 299:11-8. 2005
    ..PICUP provides a snapshot of the native oligomerization state of proteins and can be used for assembly state analysis of a wide variety of peptides and proteins...
  7. pmc Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease
    Alon Monsonego
    Center for Neurologic Diseases, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 112:415-22. 2003
    ....
  8. ncbi request reprint Preparation of aggregate-free, low molecular weight amyloid-beta for assembly and toxicity assays
    Gal Bitan
    Center for Neurologic Diseases, Brigham and Women s Hospital and Department of Neurology, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 299:3-9. 2005
    ..In this chapter, we describe the preparation of LMW Abeta using size exclusion chromatography and filtration. The advantages and disadvantages of each method are discussed...
  9. ncbi request reprint Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies
    Marina D Kirkitadze
    Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA
    J Neurosci Res 69:567-77. 2002
    ..The archetypal features of the assembly-dependent neuropathogenetic effects of Abeta may thus be of relevance not only to AD but to these other disorders as well...
  10. pmc Structural study of metastable amyloidogenic protein oligomers by photo-induced cross-linking of unmodified proteins
    Gal Bitan
    UCLA, Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA
    Methods Enzymol 413:217-36. 2006
    ....
  11. ncbi request reprint Elucidating amyloid beta-protein folding and assembly: A multidisciplinary approach
    David B Teplow
    Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Acc Chem Res 39:635-45. 2006
    ..An integrated multidisciplinary program is required. We discuss here the synergistic application of in hydro, in vacuo, and in silico methods to the study of the amyloid beta-protein, the key pathogenetic agent in Alzheimer's disease...