Bruce Bistrian

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The systemic inflammatory response and its impact on iron nutriture in end-stage renal disease
    B R Bistrian
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Kidney Dis 34:S35-9. 1999
  2. ncbi request reprint Systemic response to inflammation
    Bruce Bistrian
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Nutr Rev 65:S170-2. 2007
  3. ncbi request reprint Clinical aspects of essential fatty acid metabolism: Jonathan Rhoads Lecture
    Bruce R Bistrian
    Laboratory of Nutrition and Infection, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    JPEN J Parenter Enteral Nutr 27:168-75. 2003
  4. ncbi request reprint Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 52:868-74. 2003
  5. doi request reprint Lipid globule size in total nutrient admixtures prepared in three-chamber plastic bags
    David F Driscoll
    Beth Israel Deaconess Medical Center BIDMC, Boston, MA, USA
    Am J Health Syst Pharm 66:649-56. 2009
  6. doi request reprint Incidence of hypertriglyceridemia in critically ill neonates receiving lipid injectable emulsions in glass versus plastic containers: a retrospective analysis
    Camilia R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Pediatr 152:232-6. 2008
  7. ncbi request reprint The influence of medium-chain triglycerides on the stability of all-in-one formulations
    David F Driscoll
    Department of Medicine, Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Pharm 240:1-10. 2002
  8. pmc A simple method of supplementation of omega-3 polyunsaturated fatty acids: use of fortified yogurt in healthy volunteers
    Karen C McCowen
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nutr Clin Pract 25:641-5. 2010
  9. doi request reprint Hepatic indicators of oxidative stress and tissue damage accompanied by systemic inflammation in rats following a 24-hour infusion of an unstable lipid emulsion admixture
    David F Driscoll
    Harvard Medical School, Boston, MA, USA
    JPEN J Parenter Enteral Nutr 33:327-35. 2009
  10. ncbi request reprint The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells
    John D Palombo
    Departments of Surgery and Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 21 27 Burlington Avenue, 503C, Boston, MA 02215, USA
    Cancer Lett 177:163-72. 2002

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The systemic inflammatory response and its impact on iron nutriture in end-stage renal disease
    B R Bistrian
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Kidney Dis 34:S35-9. 1999
    ....
  2. ncbi request reprint Systemic response to inflammation
    Bruce Bistrian
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Nutr Rev 65:S170-2. 2007
    ..Therapies to down-regulate the systemic inflammatory response by targeting the source of inflammation may dramatically improve patient outcome in chronic inflammatory states and some acute inflammatory conditions...
  3. ncbi request reprint Clinical aspects of essential fatty acid metabolism: Jonathan Rhoads Lecture
    Bruce R Bistrian
    Laboratory of Nutrition and Infection, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    JPEN J Parenter Enteral Nutr 27:168-75. 2003
    ....
  4. ncbi request reprint Hyperglycemia induced by glucose infusion causes hepatic oxidative stress and systemic inflammation, but not STAT3 or MAP kinase activation in liver in rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 52:868-74. 2003
    ..These data suggest that acute (3 hours) hyperglycemia causes hepatic oxidative stress and activates a low-grade systemic inflammation but does not affect key components of the IL-6 signaling pathway in liver...
  5. doi request reprint Lipid globule size in total nutrient admixtures prepared in three-chamber plastic bags
    David F Driscoll
    Beth Israel Deaconess Medical Center BIDMC, Boston, MA, USA
    Am J Health Syst Pharm 66:649-56. 2009
    ..The stability of injectable lipid emulsions in three-chamber plastic (3CP) bags, applying the globule-size limits established by United States Pharmacopeia ( USP ) chapter 729, was studied...
  6. doi request reprint Incidence of hypertriglyceridemia in critically ill neonates receiving lipid injectable emulsions in glass versus plastic containers: a retrospective analysis
    Camilia R Martin
    Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Pediatr 152:232-6. 2008
    ..To evaluate plasma clearance of lipid injectable emulsions packaged in either glass or plastic containers in neonates from 2 7-month periods, 1 year apart...
  7. ncbi request reprint The influence of medium-chain triglycerides on the stability of all-in-one formulations
    David F Driscoll
    Department of Medicine, Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Int J Pharm 240:1-10. 2002
    ..However, stabilization is lost if the MCT and LCT emulsions are mixed from separate starting emulsions and then compounded as an all-in-one formulation. The extemporaneous mixing of commercial lipid emulsions is not recommended...
  8. pmc A simple method of supplementation of omega-3 polyunsaturated fatty acids: use of fortified yogurt in healthy volunteers
    Karen C McCowen
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Nutr Clin Pract 25:641-5. 2010
    ..The aim of the present study was to supplement yogurt with docosahexaenoic acid and assess whether this fatty acid could be incorporated into plasma lipids...
  9. doi request reprint Hepatic indicators of oxidative stress and tissue damage accompanied by systemic inflammation in rats following a 24-hour infusion of an unstable lipid emulsion admixture
    David F Driscoll
    Harvard Medical School, Boston, MA, USA
    JPEN J Parenter Enteral Nutr 33:327-35. 2009
    ..Development of a rat model of a stable vs unstable lipid infusion would enable a study of the potential risk. Design: Prospective, randomized, controlled study...
  10. ncbi request reprint The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells
    John D Palombo
    Departments of Surgery and Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 21 27 Burlington Avenue, 503C, Boston, MA 02215, USA
    Cancer Lett 177:163-72. 2002
    ..Novel CLA preparations may prove effective as chemopreventive supplements for individuals at risk of or diagnosed with colorectal or prostate cancer...
  11. ncbi request reprint Physical stability of 20% lipid injectable emulsions via simulated syringe infusion: effects of glass vs plastic product packaging
    David F Driscoll
    Department of Medicine, Division of Clinical Nutrition and Nutrition Infection Laboratory, B I Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    JPEN J Parenter Enteral Nutr 31:148-53. 2007
    ..We tested the possible stability differences between 20% lipid injectable emulsions in either P or G in a simulated neonatal syringe infusion study...
  12. ncbi request reprint Stability of total nutrient admixtures with lipid injectable emulsions in glass versus plastic packaging
    David F Driscoll
    Department of Medicine, B I Deaconess Medical Center, Boston, MA 02215, USA
    Am J Health Syst Pharm 64:396-403. 2007
    ..The physical stability of two emulsions compounded as part of a total nutrient admixture (TNA) was studied in lipids packaged in either glass or plastic containers...
  13. ncbi request reprint Establishing a stability window for medium- and long-chain-triglyceride lipid-based total nutrient admixtures using USP standards
    David F Driscoll
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Health Syst Pharm 63:2135-43. 2006
    ..The stability window of medium-chain triglyceride (MCT) and long-chain-triglyceride (LCT) lipid-based total nutrient admixtures (TNAs) was studied...
  14. ncbi request reprint Pathological consequences to reticuloendothelial system organs following infusion of unstable all-in-one mixtures in rats
    David F Driscoll
    Department of Medicine, Division of Clinical Nutrition, Beth Israel Deaconess Medical Center BIDMC, Harvard Medical School, Boston, MA, USA
    Clin Nutr 25:842-50. 2006
    ..Recent evidence of lung injury from the infusion of unstable lipid injectable emulsions as all-in-one mixtures (AIOs) was shown in a guinea pig infusion model...
  15. ncbi request reprint Pathological consequences from the infusion of unstable lipid emulsion admixtures in guinea pigs
    David F Driscoll
    Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Clin Nutr 24:105-13. 2005
    ..7+/-2.2 micromol(-1)g, P=0.944). These preliminary data suggest that infusion of unstable injectable lipid emulsions has pathological consequences showing greater evidence of oxidative stress in the lungs...
  16. doi request reprint Stability of MCT/LCT-based total nutrient admixtures for neonatal use over 30 hours at room temperature: applying pharmacopeial standards
    David F Driscoll
    Nutrition Infection Laboratory, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 34:305-12. 2010
    ..Stability assessment of neonatal TNAs with AA <2% or > or =3% were tested...
  17. ncbi request reprint Effects of protein malnutrition on IL-6-mediated signaling in the liver and the systemic acute-phase response in rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Rm 569, 21 27 Burlington Bldg, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 287:R801-8. 2004
    ..The capacity for response to IL-6 is preserved, suggesting adaptive preservation of acute-phase responsiveness during malnutrition...
  18. doi request reprint Nutrition support in the intensive care unit: an evolving science
    George L Blackburn
    Center for the Study of Nutrition Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Feldberg 880, East Campus, 330 Brookline Ave, Boston, MA 02215, USA
    Arch Surg 145:533-8. 2010
    ..It will review parenteral nutrition from its inception to its current standing in ICU patient care and discuss the future role of parenteral nutrition in a rapidly changing and increasingly diverse population...
  19. doi request reprint Effect of a fish oil-containing beverage on changes in plasma lipid fatty acids in patients with malabsorption
    Karen C McCowen
    Harvard Vanguard Medical Associates, Boston, MA 02215, USA
    Nutr Clin Pract 25:517-23. 2010
    ..The authors wanted to determine whether fish oil could be absorbed and incorporated into plasma fatty acids and reduce markers of inflammation...
  20. pmc Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study
    Sassan Pazirandeh
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    JPEN J Parenter Enteral Nutr 31:511-6. 2007
    ....
  21. ncbi request reprint Inhibition of interleukin-6-activated janus kinases/signal transducers and activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 30:202-11. 2002
    ..The purpose of this study was to examine the effects of endotoxin on interleukin-6 activation of STATs and mitogen-activated protein (MAP) kinase pathways in rat liver in vivo...
  22. pmc Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications
    Robert A M Strijbosch
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 57:698-707. 2008
    ..This can presumably be attributed to the fact that fish oil contains not only a small amount of linoleic acid, but also arachidonic acid, which has greater efficiency to meet omega-6 fatty acid requirements...
  23. ncbi request reprint Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity
    Lalita Khaodhiar
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    JPEN J Parenter Enteral Nutr 28:410-5. 2004
    ..In this study, we examined the correlation of these markers with BMI in nonobese, obese, and morbidly obese individuals to explore this relationship across the broad range of obesity...
  24. ncbi request reprint Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Pediatrics 118:e197-201. 2006
    ..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease...
  25. ncbi request reprint Disturbances in essential fatty acid metabolism in patients receiving long-term home parenteral nutrition
    Pei Ra Ling
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Dig Dis Sci 47:1679-85. 2002
    ..The determination of optimal parenteral fat intakes should be investigated further as important priority in patients receiving long term HTPN...
  26. ncbi request reprint Liver and skeletal muscle lipids have differing fatty acid profiles in short-gut rats fed via parenteral nutrition
    Karen C McCowen
    Beth Israel Deaconess Medical Center, Boston, Massachusetts
    JPEN J Parenter Enteral Nutr 30:27-31. 2006
    ..The goal of this study was to determine fatty acid profiles in skeletal muscle and liver in short-gut rats treated with PN compared with sham rats...
  27. ncbi request reprint Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, and the Division of Endocrinology, Rhode Island Hospital, Providence, RI, USA
    Crit Care Med 35:555-60. 2007
    ....
  28. ncbi request reprint Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats
    Pei Ra Ling
    Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:1084-9. 2005
    ..The aim of this study was to investigate whether hyperglycemia enhances the systemic inflammatory response and oxidative stress induced by endotoxin...
  29. ncbi request reprint Immunonutrition: problematic or problem solving?
    Karen C McCowen
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 77:764-70. 2003
    ..If future trials can consider these vital points, level 1 recommendations in favor of immunonutrition might be justified, although presently such evidence is lacking for most clinical indications...
  30. doi request reprint Physical compatibility of neonatal total parenteral nutrition admixtures containing organic calcium and inorganic phosphate salts in a simulated infusion at 37 degrees C
    Hardeep Singh
    Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA
    Pediatr Crit Care Med 10:213-6. 2009
    ..Within an incubator environment at 37 degrees C, we evaluated the physical compatibility of calcium (Ca) and phosphate (P) in simulated neonatal total parenteral nutrition (TPN) infusions...
  31. doi request reprint Brief history of parenteral and enteral nutrition in the hospital in the USA
    Bruce R Bistrian
    Clinical Nutrition, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Nestle Nutr Workshop Ser Clin Perform Programme 12:127-36. 2009
    ....
  32. pmc Effects of medium-chain triglycerides, long-chain triglycerides, or 2-monododecanoin on fatty acid composition in the portal vein, intestinal lymph, and systemic circulation in rats
    Yi Qian Nancy You
    Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    JPEN J Parenter Enteral Nutr 32:169-75. 2008
    ..This study sought to determine the effects of long-chain triglycerides (LCT), medium-chain triglycerides (MCT), and 2-monododecanoin (2mono) on intestinal fatty acid composition during continuous feeding over a brief period...
  33. doi request reprint Pharmacopeial compliance of fish oil-containing parenteral lipid emulsion mixtures: Globule size distribution (GSD) and fatty acid analyses
    David F Driscoll
    Nutrition Infection Laboratory, Department of Medicine, B I Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Int J Pharm 379:125-30. 2009
    ..This latter finding suggests the n3-FA content of the fish oil source and/or the applied manufacturing processes in these products is different...
  34. ncbi request reprint Essential fatty acids and their derivatives
    Karen C McCowen
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Gastroenterol 21:207-15. 2005
    ..Our main focus will be the association between essential fatty acid status and various disease states, as well as the effects of supplementation with essential fatty acids or their derivatives on a number of clinical outcomes...
  35. pmc Metabolic syndrome and serum fatty acid patterns in serum phospholipids in hypertriglyceridemic persons with human immunodeficiency virus
    Margo N Woods
    Department of Public Health and Family Medicine, Nutrition Infection Unit, Tufts University School of Medicine, Boston, MA 02111, USA
    Am J Clin Nutr 89:1180-7. 2009
    ..High triglyceride concentrations and low HDL-cholesterol concentrations are the most common health abnormalities and raise concerns about an increased risk of cardiovascular disease...
  36. pmc Comparison of the effects of food versus protein restriction on selected nutritional and inflammatory markers in rats
    Pei Ra Ling
    Department of Medicine, Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Metabolism 58:835-42. 2009
    ....
  37. doi request reprint Calcium and phosphate compatibility in low-osmolarity parenteral nutrition admixtures intended for peripheral vein administration
    Julie Joy
    Nutrition Infection Laboratory, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 34:46-54. 2010
    ..Three concentrations of amino acids (AA) and 2 concentrations of calcium gluconate and sodium phosphate injections on the compatibility of Ca and P in LO-PN admixtures were studied...
  38. pmc Effect of a dietary intervention and n-3 fatty acid supplementation on measures of serum lipid and insulin sensitivity in persons with HIV
    Margo N Woods
    Department of Public Health and Community Medicine, Nutrition Infection Unit, Tufts University School of Medicine, Boston, MA, USA
    Am J Clin Nutr 90:1566-78. 2009
    ..Elevated serum triglyceride and low HDL-cholesterol concentrations have been reported in persons with HIV...
  39. ncbi request reprint Physicochemical stability of highly concentrated total nutrient admixtures for fluid-restricted patients
    David F Driscoll
    Department of Medicine, Nutrition Infection Laboratory, Beth Israel Deaconess Medical Center BIDMC, Boston, MA 02215, USA
    Am J Health Syst Pharm 63:79-85. 2006
    ..The physicochemical stability of highly concentrated total nutrient admixtures (TNAs) for fluid-restricted patients was studied...
  40. ncbi request reprint Abnormal regulation of serum lipid fatty acid profiles in short gut rats fed parenteral nutrition with lipid
    Karen C McCowen
    Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 53:273-7. 2004
    ..Therefore, the short gut rat is an appropriate model to study further arachidonic acid excess in home TPN patients...
  41. ncbi request reprint Patterns of plasma leptin and insulin concentrations in hospitalized patients after the initiation of total parenteral nutrition
    Karen C McCowen
    Nutrition Support Service, Departments of Medicine and Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Am J Clin Nutr 75:931-5. 2002
    ..The regulation of leptin in patients with critical illness is poorly understood. Sex, diet, body mass, and cytokines may all play a role...
  42. doi request reprint Case 20-2008: Abdominal pain and weakness after gastric bypass surgery
    Bruce R Bistrian
    N Engl J Med 359:1850-1; author reply 1852. 2008
  43. ncbi request reprint Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model
    Ian P J Alwayn
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1011-9. 2006
    ..This may be related to increased expression and activation of PPAR-alpha or IL-6, respectively...
  44. ncbi request reprint Nutritional and metabolic support in the adult intensive care unit: key controversies
    Bruce R Bistrian
    Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, MA, USA
    Crit Care Med 34:1525-31. 2006
    ..To discuss certain important features of nutrition and metabolism in the intensive care unit...
  45. ncbi request reprint Physical compatibility of neonatal total parenteral nutrient admixtures containing organic calcium and inorganic phosphate salts
    Mansi J Parikh
    Bristol Myers Squibb, Wallingford, CT, USA
    Am J Health Syst Pharm 62:1177-83. 2005
    ..The compatibility of calcium and phosphate salts in total parenteral nutrient (TPN) admixtures at the highest concentrations recommended for preterm and term infants was studied...
  46. ncbi request reprint New Food and Drug Administration requirements for inclusion of vitamin K in adult parenteral multivitamins
    Cynthia J Helphingstine
    Biotron Group, Inc, Highland Park, Illinois 60035 2043, USA
    JPEN J Parenter Enteral Nutr 27:220-4. 2003
    ..If marketed globally, these clinical practice issues may be more pronounced outside of the United States, where dual feeding is common, and patients may receive vitamin K from other sources...
  47. ncbi request reprint Hyperglycemia in acutely ill patients
    Victor M Montori
    Division of Endocrinology, Metabolism and Internal Medicine, Mayo Clinic, 200 First St SW, W18, Rochester, MN 55905, USA
    JAMA 288:2167-9. 2002