Research Topics
Genomes and Genes
| Joseph BiedermanSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
Am J Psychiatry 163:1730-8. 2006..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescentsTimothy E Wilens
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Pediatr Adolesc Med 162:916-21. 2008..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)...- A randomized, double-blind, placebo-controlled, parallel-group study of SLI381 (Adderall XR) in children with attention-deficit/hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Pediatrics 110:258-66. 2002..A secondary objective was to assess the diurnal variation in responses based on morning and afternoon assessments... 
Sex differences in the functional neuroanatomy of working memory in adults with ADHDEve M Valera
Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
Am J Psychiatry 167:86-94. 2010..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...- Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHDTheresa Harpold
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 195:601-5. 2007..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder... - Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 170:199-203. 2009..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD... - Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary studyJoseph Biederman
Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies... - Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depressionJoseph Biederman
Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
J Affect Disord 82:209-16. 2004..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias... - A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorderGagan Joshi
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 20:7-14. 2010..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)... - Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depressionJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Psychiatry Res 153:245-52. 2007.... - Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Dev Behav Pediatr 31:485-90. 2010.... - Antecedents to panic disorder in nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:1179-86. 2006..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults... - An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertensionTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 67:696-702. 2006.... - A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHDMichael C Monuteaux
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology... - The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorderJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
Biol Psychiatry 57:1485-92. 2005..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus... - The child behavior checklist broad-band scales predict subsequent psychopathology: A 5-year follow-upCarter R Petty
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Warren 705, 15 Parkman Street, Boston, MA 02114, USA
J Anxiety Disord 22:532-9. 2008..To evaluate the utility of the Child Behavior Check list (CBCL) for identifying children of parents with panic disorder or major depression at high-risk for future psychopathology... - A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depressionJoseph Biederman
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Psychol Med 36:1141-52. 2006..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence... - Executive functioning in offspring at risk for depression and anxietyJamie A Micco
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
Depress Anxiety 26:780-90. 2009..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic... - Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control studyJoseph Biederman
Clinical and Research Programs in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:409-17. 2010..Few follow-up studies have been conducted of girls with ADHD, and none have followed girls into adulthood. The authors sought to estimate the prevalence of psychopathology in girls with and without ADHD followed into young adulthood... - Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot studyNikos Makris
Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
J Atten Disord 13:407-13. 2010..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD... - Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-upDina R Hirshfeld-Becker
Department of Psychiatry, Massachusetts General Hospital, USA
Am J Psychiatry 169:1175-84. 2012..The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder... - Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference taskGeorge Bush
Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Arch Gen Psychiatry 65:102-14. 2008..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized... - Childhood antecedents to panic disorder in referred and nonreferred adultsJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 15:549-61. 2005..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder... - Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidityThomas J Spencer
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 67:415-20. 2006.... - Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal studyMichael C Monuteaux
The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Psychol Med 37:1731-41. 2007..However, it is unclear how these results extend to females. Our aim was to examine the predictors, clinical characteristics, and functional outcome of CD in a sample of female youth with and without ADHD... - Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHDJoseph Biederman
Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 195:240-6. 2007..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone... - Association of bipolar and substance use disorders in parents of adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 62:129-34. 2007..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism... - Characterizing non-OCD anxiety disorders in psychiatrically referred children and adolescentsPaul Hammerness
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02138, United States
J Affect Disord 105:213-9. 2008..To characterize childhood and adolescent anxiety disorders in a psychiatric clinic... - Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot studyDina R Hirshfeld-Becker
Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
Psychiatry Res 145:155-67. 2006..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood... - Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysisCarter R Petty
Massachusetts General Hospital, Boston, MA 02114, USA
J Psychiatr Res 43:345-52. 2009..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)... - An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders: II. Tolerability and pharmacokineticsPaul Hammerness
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA
J Child Adolesc Psychopharmacol 19:493-9. 2009..The aim of this study was to evaluate the tolerability of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD)... - The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal studyMichael C Monuteaux
Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Child Psychol Psychiatry 51:233-41. 2010..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence... - Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled studyJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
J Affect Disord 94:191-7. 2006..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring... - Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHDTimothy E Wilens
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston MA 02114, USA
J Am Acad Child Adolesc Psychiatry 50:543-53. 2011..The main aims of this study were to identify clinically meaningful characteristics of children that predicted the future development of SUDs and to see whether the role of these characteristics varied by sex... - Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHDJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:460-7. 2006..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported... - Representativeness of participants in a clinical trial for attention-deficit/hyperactivity disorder? Comparison with adults from a large observational studyCraig B H Surman
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Ste 2000, 185 Alewife Brook Pkwy, Cambridge, MA 02138, USA
J Clin Psychiatry 71:1612-6. 2010..In particular, exclusion criteria may frequently exclude individuals with comorbid mental health conditions, which are common in the adult ADHD population... - Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycleJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
J Clin Psychiatry 72:11-6. 2011.... - Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting courseJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
Psychiatry Res 170:177-82. 2009..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD... - Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled studyCraig B H Surman
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Cambridge, MA 02138, USA
J Clin Psychiatry 70:1523-9. 2009..To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults... - Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
Bipolar Disord 11:298-306. 2009..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases... - Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family studyTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
J Clin Psychiatry 70:259-65. 2009..However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear... - The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up studyJoseph Biederman
Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Dev Behav Pediatr 29:501-7. 2008..However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD... - Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescenceJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Dev Neuropsychol 33:44-61. 2008..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence... - New insights into the comorbidity between ADHD and major depression in adolescent and young adult femalesJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:426-34. 2008..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females... - Familial risk analyses of attention deficit hyperactivity disorder and substance use disordersJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
Am J Psychiatry 165:107-15. 2008..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature... - Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptomsMichael C Monuteaux
Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 48:757-64. 2009..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD... - Adaptive phase I study of OROS methylphenidate treatment of attention deficit hyperactivity disorder with epilepsyJoseph Gonzalez-Heydrich
Department of Psychiatry, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Epilepsy Behav 18:229-37. 2010..The goal of this study was to pilot a randomized controlled trial of OROS methylphenidate (OROS-MPH) to treat attention deficit hyperactivity disorder (ADHD) plus epilepsy... - Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-upDina R Hirshfeld-Becker
Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
Biol Psychiatry 62:565-72. 2007..In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders... - A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled studyJoseph Biederman
Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 67:727-35. 2006.... - The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysisJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 70:732-40. 2009..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder... - How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlatesJanet Wozniak
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 58:583-8. 2005..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms... - New developments in the treatment of ADHDJoseph Biederman
Dept. of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 67:148-59. 2006 - Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspringJoseph Biederman
Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, 02114, USA
Depress Anxiety 22:114-20. 2005..These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood... - A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorderThomas Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 57:456-63. 2005..A previous, pilot study by our group suggested that these results were due to inadequate dosing... - Moderating effects of major depression on patterns of comorbidity in patients with panic disorderJoseph Biederman
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
Psychiatry Res 126:143-9. 2004..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults... - Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorderTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 66:253-9. 2005..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse... - Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA, USA
J Dev Behav Pediatr 33:236-43. 2012.... - Working memory network alterations and associated symptoms in adults with ADHD and Bipolar DisorderAriel Brown
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Psychiatr Res 46:476-83. 2012..We conclude that comorbid ADHD + BPD is associated with alterations across anterior and posterior nodes of the working memory network, and symptoms of each disorder are related to anatomically and functionally distinct brain regions... - Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replicationRonald C Kessler
Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
Biol Psychiatry 57:1442-51. 2005..Despite growing interest in adult attention-deficit/hyperactivity disorder (ADHD), little is known about predictors of persistence of childhood cases into adulthood... - Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled studyTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Drug Alcohol Depend 95:188-98. 2008..Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use... - Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
J Clin Psychiatry 70:1178-85. 2009..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth... - Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disordersDina R Hirshfeld-Becker
Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
Am J Psychiatry 161:547-55. 2004..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children... - Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorderAriel B Brown
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples... - Impact of executive function deficits in youth with bipolar I disorder: a controlled studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 186:58-64. 2011..Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning... - Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?Larry J Seidman
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
Dev Neuropsychol 27:79-105. 2005..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years... - Novel treatments for attention-deficit/hyperactivity disorder in childrenThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 63:16-22. 2002.... - Gender effects on attention-deficit/hyperactivity disorder in adults, revisitedJoseph Biederman
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 55:692-700. 2004..These results bear striking similarities to findings reported in pediatric samples, supporting the validity of ADHD and stressing the importance of identifying and treating the disorder in adulthood... - Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibitionJordan W Smoller
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 54:1376-81. 2003..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype... - Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youthJoseph Biederman
Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
J Nerv Ment Dis 192:607-14. 2004..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention... - A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorderEric Mick
Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:1021-7. 2003..CONCLUSIONS: While there was a significant heterogeneity in estimates between studies, a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression was identified... - Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onsetEric Mick
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 13:453-62. 2003..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder... - Psychopathology in the offspring of parents with bipolar disorder: a controlled studyAude Henin
Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
Biol Psychiatry 58:554-61. 2005..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth... - Temperamental correlates of disruptive behavior disorders in young children: preliminary findingsDina R Hirshfeld-Becker
Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
Biol Psychiatry 51:563-74. 2002..Longitudinal studies using behavioral assessments of behavioral disinhibition are needed to confirm these findings... - Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research ProgramJoseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 53:952-60. 2003..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD... - Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youthJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
J Affect Disord 83:207-14. 2004..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample... - Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescentsJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA, USA
J Pediatr 152:394-9. 2008..This secondary analysis evaluated the efficacy of modafinil in children and adolescents by subtype of attention-deficit/hyperactivity disorder (ADHD) using pooled data from 3 double-blind, placebo-controlled studies... - Attention-deficit/hyperactivity disorder: a selective overviewJoseph Biederman
Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 57:1215-20. 2005..Such alterations in dopaminergic and noradrenergic function are apparently necessary for the clinical efficacy of pharmacologic treatments of ADHD... - Association between attention-deficit/hyperactivity disorder and bulimia nervosa: analysis of 4 case-control studiesCraig B H Surman
Clinical and Research Program in Pediatric Psychopharmacology at Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
J Clin Psychiatry 67:351-4. 2006..If confirmed, this association between bulimia nervosa and ADHD could have important clinical and therapeutic implications... - Presenting ADHD symptoms, subtypes, and comorbid disorders in clinically referred adults with ADHDTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, YAW 6A, 55 Fruit Street, Boston, MA 02114, USA
J Clin Psychiatry 70:1557-62. 2009..Comorbidity among adults with ADHD is also of great interest due to the high rates of psychiatric comorbidity, which can lead to a more persistent ADHD among adults... - A naturalistic 10-year prospective study of height and weight in children with attention-deficit hyperactivity disorder grown up: sex and treatment effectsJoseph Biederman
Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
J Pediatr 157:635-40, 640.e1. 2010..To assess the effect of attention-deficit/hyperactivity disorder (ADHD) and its treatment on growth outcomes in children followed into adulthood... - Diagnostic threshold for conduct disorder in girls and boysAlysa E Doyle
Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC-725, 15 Parkman Street, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 191:379-86. 2003..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender... - How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHDJoseph Biederman
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA
Psychiatry Res 177:299-304. 2010..Persistence of ADHD is associated with greater psychiatric comorbidity, familiality and functional impairments... - Growth deficits and attention-deficit/hyperactivity disorder revisited: impact of gender, development, and treatmentJoseph Biederman
Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Pediatrics 111:1010-6. 2003..Although the relationship between putative growth deficits and attention-deficit/hyperactivity disorder (ADHD) has been examined in boys, this issue has not been evaluated in girls... - The clinical characteristics of unipolar vs. bipolar major depression in ADHD youthJanet Wozniak
Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Affect Disord 82:S59-69. 2004..To investigate the characteristics of unipolar vs. bipolar depression in youth using a sample of children referred for a study on attention deficit hyperactivity disorder (ADHD)... - Convergence between the Achenbach youth self-report and structured diagnostic interview diagnoses in ADHD and non-ADHD youthRobert Doyle
Department of Psychiatry, Harvard Medical School, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 195:350-2. 2007..These findings indicate that the YSR could serve as a rapid and cost-effective diagnostic tool to identify major psychopathology in high-risk adolescents... - Investigation of parent-of-origin effects in ADHD candidate genesJang Woo Kim
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes... - Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorderJoseph Biederman
Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 69:1150-6. 2008..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)... - Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependencyAmy L Hahesy
Pediatric and Adult Psychopharmacology Clinic, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
Psychiatry Res 109:245-53. 2002..These findings further highlight the importance of targeting antecedent disorders for preventive and early intervention programs aimed at reducing the risk for SUD... - Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorderDaniel A Geller
Pediatric OCD Problem, WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Am J Psychiatry 160:1919-28. 2003.... - Efficacy and safety of mixed amphetamine salts extended release (Adderall XR) in the management of attention-deficit/hyperactivity disorder in adolescent patients: a 4-week, randomized, double-blind, placebo-controlled, parallel-group studyThomas J Spencer
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Ther 28:266-79. 2006..The ability to recognize and diagnose attention-deficit/hyperactivity disorder (ADHD) has increased in recent years. The persistence of ADHD symptoms puts adolescents with ADHD at risk for long-term adverse psychosocial outcomes... - Correlates of ADHD among children in pediatric and psychiatric clinicsBetsy Busch
Department of Pediatrics, Tufts University School of Medicine in Boston, USA
Psychiatr Serv 53:1103-11. 2002..These findings suggest that children cared for in pediatric practice have similar levels of comorbidity and dysfunction as psychiatrically referred youth... - Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disordersMichael W Otto
Massachusetts General Hospital and Harvard Medical School, MA, United States
J Anxiety Disord 21:888-902. 2007..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children... - Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorderTatiana Roman
Department of Genetics, Federal University of Rio Grande do Sul, Brazil
Pharmacogenetics 12:497-9. 2002..01). Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH... - Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiologyThomas J Spencer
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Ambul Pediatr 7:73-81. 2007.... - A post hoc subgroup analysis of an 18-day randomized controlled trial comparing the tolerability and efficacy of mixed amphetamine salts extended release and atomoxetine in school-age girls with attention-deficit/hyperactivity disorderJoseph Biederman
Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Ther 28:280-93. 2006.... - Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter geneJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Addict Behav 31:1088-99. 2006..A sliding window of analysis of 3 SNPs also resulted in only nominal associations. CONCLUSIONS: SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD... - Laboratory-observed behavioral disinhibition in the young offspring of parents with bipolar disorder: a high-risk pilot studyDina R Hirshfeld-Becker
Mass General Hospital Pediatric Psychopharmacology Program, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
Am J Psychiatry 163:265-71. 2006..This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder... - The CBCL predicts DSM bipolar disorder in children: a receiver operating characteristic curve analysisStephen V Faraone
Medical Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Bipolar Disord 7:518-24. 2005..The CBCL-PBD profile on the Child Behavior Checklist (CBCL) has been consistently reported showing deviant findings on the Attention Problems, Aggressive Behavior, and Anxious-Depressed subscales... - Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHDSherif Karama
Department of Psychiatry, McGill University, Montreal, Canada
BMC Psychiatry 8:45. 2008..Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder... - Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescentsTerri L Harpold
Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
J Affect Disord 88:19-26. 2005..Considering the morbidity and dysfunction as well as the differing therapeutic needs associated with bipolar and anxiety symptomatology, appropriate therapeutic approaches will be needed for the management of youth with this comorbidity... - Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorderJoseph Biederman
Department of Psychiatry, Harvard Medical School, USA
Biol Psychiatry 59:258-64. 2006....