Joseph Biederman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
  2. pmc Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents
    Timothy E Wilens
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Pediatr Adolesc Med 162:916-21. 2008
  3. ncbi request reprint A randomized, double-blind, placebo-controlled, parallel-group study of SLI381 (Adderall XR) in children with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 110:258-66. 2002
  4. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
  5. ncbi request reprint Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
  6. ncbi request reprint Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
  7. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
  8. pmc Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
  9. doi request reprint A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
  10. pmc Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Impact of psychometrically defined deficits of executive functioning in adults with attention deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, 32 Fruit St, Boston, 02114, USA
    Am J Psychiatry 163:1730-8. 2006
    ..The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD)...
  2. pmc Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents
    Timothy E Wilens
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Pediatr Adolesc Med 162:916-21. 2008
    ..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  3. ncbi request reprint A randomized, double-blind, placebo-controlled, parallel-group study of SLI381 (Adderall XR) in children with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pediatrics 110:258-66. 2002
    ..A secondary objective was to assess the diurnal variation in responses based on morning and afternoon assessments...
  4. pmc Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  5. ncbi request reprint Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
    ..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias...
  6. ncbi request reprint Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
    ..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder...
  7. pmc Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  8. pmc Sex differences in the functional neuroanatomy of working memory in adults with ADHD
    Eve M Valera
    Department of Psychiatry, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
    Am J Psychiatry 167:86-94. 2010
    ..The authors examined sex differences in the neural functioning of adults with ADHD during performance of a verbal working memory task...
  9. doi request reprint A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorder
    Gagan Joshi
    Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 20:7-14. 2010
    ..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)...
  10. pmc Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007
    ....
  11. pmc Difficulties in emotional regulation and substance use disorders: a controlled family study of bipolar adolescents
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Drug Alcohol Depend 132:114-21. 2013
    ..To this end, we examined to what extent DESR was associated with SUD in a high-risk sample of adolescents with and without BD...
  12. doi request reprint Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 31:485-90. 2010
    ....
  13. ncbi request reprint An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:696-702. 2006
    ....
  14. ncbi request reprint Antecedents to panic disorder in nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:1179-86. 2006
    ..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults...
  15. pmc Anterior cingulate volumetric alterations in treatment-naïve adults with ADHD: a pilot study
    Nikos Makris
    Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Atten Disord 13:407-13. 2010
    ..Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD...
  16. pmc The child behavior checklist broad-band scales predict subsequent psychopathology: A 5-year follow-up
    Carter R Petty
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Warren 705, 15 Parkman Street, Boston, MA 02114, USA
    J Anxiety Disord 22:532-9. 2008
    ..To evaluate the utility of the Child Behavior Check list (CBCL) for identifying children of parents with panic disorder or major depression at high-risk for future psychopathology...
  17. doi request reprint Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control study
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 167:409-17. 2010
    ..Few follow-up studies have been conducted of girls with ADHD, and none have followed girls into adulthood. The authors sought to estimate the prevalence of psychopathology in girls with and without ADHD followed into young adulthood...
  18. ncbi request reprint The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    Biol Psychiatry 57:1485-92. 2005
    ..To evaluate this further, we genotyped additional families for this marker and a panel of markers encompassing the CRH locus...
  19. ncbi request reprint A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 36:1141-52. 2006
    ..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence...
  20. doi request reprint A preliminary study of dopamine D4 receptor genotype and structural brain alterations in adults with ADHD
    Michael C Monuteaux
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1436-41. 2008
    ..These result support the heterogeneity of ADHD and provides insights as to its underlying pathophysiology...
  21. doi request reprint Executive functioning in offspring at risk for depression and anxiety
    Jamie A Micco
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
    Depress Anxiety 26:780-90. 2009
    ..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic...
  22. doi request reprint The effects of lisdexamfetamine dimesylate on driving behaviors in young adults with ADHD assessed with the Manchester driving behavior questionnaire
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Adolesc Health 51:601-7. 2012
    ..The focus of this report is on assessing the impact of lisdexamfetamine dimesylate (LDX) on driving behaviors in young adults with ADHD using a validated driving behavior questionnaire...
  23. ncbi request reprint Psychopathology in adolescent offspring of parents with panic disorder, major depression, or both: a 10-year follow-up
    Dina R Hirshfeld-Becker
    Department of Psychiatry, Massachusetts General Hospital, USA
    Am J Psychiatry 169:1175-84. 2012
    ..The authors examined the specificity and course of psychiatric disorders from early childhood through adolescence in offspring of parents with confirmed panic disorder and major depressive disorder...
  24. doi request reprint Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    George Bush
    Departments of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 65:102-14. 2008
    ..Stimulant medications are effective treatments for ADHD, but their neural effects have not been fully characterized...
  25. ncbi request reprint Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled study
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
    J Affect Disord 94:191-7. 2006
    ..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring...
  26. ncbi request reprint Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
    Psychiatry Res 145:155-67. 2006
    ..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood...
  27. ncbi request reprint Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity
    Thomas J Spencer
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:415-20. 2006
    ....
  28. ncbi request reprint Childhood antecedents to panic disorder in referred and nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:549-61. 2005
    ..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder...
  29. ncbi request reprint Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 59:460-7. 2006
    ..Association with a single nucleotide polymorphism (SNP; G861C) has been observed, but more extensive linkage disequilibrium analyses have not been reported...
  30. pmc The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal study
    Michael C Monuteaux
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 51:233-41. 2010
    ..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence...
  31. pmc An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders: II. Tolerability and pharmacokinetics
    Paul Hammerness
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA
    J Child Adolesc Psychopharmacol 19:493-9. 2009
    ..The aim of this study was to evaluate the tolerability of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD)...
  32. pmc Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHD
    Timothy E Wilens
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 50:543-53. 2011
    ..The main aims of this study were to identify clinically meaningful characteristics of children that predicted the future development of SUDs and to see whether the role of these characteristics varied by sex...
  33. ncbi request reprint Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal study
    Michael C Monuteaux
    The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 37:1731-41. 2007
    ..However, it is unclear how these results extend to females. Our aim was to examine the predictors, clinical characteristics, and functional outcome of CD in a sample of female youth with and without ADHD...
  34. ncbi request reprint Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
    ..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...
  35. ncbi request reprint Association of bipolar and substance use disorders in parents of adolescents with bipolar disorder
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 62:129-34. 2007
    ..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism...
  36. pmc Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
    ..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)...
  37. ncbi request reprint Characterizing non-OCD anxiety disorders in psychiatrically referred children and adolescents
    Paul Hammerness
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02138, United States
    J Affect Disord 105:213-9. 2008
    ..To characterize childhood and adolescent anxiety disorders in a psychiatric clinic...
  38. doi request reprint Stability of executive function deficits in girls with ADHD: a prospective longitudinal followup study into adolescence
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dev Neuropsychol 33:44-61. 2008
    ..These findings document the stability of EFDs in girls with ADHD from childhood into adolescence...
  39. ncbi request reprint Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    Am J Psychiatry 165:107-15. 2008
    ..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature...
  40. ncbi request reprint A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:727-35. 2006
    ....
  41. pmc The longitudinal course of comorbid oppositional defiant disorder in girls with attention-deficit/hyperactivity disorder: findings from a controlled 5-year prospective longitudinal follow-up study
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Dev Behav Pediatr 29:501-7. 2008
    ..However, most of the available information on the subject derives from predominantly male samples. This study evaluated the longitudinal course and impact of comorbid ODD in a large sample of girls with ADHD...
  42. pmc Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family study
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    J Clin Psychiatry 70:259-65. 2009
    ..However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear...
  43. pmc Clinical outcomes of laboratory-observed preschool behavioral disinhibition at five-year follow-up
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Cambridge, MA 02138, USA
    Biol Psychiatry 62:565-72. 2007
    ..In the present study, our objective was to examine the diagnostic outcome in middle childhood of behavioral disinhibition assessed at preschool age among offspring at risk for anxiety and mood disorders...
  44. ncbi request reprint New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:426-34. 2008
    ..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females...
  45. pmc The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 70:732-40. 2009
    ..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder...
  46. doi request reprint Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycle
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
    J Clin Psychiatry 72:11-6. 2011
    ....
  47. pmc Representativeness of participants in a clinical trial for attention-deficit/hyperactivity disorder? Comparison with adults from a large observational study
    Craig B H Surman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Ste 2000, 185 Alewife Brook Pkwy, Cambridge, MA 02138, USA
    J Clin Psychiatry 71:1612-6. 2010
    ..In particular, exclusion criteria may frequently exclude individuals with comorbid mental health conditions, which are common in the adult ADHD population...
  48. pmc Adaptive phase I study of OROS methylphenidate treatment of attention deficit hyperactivity disorder with epilepsy
    Joseph Gonzalez-Heydrich
    Department of Psychiatry, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Epilepsy Behav 18:229-37. 2010
    ..The goal of this study was to pilot a randomized controlled trial of OROS methylphenidate (OROS-MPH) to treat attention deficit hyperactivity disorder (ADHD) plus epilepsy...
  49. ncbi request reprint Moderating effects of major depression on patterns of comorbidity in patients with panic disorder
    Joseph Biederman
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 126:143-9. 2004
    ..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults...
  50. ncbi request reprint Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:253-9. 2005
    ..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse...
  51. ncbi request reprint A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
    Thomas Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biol Psychiatry 57:456-63. 2005
    ..A previous, pilot study by our group suggested that these results were due to inadequate dosing...
  52. pmc Are cognitive deficits in attention deficit/hyperactivity disorder related to the course of the disorder? A prospective controlled follow-up study of grown up boys with persistent and remitting course
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA, USA
    Psychiatry Res 170:177-82. 2009
    ..More work is needed to help define the implications of these deficits in individuals with a remitting course of ADHD...
  53. ncbi request reprint Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  54. ncbi request reprint New developments in the treatment of ADHD
    Joseph Biederman
    Dept of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 67:148-59. 2006
  55. pmc Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
    Bipolar Disord 11:298-306. 2009
    ..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases...
  56. doi request reprint Association between attention-deficit/hyperactivity disorder and sleep impairment in adulthood: evidence from a large controlled study
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1523-9. 2009
    ..To examine whether sleep impairment is associated with attention-deficit/hyperactivity disorder (ADHD) in adults...
  57. ncbi request reprint How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  58. ncbi request reprint Parental predictors of pediatric panic disorder/agoraphobia: a controlled study in high-risk offspring
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, 02114, USA
    Depress Anxiety 22:114-20. 2005
    ..These findings suggest that psychiatric comorbidity with other anxiety disorders and with bipolar disorder in parents with PD and their spouses confer a particularly high risk in their offspring to develop PD/AG in childhood...
  59. pmc Severity of the aggression/anxiety-depression/attention child behavior checklist profile discriminates between different levels of deficits in emotional regulation in youth with attention-deficit hyperactivity disorder
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA, USA
    J Dev Behav Pediatr 33:236-43. 2012
    ....
  60. pmc Working memory network alterations and associated symptoms in adults with ADHD and Bipolar Disorder
    Ariel Brown
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Psychiatr Res 46:476-83. 2012
    ..We conclude that comorbid ADHD + BPD is associated with alterations across anterior and posterior nodes of the working memory network, and symptoms of each disorder are related to anatomically and functionally distinct brain regions...
  61. pmc Impact of executive function deficits in youth with bipolar I disorder: a controlled study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 186:58-64. 2011
    ..Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning...
  62. pmc Effect of dopamine transporter gene (SLC6A3) variation on dorsal anterior cingulate function in attention-deficit/hyperactivity disorder
    Ariel B Brown
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Am J Med Genet B Neuropsychiatr Genet 153:365-75. 2010
    ..Alterations in activation of attention and EF networks found previously to be involved in ADHD are likely influenced by SLC6A3 genotype. This genotype may contribute to heterogeneity of brain alterations found within ADHD samples...
  63. ncbi request reprint Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disorders
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
    Am J Psychiatry 161:547-55. 2004
    ..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children...
  64. doi request reprint Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?
    Aude Henin
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
    J Clin Psychiatry 70:1178-85. 2009
    ..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth...
  65. ncbi request reprint Impact of gender and age on executive functioning: do girls and boys with and without attention deficit hyperactivity disorder differ neuropsychologically in preteen and teenage years?
    Larry J Seidman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Dev Neuropsychol 27:79-105. 2005
    ..These findings suggest that executive dysfunctions are correlates of ADHD regardless of gender and age, at least through the late teen years...
  66. pmc Patterns and predictors of attention-deficit/hyperactivity disorder persistence into adulthood: results from the national comorbidity survey replication
    Ronald C Kessler
    Department of Health Care Policy, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Psychiatry 57:1442-51. 2005
    ..Despite growing interest in adult attention-deficit/hyperactivity disorder (ADHD), little is known about predictors of persistence of childhood cases into adulthood...
  67. pmc Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled study
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Drug Alcohol Depend 95:188-98. 2008
    ..Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use...
  68. ncbi request reprint Novel treatments for attention-deficit/hyperactivity disorder in children
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 63:16-22. 2002
    ....
  69. ncbi request reprint Gender effects on attention-deficit/hyperactivity disorder in adults, revisited
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:692-700. 2004
    ..This study reexamined gender differences in a large sample of adults with attention-deficit/hyperactivity disorder (ADHD)...
  70. ncbi request reprint Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ....
  71. ncbi request reprint A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder
    Eric Mick
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1021-7. 2003
    ..To this end, we conducted a meta-analysis of several studies that have employed the Child Behavior Checklist in the assessment of children with a diagnosis of bipolar disorder...
  72. ncbi request reprint Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youth
    Joseph Biederman
    Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
    J Nerv Ment Dis 192:607-14. 2004
    ..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention...
  73. ncbi request reprint Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  74. ncbi request reprint Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youth
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    J Affect Disord 83:207-14. 2004
    ..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample...
  75. ncbi request reprint Psychopathology in the offspring of parents with bipolar disorder: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
    Biol Psychiatry 58:554-61. 2005
    ..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
  76. ncbi request reprint Association between attention-deficit/hyperactivity disorder and bulimia nervosa: analysis of 4 case-control studies
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology at Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 67:351-4. 2006
    ..To identify whether there is an association between ADHD and bulimia nervosa, the authors systematically examined data from children and adults with and without ADHD...
  77. doi request reprint Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA, USA
    J Pediatr 152:394-9. 2008
    ..This secondary analysis evaluated the efficacy of modafinil in children and adolescents by subtype of attention-deficit/hyperactivity disorder (ADHD) using pooled data from 3 double-blind, placebo-controlled studies...
  78. ncbi request reprint Attention-deficit/hyperactivity disorder: a selective overview
    Joseph Biederman
    Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1215-20. 2005
    ..Such alterations in dopaminergic and noradrenergic function are apparently necessary for the clinical efficacy of pharmacologic treatments of ADHD...
  79. ncbi request reprint Temperamental correlates of disruptive behavior disorders in young children: preliminary findings
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
    Biol Psychiatry 51:563-74. 2002
    ..Our objective was to test the hypothesis that temperamental behavioral disinhibition measured in early childhood would be associated with disruptive behavior disorders...
  80. ncbi request reprint Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  81. ncbi request reprint Growth deficits and attention-deficit/hyperactivity disorder revisited: impact of gender, development, and treatment
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Pediatrics 111:1010-6. 2003
    ..Although the relationship between putative growth deficits and attention-deficit/hyperactivity disorder (ADHD) has been examined in boys, this issue has not been evaluated in girls...
  82. ncbi request reprint The clinical characteristics of unipolar vs. bipolar major depression in ADHD youth
    Janet Wozniak
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 82:S59-69. 2004
    ..To investigate the characteristics of unipolar vs. bipolar depression in youth using a sample of children referred for a study on attention deficit hyperactivity disorder (ADHD)...
  83. ncbi request reprint Diagnostic threshold for conduct disorder in girls and boys
    Alysa E Doyle
    Clinical and Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, ACC 725, 15 Parkman Street, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 191:379-86. 2003
    ..The current results support the possibility that differential rates of CD reflect actual differences in rates of antisocial behavior across gender...
  84. pmc Presenting ADHD symptoms, subtypes, and comorbid disorders in clinically referred adults with ADHD
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, YAW 6A, 55 Fruit Street, Boston, MA 02114, USA
    J Clin Psychiatry 70:1557-62. 2009
    ..Comorbidity among adults with ADHD is also of great interest due to the high rates of psychiatric comorbidity, which can lead to a more persistent ADHD among adults...
  85. pmc How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHD
    Joseph Biederman
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, USA
    Psychiatry Res 177:299-304. 2010
    ..Persistence of ADHD is associated with greater psychiatric comorbidity, familiality and functional impairments...
  86. ncbi request reprint Convergence between the Achenbach youth self-report and structured diagnostic interview diagnoses in ADHD and non-ADHD youth
    Robert Doyle
    Department of Psychiatry, Harvard Medical School, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:350-2. 2007
    ..These findings indicate that the YSR could serve as a rapid and cost-effective diagnostic tool to identify major psychopathology in high-risk adolescents...
  87. pmc A naturalistic 10-year prospective study of height and weight in children with attention-deficit hyperactivity disorder grown up: sex and treatment effects
    Joseph Biederman
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Pediatr 157:635-40, 640.e1. 2010
    ..To assess the effect of attention-deficit/hyperactivity disorder (ADHD) and its treatment on growth outcomes in children followed into adulthood...
  88. ncbi request reprint Investigation of parent-of-origin effects in ADHD candidate genes
    Jang Woo Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med Genet B Neuropsychiatr Genet 144:776-80. 2007
    ..Thus, we conclude that a substantial parent-of-origin effect is unlikely for these leading ADHD candidate genes...
  89. ncbi request reprint Which SSRI? A meta-analysis of pharmacotherapy trials in pediatric obsessive-compulsive disorder
    Daniel A Geller
    Pediatric OCD Problem, WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 160:1919-28. 2003
    ....
  90. ncbi request reprint Temporal association between childhood psychopathology and substance use disorders: findings from a sample of adults with opioid or alcohol dependency
    Amy L Hahesy
    Pediatric and Adult Psychopharmacology Clinic, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 15 Parkman Street, ACC 725, Boston, MA 02114, USA
    Psychiatry Res 109:245-53. 2002
    ..These findings further highlight the importance of targeting antecedent disorders for preventive and early intervention programs aimed at reducing the risk for SUD...
  91. ncbi request reprint Effects of stimulant medication on neuropsychological functioning in young adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Program of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 69:1150-6. 2008
    ..The main goal of this study was to evaluate the impact of stimulant medication on executive function deficits in a group of adolescents and young adults with attention-deficit/hyperactivity disorder (ADHD; DSM-III-R criteria)...
  92. ncbi request reprint Dopamine transporter gene and response to methylphenidate in attention-deficit/hyperactivity disorder
    Tatiana Roman
    Department of Genetics, Federal University of Rio Grande do Sul, Brazil
    Pharmacogenetics 12:497-9. 2002
    ..01). Our findings support an association between homozygosity for the 10-repeat allele at dopamine transporter gene locus and poor response to MPH...
  93. ncbi request reprint Correlates of ADHD among children in pediatric and psychiatric clinics
    Betsy Busch
    Department of Pediatrics, Tufts University School of Medicine in Boston, USA
    Psychiatr Serv 53:1103-11. 2002
    ..The authors sought to determine whether comorbidity and clinical correlates of ADHD differ among children in these two settings...
  94. pmc Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Drug Alcohol Depend 92:100-7. 2008
    ..001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD...
  95. ncbi request reprint Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary study
    Kevin M Antshel
    SUNY Upstate Medical University, NY, USA
    J Atten Disord 11:64-73. 2007
    ..Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD)...
  96. ncbi request reprint Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents
    Terri L Harpold
    Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
    J Affect Disord 88:19-26. 2005
    ..To examine the association between anxiety (ANX) and bipolar disorders (BPD) in a clinically referred pediatric sample...
  97. ncbi request reprint Is attention deficit hyperactivity disorder a valid diagnosis in the presence of high IQ? Results from the MGH Longitudinal Family Studies of ADHD
    Kevin M Antshel
    State University of New York Upstate Medical University, Department of Psychiatry and Behavioral Sciences, NY, USA
    J Child Psychol Psychiatry 48:687-94. 2007
    ..The aim of this study was to assess the validity of diagnosing attention deficit/hyperactivity disorder (ADHD) in high IQ children and to further characterize the clinical features associated with their ADHD...
  98. ncbi request reprint Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (Adderall XR), in children with ADHD
    James T McCracken
    Department of Psychiatry and Biobehavioral Sciences, Division of Child andAdolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 42:673-83. 2003
    ..Secondary objectives included examination of the time course, pharmacokinetic, and pharmacodynamic properties of SLI381...
  99. pmc Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
    ..Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder...
  100. ncbi request reprint Posttraumatic stress disorder symptoms following media exposure to tragic events: impact of 9/11 on children at risk for anxiety disorders
    Michael W Otto
    Massachusetts General Hospital and Harvard Medical School, MA, United States
    J Anxiety Disord 21:888-902. 2007
    ..Given the links between PTSD symptoms and viewing habits, parental monitoring of media exposure may be important for younger children...
  101. ncbi request reprint Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology
    Thomas J Spencer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Ambul Pediatr 7:73-81. 2007
    ....