J Biederman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Novel treatments for attention-deficit/hyperactivity disorder in children
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 63:16-22. 2002
  2. ncbi Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
  3. ncbi Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal study
    Michael C Monuteaux
    The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 37:1731-41. 2007
  4. ncbi Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Drug Alcohol Depend 92:100-7. 2008
  5. ncbi Disruptive behavior disorders in offspring of parents with major depression: associations with parental behavior disorders
    Dina R Hirshfeld-Becker
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, United States
    J Affect Disord 111:176-84. 2008
  6. ncbi Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
  7. ncbi Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
  8. ncbi Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
  9. ncbi Psychopharmacological interventions
    Joseph Biederman
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, 32 Fruit Street, YAW 6A, Boston, MA 02114, USA
    Child Adolesc Psychiatr Clin N Am 17:439-58, xi. 2008
  10. ncbi Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young
    J Biederman
    Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 10:185-92. 2000

Detail Information

Publications196 found, 100 shown here

  1. ncbi Novel treatments for attention-deficit/hyperactivity disorder in children
    Thomas J Spencer
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 63:16-22. 2002
    ....
  2. ncbi Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St, Boston, MA 02114, USA
    J Affect Disord 82:209-16. 2004
    ..This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias...
  3. ncbi Predictors, clinical characteristics, and outcome of conduct disorder in girls with attention-deficit/hyperactivity disorder: a longitudinal study
    Michael C Monuteaux
    The Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 37:1731-41. 2007
    ..However, it is unclear how these results extend to females. Our aim was to examine the predictors, clinical characteristics, and functional outcome of CD in a sample of female youth with and without ADHD...
  4. ncbi Familial transmission of derived phenotypes for molecular genetic studies of substance use disorders
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    Drug Alcohol Depend 92:100-7. 2008
    ..001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD...
  5. ncbi Disruptive behavior disorders in offspring of parents with major depression: associations with parental behavior disorders
    Dina R Hirshfeld-Becker
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, United States
    J Affect Disord 111:176-84. 2008
    ....
  6. ncbi Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children
    Eric Mick
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    BMC Psychiatry 9:2. 2009
    ..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)...
  7. ncbi Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  8. ncbi Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD
    Sherif Karama
    Department of Psychiatry, McGill University, Montreal, Canada
    BMC Psychiatry 8:45. 2008
    ..Executive function deficits are considered among the most important pathogenic pathways leading to ADHD and may index part of the heterogeneity in this disorder...
  9. ncbi Psychopharmacological interventions
    Joseph Biederman
    Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, 32 Fruit Street, YAW 6A, Boston, MA 02114, USA
    Child Adolesc Psychiatr Clin N Am 17:439-58, xi. 2008
    ..Cognitive and cognitive/behaviorally based psychotherapies combined with medication may play a role in treating behavioral and organizational issues and comorbid psychopathology...
  10. ncbi Therapeutic dilemmas in the pharmacotherapy of bipolar depression in the young
    J Biederman
    Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 10:185-92. 2000
    ..Because bipolar youth commonly come to clinical practice with depression, these results underscore the importance of assessing a lifetime history of bipolar disorder in making treatment decisions in depressed youth...
  11. ncbi Advances in the neurobiology of pediatric bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Yawkey Center for Outpatient Care - YAW-6A-6900, 32 Fruit Street, Boston, MA, USA
    Biol Psychiatry 58:515-6. 2005
  12. ncbi A simulated workplace experience for nonmedicated adults with and without ADHD
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, ACC 7, Boston, Massachusetts 02114, USA
    Psychiatr Serv 56:1617-20. 2005
    ..The results of this study suggest that ADHD among adults is associated with significant deficits in performance of workplace tasks, internal experiences, and external observations of core symptoms of ADHD...
  13. ncbi Effect of comorbid symptoms of oppositional defiant disorder on responses to atomoxetine in children with ADHD: a meta-analysis of controlled clinical trial data
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital Harvard Medical School, Yawkey Center for Outpatient Care 6A, Boston, MA 02114, USA
    Psychopharmacology (Berl) 190:31-41. 2007
    ....
  14. ncbi Differential effect of environmental adversity by gender: Rutter's index of adversity in a group of boys and girls with and without ADHD
    Joseph Biederman
    Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Psychiatry 159:1556-62. 2002
    ..This study examined the effect of gender in mediating the association between environmental adversity and the risk of attention deficit hyperactivity disorder (ADHD) and associated impairments...
  15. ncbi Can self-reported behavioral scales assess executive function deficits? A controlled study of adults with ADHD
    Joseph Biederman
    Pediatric Psychopharmacology and Adult ADHD Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:240-6. 2007
    ..Scores on the CBS above the 50th percentile identify adults with ADHD at significantly higher risk for functional morbidity beyond that conferred by the diagnosis of ADHD alone...
  16. ncbi Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 62:970-6. 2007
    ..Pharmacologically active d-amphetamine is released from lisdexamfetamine following oral ingestion...
  17. ncbi Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 159:36-42. 2002
    ..In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic...
  18. ncbi Methodological complexities in the diagnosis of major depression in youth: an analysis of mother and youth self-reports
    E B Braaten
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Child Adolesc Psychopharmacol 11:395-407. 2001
    ..To this end we evaluated whether morbidity and functional correlates on the diagnosis of MDD in youth vary by informant source...
  19. ncbi The Massachusetts General Hospital studies of gender influences on attention-deficit/hyperactivity disorder in youth and relatives
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 27:225-32. 2004
    ..These similar patterns provide further evidence for the idea that, when ADHD is diagnosed in girls it corresponds to the same disorder diagnosed in boys...
  20. ncbi Attention-deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Lancet 366:237-48. 2005
    ..Other investigations have also clarified the appropriate role of targeted psychosocial treatments in the context of ongoing pharmacotherapy...
  21. ncbi Current concepts in the validity, diagnosis and treatment of paediatric bipolar disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114 3139, USA
    Int J Neuropsychopharmacol 6:293-300. 2003
    ..The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis...
  22. ncbi Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorder
    J Biederman
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
    J Child Adolesc Psychopharmacol 9:247-56. 1999
    ..Although TCAs can be helpful in the management of ADHD children with manic symptoms, these drugs should be used with caution since they can also have a destabilizing effect on manic symptoms...
  23. ncbi Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources
    J Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Am Acad Child Adolesc Psychiatry 38:966-75. 1999
    ..The aim of this study was to examine clinical correlates of ADHD in females using comprehensive assessments in multiple domains of functioning...
  24. ncbi Impact of comorbidity in adults with attention-deficit/hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
    J Clin Psychiatry 65:3-7. 2004
    ..More studies are needed on the outcomes of adults with this disorder, especially cost-of-illness studies...
  25. ncbi Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder
    J Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Pediatrics 104:e20. 1999
    ..To assess the risk for substance use disorders (SUD) associated with previous exposure to psychotropic medication in a longitudinal study of boys with attention-deficit/hyperactivity disorder (ADHD)...
  26. ncbi Pharmacotherapy for attention-deficit/hyperactivity disorder (ADHD) decreases the risk for substance abuse: findings from a longitudinal follow-up of youths with and without ADHD
    Joseph Biederman
    Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 64:3-8. 2003
    ..Findings included confirmation that, in fact, stimulant therapy protected medicated ADHD patients against substance use disorder, which occurred at rates that were 3 to 4 times greater among people with untreated ADHD...
  27. ncbi Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: findings from a high-risk sample of siblings
    S Milberger
    Pediatric Pharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Child Psychol 27:352-8. 1998
    ..Moreover, they highlight the importance of programs aimed at smoking prevention in nonsmoking women and smoking cessation in smoking women of child-bearing age...
  28. ncbi Patterns of remission and symptom decline in conduct disorder: a four-year prospective study of an ADHD sample
    J Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Am Acad Child Adolesc Psychiatry 40:290-8. 2001
    ..To evaluate systematically the longitudinal course of conduct disorder (CD) in a sample of youths with attention-deficit hyperactivity disorder (ADHD) to determine the effects of a persistent course on outcome...
  29. ncbi Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type
    J Biederman
    Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:816-8. 2000
    ..Symptom decline in attention deficit hyperactivity disorder (ADHD) was examined with different definitions of remission...
  30. ncbi Evidence-based pharmacotherapy for attention-deficit hyperactivity disorder
    Joseph Biederman
    Massachusetts General Hospital, ACC 725, Boston, MA 02114, USA
    Int J Neuropsychopharmacol 7:77-97. 2004
    ..Further, more research is needed on the efficacy of treatment for comorbid ADHD, use of combined medications, and the combination of medication and psychosocial treatment...
  31. ncbi Family study of girls with attention deficit hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Psychiatry 157:1077-83. 2000
    ..To help fill this gap in the literature, the authors assessed the familial transmission of ADHD in families ascertained through girls...
  32. ncbi Neurocognitive impairment in unaffected siblings of youth with bipolar disorder
    A E Doyle
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
    Psychol Med 39:1253-63. 2009
    ..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis...
  33. ncbi A controlled study of behavioral inhibition in children of parents with panic disorder and depression
    J F Rosenbaum
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 157:2002-10. 2000
    ..Several lines of evidence suggest that behavioral inhibition is an index of anxiety proneness. The authors sought to replicate prior findings and examine the specificity of the association between behavioral inhibition and anxiety...
  34. ncbi Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD
    T J Spencer
    Pediatric Psychopharmacology Unit (WACC 725, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114-3117, USA
    Am J Psychiatry 158:611-7. 2001
    ....
  35. ncbi The long-term longitudinal course of oppositional defiant disorder and conduct disorder in ADHD boys: findings from a controlled 10-year prospective longitudinal follow-up study
    J Biederman
    Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 38:1027-36. 2008
    ....
  36. ncbi Efficacy of a mixed amphetamine salts compound in adults with attention-deficit/hyperactivity disorder
    T Spencer
    Pediatric Psychopharmacology Unit (ACC-725, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    Arch Gen Psychiatry 58:775-82. 2001
    ..More work is needed to evaluate the long-term effects of Adderall, or other amphetamine compounds, in the treatment of adults with ADHD...
  37. ncbi Patterns of psychopathology and dysfunction in high-risk children of parents with panic disorder and major depression
    J Biederman
    Pediatric Psychopharmacology Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:49-57. 2001
    ....
  38. ncbi Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions
    K L Lunetta
    Department of Biostatistical Science, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Am J Hum Genet 66:605-14. 2000
    ..We apply our methods to a sample of families with attention-deficit/hyperactivity disorder and provide examples of how covariates and gene-environment and gene-gene interactions can be incorporated...
  39. ncbi A controlled clinical trial of bupropion for attention deficit hyperactivity disorder in adults
    T E Wilens
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 158:282-8. 2001
    ..The authors report results from a controlled investigation to determine the anti-ADHD efficacy of bupropion in adult patients with DSM-IV ADHD...
  40. ncbi A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidity
    J Wozniak
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, USA
    Psychol Med 40:1079-88. 2010
    ..To estimate the spectrum of familial risk for psychopathology in first-degree relatives of children with unabridged DSM-IV bipolar-I disorder (BP-I)...
  41. ncbi Social impairment in girls with ADHD: patterns, gender comparisons, and correlates
    R W Greene
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Am Acad Child Adolesc Psychiatry 40:704-10. 2001
    ....
  42. ncbi Further evidence of association between two NET single-nucleotide polymorphisms with ADHD
    J W Kim
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mol Psychiatry 13:624-30. 2008
    ..This is the first time that identical alleles of NET from different studies were implicated, and thus our report provides further evidence that the NET gene is involved in the etiology of ADHD...
  43. ncbi Lack of association between parental alcohol or drug addiction and behavioral inhibition in children
    J Biederman
    Department of Psychiatry Unit of Clinical Psychopharmacology, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1731-3. 2001
    ..CONCLUSIONS: These results are not consistent with the hypothesis linking behavioral inhibition to addictions...
  44. ncbi Genetic risk for conduct disorder symptom subtypes in an ADHD sample: specificity to aggressive symptoms
    Michael C Monuteaux
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 48:757-64. 2009
    ..The aim of this study was to examine the role of the COMT and SLC6A4 genes in the risk for CD and its symptomatic subtypes in the context of ADHD...
  45. ncbi Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study
    Joseph Biederman
    Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1511-8. 2008
    ..Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies...
  46. ncbi Deficient emotional self-regulation and pediatric attention deficit hyperactivity disorder: a family risk analysis
    J Biederman
    Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Yawkey Center for Outpatient Care, Boston, MA 02114 3139, USA
    Psychol Med 42:639-46. 2012
    ..Family studies provide a method of clarifying the co-occurrence of clinical features, but no family studies have yet addressed ADHD and DESR in children...
  47. ncbi Diagnostic efficiency of neuropsychological test scores for discriminating boys with and without attention deficit-hyperactivity disorder
    A E Doyle
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:477-88. 2000
    ..The prognostic implications of variable neuropsychological deficits in children with ADHD require further investigation...
  48. ncbi Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disorders
    T J Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 49:1062-70. 2001
    ..What was previously considered refractory ADHD, oppositionality, aggression, and conduct disorder may respond after mood stabilization. We review these issues in this article...
  49. ncbi Learning disabilities and executive dysfunction in boys with attention-deficit/hyperactivity disorder
    L J Seidman
    Department of Psychiatry, Harvard Medical School at Massachusetts General Hospital, Boston 02114, USA
    Neuropsychology 15:544-56. 2001
    ..These data indicate that comorbid LD, especially arithmetic disability, significantly increases the severity of executive function impairment in ADHD...
  50. ncbi Is oppositional defiant disorder a meaningful diagnosis in adults? Results from a large sample of adults with ADHD
    Theresa Harpold
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:601-5. 2007
    ..A better understanding of the course, phenomenology, and clinical significance of ODD in adults is needed to better understand therapeutic approaches for this disorder...
  51. ncbi Parsing the familiality of oppositional defiant disorder from that of conduct disorder: a familial risk analysis
    Carter R Petty
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Psychiatr Res 43:345-52. 2009
    ..Family risk analysis can provide an improved understanding of the association between attention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD), attending to the comorbidity with conduct disorder (CD)...
  52. ncbi Psychopathology in the young offspring of parents with bipolar disorder: a controlled pilot study
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, 185 Alewife Brook Parkway, Suite 2100, Cambridge, MA 02138, USA
    Psychiatry Res 145:155-67. 2006
    ..Results support the hypotheses of elevated behavior, anxiety, and mood disorders among offspring at risk for bipolar disorder, and suggest that this psychopathology is already evident in early childhood...
  53. ncbi Assessing symptoms of attention deficit hyperactivity disorder in children and adults: which is more valid?
    S V Faraone
    Massachusetts General Hospital, Boston 02114, USA
    J Consult Clin Psychol 68:830-42. 2000
    ..They do not support the idea that parents of ADHD children are biased to report ADHD symptoms in themselves because of their exposure to an ADHD child...
  54. ncbi A pilot controlled clinical trial of ABT-418, a cholinergic agonist, in the treatment of adults with attention deficit hyperactivity disorder
    T E Wilens
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Psychiatry 156:1931-7. 1999
    ..Recent reports have suggested the potential usefulness of cholinergic agents for ADHD. To this end, the authors completed a controlled study of ABT-418, a novel cholinergic activating agent, for the treatment of adults with ADHD...
  55. ncbi A family study of psychiatric comorbidity in girls and boys with attention-deficit/hyperactivity disorder
    S V Faraone
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
    Biol Psychiatry 50:586-92. 2001
    ..Although this is consistent with prior work suggesting more similarities than differences in the nature of psychiatric comorbidity in ADHD boys and girls, we cannot make strong conclusions, owing to the possibility of cohort effects...
  56. ncbi Risperidone treatment for juvenile bipolar disorder: a retrospective chart review
    J A Frazier
    Child Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Am Acad Child Adolesc Psychiatry 38:960-5. 1999
    ..To investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania...
  57. ncbi Moderating effects of major depression on patterns of comorbidity in patients with panic disorder
    Joseph Biederman
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatry Res 126:143-9. 2004
    ..Overanxious disorder was associated with both panic disorder and major depression. Major depression has important moderating effects on patterns of comorbidity of panic disorder in referred adults...
  58. ncbi Gender effects on attention-deficit/hyperactivity disorder in adults, revisited
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:692-700. 2004
    ..These results bear striking similarities to findings reported in pediatric samples, supporting the validity of ADHD and stressing the importance of identifying and treating the disorder in adulthood...
  59. ncbi Lack of association between behavioral inhibition and psychosocial adversity factors in children at risk for anxiety disorders
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Cambridge, MA 02138, USA
    Am J Psychiatry 161:547-55. 2004
    ..To explore whether this association was mediated by environmental factors, the authors examined associations between psychosocial adversity variables and behavioral inhibition in this group of children...
  60. ncbi The influence of sex on the course and psychiatric correlates of ADHD from childhood to adolescence: a longitudinal study
    Michael C Monuteaux
    Clinical and Research Programs in Pediatric Psychiatry and Adult ADHD, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
    J Child Psychol Psychiatry 51:233-41. 2010
    ..The purpose of this study was to examine the effect of sex on the course and psychiatric correlates of ADHD from childhood into adolescence...
  61. ncbi A preliminary meta-analysis of the child behavior checklist in pediatric bipolar disorder
    Eric Mick
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:1021-7. 2003
    ..CONCLUSIONS: While there was a significant heterogeneity in estimates between studies, a consistent pattern of elevations in inattention/hyperactivity, depression/anxiety, and aggression was identified...
  62. ncbi Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onset
    Eric Mick
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:453-62. 2003
    ..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder...
  63. ncbi Phenomenology of childhood psychosis: findings from a large sample of psychiatrically referred youth
    Joseph Biederman
    Clinical Program in Pediatric Psychopharmacology and Adult ADHD, Massachusetts General Hospital, Boston, USA
    J Nerv Ment Dis 192:607-14. 2004
    ..In conclusion, childhood-onset psychosis in referred youth is common and highly morbid. It remains an important topic of research deserving full clinical and scientific attention...
  64. ncbi Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition
    Jordan W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 54:1376-81. 2003
    ..Transgenic mice overexpressing CRH exhibit BI-like behaviors, implicating this gene in the development of the phenotype...
  65. ncbi How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates
    Janet Wozniak
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 58:583-8. 2005
    ..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms...
  66. ncbi Executive functioning in offspring at risk for depression and anxiety
    Jamie A Micco
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 85 Alewife Brook Parkway, Suite 2000, Cambridge, MA 02138, USA
    Depress Anxiety 26:780-90. 2009
    ..Studies of at-risk offspring can shed light on this question by examining whether EFDs characterize children at high risk for depression and anxiety who are not yet symptomatic...
  67. ncbi Antecedents to panic disorder in nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 67:1179-86. 2006
    ..The current study examined both childhood and adult comorbid disorders as potential antecedent disorders to panic disorder in a large sample of nonreferred adults...
  68. ncbi An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertension
    Timothy E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:696-702. 2006
    ....
  69. ncbi Developmental trajectories of anxiety disorders in offspring at high risk for panic disorder and major depression
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    Psychiatry Res 153:245-52. 2007
    ....
  70. ncbi Characterizing non-OCD anxiety disorders in psychiatrically referred children and adolescents
    Paul Hammerness
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02138, United States
    J Affect Disord 105:213-9. 2008
    ..To characterize childhood and adolescent anxiety disorders in a psychiatric clinic...
  71. ncbi A controlled longitudinal 5-year follow-up study of children at high and low risk for panic disorder and major depression
    Joseph Biederman
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 36:1141-52. 2006
    ..To evaluate the longitudinal course of psychiatric disorders in children of parents with panic disorder (PD) and major depression (MD) as they transition through the period of risk from childhood into adolescence...
  72. ncbi Separating attention deficit hyperactivity disorder and learning disabilities in girls: a familial risk analysis
    A E Doyle
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1666-72. 2001
    ....
  73. ncbi Long-term stability of the Child Behavior Checklist in a clinical sample of youth with attention deficit hyperactivity disorder
    J Biederman
    Harvard Medical School, Massachusetts General Hospital and McLean Hospital, Boston, MA, USA
    J Clin Child Psychol 30:492-502. 2001
    ..These results support the informativeness of the CBCL as a useful measure of longitudinal course in clinical samples of youth with ADHD...
  74. ncbi Genetic association analysis of behavioral inhibition using candidate loci from mouse models
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Med Genet 105:226-35. 2001
    ..This study illustrates the potential utility of using candidate genes derived from mouse models to dissect the genetic basis of BI, a possible intermediate phenotype for panic and phobic disorders...
  75. ncbi Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Clin Psychiatry 62:10-5. 2001
    ..Treatment requires a combined pharmacotherapy approach to address issues of comorbidity. Atypical antipsychotic medications have provided promising treatment results, but additional controlled clinical trials are needed...
  76. ncbi Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorder
    J Wozniak
    Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    J Affect Disord 64:121-31. 2001
    ..Furthermore, they suggest that the comorbid condition of CD+BPD may be a distinct nosological entity. This suggests that clinicians treating CD or BPD children should consider the treatment implications of this comorbid condition...
  77. ncbi Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescents
    Timothy E Wilens
    Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Arch Pediatr Adolesc Med 162:916-21. 2008
    ..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
  78. ncbi Effects of parental anxiety disorders in children at high risk for panic disorder: a controlled study
    Joseph Biederman
    Massachusetts General Hospital, Pediatric Psychopharmacology Research, Boston, MA 02114, United States
    J Affect Disord 94:191-7. 2006
    ..To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring...
  79. ncbi Modafinil improves symptoms of attention-deficit/hyperactivity disorder across subtypes in children and adolescents
    Joseph Biederman
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA, USA
    J Pediatr 152:394-9. 2008
    ..This secondary analysis evaluated the efficacy of modafinil in children and adolescents by subtype of attention-deficit/hyperactivity disorder (ADHD) using pooled data from 3 double-blind, placebo-controlled studies...
  80. ncbi Familial risk analyses of attention deficit hyperactivity disorder and substance use disorders
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
    Am J Psychiatry 165:107-15. 2008
    ..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature...
  81. ncbi Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, USA
    Biol Psychiatry 59:258-64. 2006
    ....
  82. ncbi Psychopathology in the offspring of parents with bipolar disorder: a controlled study
    Aude Henin
    Pediatric Psychopharmacology Unit and Harvard Bipolar Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02138, USA
    Biol Psychiatry 58:554-61. 2005
    ..To examine the risk for psychopathology in offspring at risk for bipolar disorder and the course of psychiatric disorders in these youth...
  83. ncbi Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youth
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    J Affect Disord 83:207-14. 2004
    ..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample...
  84. ncbi Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescents
    Terri L Harpold
    Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
    J Affect Disord 88:19-26. 2005
    ..Considering the morbidity and dysfunction as well as the differing therapeutic needs associated with bipolar and anxiety symptomatology, appropriate therapeutic approaches will be needed for the management of youth with this comorbidity...
  85. ncbi Attention-deficit/hyperactivity disorder: a selective overview
    Joseph Biederman
    Department of Pediatric Psychopharmacology Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 57:1215-20. 2005
    ..Such alterations in dopaminergic and noradrenergic function are apparently necessary for the clinical efficacy of pharmacologic treatments of ADHD...
  86. ncbi Effect of candidate gene polymorphisms on the course of attention deficit hyperactivity disorder
    Joseph Biederman
    Pediatric Psychopharmacology Department, Massachusetts General Hospital, Boston, MA, USA
    Psychiatry Res 170:199-203. 2009
    ..94) and 5HTTLPR long allele. Our findings suggest that the DRD4 7-repeat allele is associated with a more persistent course of ADHD...
  87. ncbi Association between attention-deficit/hyperactivity disorder and bulimia nervosa: analysis of 4 case-control studies
    Craig B H Surman
    Clinical and Research Program in Pediatric Psychopharmacology at Massachusetts General Hospital and Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 67:351-4. 2006
    ..If confirmed, this association between bulimia nervosa and ADHD could have important clinical and therapeutic implications...
  88. ncbi Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder
    Timothy E Wilens
    Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:253-9. 2005
    ..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse...
  89. ncbi Childhood antecedents to panic disorder in referred and nonreferred adults
    Joseph Biederman
    Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 15:549-61. 2005
    ..We used a recursive partitioning method to examine antecedent childhood anxiety disorders in large samples of referred and nonreferred subjects with and without panic disorder...
  90. ncbi Temperamental correlates of disruptive behavior disorders in young children: preliminary findings
    Dina R Hirshfeld-Becker
    Pediatric Psychopharmacology Unit, Department of Psychiatry, Massachusetts General Hospital, Building 149, 13th Street, Boston, MA 02129, USA
    Biol Psychiatry 51:563-74. 2002
    ..Longitudinal studies using behavioral assessments of behavioral disinhibition are needed to confirm these findings...
  91. ncbi Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research Program
    Joseph Biederman
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 53:952-60. 2003
    ..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD...
  92. ncbi Re-examining comorbidity of Obsessive Compulsive and Attention-Deficit Hyperactivity Disorder using an empirically derived taxonomy
    D A Geller
    Pediatric OCD Clinic, Massachusetts General Hospital, WACC 725, 15 Parkman Street, Boston, MA 02114, USA
    Eur Child Adolesc Psychiatry 13:83-91. 2004
    ....
  93. ncbi An open-label, dose-ranging study of atomoxetine in children with attention deficit hyperactivity disorder
    T Spencer
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    J Child Adolesc Psychopharmacol 11:251-65. 2001
    ..These results support additional controlled trials of atomoxetine in cases of pediatric ADHD...
  94. ncbi Further evidence of association between behavioral inhibition and social anxiety in children
    J Biederman
    Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
    Am J Psychiatry 158:1673-9. 2001
    ..1 versus 50.8). CONCLUSIONS: This study adds to the growing literature suggesting an association between behavioral inhibition and social anxiety disorder and an inverse relationship between inhibition and disruptive behavior disorders...
  95. ncbi Methylphenidate in treatment of adults with Attention-Deficit/Hyperactivity Disorder
    J Biederman
    Pediatric Psychopharmacology Unit, Child Psychiatry Service, Massachusetts General Hospital, Boston 02114, USA
    J Atten Disord 6:S101-7. 2002
    ..Future research is needed to evaluate the safety and efficacy of long-term treatment with methylphenidate (MPH)...
  96. ncbi Is bipolar disorder a risk for cigarette smoking in ADHD youth?
    T E Wilens
    Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
    Am J Addict 9:187-95. 2000
    ..These data coupled with the literature strongly suggest that juveniles with BPD need to be carefully monitored for the early initiation of cigarette smoking and substance abuse...
  97. ncbi Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions
    J W Smoller
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Med Genet 105:195-206. 2001
    ..05, P = 0.035). While these linkage results are merely suggestive, this study illustrates the potential advantages of using mouse gene-mapping results and exploring alternative phenotype definitions in linkage studies of anxiety disorder...
  98. ncbi New insights into the comorbidity between ADHD and major depression in adolescent and young adult females
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 47:426-34. 2008
    ..The main aim of this study was to evaluate the association between attention-deficit/hyperactivity disorder (ADHD) and major depression (MD) in adolescent and young adult females...
  99. ncbi The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysis
    Joseph Biederman
    Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 70:732-40. 2009
    ..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder...
  100. ncbi Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family study
    Timothy E Wilens
    Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
    J Clin Psychiatry 70:259-65. 2009
    ..However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear...
  101. ncbi A comparison of once-daily and divided doses of modafinil in children with attention-deficit/hyperactivity disorder: a randomized, double-blind, and placebo-controlled study
    Joseph Biederman
    Department of Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
    J Clin Psychiatry 67:727-35. 2006
    ....