Rebecca A Betensky

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Influence of unrecognized molecular heterogeneity on randomized clinical trials
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    J Clin Oncol 20:2495-9. 2002
  2. pmc A latent class model with hidden Markov dependence for array CGH data
    Stacia M DeSantis
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, South Carolina 29403, USA
    Biometrics 65:1296-305. 2009
  3. pmc Histology-based expression profiling yields novel prognostic markers in human glioblastoma
    Shumin Dong
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
    J Neuropathol Exp Neurol 64:948-55. 2005
  4. doi request reprint Identification of tissue contamination by polymorphic deletion probe fluorescence in situ hybridization
    Sarah Chiang
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Harvard School of Public Health, Boston, MA 02114, USA
    Am J Surg Pathol 36:1464-71. 2012
  5. ncbi request reprint A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations
    David A Engler
    Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, and Massachusetts General Hospital, Department of Pathology, Charlestown 02129, USA
    Biostatistics 7:399-421. 2006
  6. ncbi request reprint Genetic analyses for predictors of radiation response in glioblastoma
    Helen A Shih
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 63:704-10. 2005
  7. pmc High-dose methotrexate for elderly patients with primary CNS lymphoma
    Jay Jiguang Zhu
    Department of Neurology, Tufts New England Medical Center, Boston, MA, USA
    Neuro Oncol 11:211-5. 2009
  8. doi request reprint Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 20:810-7. 2011
  9. ncbi request reprint Age-dependent prognostic effects of genetic alterations in glioblastoma
    Tracy T Batchelor
    Molecular Neuro oncology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 10:228-33. 2004
  10. ncbi request reprint Feature-specific penalized latent class analysis for genomic data
    E Andres Houseman
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA
    Biometrics 62:1062-70. 2006

Detail Information

Publications79

  1. ncbi request reprint Influence of unrecognized molecular heterogeneity on randomized clinical trials
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    J Clin Oncol 20:2495-9. 2002
    ..Despite this reliance on histology and the assumption that histology defines the disease, underlying molecular heterogeneity likely differentiates among patients' outcomes...
  2. pmc A latent class model with hidden Markov dependence for array CGH data
    Stacia M DeSantis
    Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, Charleston, South Carolina 29403, USA
    Biometrics 65:1296-305. 2009
    ..We demonstrate our technique on a study of brain tumors, for which our approach is capable of identifying subsets of tumors with different genomic profiles, and differentiates classes by survival much better than unsupervised methods...
  3. pmc Histology-based expression profiling yields novel prognostic markers in human glioblastoma
    Shumin Dong
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, 02129, USA
    J Neuropathol Exp Neurol 64:948-55. 2005
    ....
  4. doi request reprint Identification of tissue contamination by polymorphic deletion probe fluorescence in situ hybridization
    Sarah Chiang
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Harvard School of Public Health, Boston, MA 02114, USA
    Am J Surg Pathol 36:1464-71. 2012
    ....
  5. ncbi request reprint A pseudolikelihood approach for simultaneous analysis of array comparative genomic hybridizations
    David A Engler
    Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, and Massachusetts General Hospital, Department of Pathology, Charlestown 02129, USA
    Biostatistics 7:399-421. 2006
    ..Software for this approach is available at http://www.biostat.harvard.edu/ approximately betensky/papers.html...
  6. ncbi request reprint Genetic analyses for predictors of radiation response in glioblastoma
    Helen A Shih
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 63:704-10. 2005
    ..It has been previously reported that epidermal growth factor receptor (EGFR) gene amplification and TP53 mutation correlate with the response to RT in patients with glioblastoma...
  7. pmc High-dose methotrexate for elderly patients with primary CNS lymphoma
    Jay Jiguang Zhu
    Department of Neurology, Tufts New England Medical Center, Boston, MA, USA
    Neuro Oncol 11:211-5. 2009
    ..High-dose MTX should be considered as a feasible treatment option in elderly patients with PCNSL...
  8. doi request reprint Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    Matija Snuderl
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cancer Cell 20:810-7. 2011
    ..The stable coexistence of different clones within the same tumor will have important clinical implications for tumor resistance to targeted therapies...
  9. ncbi request reprint Age-dependent prognostic effects of genetic alterations in glioblastoma
    Tracy T Batchelor
    Molecular Neuro oncology Laboratory, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 10:228-33. 2004
    ..Although the genetic alterations in glioblastoma have been well characterized, reports regarding their prognostic effects have been inconsistent...
  10. ncbi request reprint Feature-specific penalized latent class analysis for genomic data
    E Andres Houseman
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA
    Biometrics 62:1062-70. 2006
    ..For this data set, the existing unpenalized latent class methodology does not produce estimates. Additionally, we show that posterior classes obtained from this method are associated with survival for these patients...
  11. pmc Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment
    Daniel P Cahill
    Molecular Pathology Unit, Neurosurgical Service, Brain Tumor Center, and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 13:2038-45. 2007
    ..However, the extent of involvement of MSH6 in glioblastoma is unknown. We sought to determine the overall frequency and clinical relevance of MSH6 alterations in glioblastomas...
  12. pmc Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss
    Matija Snuderl
    Pathology Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114 2698, USA
    Clin Cancer Res 15:6430-7. 2009
    ..The purpose of this study was to evaluate the prognostic significance of polysomy of chromosomes 1 and 19 in the setting of 1p/19q codeletion...
  13. pmc The SIST-M: predictive validity of a brief structured clinical dementia rating interview
    Olivia I Okereke
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Alzheimer Dis Assoc Disord 26:225-31. 2012
    ....
  14. ncbi request reprint Testing goodness of fit of a uniform truncation model
    Micha Mandel
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 63:405-12. 2007
    ..In this article, we introduce several goodness-of-fit tests for the truncation distribution and investigate their performance in the presence of censored event times using simulation. We demonstrate the use of our tests on two data sets...
  15. ncbi request reprint The volume-outcome relationship: don't believe everything you see
    Caprice K Christian
    Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    World J Surg 29:1241-4. 2005
    ..This paper investigates methodological limitations of the volume-outcome relationship. A brief overview of quality measurement is followed by a discussion of two important aspects of the relationship...
  16. ncbi request reprint Hospital volume versus outcome: an unusual example of bivariate association
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 62:598-604. 2006
    ..The frequently preferred nonparametric measures of bivariate association are inappropriate as they are unable to discriminate between correlation and dependence...
  17. pmc Analysis of familial aggregation studies with complex ascertainment schemes
    Abigail G Matthews
    MGH Biostatistics Center, Boston, MA 02114, USA
    Stat Med 27:5076-92. 2008
    ..We propose adjusting for complex ascertainment schemes through a joint model for the outcomes of disease and ascertainment. This approach improves upon previous simplifying assumptions regarding the ascertainment process...
  18. pmc Application of signal processing techniques for estimating regions of copy number variations in human meningioma DNA
    Catherine Stamoulis
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:6973-6. 2009
    ..The residual signals from this process were analyzed to identify disease-related copy number changes. We were able to identify distinct local changes at different chromosomes in patients with recurrent versus primary meningiomas...
  19. pmc Genome-wide comparison of paired fresh frozen and formalin-fixed paraffin-embedded gliomas by custom BAC and oligonucleotide array comparative genomic hybridization: facilitating analysis of archival gliomas
    Gayatry Mohapatra
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Acta Neuropathol 121:529-43. 2011
    ..In combination, these advances should facilitate genome-wide analysis of rare, small and/or histologically heterogeneous gliomas from FFPE tissues...
  20. pmc Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease
    Joanne Clark
    Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Room CLS 638, Boston, MA 02215, USA
    BMC Med Genet 12:69. 2011
    ..In the current study we analyzed whether rs8192678 or other PGC-1α SNPs affect PD risk or age of onset, singularly or in association with the A10398G SNP...
  21. ncbi request reprint Analysis of clonal immunoglobulin heavy chain rearrangements in ocular lymphoma
    Joachim M Baehring
    Brain Tumor Center, Department of Neurology, Massachusetts General Hospital, 100 Blossom Street, Boston, MA 02114, USA
    Cancer 104:591-7. 2005
    ..The analysis of immunoglobulin heavy chain (IgH) gene rearrangements (AIGHR) was used as an adjunct to cytopathology and flow cytometry in systemic lymphoma. In IOL, the sensitivity and specificity of AIGHR are unknown...
  22. ncbi request reprint The use of frailty hazard models for unrecognized heterogeneity that interacts with treatment: considerations of efficiency and power
    Yi Li
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 58:232-6. 2002
    ..Further, there may be a substantial loss of power in the presence of the frailty with or without an interaction with treatment...
  23. ncbi request reprint AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
    Markus J Riemenschneider
    Department of Pathology, Molecular Neuro oncology Laboratory, Molecular Pathology Unit and Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Cancer Res 66:5618-23. 2006
    ..Moreover, they suggest that downstream p-AKT effects are primarily mediated by S6 kinase signaling, thus enhancing proliferation rather than inhibiting apoptosis...
  24. pmc In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation
    Markus J Riemenschneider
    Department of Pathology, Molecular Neuro oncology Laboratory, 149 7151, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Am J Pathol 167:1379-87. 2005
    ..Thus, FAK may act in glioblastoma as a downstream target of growth factor signaling, with integrins enhancing the impact of such signaling in the tumor microenvironment...
  25. ncbi request reprint Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes
    Joachim M Baehring
    Pappas Center for Neuro Oncology, Yawkey 9E, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neurol Sci 247:208-16. 2006
    ..To determine the sensitivity and specificity of clonal immunoglobulin heavy chain gene rearrangement (IGHR) analysis in the distinction of benign and malignant lymphoproliferative diseases...
  26. ncbi request reprint Treatment of relapsed central nervous system lymphoma with high-dose methotrexate
    Scott R Plotkin
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 10:5643-6. 2004
    ..The optimal management of these patients has not been determined. We performed a multicenter, retrospective study of high-dose methotrexate in patients with relapsed central nervous system lymphoma...
  27. ncbi request reprint The borderline or weakly positive Hybrid Capture II HPV test: a statistical and comparative (PCR) analysis
    Jerome M Federschneider
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Mass 02115, USA
    Am J Obstet Gynecol 191:757-61. 2004
    ..Recent studies have hypothesized that laboratory contamination may influence interpretation of Hybrid Capture II (HCII) human papillomavirus (HPV) detection assay values...
  28. ncbi request reprint Tests of association under misclassification: application to histological sampling in oncology
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    Stat Med 26:4808-16. 2007
    ..In this study, calcification, a feature related to the imaging parameters, was potentially misclassified as not present...
  29. pmc Statistical considerations for immunohistochemistry panel development after gene expression profiling of human cancers
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Ave, Boston, Massachusetts 02115, USA
    J Mol Diagn 7:276-82. 2005
    ..Simulation approaches for computing power and sample size that are based on existing gene expression data provide a powerful tool for efficient design of follow-up genomic studies...
  30. ncbi request reprint A penalized latent class model for ordinal data
    Stacia M DeSantis
    Department of Biostatistics, Harvard University, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 9:249-62. 2008
    ..We illustrate our methodology in a study of schwannoma, a peripheral nerve sheath tumor, that included 3 clinical subtypes and 23 ordinal histological measures...
  31. ncbi request reprint Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
    Catherine L Nutt
    Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 63:1602-7. 2003
    ..These data suggest that class prediction models, based on defined molecular profiles, classify diagnostically challenging malignant gliomas in a manner that better correlates with clinical outcome than does standard pathology...
  32. pmc Prognostic value of tumor microinvasion and metalloproteinases expression in intracranial pediatric ependymomas
    Matija Snuderl
    Pathology Service, Massachusetts General Hospital, Boston, MA 02114, USA
    J Neuropathol Exp Neurol 67:911-20. 2008
    ....
  33. ncbi request reprint A computationally simple bivariate survival estimator for efficacy and safety
    Denise Scholtens
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Lifetime Data Anal 12:365-87. 2006
    ..In addition, we derive its covariance with respect to calendar time of analysis, allowing for its use in sequential studies...
  34. ncbi request reprint Multivariate logistic regression for familial aggregation in age at disease onset
    Abigail G Matthews
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Lifetime Data Anal 13:191-209. 2007
    ..Properties of this model are explored in simulation studies, and the method is applied to a large family study of cancer conducted by the National Cancer Institute-sponsored Cancer Genetics Network (CGN)...
  35. doi request reprint Genetic determinants of hearing loss associated with vestibular schwannomas
    Konstantina M Stankovic
    Department of Otolaryngology and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Otol Neurotol 30:661-7. 2009
    ..The severity of hearing loss (HL) associated with vestibular schwannomas (VSs) is influenced by genes expressed by the VSs...
  36. ncbi request reprint Analysis of a molecular genetic neuro-oncology study with partially biased selection
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Biostatistics 4:167-78. 2003
    ..Here we examine approaches for utilizing the entire study population, as well as the assumptions required for doing so. We illustrate that there are both costs and benefits to using the 25 selected patients...
  37. ncbi request reprint DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis
    Hikaru Sasaki
    Molecular Neuro Oncology and Pathology Laboratories, Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Cancer Res 62:1790-6. 2002
    ..These data suggest that DMBT1 polymorphisms are not likely primary targets of 10q loss in malignant gliomas and do not support a major role for DMBT1 in gliomagenesis...
  38. ncbi request reprint A local likelihood proportional hazards model for interval censored data
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts 02115, USA
    Stat Med 21:263-75. 2002
    ..For estimation, we extend the modified EM algorithm suggested by Betensky, Lindsey, Ryan and Wand. We illustrate the method with data on times to deterioration of breast cosmeses and HIV-1 infection rates among haemophiliacs...
  39. ncbi request reprint Family history of diabetes is a major determinant of endothelial function
    Allison B Goldfine
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    J Am Coll Cardiol 47:2456-61. 2006
    ..We evaluated whether endothelial dysfunction was present in nondiabetic persons with a family history (FH) of diabetes and assessed its relationship with insulin resistance and atherosclerosis risk factors...
  40. ncbi request reprint Testing for dependence between failure time and visit compliance with interval-censored data
    Rebecca A Betensky
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Biometrics 58:58-63. 2002
    ..We illustrate the method with data from an AIDS study and we investigate the power of the test through a simulation study...
  41. pmc Primary leptomeningeal lymphoma: International Primary CNS Lymphoma Collaborative Group report
    Jennie W Taylor
    From the Massachusetts General Hospital J W T, T B, R A B, Boston Mayo Clinic E P F, B P O, Rochester, MN Hadassah Hebrew University Medical Center T S, Jerusalem, Israel Memorial Sloan Kettering A O, L D, New York, NY Yale University J B, New Haven, CT Saitama Medical University R N, Japan Kings College Hospital F P, London, UK University of Washington M C, Seattle LOC National Expert Center K H X, A G A, APHP, UPMC, Pitie Salpetriere, Paris Centre Leon Berard J Y B, Lyon, France Campus Benjamin Franklin A K, Charite Universitatsmedizin Berlin, Germany Department of Biostatistics R A B, Harvard School of Public Health, Boston, MA and University of Virginia M B S L, D S, Charlottesville
    Neurology 81:1690-6. 2013
    ..To evaluate clinical presentation, optimal diagnostic evaluation and treatment, and outcome in primary leptomeningeal lymphoma, a rare form of primary CNS lymphoma without parenchymal or systemic involvement...
  42. pmc An analysis of adaptive design variations on the sequential parallel comparison design for clinical trials
    Michael Y Mi
    Harvard MIT Division of Health Sciences and Technology, Harvard Medical School, Harvard University, Boston, MA, USA
    Clin Trials 10:207-15. 2013
    ..The SPCD theoretically has the potential to reduce the sample-size requirement for a clinical trial and to simultaneously enrich the study population to be less responsive to the placebo...
  43. pmc Imperfect gold standards for biomarker evaluation
    Sushrut S Waikar
    aRenal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Trials 10:696-700. 2013
    ..Novel tubular injury biomarkers may revolutionize the diagnosis of AKI; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard...
  44. pmc Calcineurin activation causes retinal ganglion cell degeneration
    Juan Qu
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 18:2828-38. 2012
    ..In this study, we tested whether calcineurin activation by itself, even in the absence of ocular hypertension, is sufficient to cause RGC degeneration...
  45. pmc Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy
    Gregory A Dierksen
    Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Neurol 68:545-8. 2010
    ..0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition...
  46. ncbi request reprint Effects of unmeasured heterogeneity in the linear transformation model for censored data
    Bin Zhang
    Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA
    Lifetime Data Anal 12:191-203. 2006
    ..Numerical studies under a proportional odds model show that the loss of efficiency and the loss of power can be substantial when the heterogeneity, as embodied by a frailty, is ignored...
  47. pmc Bone involvement predicts poor outcome in atypical meningioma
    Darlene Gabeau-Lacet
    Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Neurosurg 111:464-71. 2009
    ..The authors identified clinical features associated with progression and death in atypical meningioma (AM)...
  48. pmc A novel signal processing approach for the detection of copy number variations in the human genome
    Catherine Stamoulis
    Department of Radiology, Harvard School of Public Health, Boston, MA 02115, USA
    Bioinformatics 27:2338-45. 2011
    ..Therefore, robust methodologies are needed for their detection. Furthermore, for meaningful identification of pathological CNVs, estimation of normal allelic aberrations is necessary...
  49. pmc Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints
    Eric A Macklin
    MGH BiostatisticsCenter, Massachusetts General Hospital, 50 Staniford St, Boston, MA 02114, USA
    J Alzheimers Dis 36:475-86. 2013
    ..The approach tested here might improve efficiency of prodromal AD trials using other potential measures and could be generalized to other diseases with long prodromal phases. ..
  50. pmc Imperfect gold standards for kidney injury biomarker evaluation
    Sushrut S Waikar
    Brigham and Women s Hospital, Renal Division, 75 Francis Street, MRB 4, Boston, MA 02115, USA
    J Am Soc Nephrol 23:13-21. 2012
    ..The results of this study suggest that small changes in serum creatinine alone should not be used to define acute kidney injury in biomarker or interventional studies...
  51. ncbi request reprint BCL-6 expression predicts improved survival in patients with primary central nervous system lymphoma
    Kristina M Braaten
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 9:1063-9. 2003
    ..v. high-dose methotrexate therapy...
  52. pmc Diagnosis of hydatidiform moles by polymorphic deletion probe fluorescence in situ hybridization
    Sarah Chiang
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Mol Diagn 13:406-15. 2011
    ..PDP FISH can be used in clinical practice and research studies to subclassify hydatidiform moles and evaluate unusual products of conception...
  53. pmc Genomic profiling distinguishes familial multiple and sporadic multiple meningiomas
    Yiping Shen
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, 02114, USA
    BMC Med Genomics 2:42. 2009
    ....
  54. pmc Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale
    Rohit Bakshi
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Neurol 65:1449-53. 2008
    ..Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS)...
  55. ncbi request reprint Risk factors for perineal wound complications following abdominoperineal resection
    Caprice K Christian
    Department of Surgery, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Dis Colon Rectum 48:43-8. 2005
    ..Perineal wound complications are common following abdominoperineal resection. This study investigates the factors contributing to these complications...
  56. ncbi request reprint Predicting in vitro fertilization live birth using stimulation day 6 estradiol, age, and follicle-stimulating hormone
    Serene S Srouji
    Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Fertil Steril 84:795-7. 2005
    ..A retrospective analysis of IVF data was performed to determine predictors of live birth rate in four common stimulation protocols. A combination of day 6 E2 levels, age, and day 3 FSH levels can be used to predict cycle outcome...
  57. ncbi request reprint Malignant peripheral nerve sheath tumor: the clinical spectrum and outcome of treatment
    Joachim M Baehring
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neurology 61:696-8. 2003
    ..Presented is a series of 54 patients with MPNST seen at a single institution over a 10-year period. In this series, tumor diameter of <5 cm, gross total resection of the tumor, and younger age were favorable prognostic variables...
  58. ncbi request reprint Hazard regression for interval-censored data with penalized spline
    Tianxi Cai
    Department of Biostatistics, Harvard University, Boston, Massachusetts 02115, USA
    Biometrics 59:570-9. 2003
    ..We illustrate our approach with two well-known interval-censored data sets. Extensive numerical studies are conducted to evaluate the efficacy of the new procedure...
  59. doi request reprint Digital quantification of precursor frequency in the fallopian tube and its significance
    Jonathan G Bijron
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Mod Pathol 25:1654-61. 2012
    ..This has important implications for assessing precursor frequency both in the fallopian tube and in other organs-such as prostate, pancreas and colon-where epithelial precursors are integral to carcinogenesis...
  60. pmc Corelease of dopamine and GABA by a retinal dopaminergic neuron
    Hajime Hirasawa
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 32:13281-91. 2012
    ....
  61. pmc Application of futility analysis to refine jitter recordings in myasthenia gravis
    Pushpa Narayanaswami
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, TCC 8, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Muscle Nerve 45:486-91. 2012
    ..We applied principles of futility analysis from clinical trials in an attempt to reduce that requirement...
  62. ncbi request reprint Histopathological-molecular genetic correlations in referral pathologist-diagnosed low-grade "oligodendroglioma"
    Hikaru Sasaki
    Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neuropathol Exp Neurol 61:58-63. 2002
    ..As a result, such objective molecular genetic analyses should be incorporated into patient management and into clinical trials of low-grade diffuse gliomas...
  63. ncbi request reprint Analysis of co-aggregation of cancer based on registry data
    Abigail G Matthews
    Massachusetts General Hospital Biostatistics Center, Boston, MA 02114, USA
    Community Genet 9:87-92. 2006
    ..An exploratory analysis of co-aggregation of cancers using registry-based data...
  64. pmc The Leapfrog volume criteria may fall short in identifying high-quality surgical centers
    Caprice K Christian
    Department of Surgery, Brigham and Women s Hospital, Boston, MA 021115, USA
    Ann Surg 238:447-55; discussion 455-7. 2003
    ..We determined whether the Leapfrog thresholds represent the optimal cutoffs to discriminate between high- and low-mortality hospitals...
  65. ncbi request reprint Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis
    Hongwei Bai
    Department of Pathology, Brigham and Women s Hospital, and the Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Hum Pathol 34:559-64. 2003
    ..Whether CSKs are associated with other forms of HPV infection remains to be determined...
  66. pmc Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Transl Sci 1:200-8. 2008
    ..Our results demonstrate the comparative value of multiple biomarkers in the diagnosis and prognosis of AKI...
  67. ncbi request reprint Somatic mitochondrial DNA mutations in single neurons and glia
    Ippolita Cantuti-Castelvetri
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neurobiol Aging 26:1343-55. 2005
    ..These mutations may contribute to changes in brain function during normal aging and neurodegenerative disorders...
  68. pmc Microbleeds versus macrobleeds: evidence for distinct entities
    Steven M Greenberg
    MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
    Stroke 40:2382-6. 2009
    ..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
  69. ncbi request reprint Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas
    Ana Fernandez-Teijeiro
    Division of Neuroscience, Department of Neurology, Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston MA 02115, USA
    J Clin Oncol 22:994-8. 2004
    ..Outcome predictions on the basis of microarray gene expression profiles have been the most accurate to date. We ask in a multivariate model whether clinical parameters enhance survival predictions of gene expression profiles...
  70. ncbi request reprint Power calculations for familial aggregation studies
    Nusrat Rabbee
    Department of Statistics, University of California, Berkeley, California, USA
    Genet Epidemiol 26:316-27. 2004
    ..We also present simulation studies of power for both single- and two-disease cases, both under random and nonrandom sampling...
  71. ncbi request reprint Expression of oligodendroglial and astrocytic lineage markers in diffuse gliomas: use of YKL-40, ApoE, ASCL1, and NKX2-2
    Audrey Rousseau
    Molecular Pathology Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Neuropathol Exp Neurol 65:1149-56. 2006
    ..In addition to GFAP, therefore, YKL-40, ApoE, ASCL1, and NKX2-2 represent promising tumor cell markers to distinguish oligodendrogliomas from astrocytomas...
  72. ncbi request reprint Local likelihood analysis of the latency distribution with interval censored intermediate events
    Judith D Bebchuk
    University of Minnesota, Minneapolis, USA
    Stat Med 21:3475-91. 2002
    ..Simulations are presented to assess the performance of the estimation procedure...
  73. ncbi request reprint YKL-40 is a differential diagnostic marker for histologic subtypes of high-grade gliomas
    Catherine L Nutt
    Molecular Neuro Oncology Laboratory and Molecular Pathology Unit, Department of Pathology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Clin Cancer Res 11:2258-64. 2005
    ....
  74. ncbi request reprint Tests for treatment group differences in the hazards for survival, before and after the occurrence of an intermediate event
    Judith D Bebchuk
    University of Minnesota Division of Biostatistics, Minneapolis, MN 55414, USA
    Stat Med 24:359-78. 2005
    ..We develop analytic approximations for the power of the derived score tests for treatment differences in the hazard functions and evaluate them through simulations. We apply our results to AIDS Clinical Trials Group (ACTG) protocol 021...
  75. ncbi request reprint Methods to classify familial relationships in the presence of laboratory errors, without parental data
    Bin Zhang
    Wyeth Research, 35 CambridgePark Dr, Cambridge, MA 02140, USA
    Hum Genet 119:642-8. 2006
    ..For full-siblings versus half-siblings, the Bayes factor classification rule generally outperforms Ehm and Wagner's method (in Am J Hum Genet 62:181-188, 1998), especially when full-sibling proportion is high...
  76. pmc Estimating time-to-event from longitudinal ordinal data using random-effects Markov models: application to multiple sclerosis progression
    Micha Mandel
    Department of Statistics, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, Israel
    Biostatistics 9:750-64. 2008
    ....
  77. ncbi request reprint Activation of STAT3, MAPK, and AKT in malignant astrocytic gliomas: correlation with EGFR status, tumor grade, and survival
    Masahiro Mizoguchi
    Molecular Pathology Unit and Molecular Neuro Oncology Laboratory, Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Neuropathol Exp Neurol 65:1181-8. 2006
    ..Taken together, these findings begin to elucidate the interrelationship between these signaling pathways in astrocytic gliomas in vivo...
  78. ncbi request reprint Imaging correlates of molecular signatures in oligodendrogliomas
    Joseph F Megyesi
    Department of Clinical Neurological Sciences, University of Western Ontario and London Regional Cancer Centre, London, Ontario, Canada
    Clin Cancer Res 10:4303-6. 2004
    ..These data encourage prospective evaluation of molecular alterations and magnetic resonance imaging characteristics of glial neoplasms...
  79. pmc Glioma test array for use with formalin-fixed, paraffin-embedded tissue: array comparative genomic hybridization correlates with loss of heterozygosity and fluorescence in situ hybridization
    Gayatry Mohapatra
    Department of Pathology, Cancer Center and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston 02129, USA
    J Mol Diagn 8:268-76. 2006
    ..These results suggest that aCGH could offer an improved molecular diagnostic approach for gliomas because of its ability to detect clinically relevant molecular alterations in small FFPE specimens...