Lars Bertram

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
  2. pmc The genetic epidemiology of neurodegenerative disease
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 115:1449-57. 2005
  3. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
  4. pmc Genetic research in schizophrenia: new tools and future perspectives
    Lars Bertram
    Genetics and Aging Research Unit, MGH East MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Schizophr Bull 34:806-12. 2008
  5. doi Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Neurosci 9:768-78. 2008
  6. ncbi The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurobiol Aging 28:18.e1-4. 2007
  7. pmc GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results
    Brit Maren M Schjeide
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th St, Charlestown, MA 02129, USA
    Arch Neurol 66:250-4. 2009
  8. pmc Assessment of Alzheimer's disease case-control associations using family-based methods
    Brit Maren M Schjeide
    MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurogenetics 10:19-25. 2009
  9. pmc Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
    Lars Bertram
    Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Hum Genet 83:623-32. 2008
  10. ncbi Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families
    Minji Kim
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington 40536, USA
    J Biol Chem 282:7825-32. 2007

Research Grants

  1. SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENES
    Lars Bertram; Fiscal Year: 2007

Detail Information

Publications33

  1. pmc A QTL genome scan of the metabolic syndrome and its component traits
    Matthew B McQueen
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    BMC Genet 4:S96. 2003
    ..We used genotype and phenotype data from the Framingham Heart Study to perform a full-genome scan for quantitative trait loci underlying the metabolic syndrome...
  2. pmc The genetic epidemiology of neurodegenerative disease
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Clin Invest 115:1449-57. 2005
    ....
  3. ncbi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 39:17-23. 2007
    ..67 for protective alleles). Our database provides a powerful tool for deciphering the genetics of Alzheimer disease, and it serves as a potential model for tracking the most viable gene candidates in other genetically complex diseases...
  4. pmc Genetic research in schizophrenia: new tools and future perspectives
    Lars Bertram
    Genetics and Aging Research Unit, MGH East MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Schizophr Bull 34:806-12. 2008
    ..20 [range 1.06-1.45]) but nominally significant risk effects. This review discusses some of the strengths and limitations of the SzGene database, which could become a useful bioinformatics tool within the schizophrenia research community...
  5. doi Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, Massachusetts 02129, USA
    Nat Rev Neurosci 9:768-78. 2008
    ..This Review discusses the putative pathogenetic roles and common biochemical pathways of some of the most genetically and biologically compelling of these potential AD risk factors...
  6. ncbi The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neurobiol Aging 28:18.e1-4. 2007
    ..Based on our data, it seems unlikely that these genetic variants in LDLR make a significant contribution to AD risk in the general population...
  7. pmc GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results
    Brit Maren M Schjeide
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th St, Charlestown, MA 02129, USA
    Arch Neurol 66:250-4. 2009
    ..To our knowledge, these findings have not been independently replicated...
  8. pmc Assessment of Alzheimer's disease case-control associations using family-based methods
    Brit Maren M Schjeide
    MassGeneral Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurogenetics 10:19-25. 2009
    ..Further fine-mapping and functional analyses are warranted to elucidate the potential biochemical mechanisms and epidemiological relevance of these genes...
  9. pmc Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE
    Lars Bertram
    Genetics and Aging Research Unit, Mass General Institute for Neurodegenerative Disease MIND, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Hum Genet 83:623-32. 2008
    ....
  10. ncbi Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families
    Minji Kim
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington 40536, USA
    J Biol Chem 282:7825-32. 2007
    ....
  11. doi Effects of ubiquilin 1 on the unfolded protein response
    Alice Lu
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, 02129 4404, USA
    J Mol Neurosci 38:19-30. 2009
    ..These findings suggest that overexpression UBQLN1 transcript variants TV1-3, but not TV4, exert a protective effect during the UPR by attenuating CHOP induction and potentially increasing cell viability...
  12. pmc Association of GSK3B with Alzheimer disease and frontotemporal dementia
    Barbara A J Schaffer
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, 2506 Gonda, 695 Charles E Young Dr S, Los Angeles, CA 90095 1761, USA
    Arch Neurol 65:1368-74. 2008
    ..As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not been found...
  13. doi Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
    Nicole C Allen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Genet 40:827-34. 2008
    ..As such, it could serve as a model for field synopses of genetic associations in other common and genetically complex disorders...
  14. ncbi Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion
    Mikko Hiltunen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Biol Chem 281:32240-53. 2006
    ..These findings suggest that changes in UBQLN1 steady-state levels affect APP trafficking and processing, thereby influencing the generation of Abeta...
  15. ncbi The current status of Alzheimer's disease genetics: what do we tell the patients?
    Lars Bertram
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Pharmacol Res 50:385-96. 2004
    ..This review focuses on the analytic tools used to identify genes in complex diseases, and then provides a summary of recent linkage and association findings indicating the existence of novel late-onset AD genes on several chromosomes...
  16. pmc Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease
    Maija Pihlajamaki
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, MA, USA
    Alzheimer Dis Assoc Disord 24:28-36. 2010
    ..Altered fMRI activity of the posteromedial areas of the brain default network may be an early indicator of risk for AD...
  17. doi Association of UBQLN1 mutation with Brown-Vialetto-Van Laere syndrome but not typical ALS
    Paloma González-Pérez
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Neurobiol Dis 48:391-8. 2012
    ..Genetic variants in UBQLN1 gene have been linked to neurodegeneration and mutations in UBQLN2 have recently been identified as a rare cause of amyotrophic lateral sclerosis (ALS)...
  18. ncbi Family-based association between Alzheimer's disease and variants in UBQLN1
    Lars Bertram
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown 02129, USA
    N Engl J Med 352:884-94. 2005
    ..The gene encoding ubiquilin 1 (UBQLN1) is one of several candidate genes for Alzheimer's disease located near a well-established linkage peak on chromosome 9q22...
  19. ncbi Alzheimer's disease: one disorder, too many genes?
    Lars Bertram
    Genetics and Aging Research Unit, Department of Neurology and Mass General Institute for Neurodegenerative Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Hum Mol Genet 13:R135-41. 2004
    ..This should serve to greatly decrease the likelihood of false positive and false negative findings reported in future years...
  20. ncbi Results of a high-resolution genome screen of 437 Alzheimer's disease families
    Deborah Blacker
    Massachusetts General Hospital, Charlestown, MA, USA
    Hum Mol Genet 12:23-32. 2003
    ..Although some of these will surely prove to be false positives, these linkage signals should provide a valuable framework for future studies aimed at identifying additional susceptibility genes for late-onset AD...
  21. ncbi Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin
    Aleister J Saunders
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Hum Mol Genet 12:2765-76. 2003
    ..However, the negative case - control studies suggest that any underlying pathogenic polymorphisms have a modest effect, and may operate primarily among individuals with a family history of AD...
  22. ncbi Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
    Rudolph E Tanzi
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachussetts General Hospital, Harvard Medical School, Charlestown, Massachussetts 02129, USA
    Cell 120:545-55. 2005
    ..Here we assess the amyloid hypothesis based on both known and putative Alzheimer's disease genes...
  23. ncbi Family-based association test for time-to-onset data with time-dependent differences between the hazard functions
    Hongyu Jiang
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:124-32. 2006
    ..In addition to power increases of 100% over the original FBAT-Logrank test, we also gain insight into the age at which a genotype exerts the greatest influence on disease risk...
  24. pmc Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
    Wesley Farris
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Pathol 164:1425-34. 2004
    ..Our findings have relevance for the emerging genetic evidence suggesting that IDE may be a late-onset AD-risk gene, and for the epidemiological relationships among hyperinsulinemia, DM2, and AD...
  25. pmc Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer disease neuroimaging initiative
    Owen Carmichael
    Department of Neurology, School of Medicine, University of California, Davis, CA, USA
    Arch Neurol 67:1370-8. 2010
    ....
  26. ncbi Exploring candidate gene associations with neuropsychological performance
    Matthew B McQueen
    Institute for Behavioral Genetics, University of Colorado at Boulder, Boulder, Colorado 80309 0447, USA
    Am J Med Genet B Neuropsychiatr Genet 144:987-91. 2007
    ....
  27. ncbi Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
    Marian L Hamshere
    Biostatistics and Bioinformatics Unit, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK
    Hum Mol Genet 16:2703-12. 2007
    ..Where samples overlapped, the genotyping consistency was high, estimated to average at 97.3%. Our large-scale linkage analysis consolidates clear evidence for a susceptibility locus for LOAD on 10q21.2...
  28. pmc Insulin-degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population
    Saila Vepsäläinen
    J Med Genet 44:606-8. 2007
    ..Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD...
  29. pmc Is alpha-T catenin (VR22) an Alzheimer's disease risk gene?
    Lars Bertram
    J Med Genet 44:e63. 2007
    ..In these papers, evidence for association is mostly observed in multiplex families with Alzheimer's disease, whereas case-control samples of sporadic Alzheimer's disease are predominantly negative...
  30. ncbi Follow-up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort
    Rodney T Perry
    Department of Epidemiology and International Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Med Genet B Neuropsychiatr Genet 144:220-7. 2007
    ..In an effort to pinpoint this putative AD susceptibility gene, we have begun to analyze SNPs in other candidate genes in and around this narrowed region to test for additional associations to AD...
  31. doi Alzheimer's disease: The latest suspect
    Rudolph E Tanzi
    Nature 454:706-8. 2008
  32. pmc Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples
    Lars Bertram
    Am J Hum Genet 79:180-3; author reply 183-4. 2006
  33. pmc Evaluation of the potential excess of statistically significant findings in published genetic association studies: application to Alzheimer's disease
    Fotini K Kavvoura
    Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    Am J Epidemiol 168:855-65. 2008
    ..The excess was seen for all levels of statistical significance and also for studies with borderline P values (P = 0.05-0.10). The excess of significant findings may represent significance-chasing biases in a setting of massive testing...

Research Grants3

  1. SEARCH FOR NOVEL EARLY-ONSET ALZHEIMER'S GENES
    Lars Bertram; Fiscal Year: 2007
    ..While we have devised a strategy that integrates the best available methods to identify complex disease genes, we will routinely adjust our strategy to account for methodologic advances in this rapidly evolving field. ..