Research Topics
| Gerard T BerrySummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Galactosemia: when is it a newborn screening emergency?Gerard T Berry
The Manton Center for Orphan Disease Research, Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Mol Genet Metab 106:7-11. 2012..The purpose of this review is to help the clinician make the correct therapeutic decision after an NBS test has returned positive for galactosemia...
Is prenatal myo-inositol deficiency a mechanism of CNS injury in galactosemia?Gerard T Berry
Division of Genetics, Children s Hospital Boston, Center for Life Sciences Building, Boston, MA, 02115, USA
J Inherit Metab Dis 34:345-55. 2011..If myo-inositol deficiency is found to exist in the GALT-deficient fetal brain, then the use of myo-inositol to treat the fetus via oral supplementation of the pregnant female may warrant consideration...
Galactosemia and amenorrhea in the adolescentGerard T Berry
Division of Genetics, Children s Hospital Boston, Boston, Masschusetts 02115, USA
Ann N Y Acad Sci 1135:112-7. 2008....
Ultra fast and sensitive liquid chromatography tandem mass spectrometry based assay for galactose-1-phosphate uridylyltransferase and galactokinase deficienciesYijun Li
The Manton Center for Orphan Disease Research, Division of Genetics, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Mol Genet Metab 102:33-40. 2011..No GALK activity was detected in a GALK deficient sample we analyzed. Lastly, we tested the feasibility of adapting this LC-MS/MS based GALT/GALK assay as a newborn screening (NBS) test...
Sensitive isotope dilution liquid chromatography/tandem mass spectrometry method for quantitative analysis of bumetanide in serum and brain tissueYijun Li
Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
J Chromatogr B Analyt Technol Biomed Life Sci 879:998-1002. 2011..p.) injection of bumetanide, and were used to calculate bumetanide permeability through the blood-brain barrier...
The adult galactosemic phenotypeSusan E Waisbren
Children s Hospital Boston, Boston, MA, USA
J Inherit Metab Dis 35:279-86. 2012..Data on how individuals with galactosemia fare as adults will improve our ability to predict disease progression...
Quantification of galactose-1-phosphate uridyltransferase enzyme activity by liquid chromatography-tandem mass spectrometryYijun Li
The Manton Center for Orphan Disease Research, Division of Genetics, Department of Pediatrics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Clin Chem 56:772-80. 2010..We developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based assay for GALT enzyme activity measurement...
Exploring concordance and discordance for return of incidental findings from clinical sequencingRobert C Green
Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Genet Med 14:405-10. 2012..The aim of this study was to explore specific conditions and types of genetic variants that specialists in genetics recommend should be returned as incidental findings in clinical sequencing...
Back to the future: from genome to metabolomeJoseph V Thakuria
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Hum Mutat 33:809-12. 2012..Our initial focus targets 88 genes involved in 68 metabolic disturbances with established evidence-based nutritional and/or pharmacological therapy as part of standard medical care...
Epimerase-deficiency galactosemia is not a binary conditionKimberly K Openo
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Hum Genet 78:89-102. 2006..Long-term follow-up studies of these and other patients will be required to elucidate the clinical significance of these biochemical abnormalities and the potential impact of dietary intervention on outcome...
Extended [13C]galactose oxidation studies in patients with galactosemiaGerard T Berry
Department of Pediatrics, Division of Human Genetics and Molecular Biology and the Metabolic Research Laboratory, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
Mol Genet Metab 82:130-6. 2004..This capacity enables the galactosemic to maintain a balance of galactose disposal with the galactose burden imposed by endogenous formation and dietary intake...
