Research Topics
| Sabina BerrettaSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Extracellular matrix abnormalities in schizophreniaSabina Berretta
Translational Neuroscience Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neuropharmacology 62:1584-97. 2012....- Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdalaS Berretta
Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
Neuroscience 132:943-53. 2005..Thus, our findings raise the possibility that the infralimbic cortex inhibits conditioned fear via the excitation of intercalated cells and the consequent inhibition of central amygdala neurons... 
Cortico-amygdala circuits: role in the conditioned stress responseSabina Berretta
Harvard Medical School, Department of Psychiatry, 25 Shattuck Street, Boston, Massachusetts 02115, USA
Stress 8:221-32. 2005..Within the scope of this review, current evidence relative to the interaction between the amygdala and cortical networks will be considered in relationship to the integration of the conditioned response to stress...- Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophreniaSabina Berretta
Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 62:884-93. 2007..Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial... 
Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophreniaHarry Pantazopoulos
Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
Arch Gen Psychiatry 67:155-66. 2010....- A rodent model of schizophrenia derived from postmortem studiesSabina Berretta
Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
Behav Brain Res 204:363-8. 2009.... - The amygdala modulates neuronal activation in the hippocampus in response to spatial noveltyArchana Sheth
Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
Hippocampus 18:169-81. 2008..These findings also raise the possibility that amygdala abnormalities may contribute to impairments in cognitive information processing in subjects with major psychoses... - Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneuronsSabina Berretta
Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
Hippocampus 14:876-94. 2004..These similarities suggest that, in this disease, a disruption of GABAergic transmission within the amygdala may play a significant role in the induction of abnormalities in the hippocampus... - Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophreniaHarry Pantazopoulos
Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 61:640-52. 2007..These neurons play a pivotal role within ECx intrinsic circuits... - A rat model for neural circuitry abnormalities in schizophreniaSabina Berretta
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Protoc 1:833-9. 2006..This has established the construct and predictive validity of this model for studying limbic-lobe circuitry abnormalities. We propose that this modeling strategy may provide a valid alternative to isomorphic models of these diseases... - Subpopulations of neurons expressing parvalbumin in the human amygdalaHarry Pantazopoulos
Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
J Comp Neurol 496:706-22. 2006..Such properties suggest that each of these neuronal subpopulations may play a specific role within the intrinsic circuitry of the amygdala... - Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdalaHarry Pantazopoulos
Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
Brain Res 1207:84-95. 2008..These results suggest that astrocytes are the main cell type expressing CSPGs in the adult human amygdala. Their highly segregated distribution pattern suggests that these cells serve specialized functions within human amygdalar nuclei... - DNA fragmentation decreased in schizophrenia but not bipolar disorderFrancine M Benes
Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
Arch Gen Psychiatry 60:359-64. 2003..Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder...
Research Grants
- Amygdalar and Thalamic Abnormalities in SchizophreniaSabina Berretta; Fiscal Year: 2002....
- Cortico-Amygdalo-Thalamic Circuitry in HumansSabina Berretta; Fiscal Year: 2007..More in general, results obtained from the investigations described in this proposal will be relevant to the study of the physiological functions of AMYG and of its role in major psychiatric diseases. ..
- 'Partial' Rodent Model for GABA Defect in SchizophreniaSabina Berretta; Fiscal Year: 2007..The significance of these studies resides in their potential of providing functional links between neurochemical abnormalities in schizophrenia detected in interconnected limbic brain regions. ..
- Supplement/'Partial' Rodent Model for GABA Defect in Schizophrenia/MH 066280Sabina Berretta; Fiscal Year: 2006..N. Lange, a Biostatistician at McLean Hospital. In summary, the funding here requested will greatly improve the productivity of this laboratory and ensure that the currently funded projects will be brought to a timely completion. ..
- Disruption of Extracellular Matrix-Glial Interactions in SchizophreniaSabina Berretta; Fiscal Year: 2011....