Sabina Berretta

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Searching human brain for mechanisms of psychiatric disorders. Implications for studies on schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Program in Neuroscience, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Electronic address
    Schizophr Res 167:91-7. 2015
  2. doi request reprint Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA Dept of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Program in Neuroscience, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Electronic address
    Schizophr Res 167:18-27. 2015
  3. pmc Extracellular matrix abnormalities in schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 62:1584-97. 2012
  4. pmc Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala
    S Berretta
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuroscience 132:943-53. 2005
  5. ncbi request reprint Cortico-amygdala circuits: role in the conditioned stress response
    Sabina Berretta
    Harvard Medical School, Department of Psychiatry, 25 Shattuck Street, Boston, Massachusetts 02115, USA
    Stress 8:221-32. 2005
  6. ncbi request reprint Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:884-93. 2007
  7. pmc Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
    Arch Gen Psychiatry 67:155-66. 2010
  8. doi request reprint A rodent model of schizophrenia derived from postmortem studies
    Sabina Berretta
    Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
    Behav Brain Res 204:363-8. 2009
  9. ncbi request reprint The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty
    Archana Sheth
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 18:169-81. 2008
  10. ncbi request reprint Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons
    Sabina Berretta
    Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Hippocampus 14:876-94. 2004

Collaborators

Detail Information

Publications19

  1. doi request reprint Searching human brain for mechanisms of psychiatric disorders. Implications for studies on schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Program in Neuroscience, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Electronic address
    Schizophr Res 167:91-7. 2015
    ....
  2. doi request reprint Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA Dept of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Program in Neuroscience, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Electronic address
    Schizophr Res 167:18-27. 2015
    ..In turn, these mechanisms may contribute to the dysfunction of GABAergic neurons. ..
  3. pmc Extracellular matrix abnormalities in schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 62:1584-97. 2012
    ....
  4. pmc Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala
    S Berretta
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Neuroscience 132:943-53. 2005
    ..Thus, our findings raise the possibility that the infralimbic cortex inhibits conditioned fear via the excitation of intercalated cells and the consequent inhibition of central amygdala neurons...
  5. ncbi request reprint Cortico-amygdala circuits: role in the conditioned stress response
    Sabina Berretta
    Harvard Medical School, Department of Psychiatry, 25 Shattuck Street, Boston, Massachusetts 02115, USA
    Stress 8:221-32. 2005
    ..Within the scope of this review, current evidence relative to the interaction between the amygdala and cortical networks will be considered in relationship to the integration of the conditioned response to stress...
  6. ncbi request reprint Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia
    Sabina Berretta
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 62:884-93. 2007
    ..Growing evidence supports a pivotal role for the amygdala in the pathogenesis of bipolar disorder (BD) and schizophrenia (SZ). However, the occurrence of morphologic changes in the amygdala is currently controversial...
  7. pmc Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
    Arch Gen Psychiatry 67:155-66. 2010
    ....
  8. doi request reprint A rodent model of schizophrenia derived from postmortem studies
    Sabina Berretta
    Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
    Behav Brain Res 204:363-8. 2009
    ....
  9. ncbi request reprint The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty
    Archana Sheth
    Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    Hippocampus 18:169-81. 2008
    ..These findings also raise the possibility that amygdala abnormalities may contribute to impairments in cognitive information processing in subjects with major psychoses...
  10. ncbi request reprint Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons
    Sabina Berretta
    Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Hippocampus 14:876-94. 2004
    ..These similarities suggest that, in this disease, a disruption of GABAergic transmission within the amygdala may play a significant role in the induction of abnormalities in the hippocampus...
  11. pmc Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 61:640-52. 2007
    ..These neurons play a pivotal role within ECx intrinsic circuits...
  12. pmc Developmental pattern of perineuronal nets in the human prefrontal cortex and their deficit in schizophrenia
    Sarah A Mauney
    Laboratory of Cellular Neuropathology, McLean Hospital, Belmont, MA 02478, USA
    Biol Psychiatry 74:427-35. 2013
    ..They regulate the postnatal experience-dependent maturation of brain circuits and maintain their functional integrity in the mature brain by stabilizing their synaptic architecture...
  13. ncbi request reprint A rat model for neural circuitry abnormalities in schizophrenia
    Sabina Berretta
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Protoc 1:833-9. 2006
    ..This has established the construct and predictive validity of this model for studying limbic-lobe circuitry abnormalities. We propose that this modeling strategy may provide a valid alternative to isomorphic models of these diseases...
  14. pmc Subpopulations of neurons expressing parvalbumin in the human amygdala
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
    J Comp Neurol 496:706-22. 2006
    ..Such properties suggest that each of these neuronal subpopulations may play a specific role within the intrinsic circuitry of the amygdala...
  15. pmc Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdala
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Brain Res 1207:84-95. 2008
    ..These results suggest that astrocytes are the main cell type expressing CSPGs in the adult human amygdala. Their highly segregated distribution pattern suggests that these cells serve specialized functions within human amygdalar nuclei...
  16. pmc Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia
    Harry Pantazopoulos
    Department of Psychiatry, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA Translational Neuroscience Laboratory, McLean Hospital, 115 Mill St, Belmont, MA 02478, USA
    Schizophr Res 150:366-72. 2013
    ..Given the role CSPGs play in OE cell differentiation and axon guidance, we suggest that altered CSPG expression may contribute to ORN lineage dysregulation, and olfactory identification abnormalities, observed in SZ. ..
  17. pmc Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia
    Matej Markota
    Department of Psychiatry, Harvard Medical School, Boston, MA Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA
    Schizophr Bull 40:984-91. 2014
    ..Concurrent decrease of noradrenaline in the ABN may disrupt memory consolidation. ..
  18. ncbi request reprint DNA fragmentation decreased in schizophrenia but not bipolar disorder
    Francine M Benes
    Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Arch Gen Psychiatry 60:359-64. 2003
    ..Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder...
  19. doi request reprint In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
    Harry Pantazopoulos
    Translational Neuroscience Laboratory, McLean Hospital, Belmont, MA 02478, USA Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA
    Neural Plast 2016:9847696. 2016
    ..Here we review the evidence for PNN/ECM-related pathology in these disorders, with particular emphasis on schizophrenia, and discuss the hypothesis that such pathology may significantly contribute to synaptic dysfunction. ..

Research Grants4

  1. Amygdalar and Thalamic Abnormalities in Schizophrenia
    Sabina Berretta; Fiscal Year: 2002
    ....
  2. Cortico-Amygdalo-Thalamic Circuitry in Humans
    Sabina Berretta; Fiscal Year: 2007
    ..More in general, results obtained from the investigations described in this proposal will be relevant to the study of the physiological functions of AMYG and of its role in major psychiatric diseases. ..
  3. 'Partial' Rodent Model for GABA Defect in Schizophrenia
    Sabina Berretta; Fiscal Year: 2008
    ..The significance of these studies resides in their potential of providing functional links between neurochemical abnormalities in schizophrenia detected in interconnected limbic brain regions. ..
  4. Extracellular matrix abnormalities in the medial temporal lobe of subjects with s
    Sabina Berretta; Fiscal Year: 2008
    ..The proposed studies will provide potentially critical information needed to improve our understanding of these two disorders and their pharmacological treatment. [unreadable] [unreadable] [unreadable]..