O Berezovska

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity
    O Berezovska
    Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 920:223-6. 2000
  2. ncbi request reprint Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons
    C Jack
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Brain Res Mol Brain Res 87:166-74. 2001
  3. ncbi request reprint Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage
    O Berezovska
    Alzheimer's Disease Research Laboratory, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:30018-23. 2001
  4. ncbi request reprint Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
    O Berezovska
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, California, USA
    J Neurochem 75:583-93. 2000
  5. ncbi request reprint Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus
    A Kinoshita
    Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurochem 82:839-47. 2002
  6. ncbi request reprint Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
    L Puglielli
    Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, Massachusetts 02129-4404, USA
    Nat Cell Biol 3:905-12. 2001
  7. ncbi request reprint Biochemical and immunocytochemical characterization of calsenilin in mouse brain
    N F Zaidi
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th Street, Charlestown, MA 02129, USA
    Neuroscience 114:247-63. 2002
  8. ncbi request reprint Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
    O Berezovska
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Neuropathol Exp Neurol 57:738-45. 1998
  9. ncbi request reprint Developmental regulation of presenilin mRNA expression parallels notch expression
    O Berezovska
    Alzheimer Research Unit, Laboratory of Genetics and Aging, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Neuropathol Exp Neurol 56:40-4. 1997

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity
    O Berezovska
    Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 920:223-6. 2000
    ....
  2. ncbi request reprint Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons
    C Jack
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Brain Res Mol Brain Res 87:166-74. 2001
    ..These results support the hypothesis that PS1 deficiency blocks neuronal Notch1 processing and signaling...
  3. ncbi request reprint Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage
    O Berezovska
    Alzheimer's Disease Research Laboratory, Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:30018-23. 2001
    ..In summary, two complementary approaches suggest that APP and Notch1 are physiologically relevant competitive substrates for gamma-secretase activity...
  4. ncbi request reprint Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling
    O Berezovska
    Alzheimer s Disease Research Laboratory, Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Charlestown, California, USA
    J Neurochem 75:583-93. 2000
    ..The latter is an important finding from the perspective of therapeutic treatment of Alzheimer's disease by targeting gamma-secretase processing of APP to reduce Abeta production...
  5. ncbi request reprint Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus
    A Kinoshita
    Alzheimer Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Neurochem 82:839-47. 2002
    ..Visualization of the APP-CT-Fe65 complex in the nucleus may serve as a readout for processes that modify gamma secretase release of APP-CT...
  6. ncbi request reprint Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide
    L Puglielli
    Genetics and Aging Research Unit, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, Massachusetts 02129-4404, USA
    Nat Cell Biol 3:905-12. 2001
    ..We also show that pharmacological inhibitors of ACAT, developed for the treatment of atherosclerosis, are potent modulators of Abeta generation, indicating their potential for use in the treatment of Alzheimer's disease...
  7. ncbi request reprint Biochemical and immunocytochemical characterization of calsenilin in mouse brain
    N F Zaidi
    Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114, 16th Street, Charlestown, MA 02129, USA
    Neuroscience 114:247-63. 2002
    ..Finally, the expression pattern of calsenilin, which is similar to that of the presenilin(s), suggests that the common locations of these two proteins provide an opportunity for physical interaction in vivo...
  8. ncbi request reprint Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
    O Berezovska
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Neuropathol Exp Neurol 57:738-45. 1998
    ..The alteration in Notch1 expression in sporadic Alzheimer disease raises the possibility that disruption of Notch1/PS-1 functional interactions may occur in Alzheimer disease...
  9. ncbi request reprint Developmental regulation of presenilin mRNA expression parallels notch expression
    O Berezovska
    Alzheimer Research Unit, Laboratory of Genetics and Aging, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    J Neuropathol Exp Neurol 56:40-4. 1997
    ..These observations show that, like Notch, PS1 and PS2 are strongly developmentally regulated, and support the plausibility of an interaction between PSs and Notch...