LARRY IRA BENOWITZ

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc The impact of discrete modes of spinal cord injury on bladder muscle contractility
    Abhishek Seth
    Urological Diseases Research Center, Boston Children s Hospital, Boston, MA 02115, USA
    BMC Urol 13:24. 2013
  2. doi request reprint Inflammation and axon regeneration
    Larry I Benowitz
    Laboratory for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 24:577-83. 2011
  3. pmc Optic nerve regeneration
    Larry I Benowitz
    F M Kirby Neurobiology Center, Children s Hospital Boston, Department of Surgery, Harvard Medical School, Massachusetts, USA
    Arch Ophthalmol 128:1059-64. 2010
  4. pmc Promoting axonal rewiring to improve outcome after stroke
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Program, Children s Hospital, USA
    Neurobiol Dis 37:259-66. 2010
  5. pmc Rewiring the injured CNS: lessons from the optic nerve
    Larry Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and Neurobiology Program, Children s Hospital, Boston, MA 02115, USA
    Exp Neurol 209:389-98. 2008
  6. ncbi request reprint Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and Neurobiology Program, Children s Hospital, Boston, Massachusetts, USA
    Dev Neurobiol 67:1148-65. 2007
  7. pmc Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways
    Barbara Lorber
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 12:1407-14. 2009
  8. ncbi request reprint Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
    Yuqin Yin
    Department of Neurosurgery and Neurobiology Program, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 9:843-52. 2006
  9. ncbi request reprint Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP
    Yiming Li
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:7830-8. 2003
  10. pmc Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion
    Takuji Kurimoto
    Laboratory for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 30:15654-63. 2010

Research Grants

  1. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 2007
  2. Adaptive rewiring of the mature brain after injury
    Larry Benowitz; Fiscal Year: 2007
  3. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    LARRY IRA BENOWITZ; Fiscal Year: 2010
  4. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 2002
  5. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1999
  6. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1991
  7. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1993
  8. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    LARRY IRA BENOWITZ; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. pmc The impact of discrete modes of spinal cord injury on bladder muscle contractility
    Abhishek Seth
    Urological Diseases Research Center, Boston Children s Hospital, Boston, MA 02115, USA
    BMC Urol 13:24. 2013
    ..The goal of this study is to compare the impact of complete spinal cord transection versus clip compression at thoracic vertebra eight (T8) on bladder muscle contractility...
  2. doi request reprint Inflammation and axon regeneration
    Larry I Benowitz
    Laboratory for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Neurol 24:577-83. 2011
    ....
  3. pmc Optic nerve regeneration
    Larry I Benowitz
    F M Kirby Neurobiology Center, Children s Hospital Boston, Department of Surgery, Harvard Medical School, Massachusetts, USA
    Arch Ophthalmol 128:1059-64. 2010
    ..These findings give hope that clinically meaningful regeneration may become a reality within a few years if regenerating axons can be guided to their appropriate destinations...
  4. pmc Promoting axonal rewiring to improve outcome after stroke
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Program, Children s Hospital, USA
    Neurobiol Dis 37:259-66. 2010
    ..These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke...
  5. pmc Rewiring the injured CNS: lessons from the optic nerve
    Larry Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and Neurobiology Program, Children s Hospital, Boston, MA 02115, USA
    Exp Neurol 209:389-98. 2008
    ....
  6. ncbi request reprint Combinatorial treatments for promoting axon regeneration in the CNS: strategies for overcoming inhibitory signals and activating neurons' intrinsic growth state
    Larry I Benowitz
    Laboratories for Neuroscience Research in Neurosurgery and Neurobiology Program, Children s Hospital, Boston, Massachusetts, USA
    Dev Neurobiol 67:1148-65. 2007
    ..Similar conclusions are emerging from studies in other systems, pointing to a need to consider combinatorial treatments in the clinical setting...
  7. pmc Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways
    Barbara Lorber
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts, USA
    Nat Neurosci 12:1407-14. 2009
    ..DRG neurons regenerating axons in vivo showed elevated Mst3b activity, and reducing Mst3b expression attenuated regeneration and p42/44 MAPK activation. Thus, Mst3b regulates axon regeneration in both CNS and PNS neurons...
  8. ncbi request reprint Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells
    Yuqin Yin
    Department of Neurosurgery and Neurobiology Program, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 9:843-52. 2006
    ..Oncomodulin also stimulates outgrowth from peripheral sensory neurons. Thus, oncomodulin is a new growth factor for neurons of the mature central and peripheral nervous systems...
  9. ncbi request reprint Axon regeneration in goldfish and rat retinal ganglion cells: differential responsiveness to carbohydrates and cAMP
    Yiming Li
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:7830-8. 2003
    ..The axon-promoting effects of mannose are highly specific and are unrelated to energy metabolism or glycoprotein synthesis...
  10. pmc Long-distance axon regeneration in the mature optic nerve: contributions of oncomodulin, cAMP, and pten gene deletion
    Takuji Kurimoto
    Laboratory for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 30:15654-63. 2010
    ..Thus, treatments that synergistically alter the intrinsic growth state of RGCs produce unprecedented levels of axon regeneration in the optic nerve, a CNS pathway long believed to be incapable of supporting such growth...
  11. ncbi request reprint Inosine stimulates axon growth in vitro and in the adult CNS
    Larry I Benowitz
    Children s Hospital, Laboratories for Neuroscience Research in Neurosurgery, Harvard Medical School, Program in Neuroscience, Department of Surgery, 300 Longwood Avenue, Boston, MA 02115, USA
    Prog Brain Res 137:389-99. 2002
    ..Further understanding of the molecular changes that lie upstream and downstream of N-kinase may lead to new insights into the control of axon growth and to novel methods to improve functional outcome in patients with CNS injury...
  12. pmc Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb
    Laila Zai
    Laboratories for Neuroscience Research in Neurosurgery and F M Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Neurosci 29:8187-97. 2009
    ..Thus, inosine alters gene expression in neurons contralateral to a stroke, enhances the ability of these neurons to form connections on the denervated side of the spinal cord, and improves performance with the impaired limb...
  13. ncbi request reprint Macrophage-derived factors stimulate optic nerve regeneration
    Yuqin Yin
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 23:2284-93. 2003
    ..Thus, macrophages produce proteins with both positive and negative effects on RGCs, and the effects of macrophages can be optimized by the timing of their activation...
  14. pmc Oncomodulin links inflammation to optic nerve regeneration
    Yuqin Yin
    Department of Surgery and Anesthesiology, Children s Hospital, Laboratory for Neuroscience Research in Neurosurgery, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:19587-92. 2009
    ..These results were verified in different strains, species, and experimental models, and establish Ocm as a potent growth-promoting signal between the innate immune system and neurons in vivo...
  15. ncbi request reprint Switching mature retinal ganglion cells to a robust growth state in vivo: gene expression and synergy with RhoA inactivation
    Dietmar Fischer
    Laboratories for Neuroscience Research in Neurosurgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8726-40. 2004
    ....
  16. ncbi request reprint Tumor necrosis factor-alpha mediates oligodendrocyte death and delayed retinal ganglion cell loss in a mouse model of glaucoma
    Toru Nakazawa
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:12633-41. 2006
    ..Thus TNF-alpha provides an essential, although indirect, link between OH and RGC loss in vivo. Blocking TNF-alpha signaling or inflammation, therefore, may be helpful in treating glaucoma...
  17. pmc Nerve growth factor controls GAP-43 mRNA stability via the phosphoprotein ARPP-19
    Nina Irwin
    Department of Neurosurgery, Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:12427-31. 2002
    ..These findings demonstrate that ARPP-19 is an important link between NGF signaling and post-transcriptional control of neuronal gene expression...
  18. pmc Inosine induces axonal rewiring and improves behavioral outcome after stroke
    Peng Chen
    Department of Neurosurgery, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:9031-6. 2002
    ..This growth was paralleled by improved performance on several behavioral measures...
  19. ncbi request reprint Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state
    Dietmar Fischer
    Department of Neurosurgery, Children s Hospital Boston, Massachusetts 02115, USA
    J Neurosci 24:1646-51. 2004
    ..We conclude that gene therapy is an effective approach to enhancing axon regeneration in the CNS and that inactivation of NgR functioning greatly enhances axon regeneration provided the intrinsic growth program of neurons is activated...

Research Grants25

  1. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 2007
    ..abstract_text> ..
  2. Adaptive rewiring of the mature brain after injury
    Larry Benowitz; Fiscal Year: 2007
    ..These studies will increase our understanding of plasticity in the mature brain and potentially enable us to improve functional outcome after injury. ..
  3. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    LARRY IRA BENOWITZ; Fiscal Year: 2010
    ..Information gained from these studies is likely to be relevant to treating injury to the optic nerve and other parts of CNS. ..
  4. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 2002
    ..These studies will provide new insights into the basic mechanisms that control axon growth in the primary visual pathway, and enhance our ability to restore visual function after injury or in glaucoma. ..
  5. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1999
    ....
  6. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1991
    ..The identification of these factors may provide insights valuable for ultimately effecting growth of neurons after damage in the mammalian visual system...
  7. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    Larry Benowitz; Fiscal Year: 1993
    ..Together, these studies represent an integrated approach to understanding the cellular and molecular biology underlying regeneration in the visual system, knowledge that may eventually be applied for inducing visual recovery in man...
  8. MOLECULAR BASES OF NEURONAL CONNECTIVITY
    LARRY IRA BENOWITZ; Fiscal Year: 2010
    ..Information gained from these studies is likely to be relevant to treating injury to the optic nerve and other parts of CNS. ..