Ofra Benny

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Broad spectrum antiangiogenic treatment for ocular neovascular diseases
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:. 2010
  2. pmc An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, 1 Blackfan Circle, St Karp Research Building, Boston, Massachusetts 02215, USA
    Nat Biotechnol 26:799-807. 2008
  3. pmc Novel technologies for antiangiogenic drug delivery in the brain
    Ofra Benny
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, MA, USA
    Cell Adh Migr 3:224-9. 2009
  4. doi request reprint Dendritic cells augment choroidal neovascularization
    Kei Nakai
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 49:3666-70. 2008
  5. doi request reprint Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability
    Ofer Fainaru
    Vascular Biology Program, Children s Hospital Boston, Department of Surgery, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 22:3728-35. 2008
  6. pmc Suppression of autoimmune retinal inflammation by an antiangiogenic drug
    Takeru Yoshimura
    Department of Surgery, Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e66219. 2013
  7. ncbi request reprint Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis
    Ofer Fainaru
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 22:522-9. 2008
  8. pmc Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis
    Christian M Becker
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:1782-91. 2011
  9. doi request reprint The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action
    Avner Adini
    Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Angiogenesis 16:405-16. 2013
  10. pmc Epoxyeicosanoids promote organ and tissue regeneration
    Dipak Panigrahy
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:13528-33. 2013

Collaborators

Detail Information

Publications11

  1. pmc Broad spectrum antiangiogenic treatment for ocular neovascular diseases
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:. 2010
    ..Several unique properties make Lodamin especially beneficial for ophthalmic use. Our results support the concept that broad spectrum antiangiogenic drugs are promising agents for AMD treatment and prevention...
  2. pmc An orally delivered small-molecule formulation with antiangiogenic and anticancer activity
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, 1 Blackfan Circle, St Karp Research Building, Boston, Massachusetts 02215, USA
    Nat Biotechnol 26:799-807. 2008
    ..We show that Lodamin is an oral nontoxic antiangiogenic drug that can be chronically administered for cancer therapy or metastasis prevention...
  3. pmc Novel technologies for antiangiogenic drug delivery in the brain
    Ofra Benny
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, MA, USA
    Cell Adh Migr 3:224-9. 2009
    ..We also discuss an example in which modifying the properties of an antiangiogenic compound enhanced its clinical efficacy in treating tumors while simultaneously mitigating undesirable neurological side-effects...
  4. doi request reprint Dendritic cells augment choroidal neovascularization
    Kei Nakai
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 49:3666-70. 2008
    ..The purpose of the present study was to investigate the role of DCs in the development of CNV...
  5. doi request reprint Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability
    Ofer Fainaru
    Vascular Biology Program, Children s Hospital Boston, Department of Surgery, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 22:3728-35. 2008
    ..The potential of doxycyline as a therapeutic inhibitor of vascular hyperpermeability in human clinical conditions is promising and warrants further studies...
  6. pmc Suppression of autoimmune retinal inflammation by an antiangiogenic drug
    Takeru Yoshimura
    Department of Surgery, Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e66219. 2013
    ..This effect was attributed in part to a reduction in retinal proinflammatory cytokines, down regulation of MetAP2 expression in purified lymph node CD4(+) T cells, and a general normalization of the systemic immune reaction...
  7. ncbi request reprint Dendritic cells support angiogenesis and promote lesion growth in a murine model of endometriosis
    Ofer Fainaru
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Boston, MA 02115, USA
    FASEB J 22:522-9. 2008
    ..93+/-32 cells, P=0.02). Based on these findings, we suggest a novel role for DCs in supporting angiogenesis and promoting lesion growth both in endometriosis and in tumors...
  8. pmc Circulating endothelial progenitor cells are up-regulated in a mouse model of endometriosis
    Christian M Becker
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Am J Pathol 178:1782-91. 2011
    ....
  9. doi request reprint The stem cell marker prominin-1/CD133 interacts with vascular endothelial growth factor and potentiates its action
    Avner Adini
    Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Angiogenesis 16:405-16. 2013
    ..Additionally, prominin-1 promotes tumor growth by supporting angiogenesis and inhibiting tumor cell apoptosis...
  10. pmc Epoxyeicosanoids promote organ and tissue regeneration
    Dipak Panigrahy
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:13528-33. 2013
    ..Thus, our observations indicate a central role for EETs in organ and tissue regeneration and their contribution to tissue homeostasis. ..
  11. ncbi request reprint Novel local drug delivery system using thermoreversible gel in combination with polymeric microspheres or liposomes
    Takao Arai
    Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Anticancer Res 30:1057-64. 2010
    ..The purpose of our study was to evaluate the application of thermoreversible gelation polymer (TGP) as a local drug delivery system for malignant glioma...