Research Topics
| T BennerSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Cerebral MR perfusion imaging: first clinical application of a 1 M gadolinium chelate (Gadovist 1.0) in a double-blinded randomized dose-finding studyT Benner
Department of Neuroradiology, University of Heidelberg Medical School, D 69120 Heidelberg, Germany
J Magn Reson Imaging 12:371-80. 2000..3 mmol/kg as the diagnostically adequate dose given the gradient-echo sequence and field strength used. Gadovist 1.0 has been shown to be a safe and well-tolerated contrast agent. J. Magn. Reson. Imaging 2000;12:371-380...- Comparison of manual and automatic section positioning of brain MR imagesThomas Benner
Department of Radiology and General Clinical Research Center, Massachusetts General Hospital, Athinoula A Martinos Center, Harvard Medical School, 149 13th St, Rm 2301, Charlestown, MA 02129, USA
Radiology 239:246-54. 2006..001). Automatic section prescription leads to improved reproducibility of imaging orientations for intra- and intersubject series in clinical practice... - Real-time RF pulse adjustment for B0 drift correctionThomas Benner
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA
Magn Reson Med 56:204-9. 2006..The proposed method corrects for apparent image shift and ensures continuously effective fat saturation over the duration of an acquisition... 
Diffusion imaging with prospective motion correction and reacquisitionThomas Benner
Department of Radiology, Athinoula A Martinos Center, Charlestown, Massachusetts, USA
Magn Reson Med 66:154-67. 2011..The presented method allows the reduction of two types of common motion related artifacts at the cost of slightly increased acquisition time...- Accuracy of gamma-variate fits to concentration-time curves from dynamic susceptibility-contrast enhanced MRI: influence of time resolution, maximal signal drop and signal-to-noiseT Benner
Department of Neuroradiology, University of Heidelberg Medical School, Germany
Magn Reson Imaging 15:307-17. 1997..This is more important the lower SNR is. The shown dependencies should be taken into account when choosing MR sequence parameters and application of contrast media... - A score to predict early risk of recurrence after ischemic strokeH Ay
Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 74:128-35. 2010..There is currently no instrument to stratify patients presenting with ischemic stroke according to early risk of recurrent stroke. We sought to develop a comprehensive prognostic score to predict 90-day risk of recurrent stroke... - Reducing motion artefacts in diffusion-weighted MRI of the brain: efficacy of navigator echo correction and pulse triggeringO Dietrich
Department of Neuroradiology, University of Heidelberg Medical School, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
Neuroradiology 42:85-91. 2000..Pulse triggering and navigator echo correction significantly improve image quality and provide a technique for high-quality DWI on standard imagers without improved gradient hardware... - Simultaneous assessment of cerebral hemodynamics and contrast agent uptake in lesions with disrupted blood-brain-barrierS Heiland
Department of Neuroradiology, University of Heidelberg Medical School, Germany
Magn Reson Imaging 17:21-7. 1999..This method may be a useful tool for characterizing, staging, and therapy monitoring of brain tumors... - Does the "keyhole" technique improve spatial resolution in MRI perfusion measurements? A study in volunteersS Heiland
Department of Neuroradiology, University of Heidelberg Medical School, Germany
Neuroradiology 43:518-24. 2001..However, it should be applied carefully, because the spatial resolution of the dynamic signal change and the cerebrovascular parameters is less than that afforded by the spatial resolution of the reconstructed images... - T₂* mapping and B₀ orientation-dependence at 7 T reveal cyto- and myeloarchitecture organization of the human cortexJ Cohen-Adad
A A Martinos Center for Biomedical Imaging, Dept of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 60:1006-14. 2012.... - Perfusion-weighted magnetic resonance imaging in patients with carotid artery disease before and after carotid endarterectomyA Doerfler
Department of Neuroradiology, University of Essen Medical School, Germany
J Vasc Surg 34:587-93. 2001.... 
In vivo evidence of disseminated subpial T2* signal changes in multiple sclerosis at 7 T: a surface-based analysisJ Cohen-Adad
AA Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 57:55-62. 2011..Our data support the presence of disseminated subpial increases in T2* signal in subjects with MS, which may reflect the diffuse subpial pathology described in neuropathology...- Real-time rigid body motion correction and shimming using cloverleaf navigatorsAndre J W van der Kouwe
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Magn Reson Med 56:1019-32. 2006..Correction for between-scan motion can be accomplished by using the same reference map for each scan repetition. Human and phantom tests demonstrated a consistent improvement in image quality if motion occurred during the acquisition... - Brain morphometry with multiecho MPRAGEAndre J W van der Kouwe
Department of Radiology, Massachusetts General Hospital, Athinoula A Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 40:559-69. 2008..Since acquisition time is the same for MEMPR as for MPRAGE, and it has better distortion properties and additional T2* information, MEMPR is recommended for morphometry studies... - Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scannerPhillip Zhe Sun
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 60:834-41. 2008..9 ppm). Furthermore, pilot endogenous APT imaging of normal human volunteers was demonstrated, warranting future APT MRI of stroke patients to elucidate its diagnostic value... - Model-based segmentation of hippocampal subfields in ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, MGH, Harvard Medical School, USA
Med Image Comput Comput Assist Interv 11:235-43. 2008..We validate the proposed technique by comparing our segmentation results with corresponding manual delineations in ultra-high resolution MRI scans of five individuals... - Comatose patients with cardiac arrest: predicting clinical outcome with diffusion-weighted MR imagingOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149 13th St, CNY 2301, Charlestown, MA 02129, USA
Radiology 252:173-81. 2009..To examine whether the severity and spatial distribution of reductions in apparent diffusion coefficient (ADC) are associated with clinical outcomes in patients who become comatose after cardiac arrest... - Toward implementing an MRI-based PET attenuation-correction method for neurologic studies on the MR-PET brain prototypeCiprian Catana
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Nucl Med 51:1431-8. 2010.... - Early time points perfusion imagingKenneth K Kwong
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Neuroimage 54:1070-82. 2011..A recipe to run ET was presented, with attention paid to the noise problem around the time of arrival (TOA) of the contrast agent... - Early experience of translating pH-weighted MRI to image human subjects at 3 TeslaPhillip Zhe Sun
Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129, USA
Stroke 41:S147-51. 2010..Tissue pH, a well-regulated physiological index that alters on disrupted tissue metabolism, may provide a surrogate metabolic imaging marker that augments the DWI and PWI for penumbra imaging... - MRI-assisted PET motion correction for neurologic studies in an integrated MR-PET scannerCiprian Catana
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Nucl Med 52:154-61. 2011..In this work, a novel algorithm for data processing and rigid-body motion correction (MC) for the MRI-compatible BrainPET prototype scanner is described, and proof-of-principle phantom and human studies are presented... - Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRIKoen Van Leemput
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Hippocampus 19:549-57. 2009..Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies... - Automated perfusion-weighted MRI using localized arterial input functionsCory Lorenz
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Division of Health Sciences and Technology, Harvard/MIT, Charlestown, Massachusetts 08129, USA
J Magn Reson Imaging 24:1133-9. 2006..Similarly, the local MTT lesion volumes had the least mean squared error (MSE). CONCLUSION: Automated CBF calculation using local AIFs is feasible and appears to produce more useful CBF maps... - Frontal connections and cognitive changes in normal aging rhesus monkeys: a DTI studyNikos Makris
Harvard Medical School Department of Neurology, Center for Morphometric Analysis, Massachusetts General Hospital, Boston, MA 02129, United States
Neurobiol Aging 28:1556-67. 2007..To our knowledge this is the first investigation reporting such alterations in the aging monkey... - Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary studyJudith D Schaechter
Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
Neurorehabil Neural Repair 16:326-38. 2002..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere... - Tracer arrival timing-insensitive technique for estimating flow in MR perfusion-weighted imaging using singular value decomposition with a block-circulant deconvolution matrixOna Wu
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Boston, Massachusetts 02129, USA
Magn Reson Med 50:164-74. 2003..Shift maps can continue to provide a sensitive reflection of disturbed hemodynamics... - On-line automatic slice positioning for brain MR imagingAndre J W van der Kouwe
Department of Radiology, MGH, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 27:222-30. 2005..Translations and rotations relative to the atlas can be set so that planning can be done in anatomical space, rather than scanner coordinates, and stored as part of the protocol allowing standardization of slice orientations... - Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiationPhillip Zhe Sun
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Magn Reson Med 65:588-94. 2011..In sum, a fast multislice relaxation self-compensated CEST MRI sequence was developed, with significantly improved sensitivity and suitable for in vivo applications... - Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gatingWei Ting Zhang
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, and Harvard Medical School, Bldg 149 2301, 13th Street, Charlestown, MA 02129, USA
Neuroimage 31:1506-12. 2006..Activation in the brainstem and the thalamus was best detected by cardiac-gated dual-echo EPI... - White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imagingDavid H Salat
Massachusetts General Hospital Massachusetts Institute of Technology Harvard Medical School, Athinoula A Martinos Center for Biomedical Imaging, Charlestown, Mass 02129 2060, USA
Stroke 37:1759-64. 2006..We used diffusion tensor imaging to evaluate the anatomic distribution of white matter degeneration in participants diagnosed with advanced CAA... - Halving imaging time of whole brain diffusion spectrum imaging and diffusion tractography using simultaneous image refocusing in EPITimothy G Reese
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 29:517-22. 2009.... - Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibersV J Wedeen
Department of Radiology, MGH Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 41:1267-77. 2008..These findings indicate that DSI tractography is able to image crossing fibers in neural tissue, an essential step toward non-invasive imaging of connectional neuroanatomy... - The Causative Classification of Stroke system: an international reliability and optimization studyE M Arsava
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Neurology 75:1277-84. 2010..We determined whether CCS demonstrates high interrater reliability in order to be useful for international multicenter studies... - In vivo imaging of cortical pathology in multiple sclerosis using ultra-high field MRICaterina Mainero
Athinoula Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, USA
Neurology 73:941-8. 2009.... - Conversion of ischemic brain tissue into infarction increases with ageHakan Ay
The AA Martinos Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Stroke 36:2632-6. 2005..We hypothesize that age is a marker for tissue susceptibility to ischemia and thus plays a role in determining tissue outcome in human stroke... - Neuroanatomic correlates of stroke-related myocardial injuryH Ay
A A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 66:1325-9. 2006..Myocardial injury can occur after ischemic stroke in the absence of primary cardiac causes. The neuroanatomic basis of stroke-related myocardial injury is not well understood... - Effect of using local arterial input functions on cerebral blood flow estimationCory Lorenz
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, Massachusetts, USA
J Magn Reson Imaging 24:57-65. 2006..CONCLUSION: The local-AIF technique results in an increase in the calculated CBF values for tissues with D/D, consistent with a reduction in the errors associated with D/D... - A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke SystemHakan Ay
AA Martinos Center for Biomedical Imaging and Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
Stroke 38:2979-84. 2007..In this article, we present an automated version of the SSS-TOAST, the Causative Classification System (CCS), to facilitate its utility in multicenter settings... - Perfusion- and diffusion-weighted magnetic resonance imaging for monitoring decompressive craniectomy in animals with experimental hemispheric strokeArnd Doerfler
Department of Neuroradiology, University of Essen Medical School, Germany
J Neurosurg 96:933-40. 2002..The aim of this study was to use two types of serial magnetic resonance (MR) imaging-perfusion-weighted (PW) and diffusion-weighted (DW)-to monitor craniectomy in rats with hemispheric stroke... - Transient ischemic attack with infarction: a unique syndrome?Hakan Ay
Department of A A Martinos Center for Biomedical Imaging and Stroke Service, Department of Radiology, Boston, MA 02129, USA
Ann Neurol 57:679-86. 2005..3% in those with ischemic stroke. TIA with infarction appears to have unique features separate from TIA without infarction and ischemic stroke. We propose identifying TSI as a separate clinical syndrome with distinct prognostic features... - A pilot study of normobaric oxygen therapy in acute ischemic strokeAneesh B Singhal
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
Stroke 36:797-802. 2005..Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke... - Preoperative and intraoperative diffusion tensor imaging-based fiber tracking in glioma surgeryChristopher Nimsky
Department of Neurosurgery, University Erlangen Nurnberg, Erlangen, Germany
Neurosurgery 56:130-7; discussion 138. 2005..To investigate the intraoperative displacement of major white matter tracts during glioma resection by comparing preoperative and intraoperative diffusion tensor imaging-based fiber tracking... - Three dimensional myoarchitecture of the human tongue determined in vivo by diffusion tensor imaging with tractographyTerry A Gaige
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Magn Reson Imaging 26:654-61. 2007..To study the anatomical relationships involving the intrinsic and extrinsic myofiber populations of the human tongue employing diffusion tensor imaging (DTI) with tractography... - Intraoperative diffusion-tensor MR imaging: shifting of white matter tracts during neurosurgical procedures--initial experienceChristopher Nimsky
Department of Neurosurgery, University Erlangen Nurnberg, Schwabachanlage 6, 91054 Erlangen, Germany
Radiology 234:218-25. 2005..To prospectively evaluate the location of white matter tracts with diffusion-tensor imaging (DTI) during neurosurgical procedures... - Magnetic resonance spectroscopy study of oxygen therapy in ischemic strokeAneesh B Singhal
Stroke 38:2851-4. 2007..N-acetyl-aspartate decreased in patients receiving room air but not in NBO-treated patients. CONCLUSIONS: These data suggest that NBO improves aerobic metabolism and preserves neuronal integrity in the ischemic brain... - Three-dimensional myoarchitecture of the bovine tongue demonstrated by diffusion spectrum magnetic resonance imaging with tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
Anat Rec A Discov Mol Cell Evol Biol 288:1173-82. 2006..We postulate that the properties associated with these myofiber tracts predict the mechanical behavior of the tissue and thus constitute a method to relate structure and function for anatomically complex muscular tissues... - Do highly concentrated gadolinium chelates improve MR brain perfusion imaging? Intraindividually controlled randomized crossover concentration comparison study of 0.5 versus 1.0 mol/L gadobutrolBernd Tombach
Dept of Clinical Radiology, Univ of Münster, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
Radiology 226:880-8. 2003..To assess the potential advantages of using a 1.0 mol/L versus 0.5 mol/L gadobutrol formulation for magnetic resonance (MR) brain perfusion imaging... - Associating the mesoscale fiber organization of the tongue with local strain rate during swallowingSamuel M Felton
Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
J Biomech 41:1782-9. 2008..These data demonstrate that lingual deformation during swallowing involves complex interactions involving intrinsic and extrinsic muscles, whose contractility is directed by the alignment of mesoscale fiber tracts... - Resolving the three-dimensional myoarchitecture of bovine esophageal wall with diffusion spectrum imaging and tractographyRichard J Gilbert
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell Tissue Res 332:461-8. 2008....