Francine Benes

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Regulation of cell cycle and DNA repair in post-mitotic GABA neurons in psychotic disorders
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 60:1232-42. 2011
  2. pmc Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Bull 33:932-6. 2007
  3. pmc Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Proc Natl Acad Sci U S A 104:10164-9. 2007
  4. pmc Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 105:20935-40. 2008
  5. ncbi request reprint Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02178, USA
    Prog Brain Res 158:153-72. 2006
  6. pmc Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 106:11731-6. 2009
  7. pmc Amygdalocortical circuitry in schizophrenia: from circuits to molecules
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA
    Neuropsychopharmacology 35:239-57. 2010
  8. pmc Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
  9. pmc DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia
    Ned Buttner
    Laboratories for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    Schizophr Res 93:33-41. 2007
  10. ncbi request reprint Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 61:649-57. 2004

Collaborators

Detail Information

Publications27

  1. doi request reprint Regulation of cell cycle and DNA repair in post-mitotic GABA neurons in psychotic disorders
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuropharmacology 60:1232-42. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  2. pmc Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Bull 33:932-6. 2007
    ..The ultimate goal is to characterize their respective underlying genotypes...
  3. pmc Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Proc Natl Acad Sci U S A 104:10164-9. 2007
    ..In BD, however, a suppression of transcription factors involved in cell differentiation may contribute to GABA dysfunction...
  4. pmc Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 105:20935-40. 2008
    ..The extensive and intricate data that has come from this study has provided insights into how a complex circuit, like the trisynaptic pathway, may be regulated in human hippocampus in both health and disease...
  5. ncbi request reprint Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02178, USA
    Prog Brain Res 158:153-72. 2006
  6. pmc Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 106:11731-6. 2009
    ....
  7. pmc Amygdalocortical circuitry in schizophrenia: from circuits to molecules
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA
    Neuropsychopharmacology 35:239-57. 2010
    ....
  8. pmc Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
    ..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease...
  9. pmc DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia
    Ned Buttner
    Laboratories for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    Schizophr Res 93:33-41. 2007
    ..These findings suggest that non-GABAergic cells may be selectively vulnerable to oxidative stress in patients with bipolar disorder...
  10. ncbi request reprint Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 61:649-57. 2004
    ..The activity of these neurons is, in turn, modulated by glutamatergic inputs furnished by pyramidal neurons...
  11. ncbi request reprint Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics
    Harry Pantazopoulos
    Laboratory for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 54:147-55. 2004
    ....
  12. doi request reprint A rodent model of schizophrenia derived from postmortem studies
    Sabina Berretta
    Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
    Behav Brain Res 204:363-8. 2009
    ....
  13. ncbi request reprint Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    Stephan Heckers
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02429, USA
    Arch Gen Psychiatry 59:521-9. 2002
    ..We tested the hypothesis that the expression of the 2 isoforms, one 65 kd (GAD(65)) and the other 67 kd (GAD(67)), is differentially affected in the hippocampus in schizophrenia and bipolar disorder...
  14. ncbi request reprint A disturbance of late myelination as a trigger for Alzheimer's disease
    Francine M Benes
    Program in Structural and Molecular Neuroscience, Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Aging 25:41-3. 2004
  15. ncbi request reprint Molecular evidence for mitochondrial dysfunction in bipolar disorder
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 61:300-8. 2004
    ..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder...
  16. ncbi request reprint Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons
    Sabina Berretta
    Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Hippocampus 14:876-94. 2004
    ..These similarities suggest that, in this disease, a disruption of GABAergic transmission within the amygdala may play a significant role in the induction of abnormalities in the hippocampus...
  17. ncbi request reprint DNA fragmentation decreased in schizophrenia but not bipolar disorder
    Francine M Benes
    Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Arch Gen Psychiatry 60:359-64. 2003
    ..Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder...
  18. doi request reprint N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA mail
    Biol Psychiatry 64:803-9. 2008
    ..In this study, we hypothesized that the subset of GABA interneurons that contained the calcium-binding protein calbindin (CB), by virtue of their preferential localization to layer 2, might be particularly affected...
  19. ncbi request reprint Increasing Interaction of amygdalar afferents with GABAergic interneurons between birth and adulthood
    Miles G Cunningham
    Laboratory of Structural Neuroscience, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    Cereb Cortex 18:1529-35. 2008
    ..The establishment of this circuitry, largely during adolescence, may contribute to the integration of emotional responses with attentional and other cognitive processes mediated within this region during corticolimbic development...
  20. ncbi request reprint Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala
    Evgeny Tsvetkov
    McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuron 34:289-300. 2002
    ....
  21. ncbi request reprint A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain
    Mark S Todtenkopf
    Laboratory for Structural Neuroscience, McLean Hospital, 115 Mill Street, 333 MRC, Belmont, MA 02478, USA
    Schizophr Res 73:79-89. 2005
    ....
  22. pmc Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 96:46-61. 2007
    ....
  23. pmc Regulation of synaptic plasticity in a schizophrenia model
    Barbara Gisabella
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 102:13301-6. 2005
    ..We demonstrate that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder...
  24. ncbi request reprint Rat modeling for GABA defects in schizophrenia
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts, USA
    Adv Pharmacol 54:73-93. 2006
  25. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
  26. ncbi request reprint Schizophrenia, II: amygdalar fiber alteration as etiology?
    Francine M Benes
    Am J Psychiatry 160:1053. 2003
  27. ncbi request reprint A rat model for neural circuitry abnormalities in schizophrenia
    Sabina Berretta
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Protoc 1:833-9. 2006
    ..This has established the construct and predictive validity of this model for studying limbic-lobe circuitry abnormalities. We propose that this modeling strategy may provide a valid alternative to isomorphic models of these diseases...

Research Grants27

  1. CORTICOLIMBIC SYSTEM IN SCHIZOPHRENIC BRAIN--ANALYSIS
    Francine Benes; Fiscal Year: 1993
    ....
  2. CORTICOLIMBIC ABNORMALITIES IN SCHIZOPHRENIC BRAIN
    Francine Benes; Fiscal Year: 2001
    ....
  3. BRAIN TISSUE RESOURCE FOR NEUROPSYCHIATRIC RESEARCH
    Francine Benes; Fiscal Year: 2002
    ..Over the next five years, all of these changes will enhance the "brain bank" in its role as a vital national resource. ..
  4. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine Benes; Fiscal Year: 2009
    ....
  5. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine M Benes; Fiscal Year: 2010
    ....