F M Benes

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
  2. ncbi DNA fragmentation decreased in schizophrenia but not bipolar disorder
    Francine M Benes
    Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Arch Gen Psychiatry 60:359-64. 2003
  3. ncbi A disturbance of late myelination as a trigger for Alzheimer's disease
    Francine M Benes
    Program in Structural and Molecular Neuroscience, Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Aging 25:41-3. 2004
  4. ncbi Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus
    F M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Psychiatry 9:932-45, 895. 2004
  5. ncbi Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA
    J Chem Neuroanat 20:259-69. 2000
  6. ncbi The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia
    F M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Mol Psychiatry 11:241-51. 2006
  7. ncbi Two-dimensional versus three-dimensional cell counting: a practical perspective
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA, USA
    Trends Neurosci 24:11-7. 2001
  8. ncbi Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Cereb Cortex 10:1014-27. 2000
  9. ncbi Amygdalo-entorhinal inputs to the hippocampal formation in relation to schizophrenia
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, Massachusetts, USA
    Ann N Y Acad Sci 911:293-304. 2000
  10. ncbi Emerging principles of altered neural circuitry in schizophrenia
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, USA
    Brain Res Brain Res Rev 31:251-69. 2000

Research Grants

  1. CORTICOLIMBIC SYSTEM AND SCHIZOPHRENIA
    Francine Benes; Fiscal Year: 2002
  2. Limbic Lobe in Schizophrenia and Bipolar Disorder
    Francine Benes; Fiscal Year: 2007
  3. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine Benes; Fiscal Year: 2007
  4. A National Resource for Postmortem Brain Research
    Francine Benes; Fiscal Year: 2007

Detail Information

Publications42

  1. ncbi Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
    ..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease...
  2. ncbi DNA fragmentation decreased in schizophrenia but not bipolar disorder
    Francine M Benes
    Laboratories for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Arch Gen Psychiatry 60:359-64. 2003
    ..Apoptosis is thought to play a role in neuronal pathology in schizophrenia and bipolar disorder...
  3. ncbi A disturbance of late myelination as a trigger for Alzheimer's disease
    Francine M Benes
    Program in Structural and Molecular Neuroscience, Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA
    Neurobiol Aging 25:41-3. 2004
  4. ncbi Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus
    F M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Psychiatry 9:932-45, 895. 2004
    ..Taken together, these results suggest that amygdalar activation may play a role in the pathophysiology and treatment of psychosis by regulating the activity of multiple GPCR and metabolic pathways in hippocampal cells...
  5. ncbi Glutamate decarboxylase(65)-immunoreactive terminals in cingulate and prefrontal cortices of schizophrenic and bipolar brain
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02178, USA
    J Chem Neuroanat 20:259-69. 2000
    ..Overall, the results of this study, though preliminary, suggest that there may be complex changes in GABAergic terminals in SZ and MD, ones that may vary with respect to primary diagnosis and neuroleptic exposure...
  6. ncbi The expression of proapoptosis genes is increased in bipolar disorder, but not in schizophrenia
    F M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Mol Psychiatry 11:241-51. 2006
    ....
  7. ncbi Two-dimensional versus three-dimensional cell counting: a practical perspective
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA, USA
    Trends Neurosci 24:11-7. 2001
    ....
  8. ncbi Convergence and plasticity of monoaminergic systems in the medial prefrontal cortex during the postnatal period: implications for the development of psychopathology
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Cereb Cortex 10:1014-27. 2000
    ....
  9. ncbi Amygdalo-entorhinal inputs to the hippocampal formation in relation to schizophrenia
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, Massachusetts, USA
    Ann N Y Acad Sci 911:293-304. 2000
    ..Overall, it seems plausible that an increase of excitatory activity entering the hippocampus from the basolateral complex via both direct and indirect pathways may make a significant contribution to the pathophysiology of schizophrenia...
  10. ncbi Emerging principles of altered neural circuitry in schizophrenia
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA, USA
    Brain Res Brain Res Rev 31:251-69. 2000
    ..Taken together, these emerging principles can provide a framework for future postmortem studies of schizophrenic brain...
  11. ncbi Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia
    S Berretta
    Laboratory for Structural Neuroscience, Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    J Comp Neurol 431:129-38. 2001
    ..Such "partial" rodent modelling provides an important strategy for deciphering the effect of altered cortico-limbic circuits in SZ...
  12. ncbi Mapping of hippocampal gene clusters regulated by the amygdala to nonlinkage sites for schizophrenia
    R E Burke
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont 02478, and Program in Neuroscience, Harvard Medical School, Boston, MA, USA
    Mol Psychiatry 11:158-71. 2006
    ....
  13. ncbi The density of pyramidal and nonpyramidal neurons in anterior cingulate cortex of schizophrenic and bipolar subjects
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Biol Psychiatry 50:395-406. 2001
    ..CONCLUSIONS: Overall, the findings reported here suggest that local circuit cells in layer II of ACCx may be decreased in bipolar disorder, whereas projection neurons in deeper laminae are decreased in schizophrenia...
  14. ncbi GluR5,6,7 subunit immunoreactivity on apical pyramidal cell dendrites in hippocampus of schizophrenics and manic depressives
    F M Benes
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, Massachusetts 02178, USA
    Hippocampus 11:482-91. 2001
    ..Taken together, the preferential reduction of GluR5,6,7-IR observed on apical dendrites of pyramidal neurons is consistent with a functional downregulation of the kainate receptor in the hippocampus of schizophrenic brain...
  15. ncbi DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophrenia
    Ned Buttner
    Laboratories for Structural Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA, United States
    Schizophr Res 93:33-41. 2007
    ..These findings suggest that non-GABAergic cells may be selectively vulnerable to oxidative stress in patients with bipolar disorder...
  16. ncbi Density of glutamic acid decarboxylase 67 messenger RNA-containing neurons that express the N-methyl-D-aspartate receptor subunit NR2A in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung-Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, and Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Arch Gen Psychiatry 61:649-57. 2004
    ..Future studies will address whether subpopulations of these neurons may be differentially affected in the 2 conditions...
  17. ncbi GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 25:1-27. 2001
    ....
  18. ncbi Differences in the cellular distribution of D1 receptor mRNA in the hippocampus of bipolars and schizophrenics
    Harry Pantazopoulos
    Laboratory for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 54:147-55. 2004
    ....
  19. ncbi Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia
    Stephan Heckers
    Laboratory of Structural Neuroscience, McLean Hospital, Belmont, MA 02429, USA
    Arch Gen Psychiatry 59:521-9. 2002
    ..Cellular GAD(67) mRNA expression was normal in both groups. CONCLUSION: We have found a region-specific deficit of GAD(65) and GAD(67) mRNA expression in bipolar disorder...
  20. ncbi A rodent model of schizophrenia derived from postmortem studies
    Sabina Berretta
    Program in Structural and Molecular Neuroscience and Laboratory for Translational Neuroscience, McLean Hospital, Belmont, MA, United States
    Behav Brain Res 204:363-8. 2009
    ....
  21. ncbi Effects of pre- and postnatal corticosterone exposure on the rat hippocampal GABA system
    D J Stone
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Hippocampus 11:492-507. 2001
    ..Under these conditions, prenatal exposure to CORT may sensitize some of these effects, but does not fundamentally alter the nature of this response...
  22. ncbi Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 105:20935-40. 2008
    ..The extensive and intricate data that has come from this study has provided insights into how a complex circuit, like the trisynaptic pathway, may be regulated in human hippocampus in both health and disease...
  23. ncbi Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02178, USA
    Proc Natl Acad Sci U S A 104:10164-9. 2007
    ..In BD, however, a suppression of transcription factors involved in cell differentiation may contribute to GABA dysfunction...
  24. ncbi Searching for unique endophenotypes for schizophrenia and bipolar disorder within neural circuits and their molecular regulatory mechanisms
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Schizophr Bull 33:932-6. 2007
    ..The ultimate goal is to characterize their respective underlying genotypes...
  25. ncbi N-methyl-D-aspartate receptor and calbindin-containing neurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA mail
    Biol Psychiatry 64:803-9. 2008
    ..In this study, we hypothesized that the subset of GABA interneurons that contained the calcium-binding protein calbindin (CB), by virtue of their preferential localization to layer 2, might be particularly affected...
  26. ncbi Amygdalocortical circuitry in schizophrenia: from circuits to molecules
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA
    Neuropsychopharmacology 35:239-57. 2010
    ....
  27. ncbi Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 106:11731-6. 2009
    ....
  28. ncbi Molecular evidence for mitochondrial dysfunction in bipolar disorder
    Christine Konradi
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Arch Gen Psychiatry 61:300-8. 2004
    ..The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder...
  29. ncbi Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons
    Sabina Berretta
    Program for Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts 02478, USA
    Hippocampus 14:876-94. 2004
    ..These similarities suggest that, in this disease, a disruption of GABAergic transmission within the amygdala may play a significant role in the induction of abnormalities in the hippocampus...
  30. ncbi Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Mailman Research Center, 115 Mill Street, Belmont, MA 02178, USA
    Prog Brain Res 158:153-72. 2006
  31. ncbi Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala
    Evgeny Tsvetkov
    McLean Hospital, Department of Psychiatry, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuron 34:289-300. 2002
    ....
  32. ncbi Increasing Interaction of amygdalar afferents with GABAergic interneurons between birth and adulthood
    Miles G Cunningham
    Laboratory of Structural Neuroscience, McLean Hospital, Harvard Medical School, Boston, MA 02478, USA
    Cereb Cortex 18:1529-35. 2008
    ..The establishment of this circuitry, largely during adolescence, may contribute to the integration of emotional responses with attentional and other cognitive processes mediated within this region during corticolimbic development...
  33. ncbi Amygdala-dependent regulation of electrical properties of hippocampal interneurons in a model of schizophrenia
    Barbara Gisabella
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02478, USA
    Biol Psychiatry 65:464-72. 2009
    ..In the present work we tested the hypothesis that BLA activation in this rodent model of SZ leads to changes in the electrical properties of interneurons located in sector CA2/3...
  34. ncbi A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain
    Mark S Todtenkopf
    Laboratory for Structural Neuroscience, McLean Hospital, 115 Mill Street, 333 MRC, Belmont, MA 02478, USA
    Schizophr Res 73:79-89. 2005
    ....
  35. ncbi Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia
    R J Baldessarini
    Department of Psychiatry and Neurology, Harvard Medical School, Boston, Mass, USA
    Am J Psychiatry 154:861-3. 1997
    ..To evaluate the hypothesis that patients with schizophrenia who have been treated with neuroleptics have a high rate of Alzheimer's disease-like neuropathology...
  36. ncbi Regulation of synaptic plasticity in a schizophrenia model
    Barbara Gisabella
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 102:13301-6. 2005
    ..We demonstrate that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder...
  37. ncbi A rat model for neural circuitry abnormalities in schizophrenia
    Sabina Berretta
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Protoc 1:833-9. 2006
    ..This has established the construct and predictive validity of this model for studying limbic-lobe circuitry abnormalities. We propose that this modeling strategy may provide a valid alternative to isomorphic models of these diseases...
  38. ncbi Differential alterations of kainate receptor subunits in inhibitory interneurons in the anterior cingulate cortex in schizophrenia and bipolar disorder
    Tsung Ung W Woo
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Schizophr Res 96:46-61. 2007
    ....
  39. ncbi Rat modeling for GABA defects in schizophrenia
    Francine M Benes
    Program in Structural and Molecular Neuroscience, McLean Hospital, Belmont, Massachusetts, USA
    Adv Pharmacol 54:73-93. 2006
  40. ncbi Schizophrenia, II: amygdalar fiber alteration as etiology?
    Francine M Benes
    Am J Psychiatry 160:1053. 2003
  41. ncbi Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..iii) Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia...
  42. ncbi Deserving the last great gift
    Francine M Benes
    Cerebrum 5:61-73. 2003
    ....

Research Grants4

  1. CORTICOLIMBIC SYSTEM AND SCHIZOPHRENIA
    Francine Benes; Fiscal Year: 2002
    ....
  2. Limbic Lobe in Schizophrenia and Bipolar Disorder
    Francine Benes; Fiscal Year: 2007
    ..By learning more about the possible role of oxidative stress, novel forms of pharmacotherapy for the major neuropsychiatric disorders may eventually be developed. ..
  3. Gene Expression in Hippocampal Circuits of Bipolars and Schizophrenics
    Francine Benes; Fiscal Year: 2007
    ....
  4. A National Resource for Postmortem Brain Research
    Francine Benes; Fiscal Year: 2007
    ..Over the next funding period, these new initiatives will enhance the functioning of the "brain bank" in its role as a vital national resource. ..