Charaf Benarafa

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
    Charaf Benarafa
    Center for Blood Research, Boston, Massachusetts 02115, USA
    J Biol Chem 277:42028-33. 2002
  2. pmc The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates
    Charaf Benarafa
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:11367-72. 2005
  3. pmc The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    Charaf Benarafa
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1901-9. 2007
  4. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
  5. pmc Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection
    Dapeng Gong
    Immune Disease Institute and Program in Cellular and Molecular Medicine at Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:592-600. 2011
  6. ncbi SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia
    Ryuji Yasumatsu
    Division of Newborn Medicine, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 291:L619-27. 2006
  7. pmc Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Biochem Biophys Res Commun 401:440-6. 2010
  8. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010
  9. pmc Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Immunol 184:5325-32. 2010
  10. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008

Collaborators

Detail Information

Publications12

  1. ncbi Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
    Charaf Benarafa
    Center for Blood Research, Boston, Massachusetts 02115, USA
    J Biol Chem 277:42028-33. 2002
    ..These data demonstrate that the four murine homologs of MNEI have met different evolutionary fates, and that EIA is the mouse ortholog of MNEI...
  2. pmc The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates
    Charaf Benarafa
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:11367-72. 2005
    ..In addition, it suggests that "newer" serpins, such as ovalbumin, have contributed to vertebrate adaptation...
  3. pmc The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection
    Charaf Benarafa
    CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1901-9. 2007
    ..Thus, regulation of pulmonary innate immunity by serpinb1 is nonredundant and is required to protect two key components, the neutrophil and SP-D, from NSP damage during the host response to infection...
  4. pmc Increased surfactant protein D fails to improve bacterial clearance and inflammation in serpinB1-/- mice
    J Michael Stolley
    Immune Disease Institute, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 47:792-9. 2012
    ....
  5. pmc Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection
    Dapeng Gong
    Immune Disease Institute and Program in Cellular and Molecular Medicine at Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Infect Dis 204:592-600. 2011
    ....
  6. ncbi SERPINB1 upregulation is associated with in vivo complex formation with neutrophil elastase and cathepsin G in a baboon model of bronchopulmonary dysplasia
    Ryuji Yasumatsu
    Division of Newborn Medicine, Children s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 291:L619-27. 2006
    ..Thus SERPINB1 upregulation in new BPD may be protective by contributing to the regulation of neutrophil proteases NE and cat G...
  7. pmc Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Biochem Biophys Res Commun 401:440-6. 2010
    ..Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration...
  8. pmc WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling
    Anna Shcherbina
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Br J Haematol 148:416-27. 2010
    ..The collective results reveal a novel function for WASP in regulating pro-aggregatory and pro-coagulant responses downstream of integrin outside-in signalling...
  9. pmc Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Immunol 184:5325-32. 2010
    ..In conclusion, our results introduce FAST as a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation...
  10. pmc Inflammation induces hemorrhage in thrombocytopenia
    Tobias Goerge
    Immune Disease Institute, Harvard Medical School, Boston, MA, USA
    Blood 111:4958-64. 2008
    ..Based on our observations, we propose that inflammation may cause life-threatening hemorrhage during thrombocytopenia...
  11. ncbi Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, 3800, Australia
    Genomics 79:349-62. 2002
    ..Compared with human, this larger mouse serpin repertoire probably reflects the need to regulate a larger proteinase repertoire arising from differing evolutionary pressures on the reproductive and immune systems...
  12. ncbi Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis
    Visith Thongboonkerd
    Kidney Disease Program, Department of Medicine, University of Louisville, Louisville, Kentucky, USA
    J Am Soc Nephrol 15:650-62. 2004
    ..The identification of these coordinated changes in protein expression in diabetic nephropathy indicates the potential value of proteomic analysis in defining pathophysiology...