David C Bellinger

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Childhood lead poisoning: the torturous path from science to policy
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 116:853-7. 2006
  2. pmc Neurobehavioral testing in human risk assessment
    Diane S Rohlman
    Center for Research on Occupational and Environmental Toxicology, L606, Oregon Health and Science University, Portland, OR 97239, USA
    Neurotoxicology 29:556-67. 2008
  3. pmc Prenatal Exposures to Environmental Chemicals and Children's Neurodevelopment: An Update
    David C Bellinger
    Boston Children s Hospital, Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Saf Health Work 4:1-11. 2013
  4. pmc A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Environ Health Perspect 120:501-7. 2012
  5. doi request reprint Comparing the population neurodevelopmental burdens associated with children's exposures to environmental chemicals and other risk factors
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, MA 02115, United States
    Neurotoxicology 33:641-3. 2012
  6. doi request reprint Very low lead exposures and children's neurodevelopment
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 20:172-7. 2008
  7. pmc The protean toxicities of lead: new chapters in a familiar story
    David C Bellinger
    Children s Hospital Boston, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Int J Environ Res Public Health 8:2593-628. 2011
  8. ncbi request reprint Lead
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 113:1016-22. 2004
  9. ncbi request reprint Invited commentary
    David C Bellinger
    Department of Neurology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Ann Thorac Surg 80:917. 2005
  10. pmc Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure: neuropsychological assessment and structural brain imaging
    David C Bellinger
    Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Circulation 124:1361-9. 2011

Research Grants

Collaborators

Detail Information

Publications87

  1. pmc Childhood lead poisoning: the torturous path from science to policy
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 116:853-7. 2006
    ....
  2. pmc Neurobehavioral testing in human risk assessment
    Diane S Rohlman
    Center for Research on Occupational and Environmental Toxicology, L606, Oregon Health and Science University, Portland, OR 97239, USA
    Neurotoxicology 29:556-67. 2008
    ..This paper reflects a summary of the talks presented at the Neurobehavioral Testing in Human Risk Assessment symposium presented at the 11th meeting of the International Neurotoxicology Association...
  3. pmc Prenatal Exposures to Environmental Chemicals and Children's Neurodevelopment: An Update
    David C Bellinger
    Boston Children s Hospital, Harvard Medical School, Harvard School of Public Health, Boston, MA, USA
    Saf Health Work 4:1-11. 2013
    ..In such cases, points of disagreement among studies are identified and suggestions provided for approaches to resolution of the inconsistencies, including greater standardization of methods for expressing exposure and assessing outcomes...
  4. pmc A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Environ Health Perspect 120:501-7. 2012
    ..Such a judgment reflects a failure to distinguish between individual and population risk. The population impact of a risk factor depends on both its effect size and its distribution (or incidence/prevalence)...
  5. doi request reprint Comparing the population neurodevelopmental burdens associated with children's exposures to environmental chemicals and other risk factors
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, MA 02115, United States
    Neurotoxicology 33:641-3. 2012
    ....
  6. doi request reprint Very low lead exposures and children's neurodevelopment
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 20:172-7. 2008
    ..The review evaluates the basis for these calls...
  7. pmc The protean toxicities of lead: new chapters in a familiar story
    David C Bellinger
    Children s Hospital Boston, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Int J Environ Res Public Health 8:2593-628. 2011
    ..Studies employing neuroimaging modalities such as volumetric, diffusion tensor, and functional MRI are providing insights into the neural bases of the cognitive impairments associated with greater lead exposure...
  8. ncbi request reprint Lead
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 113:1016-22. 2004
    ....
  9. ncbi request reprint Invited commentary
    David C Bellinger
    Department of Neurology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Ann Thorac Surg 80:917. 2005
  10. pmc Adolescents with d-transposition of the great arteries corrected with the arterial switch procedure: neuropsychological assessment and structural brain imaging
    David C Bellinger
    Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Circulation 124:1361-9. 2011
    ..Children were randomly assigned to a vital organ support method, deep hypothermia with either total circulatory arrest or continuous low-flow cardiopulmonary bypass...
  11. ncbi request reprint Teratogen update: lead and pregnancy
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Birth Defects Res A Clin Mol Teratol 73:409-20. 2005
    ..Subgroups of women who incurred substantial exposures to lead prior to pregnancy should be considered to be at increased risk...
  12. ncbi request reprint Interpretation of small effect sizes in occupational and environmental neurotoxicology: individual versus population risk
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Neurotoxicology 28:245-51. 2007
    ....
  13. ncbi request reprint Lead neurotoxicity in children: decomposing the variability in dose-effect relationships
    David C Bellinger
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Am J Ind Med 50:720-8. 2007
    ....
  14. ncbi request reprint Behaviour at eight years in children with surgically corrected transposition: The Boston Circulatory Arrest Trial
    David C Bellinger
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Cardiol Young 19:86-97. 2009
    ..Children with congenitally malformed hearts who underwent reparative surgery in infancy using a strategy of severe haemodilution and alpha stat are at increased risk of behavioural problems in middle childhood...
  15. pmc Neurological and behavioral consequences of childhood lead exposure
    David C Bellinger
    Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 5:e115. 2008
  16. pmc Lead neurotoxicity and socioeconomic status: conceptual and analytical issues
    David C Bellinger
    Children s Hospital Boston, Farley Basement Box 127, Harvard Medical School, Harvard School of Public Health, 300 Longwood Avenue, Boston, MA 02115, United States
    Neurotoxicology 29:828-32. 2008
    ....
  17. doi request reprint Late neurodevelopmental effects of early exposures to chemical contaminants: reducing uncertainty in epidemiological studies
    David C Bellinger
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Basic Clin Pharmacol Toxicol 102:237-44. 2008
    ..In addition, a systems approach to understanding the associations among contaminant exposures, covariates and health outcomes is necessary...
  18. ncbi request reprint Are children with congenital cardiac malformations at increased risk of deficits in social cognition?
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, 300 Longwood Avenue, Boston, MA 02115, USA
    Cardiol Young 18:3-9. 2008
    ..In ongoing evaluations of the children as adolescents, we are testing these hypotheses more systematically by administering several instruments specifically developed to assess "theory of mind" and alexithymia...
  19. doi request reprint Interpreting epidemiologic studies of developmental neurotoxicity: conceptual and analytic issues
    David C Bellinger
    Children s Hospital Boston, Harvard Medical School, Harvard School of Public Health, Farley Basement Box 127, Children s Hospital, Boston, MA 02115, USA
    Neurotoxicol Teratol 31:267-74. 2009
    ..A final issue discussed is the need to define standards for the conduct, analysis, and reporting of epidemiologic studies of neurotoxicity, similar to those developed for other fields...
  20. ncbi request reprint Assessing environmental neurotoxicant exposures and child neurobehavior: confounded by confounding?
    David C Bellinger
    Department of Neurology Harvard Medical School, Children s Hospital, Boston, MA 02115, USA
    Epidemiology 15:383-4. 2004
  21. doi request reprint The effect of hematocrit during hypothermic cardiopulmonary bypass in infant heart surgery: results from the combined Boston hematocrit trials
    David Wypij
    Department of Cardiology, Children s Hospital Boston, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 135:355-60. 2008
    ..The form of the relationship between continuous hematocrit levels and outcomes requires further study...
  22. ncbi request reprint The effect of duration of deep hypothermic circulatory arrest in infant heart surgery on late neurodevelopment: the Boston Circulatory Arrest Trial
    David Wypij
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, 02115, USA
    J Thorac Cardiovasc Surg 126:1397-403. 2003
    ..Our goal was to determine the functional form of the association between duration of circulatory arrest and risk of neurodevelopmental dysfunction...
  23. pmc Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    J Occup Environ Med 50:1053-61. 2008
    ..We evaluated the modifying influence of a delta-aminolevulinic acid dehydratase (ALAD) polymorphism on the relation between lead burden and cognition among older men...
  24. pmc Associations of early childhood manganese and lead coexposure with neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 120:126-31. 2012
    ..Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals...
  25. ncbi request reprint Neurodevelopmental status at eight years in children with dextro-transposition of the great arteries: the Boston Circulatory Arrest Trial
    David C Bellinger
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 126:1385-96. 2003
    ..Our goal was to determine which of the two major methods of vital organ support used in infant cardiac surgery, total circulatory arrest and low-flow cardiopulmonary bypass, results in better neurodevelopmental outcomes at school age...
  26. doi request reprint Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery
    Jane W Newburger
    Department of Cardiology, Children s Hospital Boston, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 135:347-54, 354.e1-4. 2008
    ..However, worse outcomes were concentrated in patients with hematocrit values of 20% or below, and the benefits of hematocrit values higher than 25% were uncertain...
  27. ncbi request reprint Length of stay after infant heart surgery is related to cognitive outcome at age 8 years
    Jane W Newburger
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 143:67-73. 2003
    ..To test the hypothesis that postoperative length of stay (LOS) after infant heart surgery might be an easily measured surrogate marker for various events that culminate in later adverse cognitive outcome...
  28. pmc Neuropsychological function in children with blood lead levels <10 microg/dL
    Pamela J Surkan
    Department of Environmental Health, Harvard School of Public Health, Landmark Building, 4th Floor, 401 Park Drive, Boston, MA 02115, USA
    Neurotoxicology 28:1170-7. 2007
    ..Overall, our analyses support prior research that children's blood levels <10 microg/dL are related to compromised cognition and highlight that these may especially be related to academic achievement...
  29. pmc Relationship of intraoperative cerebral oxygen saturation to neurodevelopmental outcome and brain magnetic resonance imaging at 1 year of age in infants undergoing biventricular repair
    Barry D Kussman
    Department of Anesthesiology, Children s Hospital Boston, 300 Longwood Ave, Boston, Mass 02115, USA
    Circulation 122:245-54. 2010
    ....
  30. pmc Early postnatal blood manganese levels and children's neurodevelopment
    Birgit Claus Henn
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 21:433-9. 2010
    ..Previous studies have addressed the effects of prenatal exposure, but little is known about developmental effects of early postnatal exposure...
  31. doi request reprint Prenatal exposure to mercury and fish consumption during pregnancy and attention-deficit/hyperactivity disorder-related behavior in children
    Sharon K Sagiv
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Arch Pediatr Adolesc Med 166:1123-31. 2012
    ..To investigate the association of prenatal mercury exposure and fish intake with attention-deficit/hyperactivity disorder (ADHD)-related behavior...
  32. pmc Neuropsychological measures of attention and impulse control among 8-year-old children exposed prenatally to organochlorines
    Sharon K Sagiv
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 120:904-9. 2012
    ....
  33. ncbi request reprint A dose-effect analysis of children's exposure to dental amalgam and neuropsychological function: the New England Children's Amalgam Trial
    David C Bellinger
    Children s Hospital, Boston, MA, USA
    J Am Dent Assoc 138:1210-6. 2007
    ....
  34. pmc A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study
    Emily Oken
    Department of Population Medicine, Harvard Medical School and the Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, Boston, MA 02215, USA
    Nutr J 12:33. 2013
    ..However, concern exists that this advice will lead to excess intake of methylmercury, a developmental neurotoxicant...
  35. ncbi request reprint Prediction of IQ and achievement at age 8 years from neurodevelopmental status at age 1 year in children with D-transposition of the great arteries
    Ellen McGrath
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 114:e572-6. 2004
    ..Whether test scores of CHD patients in infancy are predictive of status at school age has not been evaluated, however...
  36. pmc Maternal self-esteem, exposure to lead, and child neurodevelopment
    Pamela J Surkan
    Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 29:278-85. 2008
    ..Moreover, there was evidence that maternal self-esteem attenuated the negative effects of lead exposure, although the interaction fell short of conventional levels of statistical significance...
  37. pmc Assessing windows of susceptibility to lead-induced cognitive deficits in Mexican children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 33:1040-7. 2012
    ..The identification of susceptible periods to Pb-induced decrements in childhood cognitive abilities remains elusive...
  38. pmc Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Am J Epidemiol 167:1171-81. 2008
    ..3, -0.9) for the WRAVMA. Fish consumption of < or =2 servings/week was not associated with a benefit. Dietary recommendations for pregnant women should incorporate the nutritional benefits as well as the risks of fish intake...
  39. pmc Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study
    Pradeep Rajan
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Am J Epidemiol 166:1400-8. 2007
    ..004). These results augment evidence of a deleterious association between lead and psychiatric symptoms...
  40. pmc Adolescents with D-transposition of the great arteries repaired in early infancy demonstrate reduced white matter microstructure associated with clinical risk factors
    Michael J Rivkin
    Department of Neurology, Boston Children s Hospital, Boston, Mass 02115, USA
    J Thorac Cardiovasc Surg 146:543-9.e1. 2013
    ..We also examined correlates between patient demographic and medical risk factors and white matter as assessed by regional fractional anisotropy (FA) values...
  41. ncbi request reprint A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India
    David C Bellinger
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Int J Occup Environ Health 11:138-43. 2005
    ..0+/-22.5, respectively. Behavior ratings were not associated with blood lead level. Lead exposure is a significant problem among Indian children, with many having blood lead levels associated with increased neurodevelopmental risk...
  42. ncbi request reprint The influence of hemodilution on outcome after hypothermic cardiopulmonary bypass: results of a randomized trial in infants
    Richard A Jonas
    Department of Cardiovascular Surgery, Children s Hospital Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 126:1765-74. 2003
    ..We hypothesized that cognitive impairment and hemodynamic instability after infant cardiac surgery with cardiopulmonary bypass might be exacerbated by hemodilution...
  43. pmc Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides
    Maryse F Bouchard
    Department of Environmental Health, School of Public Health, Harvard University, Boston, MA, USA
    Pediatrics 125:e1270-7. 2010
    ..The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age...
  44. pmc Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease
    Janet S Soul
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 138:374-81. 2009
    ..We aimed to determine the incidence and type of brain injury in infants undergoing 2-ventricle repair in infancy and to determine risk factors associated with such injury...
  45. ncbi request reprint Neurodevelopmental outcome after congenital heart surgery: results from an institutional registry
    Joseph M Forbess
    Department of Cardiovascular Surgery, Children s Hospital, Boston, Mass 02115, USA
    Circulation 106:I95-102. 2002
    ..This investigation is part of an institutional effort to examine the neurodevelopment of 5-year-old children following repair or palliation of CHD...
  46. ncbi request reprint A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:366-74. 2005
    ..Also, for seven of the eight studies reviewed, effects are extrapolated from formula supplementation to maternal dietary intake...
  47. pmc Predictors of virtual radial arm maze performance in adolescent Italian children
    Joe M Braun
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Neurotoxicology 33:1203-11. 2012
    ..The radial arm maze (RAM), a rodent visuospatial learning and memory task, has a computerized version for use in children, which may help improve comparisons between animal and human studies...
  48. pmc Cadmium exposure and neurodevelopmental outcomes in U.S. children
    Timothy Ciesielski
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:758-63. 2012
    ..Low-level environmental cadmium exposure in children may be associated with adverse neurodevelopmental outcomes...
  49. pmc Low-level environmental lead exposure in childhood and adult intellectual function: a follow-up study
    Maitreyi Mazumdar
    Department of Neurology, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA, USA
    Environ Health 10:24. 2011
    ..Early life lead exposure might be a risk factor for neurocognitive impairment in adulthood...
  50. ncbi request reprint Intraoperative hyperglycemia during infant cardiac surgery is not associated with adverse neurodevelopmental outcomes at 1, 4, and 8 years
    Sarah de Ferranti
    Children s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 100:1345-52. 2004
    ..It is unknown whether intraoperative hyperglycemia in infants is associated with worse neurodevelopmental outcomes after low-flow cardiopulmonary bypass (LF), deep hypothermic circulatory arrest (CA), or both...
  51. ncbi request reprint Effect of prenatal diagnosis on outcomes in D-transposition of the great arteries
    Jodi M Bartlett
    Department of Cardiology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Pediatrics 113:e335-40. 2004
    ..We explored the impact of prenatal diagnosis on perinatal and perioperative variables and on outcomes at 1 year of age...
  52. pmc Fish consumption, methylmercury and child neurodevelopment
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Healthcare, Boston, Massachusetts 02215, USA
    Curr Opin Pediatr 20:178-83. 2008
    ..To summarize recent evidence regarding associations of early life exposure to mercury from maternal fish consumption during pregnancy, thimerosal in vaccines and dental amalgam with child neurodevelopment...
  53. pmc Dental amalgam restorations and children's neuropsychological function: the New England Children's Amalgam Trial
    David C Bellinger
    Department of Neurology, Children s Hospital Boston and Harvard Medical, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 115:440-6. 2007
    ..A concern persists that children's exposure to mercury vapor from dental amalgams produces neurotoxicity...
  54. ncbi request reprint A quantitative analysis of prenatal methyl mercury exposure and cognitive development
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:353-65. 2005
    ..7 points. This paper identifies important sources of uncertainty influencing this estimate, concluding that the plausible range of values for this loss is 0 to 1.5 IQ points...
  55. ncbi request reprint Children's cognitive health: the influence of environmental chemical exposures
    David C Bellinger
    Harvard Medical School, USA
    Altern Ther Health Med 13:S140-4. 2007
    ..Effective medical/environmental treatments for the adverse effects associated with chemical exposures are largely unknown, rendering primary prevention of exposure the most effective strategy for protecting children...
  56. ncbi request reprint Update on the clinical management of childhood lead poisoning
    Alan D Woolf
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Pediatr Clin North Am 54:271-94, viii. 2007
    ..It includes current thinking on the clinical management and prevention of childhood lead poisoning...
  57. pmc Early developmental outcome in children with hypoplastic left heart syndrome and related anomalies: the single ventricle reconstruction trial
    Jane W Newburger
    Children s Hospital Boston and Harvard Medical School, MA, USA
    Circulation 125:2081-91. 2012
    ..Survivors of the Norwood procedure may experience neurodevelopmental impairment. Clinical trials to improve outcomes have focused primarily on methods of vital organ support during cardiopulmonary bypass...
  58. ncbi request reprint Neurologic outcome of choreoathetoid encephalopathy after cardiac surgery
    Adre J Du Plessis
    Department of Neurology, Fegan 11, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts, 02115 USA
    Pediatr Neurol 27:9-17. 2002
    ....
  59. pmc Associations of maternal fish intake during pregnancy and breastfeeding duration with attainment of developmental milestones in early childhood: a study from the Danish National Birth Cohort
    Emily Oken
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Am J Clin Nutr 88:789-96. 2008
    ..Few studies have examined the overall effect of maternal fish intake during pregnancy on child development or examined whether the developmental benefits of maternal fish intake are greater in infants breastfed for a shorter duration...
  60. ncbi request reprint Visual-spatial skills in children after open-heart surgery
    David C Bellinger
    Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Dev Behav Pediatr 24:169-79. 2003
    ..In addition, these deficits do not seem to be clearly associated with the intraoperative methods or postoperative events evaluated...
  61. pmc Stunting and wasting are associated with poorer psychomotor and mental development in HIV-exposed Tanzanian infants
    Christine M McDonald
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    J Nutr 143:204-14. 2013
    ..Strategies to lower mother-to-child transmission of HIV, prevent preterm birth, and enhance child growth could contribute to improved child psychomotor and mental development...
  62. pmc Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood
    Maitreyi Mazumdar
    Department of Neurology, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Environ Health Perspect 120:702-7. 2012
    ..Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimer's disease (AD)...
  63. ncbi request reprint Neurobehavioral factors associated with referral for learning problems in a community sample: evidence for an adaptational model for learning disorders
    Deborah P Waber
    Department of Psychiatry, Children s Hospital, Boston, MA 02115, USA
    J Learn Disabil 36:467-83. 2003
    ....
  64. ncbi request reprint Neurodevelopmental outcomes after biventricular repair of congenital heart defects
    Joseph M Forbess
    Departments of Cardiovascular Surgery and Neuroepidemiology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Cardiovasc Surg 123:631-9. 2002
    ..This study was undertaken to assess neurodevelopment of children after biventricular repair of congenital heart defects...
  65. ncbi request reprint Neuropsychological and renal effects of dental amalgam in children: a randomized clinical trial
    David C Bellinger
    Department of Neurology, Children s Hospital Boston, and Harvard Medical School, Boston, Mass, USA
    JAMA 295:1775-83. 2006
    ..No randomized trials have been published that address the concern that inhalation of mercury vapor released by amalgam dental restorations causes adverse health effects...
  66. ncbi request reprint Perspectives on incorporating human neurobehavioral end points in risk assessments
    David C Bellinger
    Children s Hospital, Farley Basement Box 127, 300 Longwood Avenue, Boston, MA 02115, USA
    Risk Anal 23:163-74. 2003
    ..Use of neurobehavioral test scores involves considerations that differ little from those that the risk assessor routinely addresses in using end points commonly used in research on other topics in environmental epidemiology...
  67. pmc Prenatal organochlorine exposure and behaviors associated with attention deficit hyperactivity disorder in school-aged children
    Sharon K Sagiv
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 171:593-601. 2010
    ..76, 95% confidence interval: 1.06, 2.92) and a similar relation for p,p'-DDE. These results support an association between low-level prenatal organochlorine exposure and ADHD-like behaviors in childhood...
  68. ncbi request reprint Influence of parental stress and social support on the behavioral adjustment of children with transposition of the great arteries
    Karen J Visconti
    Department of Cardiac Surgery, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Dev Behav Pediatr 23:314-21. 2002
    ..Social support, however, did not moderate the relationship between stress and child behavior problems. Early detection of distressed families may assist in alleviating stress and reducing behavior problems...
  69. pmc Blood lead level and dental caries in school-age children
    Allison Gemmel
    New England Research Institutes, Watertown, Massachusetts, USA
    Environ Health Perspect 110:A625-30. 2002
    ..A biologic mechanism for lead cariogenicity has not been identified, however. Our data are also consistent with residual confounding by factors associated with both elevated lead exposure and dental caries...
  70. ncbi request reprint Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site
    Robert O Wright
    Harvard School of Public Health, USA
    Neurotoxicology 27:210-6. 2006
    ..No other significant relationships were found. These results suggest the need to study further the neuropsychological correlates of developmental exposure to Mn and As, particularly as a mixture...
  71. ncbi request reprint Ethical challenges in conducting pediatric environmental health research. Introduction
    David C Bellinger
    Neuroepidemiology Unit, Children s Hospital, Boston, MA 02115, USA
    Neurotoxicol Teratol 24:443. 2002
  72. pmc Children's exposure to violence and distress symptoms: influence of caretakers' psychological functioning
    Shakira Franco Suglia
    Department of Pediatrics, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA
    Int J Behav Med 18:35-43. 2011
    ....
  73. ncbi request reprint Clinical research approaches to studying pediatric anesthetic neurotoxicity
    Mary Ellen McCann
    Department of Anesthesiology, Perioperative and Pain Medicine, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Neurotoxicology 30:766-71. 2009
    ....
  74. ncbi request reprint Perspectives on incorporating human neurobehavioral end points in risk assessments
    David C Bellinger
    Children s Hospital, Boston, MA 02115, USA
    Risk Anal 22:487-98. 2002
    ..Use of neurobehavioral test scores involves considerations that differ little from those that the risk assessor routinely addresses in using end points commonly used in research on other topics in environmental epidemiology...
  75. ncbi request reprint Motor sequence learning and reading ability: is poor reading associated with sequencing deficits?
    Deborah P Waber
    Department of Psychiatry, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    J Exp Child Psychol 84:338-54. 2003
    ..Explicit learning was predicted by cognitive ability, but not by reading or attention problems. Thus, we found no evidence that poor reading is preferentially associated with a domain general deficit in sequential learning...
  76. ncbi request reprint A quantitative risk-benefit analysis of changes in population fish consumption
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:325-34. 2005
    ....
  77. pmc An approach to assessment of endocrine disruption in the National Children's Study
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 111:1691-7. 2003
    ..Nonetheless, if properly designed, the NCS could serve as an excellent resource for investigating future hypotheses regarding endocrine disruption...
  78. ncbi request reprint Early postoperative body temperature and developmental outcome after open heart surgery in infants
    Serena M Cottrell
    Department of Paediatric Intensive Care, Birmingham Children s Hospital, Steelehouse Lane, B4 6NH, Birmingham, United Kingdom
    Ann Thorac Surg 77:66-71; discussion 71. 2004
    ..We explored whether minor deviations in early postoperative body temperature after infant heart surgery affects developmental outcome...
  79. pmc Social ecology of children's vulnerability to environmental pollutants
    Bernard Weiss
    Department of Environmental Medicine, Environmental Health Sciences Center, and Center for Reproductive Epidemiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Environ Health Perspect 114:1479-85. 2006
    ..Such approaches blur the reality of how the early environment establishes enduring biologic substrates...
  80. ncbi request reprint Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City
    Martha M Téllez-Rojo
    Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico
    Pediatrics 118:e323-30. 2006
    ..Using data from a prospective study conducted in Mexico City, Mexico, we evaluated the dose-effect relationship between blood lead levels and neurodevelopment at 12 and 24 months of age...
  81. pmc Low-level environmental lead exposure and children's intellectual function: an international pooled analysis
    Bruce P Lanphear
    Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Environ Health Perspect 113:894-9. 2005
    ..5 microg/dL (p = 0.015). We conclude that environmental lead exposure in children who have maximal blood lead levels < 7.5 microg/dL is associated with intellectual deficits...
  82. pmc Protecting children from environmental toxins
    Bruce P Lanphear
    Environmental Health Center at Cincinnati Children s Hospital Medical Center, Ohio, USA
    PLoS Med 2:e61. 2005
  83. pmc Dose-response relationship of prenatal mercury exposure and IQ: an integrative analysis of epidemiologic data
    Daniel A Axelrad
    Office of Policy, Economics, and Innovation, U S Environmental Protection Agency, 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA
    Environ Health Perspect 115:609-15. 2007
    ..Prenatal exposure to mercury has been associated with adverse childhood neurologic outcomes in epidemiologic studies. Dose-response information for this relationship is useful for estimating benefits of reduced mercury exposure...
  84. pmc Helminth infection and cognitive impairment among Filipino children
    Amara E Ezeamama
    International Health Institute, Brown University, Providence, Rhode Island 02912, USA
    Am J Trop Med Hyg 72:540-8. 2005
    ..04-30). Helminth infection was associated with lower performance in three of the four cognitive domains examined in this study. These relationships remained after rigorous control for other helminths and important confounding covariates...
  85. pmc Invited commentary: persistent organic pollutants and childhood learning and behavioural disorders
    Susan A Korrick
    J Epidemiol Community Health 61:564-5. 2007
  86. ncbi request reprint Brain injury in congenital heart disease
    Jane W Newburger
    Circulation 113:183-5. 2006
  87. ncbi request reprint Intellectual impairment and blood lead levels
    David C Bellinger
    N Engl J Med 349:500-2; author reply 500-2. 2003

Research Grants12

  1. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2001
    ..abstract_text> ..
  2. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  3. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2010
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  4. Metal Exposure and Children?s Preschool Neurodevelopment
    David Bellinger; Fiscal Year: 2009
    ..The effects of exposures to combinations of metals, including lead, is also a major focus. This more closely mirrors "real world" exposures, which invariably involve a mixture of compounds rather than a single compound. ..
  5. Interdisciplinary Training: Neurodevelopmental Toxicology(RMI)
    David Bellinger; Fiscal Year: 2007
    ..Members of the faculty currently conduct a wealth of multidisciplinary research, which will provide trainees with ready opportunities to apply their training in ongoing research projects. ..
  6. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2005
    ..abstract_text> ..
  7. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2004
    ..abstract_text> ..
  8. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2003
    ..abstract_text> ..
  9. NEUROBEHAVIORAL SEQUELAE OF CARDIAC SURGERY
    David Bellinger; Fiscal Year: 2002
    ..abstract_text> ..
  10. Effects of general vs. regional anesthesia on infant neurodevelopment and apnea
    Mary Ellen McCann; Fiscal Year: 2010
    ..If general and regional awake anesthesia result in neurodevelopmental outcomes that are equivalent, this would support the safety of general anesthetics as currently used. ..