Detail Information
Publications
Stem cells and the aging hematopoietic systemIsabel Beerman
Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Curr Opin Immunol 22:500-6. 2010..Recent developments have shed light on how aging of the hematopoietic stem cell compartment contributes to hematopoietic decline through diverse mechanisms...
Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansionIsabel Beerman
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:5465-70. 2010..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging...
