Isabel Beerman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Stem cells and the aging hematopoietic system
    Isabel Beerman
    Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Opin Immunol 22:500-6. 2010
  2. doi request reprint Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
  3. pmc Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
    Isabel Beerman
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 15:37-50. 2014
  4. pmc Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    Isabel Beerman
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5465-70. 2010
  5. pmc Epigenetic regulation of hematopoietic stem cell aging
    Isabel Beerman
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, MA 02116, USA Electronic address
    Exp Cell Res 329:192-9. 2014
  6. pmc Growth hormone receptor signaling is dispensable for HSC function and aging
    Morag H Stewart
    Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA and
    Blood 124:3076-80. 2014

Collaborators

Detail Information

Publications6

  1. doi request reprint Stem cells and the aging hematopoietic system
    Isabel Beerman
    Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Opin Immunol 22:500-6. 2010
    ..Recent developments have shed light on how aging of the hematopoietic stem cell compartment contributes to hematopoietic decline through diverse mechanisms...
  2. doi request reprint Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging
    Isabel Beerman
    Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 12:413-25. 2013
    ..Our results provide evidence that epigenomic alterations of the DNA methylation landscape contribute to the functional decline of HSCs during aging...
  3. pmc Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
    Isabel Beerman
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
    Cell Stem Cell 15:37-50. 2014
    ..These results provide a potential mechanism through which premalignant mutations accrue in HSCs. ..
  4. pmc Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    Isabel Beerman
    Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5465-70. 2010
    ..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging...
  5. pmc Epigenetic regulation of hematopoietic stem cell aging
    Isabel Beerman
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, MA 02116, USA Electronic address
    Exp Cell Res 329:192-9. 2014
    ..This review will focus largely on the two most characterized epigenetic marks - DNA methylation and histone modifications - but will also discuss the potential role of non-coding RNAs in regulating HSC function during aging. ..
  6. pmc Growth hormone receptor signaling is dispensable for HSC function and aging
    Morag H Stewart
    Program in Cellular and Molecular Medicine, Boston Children s Hospital, Boston, MA Department of Stem Cell and Regenerative Medicine, Harvard University, Cambridge, MA and
    Blood 124:3076-80. 2014
    ..Although exogenous Gh induces age-dependent HSC effects, these results indicate that Ghr signaling appears largely dispensable for HSC function and aging. ..