- Stem cells and the aging hematopoietic systemIsabel Beerman
Department of Pathology, Harvard Medical School, Harvard Stem Cell Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Boston, MA 02115, USA
Curr Opin Immunol 22:500-6. 2010..Recent developments have shed light on how aging of the hematopoietic stem cell compartment contributes to hematopoietic decline through diverse mechanisms...
- Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell agingIsabel Beerman
Program in Cellular and Molecular Medicine, Division of Hematology Oncology, Boston Children s Hospital, Boston, MA 02116, USA
Cell Stem Cell 12:413-25. 2013..Our results provide evidence that epigenomic alterations of the DNA methylation landscape contribute to the functional decline of HSCs during aging...
- Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansionIsabel Beerman
Immune Disease Institute, Program in Cellular and Molecular Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:5465-70. 2010..Finally, we present data supporting a model in which clonal expansion of a class of intrinsically myeloid-biased HSCs with robust self-renewal potential is a central component of hematopoietic aging...