Mercedes Becerra

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Adaptation of a web-based, open source electronic medical record system platform to support a large study of tuberculosis epidemiology
    Hamish S F Fraser
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Inform Decis Mak 12:125. 2012
  2. doi request reprint Tuberculosis in children exposed at home to multidrug-resistant tuberculosis
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA
    Pediatr Infect Dis J 32:115-9. 2013
  3. doi request reprint Tuberculosis burden in households of patients with multidrug-resistant and extensively drug-resistant tuberculosis: a retrospective cohort study
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Lancet 377:147-52. 2011
  4. doi request reprint Recurrence after treatment for pulmonary multidrug-resistant tuberculosis
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Clin Infect Dis 51:709-11. 2010
  5. ncbi request reprint Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosis
    M C Becerra
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 4:108-14. 2000
  6. ncbi request reprint Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru
    Carole Mitnick
    Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 348:119-28. 2003
  7. ncbi request reprint Representative drug susceptibility patterns for guiding design of retreatment regimens for MDR-TB
    M L Rich
    Partners In Health, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 10:290-6. 2006
  8. ncbi request reprint Effect of administering short-course, standardized regimens in individuals infected with drug-resistant Mycobacterium tuberculosis strains
    J J Furin
    Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Microbiol Infect Dis 19:132-6. 2000
  9. ncbi request reprint Drug resistance profiles of Mycobacterium tuberculosis isolates: five years' experience and insight into treatment strategies for MDR-TB in Lima, Peru
    R Timperi
    Massachusetts State Laboratory Institute, Boston, Massachusetts 02130, USA
    Int J Tuberc Lung Dis 9:175-80. 2005
  10. ncbi request reprint Acquisition of drug resistance in multidrug-resistant Mycobacterium tuberculosis during directly observed empiric retreatment with standardized regimens
    L L Han
    Massachusetts State Laboratory Institute, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 9:818-21. 2005

Research Grants

Detail Information

Publications19

  1. pmc Adaptation of a web-based, open source electronic medical record system platform to support a large study of tuberculosis epidemiology
    Hamish S F Fraser
    Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA, USA
    BMC Med Inform Decis Mak 12:125. 2012
    ..We added new reports for study managers, and developed data extraction tools for research staff and statisticians. Further adaptation to handle direct entry of laboratory data occurred after the study was launched...
  2. doi request reprint Tuberculosis in children exposed at home to multidrug-resistant tuberculosis
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA
    Pediatr Infect Dis J 32:115-9. 2013
    ..With limited access to MDR-TB treatment, likely millions of children share the experience of chronic exposure to an infectious patient...
  3. doi request reprint Tuberculosis burden in households of patients with multidrug-resistant and extensively drug-resistant tuberculosis: a retrospective cohort study
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Lancet 377:147-52. 2011
    ..WHO recommends contact investigation in close contacts of patients with MDR and XDR tuberculosis. We aimed to assess the burden of tuberculosis disease in household contacts of such patients...
  4. doi request reprint Recurrence after treatment for pulmonary multidrug-resistant tuberculosis
    Mercedes C Becerra
    Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Clin Infect Dis 51:709-11. 2010
    ..2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve...
  5. ncbi request reprint Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosis
    M C Becerra
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 4:108-14. 2000
    ..Public ambulatory care centers in three districts of northern metropolitan Lima, Peru...
  6. ncbi request reprint Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru
    Carole Mitnick
    Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 348:119-28. 2003
    ..We evaluated the results of community-based therapy for multidrug-resistant tuberculosis in a poor section of Lima, Peru...
  7. ncbi request reprint Representative drug susceptibility patterns for guiding design of retreatment regimens for MDR-TB
    M L Rich
    Partners In Health, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 10:290-6. 2006
    ..Often drug susceptibility testing (DST) is not available for all patients, and representative DST patterns in patient populations are used to guide therapy...
  8. ncbi request reprint Effect of administering short-course, standardized regimens in individuals infected with drug-resistant Mycobacterium tuberculosis strains
    J J Furin
    Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
    Eur J Clin Microbiol Infect Dis 19:132-6. 2000
    ..Development of antituberculous-drug resistance through inadvertent, inadequate therapy appears to be the most likely explanation for the increased resistance seen in these three patients...
  9. ncbi request reprint Drug resistance profiles of Mycobacterium tuberculosis isolates: five years' experience and insight into treatment strategies for MDR-TB in Lima, Peru
    R Timperi
    Massachusetts State Laboratory Institute, Boston, Massachusetts 02130, USA
    Int J Tuberc Lung Dis 9:175-80. 2005
    ..Lima, Peru...
  10. ncbi request reprint Acquisition of drug resistance in multidrug-resistant Mycobacterium tuberculosis during directly observed empiric retreatment with standardized regimens
    L L Han
    Massachusetts State Laboratory Institute, Boston, Massachusetts, USA
    Int J Tuberc Lung Dis 9:818-21. 2005
    ..In this limited group of MDR-TB patients, acquisition of resistance was common during failure of empiric drug regimens. Further study is needed to confirm these findings...
  11. ncbi request reprint rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, Peru
    S S Shin
    Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
    Microb Drug Resist 11:26-30. 2005
    ..Isolates from 42 of these patients were subjected to DNA sequencing of the rpoB gene region responsible for rifampin resistance. We determined the frequency of types of mutations in the rpoB gene among these Peruvian isolates...
  12. ncbi request reprint Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosis
    J J Furin
    Department of Social Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Int J Tuberc Lung Dis 5:648-55. 2001
    ..A community-based treatment program for multidrug-resistant tuberculosis (MDR-TB) in an urban shantytown of Lima, Peru...
  13. pmc Comprehensive treatment of extensively drug-resistant tuberculosis
    Carole D Mitnick
    Harvard Medical School, Boston, USA
    N Engl J Med 359:563-74. 2008
    ..We describe the management of extensively drug-resistant tuberculosis and treatment outcomes among patients who were referred for individualized outpatient therapy in Peru...
  14. pmc Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment
    Molly F Franke
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1844-51. 2008
    ....
  15. ncbi request reprint Programmes and principles in treatment of multidrug-resistant tuberculosis
    Joia S Mukherjee
    Brigham and Women s Hospital, Division of Social Medicine and Health Inequalities, Boston, MA, USA
    Lancet 363:474-81. 2004
    ..As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease...
  16. ncbi request reprint From multidrug-resistant tuberculosis to DOTS expansion and beyond: making the most of a paradigm shift
    Jim Yong Kim
    Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA
    Tuberculosis (Edinb) 83:59-65. 2003
    ..This paper offers a case study of the construction of a model of good global governance that--if the opportunity is taken--can improve access to effective TB care through improving and helping to expand the WHO-recommended DOTS strategy...
  17. pmc Expanding tuberculosis case detection by screening household contacts
    Mercedes C Becerra
    Department of Social Medicine, Harvard Medical School, Boston, MA, USA
    Public Health Rep 120:271-7. 2005
    ..Our objective was to assess the feasibility and yield of a simple active case finding strategy in a high incidence population in northern Lima, Peru...
  18. pmc Isoniazid resistance and the future of drug-resistant tuberculosis
    Ted Cohen
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Microb Drug Resist 10:280-5. 2004
    ..Here we present ecological evidence to support the hypothesis that mutations at the 315 position of katG confer isoniazid resistance for Mycobacterium tuberculosis without diminishing virulence or transmissibility...
  19. ncbi request reprint Community-based therapy for children with multidrug-resistant tuberculosis
    Peter C Drobac
    Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120, USA
    Pediatrics 117:2022-9. 2006
    ....

Research Grants6

  1. Epidemiology of multidrug-resistant tuberculosis in Peru
    Mercedes Becerra; Fiscal Year: 2006
    ..tuberculosis strains. Results will serve to guide basic research in tuberculosis diagnostics and therapeutics. ..
  2. Molecular epidemiology of drug-resistant tuberculosis in Peru
    Mercedes Becerra; Fiscal Year: 2007
    This revised application is for a Mentored Faculty Development Award to prepare Dr. Mercedes Becerra for a successful career as an independent investigator in tuberculosis epidemiology. Dr...
  3. Epidemiology of multidrug-resistant tuberculosis in Peru
    Mercedes Becerra; Fiscal Year: 2007
    ..tuberculosis strains. Results will serve to guide basic research in tuberculosis diagnostics and therapeutics. ..