Research Topics
| Mercedes BecerraSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Tuberculosis in Children Exposed at Home to Multidrug-resistant TuberculosisMercedes C Becerra
From the Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA Partners In Health, Boston, MA and Lima, Peru and Division of Global Health Equity, Brigham and Women s Hospital, Boston, MA
Pediatr Infect Dis J 32:115-9. 2013..With limited access to MDR-TB treatment, likely millions of children share the experience of chronic exposure to an infectious patient...- Tuberculosis burden in households of patients with multidrug-resistant and extensively drug-resistant tuberculosis: a retrospective cohort studyMercedes C Becerra
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
Lancet 377:147-52. 2011..WHO recommends contact investigation in close contacts of patients with MDR and XDR tuberculosis. We aimed to assess the burden of tuberculosis disease in household contacts of such patients... - Recurrence after treatment for pulmonary multidrug-resistant tuberculosisMercedes C Becerra
Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA 02115, USA
Clin Infect Dis 51:709-11. 2010..2% (95% confidence interval, 3.0%-8.2%) experienced true relapse. This is an upper-bound estimate of relapse on which new regimens must improve... 
Using treatment failure under effective directly observed short-course chemotherapy programs to identify patients with multidrug-resistant tuberculosisM C Becerra
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 4:108-14. 2000..Public ambulatory care centers in three districts of northern metropolitan Lima, Peru...- Community-based therapy for multidrug-resistant tuberculosis in Lima, PeruCarole Mitnick
Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 348:119-28. 2003..We evaluated the results of community-based therapy for multidrug-resistant tuberculosis in a poor section of Lima, Peru... - Representative drug susceptibility patterns for guiding design of retreatment regimens for MDR-TBM L Rich
Partners In Health, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 10:290-6. 2006..Often drug susceptibility testing (DST) is not available for all patients, and representative DST patterns in patient populations are used to guide therapy... - Effect of administering short-course, standardized regimens in individuals infected with drug-resistant Mycobacterium tuberculosis strainsJ J Furin
Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA
Eur J Clin Microbiol Infect Dis 19:132-6. 2000..Development of antituberculous-drug resistance through inadvertent, inadequate therapy appears to be the most likely explanation for the increased resistance seen in these three patients... - Drug resistance profiles of Mycobacterium tuberculosis isolates: five years' experience and insight into treatment strategies for MDR-TB in Lima, PeruR Timperi
Massachusetts State Laboratory Institute, Boston, Massachusetts 02130, USA
Int J Tuberc Lung Dis 9:175-80. 2005..Lima, Peru... - Occurrence of serious adverse effects in patients receiving community-based therapy for multidrug-resistant tuberculosisJ J Furin
Department of Social Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Int J Tuberc Lung Dis 5:648-55. 2001..A community-based treatment program for multidrug-resistant tuberculosis (MDR-TB) in an urban shantytown of Lima, Peru... - Acquisition of drug resistance in multidrug-resistant Mycobacterium tuberculosis during directly observed empiric retreatment with standardized regimensL L Han
Massachusetts State Laboratory Institute, Boston, Massachusetts, USA
Int J Tuberc Lung Dis 9:818-21. 2005..In this limited group of MDR-TB patients, acquisition of resistance was common during failure of empiric drug regimens. Further study is needed to confirm these findings... - rpoB gene mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis in northern Lima, PeruS S Shin
Division of Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120 1613, USA
Microb Drug Resist 11:26-30. 2005..Isolates from 42 of these patients were subjected to DNA sequencing of the rpoB gene region responsible for rifampin resistance. We determined the frequency of types of mutations in the rpoB gene among these Peruvian isolates... 
Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatmentMolly F Franke
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Clin Infect Dis 46:1844-51. 2008....- Comprehensive treatment of extensively drug-resistant tuberculosisCarole D Mitnick
Harvard Medical School, Boston, USA
N Engl J Med 359:563-74. 2008..We describe the management of extensively drug-resistant tuberculosis and treatment outcomes among patients who were referred for individualized outpatient therapy in Peru... - Programmes and principles in treatment of multidrug-resistant tuberculosisJoia S Mukherjee
Brigham and Women s Hospital, Division of Social Medicine and Health Inequalities, Boston, MA, USA
Lancet 363:474-81. 2004..As treatment of MDR-TB becomes increasingly available in resource-poor areas, where it is needed most, further clinical and operational research is urgently needed to guide clinicians in the management of this disease... - From multidrug-resistant tuberculosis to DOTS expansion and beyond: making the most of a paradigm shiftJim Yong Kim
Program in Infectious Disease and Social Change, Department of Social Medicine, Harvard Medical School, 641 Huntington Avenue, Boston, MA 02115, USA
Tuberculosis (Edinb) 83:59-65. 2003..This paper offers a case study of the construction of a model of good global governance that--if the opportunity is taken--can improve access to effective TB care through improving and helping to expand the WHO-recommended DOTS strategy... - Expanding tuberculosis case detection by screening household contactsMercedes C Becerra
Department of Social Medicine, Harvard Medical School, Boston, MA, USA
Public Health Rep 120:271-7. 2005..Results suggest that contact tracing in such settings may be a powerful means of improving case detection rates for active TB disease... - Community-based therapy for children with multidrug-resistant tuberculosisPeter C Drobac
Social Medicine and Health Inequalities, Brigham and Women s Hospital, Boston, MA 02120, USA
Pediatrics 117:2022-9. 2006.... - Isoniazid resistance and the future of drug-resistant tuberculosisTed Cohen
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Microb Drug Resist 10:280-5. 2004..Here we present ecological evidence to support the hypothesis that mutations at the 315 position of katG confer isoniazid resistance for Mycobacterium tuberculosis without diminishing virulence or transmissibility...
Research Grants
- Molecular epidemiology of drug-resistant tuberculosis in PeruMercedes Becerra; Fiscal Year: 2007This revised application is for a Mentored Faculty Development Award to prepare Dr. Mercedes Becerra for a successful career as an independent investigator in tuberculosis epidemiology. Dr...
- Epidemiology of multidrug-resistant tuberculosis in PeruMercedes Becerra; Fiscal Year: 2007..tuberculosis strains. Results will serve to guide basic research in tuberculosis diagnostics and therapeutics. ..