Lino R Becerra

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
  2. ncbi Excitatory neurotransmitters in brain regions in interictal migraine patients
    Andrew Prescot
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Mol Pain 5:34. 2009
  3. ncbi Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems
    L Becerra
    P A I N Group McLean Hospital, Massachusetts General Hospital, Harvard Medical School, USA
    Neuroimage 41:252-9. 2008
  4. ncbi CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw
    L Becerra
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA, USA
    Neuroimage 54:1355-66. 2011
  5. ncbi Signal valence in the nucleus accumbens to pain onset and offset
    Lino Becerra
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont MA, United States
    Eur J Pain 12:866-9. 2008
  6. ncbi BOLD responses in somatosensory cortices better reflect heat sensation than pain
    Eric A Moulton
    Center for Pain and the Brain, Department of Psychiatry, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 32:6024-31. 2012
  7. ncbi CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry
    L Becerra
    Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital-Nuclear Magnetic Resonance Center, Department of Radiology, Charlestown, Massachusetts 02129-2060, USA
    J Neurophysiol 91:533-41. 2004
  8. ncbi Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux)
    David Borsook
    Pain Analgesia Imaging Neuroscience P A I N Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 1064, USA
    Mol Pain 3:34. 2007
  9. ncbi Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens
    I Aharon
    Athinoula Martinos NMR Center for Medical Imaging, Massachusetts General Hospital, USA
    Neurosci Lett 392:159-64. 2006
  10. ncbi Preclinical assessment of candidate analgesic drugs: recent advances and future challenges
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 319:507-14. 2006

Research Grants

  1. Temporal Quantification of CNS Activation (fMRI) to Pain
    Lino Becerra; Fiscal Year: 2002

Collaborators

Detail Information

Publications17

  1. ncbi Migraine attacks the Basal Ganglia
    Nasim Maleki
    Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Mol Pain 7:71. 2011
    ....
  2. ncbi Excitatory neurotransmitters in brain regions in interictal migraine patients
    Andrew Prescot
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Mol Pain 5:34. 2009
    ..We hypothesized that there may be differences in levels of excitatory amino acid neurotransmitters and/or their derivatives in migraine group based on their increased sensitivity to pain...
  3. ncbi Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems
    L Becerra
    P A I N Group McLean Hospital, Massachusetts General Hospital, Harvard Medical School, USA
    Neuroimage 41:252-9. 2008
    ..Such ability might have potential applications in a clinical setting in which pain needs to be assessed objectively (e.g., analgesic efficacy, pain responses during surgery)...
  4. ncbi CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw
    L Becerra
    Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA, USA
    Neuroimage 54:1355-66. 2011
    ..Our results demonstrate the ability to characterize CNS patterns of activation in response to pain in rodents while avoiding the potential complicating effects of anesthesia...
  5. ncbi Signal valence in the nucleus accumbens to pain onset and offset
    Lino Becerra
    P A I N Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont MA, United States
    Eur J Pain 12:866-9. 2008
    ..The study supports the idea that the NAc fMRI signal may provide a useful marker for the effects of pain and analgesia in healthy volunteers...
  6. ncbi BOLD responses in somatosensory cortices better reflect heat sensation than pain
    Eric A Moulton
    Center for Pain and the Brain, Department of Psychiatry, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    J Neurosci 32:6024-31. 2012
    ..These results indicate that heat intensity is encoded by the somatosensory cortices, and that pain evaluation may either arise from multimodal evaluative processes, or is a distributed process...
  7. ncbi CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry
    L Becerra
    Center for Functional Pain Neuroimaging and Therapy Research, Massachusetts General Hospital-Nuclear Magnetic Resonance Center, Department of Radiology, Charlestown, Massachusetts 02129-2060, USA
    J Neurophysiol 91:533-41. 2004
    ....
  8. ncbi Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux)
    David Borsook
    Pain Analgesia Imaging Neuroscience P A I N Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478 1064, USA
    Mol Pain 3:34. 2007
    ..Spontaneous tics showed increased activation in classic aversion circuitry that may contribute to increased levels of anxiety. We believe that this is the first report of functional imaging of brain changes in tic-doloureaux...
  9. ncbi Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens
    I Aharon
    Athinoula Martinos NMR Center for Medical Imaging, Massachusetts General Hospital, USA
    Neurosci Lett 392:159-64. 2006
    ..e., shell and core. The results support heterogeneity of function within the NAc and have implications for the understanding the contribution of NAc function to processing of pain and analgesia...
  10. ncbi Preclinical assessment of candidate analgesic drugs: recent advances and future challenges
    S S Negus
    Alcohol and Drug Abuse Research Center, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Pharmacol Exp Ther 319:507-14. 2006
    ..Integration of these complementary approaches may improve the predictive validity of analgesic drug development...
  11. ncbi An fMRI case report of photophobia: activation of the trigeminal nociceptive pathway
    E A Moulton
    McLean Hospital, P A I N Group, Brain Imaging Center, 115 Mill Street, Belmont, MA, USA
    Pain 145:358-63. 2009
    ..After recovery from photophobia, no significant activations were detected in these areas. This study may contribute to a better understanding of the pathways involved in photophobia in the human condition...
  12. ncbi Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects
    D Borsook
    PAIN Group, Brain Imaging Center, McLean Hospital, Harvard Medical School, Massachusetts, USA
    Cerebellum 7:252-72. 2008
    ..These results lead us to propose that the cerebellum may modulate the emotional and cognitive experience that distinguishes the perception of pain from the appreciation of innocuous sensory stimulation...
  13. ncbi Neuroimaging revolutionizes therapeutic approaches to chronic pain
    David Borsook
    PAIN Group, Brain Imaging Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Mol Pain 3:25. 2007
    ....
  14. ncbi fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children
    A Lebel
    P A I N Group, Department of Anesthesia, Children s Hospital Boston, MA, USA
    Brain 131:1854-79. 2008
    ..Our results suggest significant changes in CNS circuitry in patients with CRPS...
  15. ncbi Surgically induced neuropathic pain: understanding the perioperative process
    David Borsook
    Department of Anesthesia and Perioperative and Pain Medicine, Boston Childrens Hospital, Harvard Medical School, Boston, MA 02115, USA
    Ann Surg 257:403-12. 2013
    ....
  16. ncbi Breaking down the barriers: fMRI applications in pain, analgesia and analgesics
    David Borsook
    P A I N Group, Brain Imaging Center, Department of Psychiatry, McLean Hospital, Belmont, MA, USA
    Mol Pain 2:30. 2006
    ..fMRI has already provided novel insights into the neurobiology of pain. These insights should significantly advance therapeutic approaches to chronic pain...
  17. ncbi fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers
    M C Borras
    Center for Functional Pain Neuroimaging and Therapy Research, Athinoula A. Martinos Center for Biomedical Imaging, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Neurophysiol 91:2723-33. 2004
    ..Our study is an example of how fMRI can measure subtle changes in brain activation induced by pharmacological agents without cognitive effects...

Research Grants1

  1. Temporal Quantification of CNS Activation (fMRI) to Pain
    Lino Becerra; Fiscal Year: 2002
    ..He is committed to study of brain mechanisms underlying somatosensory and emotional brain circuitry and how they contribute to the experience of pain under experimental and clinical conditions in human subjects. ..