Research Topics
| M G BaxterSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesiaMark G Baxter
Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
Hippocampus 18:245-50. 2008..This factor should be considered carefully in experimental design and in cross-study comparisons of lesion effects on behavior...- Dorsolateral prefrontal lesions do not impair tests of scene learning and decision-making that require frontal-temporal interactionMark G Baxter
Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, UK
Eur J Neurosci 28:491-9. 2008..These intact abilities following DLPFC damage support specialization of function within the prefrontal cortex, and suggest that many aspects of memory and strategic and goal-directed behaviour can survive ablation of this structure... 
Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeysM G Baxter
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Hippocampus 11:61-71. 2001....- Cognitive functions of the basal forebrainM G Baxter
Department of Psychology, Harvard University, 984 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
Curr Opin Neurobiol 9:178-83. 1999..Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influencing attention... - Rhinal cortex lesions produce mild deficits in visual discrimination learning for an auditory secondary reinforcer in rhesus monkeysM G Baxter
Laboratory of Neuropsychology, National Institute of Mental Health, USA
Behav Neurosci 113:243-52. 1999.... - Impairments in conditioned stimulus processing and conditioned responding after combined selective removal of hippocampal and neocortical cholinergic inputM G Baxter
Curriculum in Neurobiology, University of North Carolina at Chapel Hill, USA
Behav Neurosci 113:486-95. 1999.... - Blocking can occur without losses in attention in rats with selective removal of hippocampal cholinergic inputM G Baxter
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Behav Neurosci 113:881-90. 1999..Although rats with selective removal of hippocampal cholinergic input may be unable to reduce attention to redundant stimuli, other mechanisms of stimulus selection remain available to them... - The amygdala and rewardMark G Baxter
Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
Nat Rev Neurosci 3:563-73. 2002..Indeed, the amygdala's role in stimulus-reward learning might be just as important as its role in processing negative affect and fear conditioning... - Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversalsE A Murray
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
Behav Neurosci 112:1291-303. 1998..None of the lesions impaired place discrimination or reversal. These results argue against the idea that the mnemonic contributions of the rhinal cortex and hippocampus are limited to object and spatial domains, respectively... - Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic inputM G Baxter
Department of Psychology, University of North Carolina at Chapel Hill 27599 3270, USA
Behav Neurosci 110:460-7. 1996..These results indicate that the cholinergic input to the hippocampus is not differentially involved in spatial learning in aged rats... - Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learningJ F Cahill
Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Eur J Neurosci 14:1856-64. 2001..This suggests that the MS/VDB modulates hippocampal involvement in place learning, but that cholinergic MS/VDB neurons are neither necessary nor sufficient for using a place strategy to solve a spatial discrimination... - Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorantsC Linster
Department of Psychology, Boston University, USA
Behav Neurosci 115:826-33. 2001..Results show that cholinergic inputs to the olfactory system influence perceptual qualities of odorants and confirm predictions made by computational models of this system... - Contribution of the cholinergic basal forebrain to proactive interference from stored odor memories during associative learning in ratsE De Rosa
Department of Psychology, Harvard University, USA
Behav Neurosci 115:314-27. 2001..125 mg/kg) relative to control rats. The results suggest that weaker cholinergic modulation after cholinergic BF lesions makes the system more sensitive to PI during blockade of the remaining cholinergic elements... - Impairments in visual discrimination learning and recognition memory produced by neurotoxic lesions of rhinal cortex in rhesus monkeysM G Baxter
Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Eur J Neurosci 13:1228-38. 2001.... - PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in ratsJoshua S Rodefer
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Eur J Neurosci 21:1070-6. 2005.... - Spatial memory performance 2 weeks after general anesthesia in adult ratsCatherine Crosby
Department of Physiology, Harvard University, Cambridge, MA, USA
Anesth Analg 101:1389-92. 2005..005). Hence, in adult rats, previous general anesthesia is not associated with impaired learning 2 wk later. In fact, previous 1.2% isoflurane-70% nitrous oxide improves maze performance 2 wk later... - Purkinje cell loss accompanies motor impairment in rats developing at altered gravityElizabeth M Sajdel-Sulkowska
Deparment of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 021115, USA
Neuroreport 16:2037-40. 2005..7-25.3%. These results imply that exposure to altered gravity during Purkinje cell birth may affect their proliferation, resulting in a decrease in Purkinje cell number, which, in turn, leads to motor impairment... - Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time taskCHRISTOPHER A CORDOVA
Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr La Jolla, CA 92053 0515, USA
Sleep 29:69-76. 2006..To develop a rodent model of the attentional dysfunction caused by sleep loss... - Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw miceJia Min Zhuo
College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
Neurobiol Aging 28:1248-57. 2007..These data indicate that the effects of normal aging in C57B6xSJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Abeta load only affects discrimination reversal learning in our study... - Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memoryBonnie R Fletcher
Fishberg Department of Neuroscience and Alfred B and Gudrun J Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
Hippocampus 17:227-34. 2007..The conclusion from these data is that cholinergic deafferentation alone cannot account for the spatial learning deficits or impaired behavioral induction of Arc transcription produced by fornix lesions... 
Spatial memory is intact in aged rats after propofol anesthesiaIn Ho Lee
Department of Anesthesiology, Korea University Guro Hospital, Seoul, Republic of Korea
Anesth Analg 107:1211-5. 2008..No studies have investigated this question in aged subjects, however, so we designed an experiment to examine the long-term effects of propofol anesthesia on spatial working memory...- Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memoryCharles R E Wilson
Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, United Kingdom
Eur J Neurosci 25:2514-22. 2007.... - Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged ratsDeborah J Culley
Department of Anesthesiology Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Anesth Analg 105:83-8. 2007.... - Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation taskMark G Baxter
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
J Neurosci 27:11327-33. 2007..This finding supports a role for the orbital prefrontal cortex in memory but places limits on the involvement of orbital prefrontal cortex in the representation and implementation of behavioral goals and strategies... - Dissociable performance on scene learning and strategy implementation after lesions to magnocellular mediodorsal thalamic nucleusAnna S Mitchell
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
J Neurosci 27:11888-95. 2007..Thus, not all functions of the prefrontal cortex require MDmc input. Instead, the involvement of MDmc in prefrontal function may be limited to situations in which new learning must occur... - Sexually dimorphic effects of hippocampal cholinergic deafferentation in ratsZachariah Jonasson
Neuroscience Program, Department of Psychology, Harvard University, William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Eur J Neurosci 20:3041-53. 2004..Together, these results indicate a sexually dimorphic function associated with MS/VDB-hippocampal cholinergic inputs. In female rats, these neurons appear to support sex-specific spatial learning processes... - Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged ratsDeborah J Culley
Department of Anesthesiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Anesth Analg 99:1393-7; table of contents. 2004..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used... - Glutamate receptor binding in the frontal cortex and dorsal striatum of aged rats with impaired attentional set-shiftingMichelle M Nicolle
Department of Neuroscience, Mayo Graduate School, Mayo Clinic, 310 Birdsall Bldg, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
Eur J Neurosci 18:3335-42. 2003..These results indicate that age-related behavioural deficits in attentional set shifting are selectively associated with neurobiological alterations in the cingulate cortex and dorsomedial striatum... - Transfer effects and conditional learning in rats with selective lesions of medial septal/diagonal band cholinergic neuronsAgnieszka M Janisiewicz
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Behav Neurosci 117:1342-52. 2003..These findings may suggest that MS/VDB cholinergic neurons play a particular role in the transfer of behavioral experience and flexibility of application of behavioral rules in memory, rather than a role in conditional learning per se... - Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortexMatthew T Fox
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
J Neurosci 23:676-81. 2003..They also suggest, importantly, that the interaction between the PPC and the frontal cortex is not limited to spatial attentional processing... - Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in ratsDeborah J Culley
Department of Anesthesia, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, USA
Anesthesiology 100:309-14. 2004..Thus, RAM performance is altered after general anesthesia for longer than predicted by the pharmacology of the drugs used, which, by inference, suggests a long-term deficit in learning/memory... - Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in ratsAnna Vale-MartÃnez
Departament de Psicobiologia i de Metodologia de les Ciencies de la Salut, Facultat de Psicologia, Edifici B, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
Eur J Neurosci 16:983-98. 2002.... - Age-related memory impairment. Is the cure worse than the disease?Mark G Baxter
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
Neuron 40:669-70. 2003..find that activation of protein kinase A, which has been reported to improve hippocampal-dependent spatial memory in aged animals, has the opposite effect on prefrontal cortex-dependent working memory in aged animals... - Septohippocampal acetylcholine: involved in but not necessary for learning and memory?Marise B Parent
Department of Psychology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303, USA
Learn Mem 11:9-20. 2004..We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function... - Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young ratsMorgan D Barense
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Learn Mem 9:191-201. 2002..These results provide a possible basis for correlating age-related changes in neurobiological markers in frontal cortex with cognitive decline... - Preserved anterograde and retrograde memory of rapidly acquired olfactory discrminations after neurotoxic hippocampal lesionsZachariah Jonasson
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Hippocampus 14:28-39. 2004..Together, these experiments refute the contention that the hippocampus is requisite for (non-spatial) olfactory memory consolidation, storage, or access, despite the condition that the information be rapidly acquired... - Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learningKaryn M Frick
Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
Hippocampus 14:244-54. 2004..The failure of BF cholinergic lesions to impair contextual fear conditioning indicates that scopolamine-induced impairments in fear conditioning may not be mediated by affecting cholinergic input to the hippocampus and neocortex... - Environment-spatial conditional learning in rats with selective lesions of medial septal cholinergic neuronsAgnieszka M Janisiewicz
Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
Hippocampus 14:265-73. 2004..They may also shed light on the involvement of cholinergic projections to the hippocampus in modulating and remodeling hippocampal spatial representations... - An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw miceJia Min Zhuo
Mayo Clinic College of Medicine, Jacksonville, FL, USA
Curr Alzheimer Res 5:385-91. 2008..These data suggest that the early emergence of reversal-learning deficits in the Tg2576 mouse may be due to the localized increase of Abeta42 in the prefrontal cortex... - Dissociable roles for cortical and subcortical structures in memory retrieval and acquisitionAnna S Mitchell
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
J Neurosci 28:8387-96. 2008..Damage of this nature may account for dense amnesia... - Effects of combined and separate removals of rostral dorsal superior temporal sulcus cortex and perirhinal cortex on visual recognition memory in rhesus monkeysWendy S Hadfield
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
J Neurophysiol 90:2419-27. 2003..We conclude that STSd is not critically involved in visual recognition memory... - Neurotoxic lesions of the medial mediodorsal nucleus of the thalamus disrupt reinforcer devaluation effects in rhesus monkeysAnna S Mitchell
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
J Neurosci 27:11289-95. 2007..This finding suggests that the neural circuitry for control of behavioral choice by changes in reinforcer value includes MDmc... - Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortexMark G Baxter
Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
Learn Mem 15:126-32. 2008..This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory... - A 20-year longitudinal study of body weight, dieting, and eating disorder symptomsPamela K Keel
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
J Abnorm Psychol 116:422-32. 2007..Despite different developmental trajectories, women demonstrated more weight dissatisfaction, dieting, and disordered eating compared with men across the period of observation... - Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set-shiftingKaty C Chen
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Eur J Neurosci 20:1081-8. 2004..Taken together with other recent data, they may also suggest an important role for cholinergic receptors outside of the neocortex in regulating these aspects of attention and executive function... - Experimental sleep fragmentation impairs attentional set-shifting in ratsJohn G McCoy
VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
Sleep 30:52-60. 2007..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats... - Asymmetry of attentional set in rhesus monkeys learning colour and shape discriminationsMark G Baxter
Department of Experimental Psychology, Oxford University, Oxford, UK
Q J Exp Psychol (Hove) 60:1-8. 2007..These results show that monkeys' ability to selectively attend to a relevant stimulus dimension and to ignore an irrelevant dimension depends on the experimenter's choice of relevant and irrelevant dimensions... - Mark G. Baxter: award for distinguished scientific early career contributions to psychologyMark G Baxter
Am Psychol 61:796-8. 2006..quot; A brief profile and a selected bibliography accompany the citation. ((c) 2006 APA, all rights reserved)... - Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescenceYolanda D Black
Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 26:9656-65. 2006..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased... - Extensive lesions of cholinergic basal forebrain neurons do not impair spatial working memoryJoseph A Vuckovich
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Learn Mem 11:87-94. 2004..Furthermore, it underscores the presence of intact memory functions after cholinergic basal forebrain damage, despite attentional impairments that follow these lesions, demonstrated in other task paradigms... - Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutationNutan Sharma
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosci 25:5351-5. 2005..Together, these data suggest that these transgenic mice provide a useful model of the DeltaGAG carrier state that can be used to probe genetic and environmental factors that can trigger the dystonic state... - Two wrongs make a right: deficits in reversal learning after orbitofrontal damage are improved by amygdala ablationMark G Baxter
Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, United Kingdom
Neuron 54:1-3. 2007