M G Baxter

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Hippocampus 18:245-50. 2008
  2. pmc Dorsolateral prefrontal lesions do not impair tests of scene learning and decision-making that require frontal-temporal interaction
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, UK
    Eur J Neurosci 28:491-9. 2008
  3. ncbi request reprint Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys
    M G Baxter
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hippocampus 11:61-71. 2001
  4. ncbi request reprint Cognitive functions of the basal forebrain
    M G Baxter
    Department of Psychology, Harvard University, 984 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Curr Opin Neurobiol 9:178-83. 1999
  5. ncbi request reprint Rhinal cortex lesions produce mild deficits in visual discrimination learning for an auditory secondary reinforcer in rhesus monkeys
    M G Baxter
    Laboratory of Neuropsychology, National Institute of Mental Health, USA
    Behav Neurosci 113:243-52. 1999
  6. ncbi request reprint Impairments in conditioned stimulus processing and conditioned responding after combined selective removal of hippocampal and neocortical cholinergic input
    M G Baxter
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, USA
    Behav Neurosci 113:486-95. 1999
  7. ncbi request reprint Blocking can occur without losses in attention in rats with selective removal of hippocampal cholinergic input
    M G Baxter
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Behav Neurosci 113:881-90. 1999
  8. ncbi request reprint The amygdala and reward
    Mark G Baxter
    Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 3:563-73. 2002
  9. ncbi request reprint Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversals
    E A Murray
    Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Behav Neurosci 112:1291-303. 1998
  10. ncbi request reprint Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input
    M G Baxter
    Department of Psychology, University of North Carolina at Chapel Hill 27599 3270, USA
    Behav Neurosci 110:460-7. 1996

Collaborators

Detail Information

Publications52

  1. pmc Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford, United Kingdom
    Hippocampus 18:245-50. 2008
    ..This factor should be considered carefully in experimental design and in cross-study comparisons of lesion effects on behavior...
  2. pmc Dorsolateral prefrontal lesions do not impair tests of scene learning and decision-making that require frontal-temporal interaction
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, UK
    Eur J Neurosci 28:491-9. 2008
    ..These intact abilities following DLPFC damage support specialization of function within the prefrontal cortex, and suggest that many aspects of memory and strategic and goal-directed behaviour can survive ablation of this structure...
  3. ncbi request reprint Opposite relationship of hippocampal and rhinal cortex damage to delayed nonmatching-to-sample deficits in monkeys
    M G Baxter
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hippocampus 11:61-71. 2001
    ....
  4. ncbi request reprint Cognitive functions of the basal forebrain
    M G Baxter
    Department of Psychology, Harvard University, 984 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Curr Opin Neurobiol 9:178-83. 1999
    ..Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influencing attention...
  5. ncbi request reprint Rhinal cortex lesions produce mild deficits in visual discrimination learning for an auditory secondary reinforcer in rhesus monkeys
    M G Baxter
    Laboratory of Neuropsychology, National Institute of Mental Health, USA
    Behav Neurosci 113:243-52. 1999
    ....
  6. ncbi request reprint Impairments in conditioned stimulus processing and conditioned responding after combined selective removal of hippocampal and neocortical cholinergic input
    M G Baxter
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill, USA
    Behav Neurosci 113:486-95. 1999
    ....
  7. ncbi request reprint Blocking can occur without losses in attention in rats with selective removal of hippocampal cholinergic input
    M G Baxter
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Behav Neurosci 113:881-90. 1999
    ..Although rats with selective removal of hippocampal cholinergic input may be unable to reduce attention to redundant stimuli, other mechanisms of stimulus selection remain available to them...
  8. ncbi request reprint The amygdala and reward
    Mark G Baxter
    Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Nat Rev Neurosci 3:563-73. 2002
    ..Indeed, the amygdala's role in stimulus-reward learning might be just as important as its role in processing negative affect and fear conditioning...
  9. ncbi request reprint Monkeys with rhinal cortex damage or neurotoxic hippocampal lesions are impaired on spatial scene learning and object reversals
    E A Murray
    Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Behav Neurosci 112:1291-303. 1998
    ..None of the lesions impaired place discrimination or reversal. These results argue against the idea that the mnemonic contributions of the rhinal cortex and hippocampus are limited to object and spatial domains, respectively...
  10. ncbi request reprint Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input
    M G Baxter
    Department of Psychology, University of North Carolina at Chapel Hill 27599 3270, USA
    Behav Neurosci 110:460-7. 1996
    ..These results indicate that the cholinergic input to the hippocampus is not differentially involved in spatial learning in aged rats...
  11. ncbi request reprint Cholinergic and noncholinergic septal neurons modulate strategy selection in spatial learning
    J F Cahill
    Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Eur J Neurosci 14:1856-64. 2001
    ..This suggests that the MS/VDB modulates hippocampal involvement in place learning, but that cholinergic MS/VDB neurons are neither necessary nor sufficient for using a place strategy to solve a spatial discrimination...
  12. ncbi request reprint Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants
    C Linster
    Department of Psychology, Boston University, USA
    Behav Neurosci 115:826-33. 2001
    ..Results show that cholinergic inputs to the olfactory system influence perceptual qualities of odorants and confirm predictions made by computational models of this system...
  13. ncbi request reprint Contribution of the cholinergic basal forebrain to proactive interference from stored odor memories during associative learning in rats
    E De Rosa
    Department of Psychology, Harvard University, USA
    Behav Neurosci 115:314-27. 2001
    ..125 mg/kg) relative to control rats. The results suggest that weaker cholinergic modulation after cholinergic BF lesions makes the system more sensitive to PI during blockade of the remaining cholinergic elements...
  14. ncbi request reprint Impairments in visual discrimination learning and recognition memory produced by neurotoxic lesions of rhinal cortex in rhesus monkeys
    M G Baxter
    Department of Psychology, Harvard University, 906 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Eur J Neurosci 13:1228-38. 2001
    ....
  15. ncbi request reprint PDE10A inhibition reverses subchronic PCP-induced deficits in attentional set-shifting in rats
    Joshua S Rodefer
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Eur J Neurosci 21:1070-6. 2005
    ....
  16. ncbi request reprint Spatial memory performance 2 weeks after general anesthesia in adult rats
    Catherine Crosby
    Department of Physiology, Harvard University, Cambridge, MA, USA
    Anesth Analg 101:1389-92. 2005
    ..005). Hence, in adult rats, previous general anesthesia is not associated with impaired learning 2 wk later. In fact, previous 1.2% isoflurane-70% nitrous oxide improves maze performance 2 wk later...
  17. ncbi request reprint Purkinje cell loss accompanies motor impairment in rats developing at altered gravity
    Elizabeth M Sajdel-Sulkowska
    Deparment of Psychiatry, Brigham and Women s Hospital, Boston, Massachusetts 021115, USA
    Neuroreport 16:2037-40. 2005
    ..7-25.3%. These results imply that exposure to altered gravity during Purkinje cell birth may affect their proliferation, resulting in a decrease in Purkinje cell number, which, in turn, leads to motor impairment...
  18. pmc Sleep deprivation in rats produces attentional impairments on a 5-choice serial reaction time task
    CHRISTOPHER A CORDOVA
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr La Jolla, CA 92053 0515, USA
    Sleep 29:69-76. 2006
    ..To develop a rodent model of the attentional dysfunction caused by sleep loss...
  19. ncbi request reprint Early discrimination reversal learning impairment and preserved spatial learning in a longitudinal study of Tg2576 APPsw mice
    Jia Min Zhuo
    College of Medicine, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Neurobiol Aging 28:1248-57. 2007
    ..These data indicate that the effects of normal aging in C57B6xSJL F1 mice are most pronounced on putative frontal cortex-dependent tasks and that increasing Abeta load only affects discrimination reversal learning in our study...
  20. ncbi request reprint Selective cholinergic depletion of the hippocampus spares both behaviorally induced Arc transcription and spatial learning and memory
    Bonnie R Fletcher
    Fishberg Department of Neuroscience and Alfred B and Gudrun J Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    Hippocampus 17:227-34. 2007
    ..The conclusion from these data is that cholinergic deafferentation alone cannot account for the spatial learning deficits or impaired behavioral induction of Arc transcription produced by fornix lesions...
  21. doi request reprint Spatial memory is intact in aged rats after propofol anesthesia
    In Ho Lee
    Department of Anesthesiology, Korea University Guro Hospital, Seoul, Republic of Korea
    Anesth Analg 107:1211-5. 2008
    ..No studies have investigated this question in aged subjects, however, so we designed an experiment to examine the long-term effects of propofol anesthesia on spatial working memory...
  22. pmc Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memory
    Charles R E Wilson
    Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, United Kingdom
    Eur J Neurosci 25:2514-22. 2007
    ....
  23. ncbi request reprint Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats
    Deborah J Culley
    Department of Anesthesiology Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesth Analg 105:83-8. 2007
    ....
  24. pmc Orbital prefrontal cortex is required for object-in-place scene memory but not performance of a strategy implementation task
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 27:11327-33. 2007
    ..This finding supports a role for the orbital prefrontal cortex in memory but places limits on the involvement of orbital prefrontal cortex in the representation and implementation of behavioral goals and strategies...
  25. pmc Dissociable performance on scene learning and strategy implementation after lesions to magnocellular mediodorsal thalamic nucleus
    Anna S Mitchell
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 27:11888-95. 2007
    ..Thus, not all functions of the prefrontal cortex require MDmc input. Instead, the involvement of MDmc in prefrontal function may be limited to situations in which new learning must occur...
  26. ncbi request reprint Sexually dimorphic effects of hippocampal cholinergic deafferentation in rats
    Zachariah Jonasson
    Neuroscience Program, Department of Psychology, Harvard University, William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Eur J Neurosci 20:3041-53. 2004
    ..Together, these results indicate a sexually dimorphic function associated with MS/VDB-hippocampal cholinergic inputs. In female rats, these neurons appear to support sex-specific spatial learning processes...
  27. ncbi request reprint Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats
    Deborah J Culley
    Department of Anesthesiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Anesth Analg 99:1393-7; table of contents. 2004
    ..05). There were no differences in total number of errors (P < or = 0.06). Thus, spatial memory is impaired for 2 wk after general anesthesia in aged rats independent of whether nitrous oxide is used...
  28. ncbi request reprint Glutamate receptor binding in the frontal cortex and dorsal striatum of aged rats with impaired attentional set-shifting
    Michelle M Nicolle
    Department of Neuroscience, Mayo Graduate School, Mayo Clinic, 310 Birdsall Bldg, 4500 San Pablo Rd, Jacksonville, FL 32224, USA
    Eur J Neurosci 18:3335-42. 2003
    ..These results indicate that age-related behavioural deficits in attentional set shifting are selectively associated with neurobiological alterations in the cingulate cortex and dorsomedial striatum...
  29. ncbi request reprint Transfer effects and conditional learning in rats with selective lesions of medial septal/diagonal band cholinergic neurons
    Agnieszka M Janisiewicz
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Behav Neurosci 117:1342-52. 2003
    ..These findings may suggest that MS/VDB cholinergic neurons play a particular role in the transfer of behavioral experience and flexibility of application of behavioral rules in memory, rather than a role in conditional learning per se...
  30. ncbi request reprint Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortex
    Matthew T Fox
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 23:676-81. 2003
    ..They also suggest, importantly, that the interaction between the PPC and the frontal cortex is not limited to spatial attentional processing...
  31. ncbi request reprint Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 100:309-14. 2004
    ..This experiment was designed to test the hypothesis that learning of new information is particularly susceptible to prolonged disruption after general anesthesia...
  32. ncbi request reprint Selective lesions of basal forebrain cholinergic neurons produce anterograde and retrograde deficits in a social transmission of food preference task in rats
    Anna Vale-Martínez
    Departament de Psicobiologia i de Metodologia de les Ciencies de la Salut, Facultat de Psicologia, Edifici B, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Eur J Neurosci 16:983-98. 2002
    ....
  33. ncbi request reprint Age-related memory impairment. Is the cure worse than the disease?
    Mark G Baxter
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Neuron 40:669-70. 2003
    ..find that activation of protein kinase A, which has been reported to improve hippocampal-dependent spatial memory in aged animals, has the opposite effect on prefrontal cortex-dependent working memory in aged animals...
  34. pmc Septohippocampal acetylcholine: involved in but not necessary for learning and memory?
    Marise B Parent
    Department of Psychology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303, USA
    Learn Mem 11:9-20. 2004
    ..We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function...
  35. pmc Aged rats are impaired on an attentional set-shifting task sensitive to medial frontal cortex damage in young rats
    Morgan D Barense
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Learn Mem 9:191-201. 2002
    ..These results provide a possible basis for correlating age-related changes in neurobiological markers in frontal cortex with cognitive decline...
  36. ncbi request reprint Preserved anterograde and retrograde memory of rapidly acquired olfactory discrminations after neurotoxic hippocampal lesions
    Zachariah Jonasson
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hippocampus 14:28-39. 2004
    ..Together, these experiments refute the contention that the hippocampus is requisite for (non-spatial) olfactory memory consolidation, storage, or access, despite the condition that the information be rapidly acquired...
  37. ncbi request reprint Effects of complete immunotoxin lesions of the cholinergic basal forebrain on fear conditioning and spatial learning
    Karyn M Frick
    Department of Psychology and Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06520, USA
    Hippocampus 14:244-54. 2004
    ..The failure of BF cholinergic lesions to impair contextual fear conditioning indicates that scopolamine-induced impairments in fear conditioning may not be mediated by affecting cholinergic input to the hippocampus and neocortex...
  38. ncbi request reprint Environment-spatial conditional learning in rats with selective lesions of medial septal cholinergic neurons
    Agnieszka M Janisiewicz
    Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
    Hippocampus 14:265-73. 2004
    ..They may also shed light on the involvement of cholinergic projections to the hippocampus in modulating and remodeling hippocampal spatial representations...
  39. ncbi request reprint An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice
    Jia Min Zhuo
    Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Curr Alzheimer Res 5:385-91. 2008
    ..These data suggest that the early emergence of reversal-learning deficits in the Tg2576 mouse may be due to the localized increase of Abeta42 in the prefrontal cortex...
  40. doi request reprint Dissociable roles for cortical and subcortical structures in memory retrieval and acquisition
    Anna S Mitchell
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 28:8387-96. 2008
    ..Damage of this nature may account for dense amnesia...
  41. ncbi request reprint Effects of combined and separate removals of rostral dorsal superior temporal sulcus cortex and perirhinal cortex on visual recognition memory in rhesus monkeys
    Wendy S Hadfield
    Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Neurophysiol 90:2419-27. 2003
    ..We conclude that STSd is not critically involved in visual recognition memory...
  42. pmc Neurotoxic lesions of the medial mediodorsal nucleus of the thalamus disrupt reinforcer devaluation effects in rhesus monkeys
    Anna S Mitchell
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 27:11289-95. 2007
    ..This finding suggests that the neural circuitry for control of behavioral choice by changes in reinforcer value includes MDmc...
  43. pmc Perseverative interference with object-in-place scene learning in rhesus monkeys with bilateral ablation of ventrolateral prefrontal cortex
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    Learn Mem 15:126-32. 2008
    ..This may represent a specific signature of ventrolateral prefrontal involvement in episodic learning and memory...
  44. ncbi request reprint A 20-year longitudinal study of body weight, dieting, and eating disorder symptoms
    Pamela K Keel
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    J Abnorm Psychol 116:422-32. 2007
    ..Despite different developmental trajectories, women demonstrated more weight dissatisfaction, dieting, and disordered eating compared with men across the period of observation...
  45. ncbi request reprint Central blockade of muscarinic cholinergic receptors disrupts affective and attentional set-shifting
    Katy C Chen
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Eur J Neurosci 20:1081-8. 2004
    ..Taken together with other recent data, they may also suggest an important role for cholinergic receptors outside of the neocortex in regulating these aspects of attention and executive function...
  46. ncbi request reprint Experimental sleep fragmentation impairs attentional set-shifting in rats
    John G McCoy
    VA Boston Healthcare System and Harvard Medical School, Brockton, MA 02301, USA
    Sleep 30:52-60. 2007
    ..To evaluate the effect of experimental sleep fragmentation (sleep interruption; SI) on complex learning in an intradimensional-extradimensional (ID/ED) set-shifting task in rats...
  47. pmc Asymmetry of attentional set in rhesus monkeys learning colour and shape discriminations
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, Oxford, UK
    Q J Exp Psychol (Hove) 60:1-8. 2007
    ..These results show that monkeys' ability to selectively attend to a relevant stimulus dimension and to ignore an irrelevant dimension depends on the experimenter's choice of relevant and irrelevant dimensions...
  48. ncbi request reprint Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence
    Yolanda D Black
    Laboratory of Neuroplasticity, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 26:9656-65. 2006
    ..These findings suggest that exposure to cocaine during adolescence has far-reaching molecular and behavioral consequences in the rat PFC that develop over time and endure long after drug administration has ceased...
  49. pmc Extensive lesions of cholinergic basal forebrain neurons do not impair spatial working memory
    Joseph A Vuckovich
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Learn Mem 11:87-94. 2004
    ..Furthermore, it underscores the presence of intact memory functions after cholinergic basal forebrain damage, despite attentional impairments that follow these lesions, demonstrated in other task paradigms...
  50. ncbi request reprint Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation
    Nutan Sharma
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 25:5351-5. 2005
    ..Together, these data suggest that these transgenic mice provide a useful model of the DeltaGAG carrier state that can be used to probe genetic and environmental factors that can trigger the dystonic state...
  51. ncbi request reprint Two wrongs make a right: deficits in reversal learning after orbitofrontal damage are improved by amygdala ablation
    Mark G Baxter
    Department of Experimental Psychology, Oxford University, South Parks Road, Oxford OX1 3UD, United Kingdom
    Neuron 54:1-3. 2007