Research Topics
| Richard C BatesSummaryAffiliation: Harvard University Country: USA Publications
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Publications
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxisRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston MA 02215, USA
Exp Cell Res 299:315-24. 2004..These studies establish that the regulated expression of a specific chemokine and its receptor are linked to the EMT and they provide a biochemical framework for understanding the mechanisms by which the EMT promotes migration...
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinomaRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 115:339-47. 2005..These findings define the alphavbeta6 integrin as an important risk factor for early-stage disease and a novel therapeutic candidate for colorectal cancer...- A CD44 survival pathway triggers chemoresistance via lyn kinase and phosphoinositide 3-kinase/Akt in colon carcinoma cellsR C Bates
Cancer Research Unit, Faculty of Medicine, The University of Newcastle, New South Wales 2308, Australia
Cancer Res 61:5275-83. 2001..The ability to suppress apoptosis might play a critical role in the onset and development of colorectal malignancies... - Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoidsRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Mol Biol Cell 14:1790-800. 2003..These results establish a novel role for the stroma in influencing EMT in colon carcinoma, and they identify a selective advantage to the stromal presence of infiltrating leukocytes in regulating malignant tumor progression... - Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoidsRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Curr Biol 13:1721-7. 2003..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development... - The epithelial-mesenchymal transition (EMT) and colorectal cancer progressionRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA
Cancer Biol Ther 4:365-70. 2005..Thus, the EMT appears to be an integral component of colorectal cancer progression and its analysis can yield novel targets for prognosis and therapy... - Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive diseaseDavid I Bellovin
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 65:10938-45. 2005..These data provide a compelling argument for the importance of both p120ctn and the EMT itself in the progression of colorectal carcinoma... - Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrinArthur M Mercurio
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Semin Cancer Biol 14:115-22. 2004.... - The association between CD36 and Lyn protein tyrosine kinase is mediated by lipidRick F Thorne
Cancer Research Unit, School of Biomedical Science, Faculty of Health, The University of Newcastle, NSW 2308, Australia
Biochem Biophys Res Commun 351:51-6. 2006..Since both CD36 and Lyn are enriched in Triton X-100-insoluble rafts at the plasma membrane, these findings point to the importance of raft-associated lipids in CD36-mediated signal transduction... - Colorectal cancer and the integrin family of cell adhesion receptors: current status and future directionsM V Agrez
Cancer Research Unit, Faculty of Medicine, University of Newcastle, Australia
Eur J Cancer 30:2166-70. 1994..A better understanding of the mechanisms involved in these events may lead to useful therapeutic strategies in the management of this disease... 
Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancerM V Agrez
Discipline of Surgical Science, Cancer Research Unit, John Hunter Hospital, Newcastle, Australia
Br J Cancer 73:887-92. 1996..This is likely to have functional implications for growth and spread of colorectal cancer...- Colorectal cancer progression: integrin alphavbeta6 and the epithelial-mesenchymal transition (EMT)Richard C Bates
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachsetts 01605, USA
Cell Cycle 4:1350-2. 2005..These findings reinforce the importance of the EMT event in late stage tumorigenesis, and define alphavbeta6 as a novel therapeutic candidate for aggressive colorectal cancer... - The alphaVbeta6 integrin as a novel molecular target for colorectal cancerRichard C Bates
University of Massachusetts Medical School, Department of Cancer Biology, Worcester, MA 01605 2324 USA
Future Oncol 1:821-8. 2005..Taken together with its normal expression pattern and known biologic functions, alphaVbeta6 thus emerges as a novel therapeutic candidate... - Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cellsRichard C Bates
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Mass 01605 2324, USA
Cells Tissues Organs 185:29-39. 2007....