Roland Baron

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Denosumab and bisphosphonates: different mechanisms of action and effects
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Bone 48:677-92. 2011
  2. pmc Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages
    Riku Kiviranta
    Department of Medicine, Massachusetts General Hospital, Harvard University, Boston, MA 02115, USA
    J Exp Med 210:969-85. 2013
  3. pmc Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
    Eric Hesse
    Department of Medicine, Harvard Medical School, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA
    J Cell Biol 191:1271-83. 2010
  4. doi request reprint WNT signaling in bone homeostasis and disease: from human mutations to treatments
    Roland Baron
    Department of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Nat Med 19:179-92. 2013
  5. ncbi request reprint Bone cells crosstalk: noncanonical Roring in the Wnt
    Roland Baron
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Cell Metab 15:415-7. 2012
  6. pmc Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:311-25. 2012
  7. pmc Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes
    Diego Correa
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Dev Cell 19:533-46. 2010
  8. pmc Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH
    Vaibhav Saini
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 288:20122-34. 2013
  9. pmc Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia
    Dutmanee Seriwatanachai
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    FASEB J 25:3057-67. 2011
  10. pmc Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    Yanqiu Liu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 122:3101-13. 2012

Collaborators

Detail Information

Publications30

  1. doi request reprint Denosumab and bisphosphonates: different mechanisms of action and effects
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA 02115, USA
    Bone 48:677-92. 2011
    ..This may explain differences in the degree and rapidity of reduction of bone resorption, their potential differential effects on trabecular and cortical bone, and the reversibility of their actions...
  2. pmc Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages
    Riku Kiviranta
    Department of Medicine, Massachusetts General Hospital, Harvard University, Boston, MA 02115, USA
    J Exp Med 210:969-85. 2013
    ..Thus, we have identified the interplay between Zfp521 and Ebf1 as a novel rheostat for bone homeostasis...
  3. pmc Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity
    Eric Hesse
    Department of Medicine, Harvard Medical School, Harvard School of Dental Medicine, Harvard University, Boston, MA 02115, USA
    J Cell Biol 191:1271-83. 2010
    ..Thus, the balance and molecular interplay between Zfp521 and Runx2 contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis...
  4. doi request reprint WNT signaling in bone homeostasis and disease: from human mutations to treatments
    Roland Baron
    Department of Medicine, Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Nat Med 19:179-92. 2013
    ..This paper reviews our current understanding of the mechanisms by which WNT signalng regulates bone homeostasis...
  5. ncbi request reprint Bone cells crosstalk: noncanonical Roring in the Wnt
    Roland Baron
    Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Cell Metab 15:415-7. 2012
    ..Maeda and colleagues now report in Nature Medicine that Wnt5a-Ror2 crosstalk between bone cells enhances bone resorption, thereby negatively regulating skeletal homeostasis (Maeda et al., 2012)...
  6. pmc Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives
    Roland Baron
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:311-25. 2012
    ..Each of these anabolic approaches has its own limitations and safety issues, but the prospects of effective anabolic therapy for osteoporosis are indeed bright...
  7. pmc Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes
    Diego Correa
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Dev Cell 19:533-46. 2010
    ..Thus, Zfp521 is an important PTHrP target gene that regulates growth plate chondrocyte proliferation and differentiation...
  8. pmc Parathyroid hormone (PTH)/PTH-related peptide type 1 receptor (PPR) signaling in osteocytes regulates anabolic and catabolic skeletal responses to PTH
    Vaibhav Saini
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 288:20122-34. 2013
    ..Taken together, these data indicate that PPR signaling in osteocytes is required for bone remodeling, and receptor signaling in osteocytes is needed for anabolic and catabolic skeletal responses. ..
  9. pmc Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia
    Dutmanee Seriwatanachai
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    FASEB J 25:3057-67. 2011
    ..This study provides the first genetic evidence that Zfp521 is required downstream of PTHR1 signaling to act on chondrocyte proliferation, differentiation, and cell death...
  10. pmc Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation
    Yanqiu Liu
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 122:3101-13. 2012
    ..Importantly, our data support a model whereby VEGF regulates differentiation through an intracrine mechanism that is distinct from the role of secreted VEGF and its receptors...
  11. doi request reprint Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src
    Martin Biosse Duplan
    Harvard School of Dental Medicine, Department of Oral Medicine, Infection and Immunity, Boston, Massachusetts, USA
    Mol Cell Biol 34:16-29. 2014
    ..Suppression of MT dynamic instability or EB1 depletion increased cortactin phosphorylation, decreasing its acetylation and affecting its interaction with EB1. Thus, dynamic MTs and podosomes interact to control bone resorption. ..
  12. pmc Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation
    Jun Guo
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 11:161-71. 2010
    ..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1...
  13. doi request reprint Zinc finger protein 521, a new player in bone formation
    Eric Hesse
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1192:32-7. 2010
    ..The balance between Zfp521 and Runx2 may therefore contribute to the regulation of osteoblast differentiation and bone formation...
  14. pmc Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Clin Invest 123:666-81. 2013
    ..Our data provide genetic evidence that deletion of CTSK in osteoclasts enhances bone formation in vivo by increasing the generation of osteoclast-derived S1P...
  15. doi request reprint The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification
    Annie Moisan
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA
    Dev Cell 20:583-96. 2011
    ..Furthermore, the constellation of anomalies in Wtx null mice suggests that this tumor suppressor broadly regulates MPCs in multiple tissues...
  16. ncbi request reprint Activin receptor signaling: a potential therapeutic target for osteoporosis
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Curr Mol Pharmacol 5:195-204. 2012
    ..These data provide evidence of a dual anabolic antiresorptive effect of the soluble ActRIIA-Fc fusion protein in the skeleton. Therefore, targeting activin receptor signaling may be useful for therapeutic intervention in osteoporosis...
  17. pmc MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice
    Weiguo Zou
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 121:4383-92. 2011
    ..Thus, our results provide a putative biochemical mechanism for the skeletal defects in human FGDY and suggest that modulating MAPK signaling may benefit these patients...
  18. doi request reprint Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass
    Marilena Marzia
    Endocrine Unit, Massachusetts General Hospital and Harvard University School of Medicine, Boston, MA 02115, USA
    Biol Chem 392:877-85. 2011
    ....
  19. pmc Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo
    Shriram Nallamshetty
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 8:e71307. 2013
    ..Collectively, these data implicate Aldh1a1 as a novel determinant of cortical bone density and marrow adiposity in the skeleton in vivo through modulation of BMP signaling. ..
  20. pmc Regulation of early adipose commitment by Zfp521
    Sona Kang
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS Biol 10:e1001433. 2012
    ..Because Zfp521 is known to promote bone development, our results suggest that it acts as a critical switch in the commitment decision between the adipogenic and osteogenic lineages...
  21. pmc c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes
    Enkhtsetseg Purev
    Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Mol Biol Cell 20:4021-30. 2009
    ..Thus, both c-Cbl and Cbl-b promote bone resorption via the stabilization of microtubules, allowing the formation of the podosome belt in osteoclasts, and by promoting osteoclast survival...
  22. pmc Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling
    Keertik Fulzele
    Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
    Blood 121:930-9. 2013
    ....
  23. pmc The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
    Matthew B Greenblatt
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 120:2457-73. 2010
    ..These results also suggest that selective p38beta agonists may represent attractive therapeutic agents to prevent bone loss associated with osteoporosis and aging...
  24. ncbi request reprint Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro
    Hong In Shin
    Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 145:1376-85. 2004
    ..These studies demonstrate the importance of gp130 signaling for osteoblast function and calcium homeostasis...
  25. pmc Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus
    Glenn C Rowe
    Department of Medicine, Harvard Medical School, Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA
    J Bone Miner Res 27:1649-58. 2012
    ..These findings may have physiological implications because ΔFosB is expressed and regulated in the hypothalamus...
  26. doi request reprint Osteoporosis in 2011: Osteoporosis therapy--dawn of the post-bisphosphonate era
    Roland Baron
    Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Endocrine Unit, 188 Longwood Avenue, Boston, MA 02115, USA
    Nat Rev Endocrinol 8:76-8. 2012
    ..Besides marked progress in basic research, the year 2011 has seen several compounds for the treatment of osteoporosis enter or progress within clinical trials...
  27. doi request reprint A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys
    Sutada Lotinun
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Bone 46:1082-8. 2010
    ..Thus, soluble ActRIIA fusion protein may be useful in the prevention and/or treatment of osteoporosis and other diseases involving accelerated bone loss...
  28. pmc Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis
    Marta Christov
    Department of Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 152:2031-6. 2011
    ..Taken together, our data suggest that Sfrp4 does not contribute to the long-term regulation of serum phosphate levels in mice...
  29. pmc Caloric restriction leads to high marrow adiposity and low bone mass in growing mice
    Maureen J Devlin
    Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Bone Miner Res 25:2078-88. 2010
    ..These results support the hypothesis that caloric restriction during rapid skeletal growth is deleterious to cortical and trabecular bone mass and architecture, in contrast to potential skeletal benefits of CR in aging animals...
  30. pmc SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts
    Fabienne Coury
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:2163-8. 2013
    ..These data suggest that maintenance of intracellular pH in osteoclasts through anion exchange regulates the actin superstructures required for bone resorption...