Research Topics
| F G BarkerSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Age-dependent differences in short-term outcome after surgical or endovascular treatment of unruptured intracranial aneurysms in the United States, 1996-2000Fred G Barker
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurosurgery 54:18-28; discussion 28-30. 2004..We compared short-term end points (mortality, discharge disposition, complications, length of stay, and charges) for clipping and coiling in a nationally representative discharge database...- Craniotomy for the resection of metastatic brain tumors in the U.S., 1988-2000: decreasing mortality and the effect of provider caseloadFred G Barker
Brain Tumor Center, Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer 100:999-1007. 2004.... - Changing neurosurgical workload in the United States, 1988-2001: craniotomy other than trauma in adultsFred G Barker
Neurosurgical Service, Massachusetts General Hospital, Department of Surgery Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 55:506-17; discussion 517-8. 2004..Most previous studies have used non-population-based data sources, such as surveys of professional society members, to explore the neurosurgical workload in the United States... - Dose-volume prediction of radiation-related complications after proton beam radiosurgery for cerebral arteriovenous malformationsFred G Barker
Proton Radiosurgery Group, Neurosurgical Service, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosurg 99:254-63. 2003..The authors studied the incidence of complications after AVM radiosurgery in relation to dose, volume, and other factors in a large patient series... - History of the AANS/CNS joint section on tumors and preface to the 20th anniversary Journal of Neuro-Oncology Special IssueFred G Barker
Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Neurooncol 69:1-18. 2004..These data suggest that the Section's goals of educating all surgeons in neurosurgical oncology are being successfully met. A bibliography of secondary sources on the history of brain tumor surgery is appended... - Surgical excision of acoustic neuroma: patient outcome and provider caseloadFred G Barker
Neurosurgical Service, Massachusetts General Hospital and the Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 113:1332-43. 2003..For many complex surgical procedures, larger hospital or surgeon caseload is associated with better patient outcome. We examined the volume-outcome relationship for surgical excision of acoustic neuromas... - Surgery for primary supratentorial brain tumors in the United States, 1988 to 2000: the effect of provider caseload and centralization of careFred G Barker
Stephen E and Catherine Pappas Center for Neuro Oncology, Neurosurgical Service, Massachusetts General Hospital, Department of Surgery Neurosurgery, Harvard Medical School, Boston, MA 02114, USA
Neuro Oncol 7:49-63. 2005..However, they do suggest a trend toward progressive centralization of craniotomies for primary brain tumor toward large-volume US centers during this interval... - Surgical and radiosurgical management of brain metastasesFred G Barker
Department of Surgery Neurosurgery, Harvard Medical School, Boston, MA, USA
Surg Clin North Am 85:329-45. 2005..Aggressive treatment of oligometastatic brain disease probably is underused in current U.S. practice... - Synthesizing medical evidence: systematic reviews and metaanalysesFred G Barker
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurosurg Focus 19:E5. 2005..References to textbooks, articles, and Internet resources are also provided. The goal is to assist readers who wish to perform their own metaanalysis or to interpret critically a published example... - Efficacy of prophylactic antibiotic therapy in spinal surgery: a meta-analysisFred G Barker
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
Neurosurgery 51:391-400; discussion 400-1. 2002..To date, individual studies have not demonstrated a significant benefit for prophylactic antibiotic therapy in spinal operations... - Prizes, lectures, and awards of the American Association of Neurological Surgeons/Congress of Neurological Surgeons Section on TumorsFred G Barker
Neurosurgical Service, Massachusetts General Hospital, and Department of Surgery Neurosurgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurg Focus 18:e11. 2005..The subsequent career of the recipients is briefly examined, in terms of the rate of full publication of award-winning abstracts and achievement of grant funding by awardees... - Age and radiation response in glioblastoma multiformeF G Barker
Neuro Oncology Service, Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, San Francisco, USA
Neurosurgery 49:1288-97; discussion 1297-8. 2001..Radiographically assessed tumor response to external beam radiation therapy is an important prognostic factor in GM. We hypothesized that older GM patients might have more radioresistant tumors... - EGFR overexpression and radiation response in glioblastoma multiformeF G Barker
Department of Neurological Surgery, Neuro Oncology Service and Brain Tumor Research Center, University of California, San Francisco, California, USA
Int J Radiat Oncol Biol Phys 51:410-8. 2001..We tested whether these abnormalities correlated with clinical heterogeneity in GM response to radiation treatment... - Temporal clustering of hemorrhages from untreated cavernous malformations of the central nervous systemF G Barker
Neurosurgical Service, Massachusetts General Hospital, Boston 02114, USA
Neurosurgery 49:15-24; discussion 24-5. 2001..To test whether CM hemorrhages tend to cluster, we reviewed pretreatment rebleeding rates after a first symptomatic hemorrhage in CM patients who later underwent surgery or radiosurgery... - Clinical and radiographic features of peritumoral infarction following resection of glioblastomaS Ulmer
Stephen E. Catherine Pappas Center for Neuro-oncology and Division of Neuroradiology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 67:1668-70. 2006..New postoperative deficits correlated well with the anatomic region of infarction in six patients. Enhancement in perioperative infarcts can mimic tumor progression on follow-up imaging studies... - In-hospital mortality and morbidity after surgical treatment of unruptured intracranial aneurysms in the United States, 1996-2000: the effect of hospital and surgeon volumeFred G Barker
Neurosurgical Service, Massachusetts General Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts
Neurosurgery 52:995-1007; discussion 1007-9. 2003.... - Craniotomy for resection of pediatric brain tumors in the United States, 1988 to 2000: effects of provider caseloads and progressive centralization and specialization of careEdward R Smith
Massachusetts General Hospital, and Department of Surgery (Neurosurgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 54:553-63; discussion 563-5. 2004..There were trends toward lower mortality rates, greater centralization of surgery, and more specialization among surgeons during this period... - Craniotomy for meningioma in the United States between 1988 and 2000: decreasing rate of mortality and the effect of provider caseloadWilliam T Curry
Brain Tumor Center, Neurosurgical Service, Massachusetts General Hospital, Boston 02114, USA
J Neurosurg 102:977-86. 2005..The annual US caseload increased, whereas the mortality rates decreased, especially at high-volume centers... - In-hospital morbidity and mortality after endovascular treatment of unruptured intracranial aneurysms in the United States, 1996-2000: effect of hospital and physician volumeBrian L Hoh
Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
AJNR Am J Neuroradiol 24:1409-20. 2003..Length of stay was shorter and total hospital charges lower at high volume centers... - Racial, ethnic, and socioeconomic disparities in patient outcomes after craniotomy for tumor in adult patients in the United States, 1988-2004William T Curry
Neurosurgical Service, Massachusetts General Hospital, and Department of Surgery, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 66:427-37; discussion 437-8. 2010..We investigated racial disparities in hospital mortality and adverse discharge disposition after brain tumor craniotomies performed in the United States from 1988 to 2004. We explored potential explanations for the disparities... - Increased prevalence of obesity and obesity-related postoperative complications in male meningioma patientsManish K Aghi
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
Clin Neurosurg 54:236-40. 2007 - Extracranial-intracranial bypass in the treatment of occlusive cerebrovascular disease and intracranial aneurysms in the United States between 1992 and 2001: a population-based studySepideh Amin-Hanjani
Neurosurgical Service, Massachusetts General Hospital, and Department of Surgery Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
J Neurosurg 103:794-804. 2005..This technically demanding procedure has become a very low-volume operation at most US centers... - In-hospital mortality rates after ventriculoperitoneal shunt procedures in the United States, 1998 to 2000: relation to hospital and surgeon volume of careEdward R Smith
Neurosurgical Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Neurosurg 100:90-7. 2004..CONCLUSIONS: Pediatric shunt procedures performed at high-volume hospitals or by high-volume surgeons were associated with lower in-hospital mortality rates, with no significant difference in LOS or hospital charges... - Is there a "July phenomenon" in pediatric neurosurgery at teaching hospitals?Edward R Smith
Neurosurgical Service, Massachusetts General Hospital, Boston 02114, USA
J Neurosurg 105:169-76. 2006.... - Diagnostic evaluation of patients with a brain mass as the presenting manifestation of cancerA N Mavrakis
Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 65:908-11. 2005..CONCLUSIONS: Chest CT and brain MRI, if used together as initial diagnostic studies, would have identified a biopsy site in 97% of patients with a newly detected brain mass... - Role of radiosurgery in the management of central nervous system metastasesJ S Loeffler
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Cancer Chemother Pharmacol 43:S11-4. 1999..The cost-effectiveness of radiosurgery compared to surgical resection favors an expanded role for this technology in the treatment of selected patients with brain metastases... - Benign adult brain tumors: an evidence-based medicine reviewManish Aghi
Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
Prog Neurol Surg 19:80-96. 2006.... - The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastomaDavid J Sher
Harvard Radiation Oncology Program, Boston, MA, USA
J Neurooncol 88:43-50. 2008..We sought to determine the relative contribution of concomitant temozolomide in patients treated by concurrent and adjuvant TMZ versus adjuvant TMZ alone in the setting of newly diagnosed GBM... - Clinical trial participation among patients enrolled in the Glioma Outcomes ProjectSusan M Chang
Department of Neurological Surgery, University of California San Francisco, 400 Parnassus Avenue, A808, San Francisco, CA 94143 0372, USA
Cancer 94:2681-7. 2002..The authors evaluated factors that influenced patient enrollment in clinical trials using a prospective, large, multi-institutional registry of patients with malignant glioma... - Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumesSteven N Kalkanis
Neurosurgical Service, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
Neurosurgery 52:1251-61; discussion 1261-2. 2003..007). CONCLUSION: Although most MVD procedures in the United States are performed at low-volume centers, mortality rates remain low. Morbidity rates are significantly lower at high-volume hospitals and with high-volume surgeons... - Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome ProjectSusan M Chang
Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, California 94143 0372, USA
J Neurosurg 98:1175-81. 2003..Factors predicting neurological outcome would also be helpful for patient selection for surgically based clinical trials... - Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicityDamien C Weber
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Neurosurgery 53:577-86; discussion 586-8. 2003..We sought to determine the tumor control rate and cranial nerve function outcomes in patients with vestibular schwannomas who were treated with proton beam stereotactic radiosurgery... - Length of stay and total hospital charges of clipping versus coiling for ruptured and unruptured adult cerebral aneurysms in the Nationwide Inpatient Sample database 2002 to 2006Brian L Hoh
Department of Neurological Surgery, University of Florida, Gainesville, Fla 32610, USA
Stroke 41:337-42. 2010..We now report an analysis of the same comparison at a national level conducted using the Nationwide Inpatient Sample database... - Phineas among the phrenologists: the American crowbar case and nineteenth-century theories of cerebral localizationF G Barker
Department of Neurosurgery, School of Medicine, University of California, San Francisco
J Neurosurg 82:672-82. 1995..His version of the case was used by David Ferrier as the keystone in the first modern theory of frontal lobe function, and this is how the case is remembered today... - Transsphenoidal surgery for pituitary tumors in the United States, 1996-2000: mortality, morbidity, and the effects of hospital and surgeon volumeFred G Barker
Brain Tumor Center, Neurosurgical Service, Departments of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 88:4709-19. 2003..This analysis suggests that higher-volume hospitals and surgeons provide superior short-term outcomes after transsphenoidal pituitary tumor surgery with shorter lengths of stay and a trend toward lower charges... - Clipping versus coiling for ruptured intracranial aneurysms: integrated medical learning at CNS 2007E Sander Connolly
Department of Neurological Surgery, Columbia University, New York City, New York, USA
Neurosurgery 66:19-34; discussion 34. 2010..At the 2007 Congress of Neurological Surgeons (CNS) Annual Meeting, a novel active learning process called Integrated Medical Learning (IML) was applied to education about this critical treatment choice... - Long-term recurrence rates of atypical meningiomas after gross total resection with or without postoperative adjuvant radiationManish K Aghi
Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
Neurosurgery 64:56-60; discussion 60. 2009..We sought to define the long-term recurrence rate of AMs after GTR, along with factors predicting recurrence, including postoperative radiation... - Proton beam radiation therapy for skull base adenoid cystic carcinomaPascal Pommier
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Otolaryngol Head Neck Surg 132:1242-9. 2006..Changes in vision at presentation and tumor involvement of the sphenoid sinus and clivus are important prognostic factors... - Limitations of diffusion-weighted imaging in the diagnosis of postoperative infectionsChristopher J Farrell
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Neurosurgery 62:577-83; discussion 577-83. 2008..We sought to determine the ability of DWI to accurately detect a broad range of postneurosurgical infections as well as identify individual factors that may limit its applicability... - The use of nasopharyngeal airways for airway diversion in anterior craniofacial resectionCarol M Lewis
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Am J Rhinol 22:529-32. 2008..Tension pneumocephalus is an uncommon, but life-threatening, postoperative complication associated with craniofacial resection. This study was performed to evaluate our institution's experience using nasal trumpets for airway diversion... - Racial, ethnic and socioeconomic disparities in the treatment of brain tumorsWilliam T Curry
Department of Surgery Neurosurgery, Pappas Center for Neuro Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Neurooncol 93:25-39. 2009..Clinical trial enrollment appears to be lower among brain tumor patients from disadvantaged groups. We propose future research both to better define disparities and to alleviate them... - Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factorsMinh Tam Truong
Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
Head Neck 31:1297-308. 2009..The purpose of this study was to determine treatment outcome and prognostic factors in patients with locally advanced primary sphenoid sinus malignancy treated with proton radiation therapy... - Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicityAnnie W Chan
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 57:60-70; discussion 60-70. 2005..To determine the outcome and toxicity in patients with vestibular schwannomas treated with conventionally fractionated stereotactic radiotherapy (SRT) and to identify prognostic factors that are predictive of outcome... - Marital status, treatment, and survival in patients with glioblastoma multiforme: a population based studySusan M Chang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Cancer 104:1975-84. 2005.... - Surgery for Parkinson disease in the United States, 1996 to 2000: practice patterns, short-term outcomes, and hospital charges in a nationwide sampleEmad N Eskandar
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Neurosurg 99:863-71. 2003..Larger-volume hospitals had superior short-term outcomes and lower charges. Future studies should address long-term functional end points, cost/benefit comparisons, and inequities in access to care... - Decreased rate of infection in glioblastoma patients with allelic loss of chromosome 10qManish K Aghi
Department of Neurological Surgery, University of California at San Francisco UCSF, San Francisco, CA 94143 0112, USA
J Neurooncol 93:115-20. 2009.... - Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannomaScott R Plotkin
Department of Neurology and Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
J Neurooncol 93:61-77. 2009..We encourage adoption of standardized endpoints early in the development of phase II trials for this population to facilitate comparison of results across trials of different agents... - Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcomeDarlene Gabeau-Lacet
Department of Pathology, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA
J Neuropathol Exp Neurol 68:1155-65. 2009..Given the heterogeneous treatment outcomes of atypical meningioma, investigation of large-scale and focal genomic alterations in multi-institutional efforts may help clarify molecular-genetic signatures of clinical use... - Hearing improvement after bevacizumab in patients with neurofibromatosis type 2Scott R Plotkin
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
N Engl J Med 361:358-67. 2009..There is no medical treatment for such tumors... - Unilateral vestibular schwannoma with other neurofibromatosis type 2-related tumors: clinical and molecular study of a unique phenotypeManish Aghi
Neurosurgical Service, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
J Neurosurg 104:201-7. 2006..Molecular genetic analysis is best performed using resected tumor specimens and will enable future studies to determine the genetic risks of individuals with mosaicism... - Clinical results: Radiosurgery and radiotherapy of cranial nerve schwannomasJohn C Flickinger
Department of Radiation Oncology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Neurosurg Clin N Am 17:121-8, vi. 2006..The low morbidity and high long-term tumor control rates with radiation treatment have made it the choice of many patients who opt for active initial management for small- or medium-sized cranial nerve schwannomas... - Magnetic resonance imaging characteristics predict epidermal growth factor receptor amplification status in glioblastomaManish Aghi
Neurosurgical Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
Clin Cancer Res 11:8600-5. 2005..EGFR overexpression correlates in experimental gliomas with increased angiogenesis, edema, and invasion. No radiographic predictors of molecular glioblastoma subtype are known... - Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patientsScott R Plotkin
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, U S A
Otol Neurotol 31:1135-43. 2010..We sought to determine the activity of erlotinib for progressive vestibular schwannoma (VS) associated with neurofibromatosis 2 (NF2)... - Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastomaChristopher E Pelloski
Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Clin Oncol 25:2288-94. 2007..We sought to evaluate the clinical significance of GBM subtypes as defined by EGFRvIII status... - Increased prevalence of obesity and obesity-related postoperative complications in male patients with meningiomasManish K Aghi
Neurosurgical Service, Massachusetts General Hospital, Department of Neurosurgery, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 61:754-60; discussion 760-1. 2007..We hypothesized that because obesity affects male steroid hormone synthesis, male patients with meningiomas might exhibit a high obesity rate, which, in turn, might increase their frequency of postoperative complications... - Rapidly rising incidence of cerebrospinal fluid shunting procedures for idiopathic intracranial hypertension in the United States, 1988-2002William T Curry
Stephen E. and Catherine Pappas Center for Neuro-Oncology, Massachusetts General Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
Neurosurgery 57:97-108; discussion 97-108. 2005..Studies to establish the best shunting method in IIH and to explore alternative treatment strategies, such as optic nerve sheath fenestration and bariatric surgery, are urgently needed... - Efficacy of prophylactic antibiotics against meningitis after craniotomy: a meta-analysisFred G Barker
Neurosurgery 60:887-94; discussion 887-94. 2007..CONCLUSION: Prophylactic antibiotics administered before craniotomy reduce rates of postoperative meningitis by approximately one-half, a statistically and clinically significant benefit... - Quality of life and individual treatment choice in trigeminal neuralgiaFred G Barker
Pain 131:234-6. 2007 - Brain metastasisFred G Barker
J Neurosurg 105:371-2; discussion 372-4. 2006 - Improving resection of malignant gliomaFred G Barker
Lancet Oncol 7:359-60. 2006 - Ventral versus dorsal decompression for cervical spondylotic myelopathy: surgeons' assessment of eligibility for randomization in a proposed randomized controlled trial: results of a survey of the Cervical Spine Research SocietyZoher Ghogawala
Department of Neurosurgery, Wallace Clinical Trials Center, Yale University School of Medicine, Greenwich Hospital, Greenwich, CT 06830, USA
Spine (Phila Pa 1976) 32:429-36. 2007..Surgeons attending a Cervical Spine Research Society (CSRS) meeting were surveyed about the surgical approach to cervical spondylotic myelopathy (CSM)...