Darrick T Balu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Neuronal D-serine regulates dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, and Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Lett 517:77-81. 2012
  2. pmc Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments
    Darrick T Balu
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 18:71-7. 2010
  3. pmc Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neurosci Biobehav Rev 35:848-70. 2011
  4. pmc The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Neurobiol Dis 45:671-82. 2012
  5. pmc Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2400-9. 2013
  6. doi request reprint D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI
    Martin A Santini
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Behav Brain Res 259:242-6. 2014
  7. pmc Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Brain Res 1392:1-7. 2011

Collaborators

Detail Information

Publications7

  1. pmc Neuronal D-serine regulates dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, and Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Lett 517:77-81. 2012
    ..Moreover, they highlight the glycine modulatory site (GMS) of the NMDAR as a potential target for therapeutic intervention in diseases characterized by synaptic deficits, like schizophrenia...
  2. pmc Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments
    Darrick T Balu
    Harvard Medical School, Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Exp Clin Psychopharmacol 18:71-7. 2010
    ....
  3. pmc Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neurosci Biobehav Rev 35:848-70. 2011
    ....
  4. pmc The NMDA receptor co-agonists, D-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Neurobiol Dis 45:671-82. 2012
    ..Moreover, they suggest that NMDAR hypofunction might, in part, be contributing to the dendritic and synaptic changes observed in schizophrenia and highlight this signaling pathway as a potential target for therapeutic intervention...
  5. pmc Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:E2400-9. 2013
    ..These results demonstrate that NMDAR hypofunction can reproduce the numerous hippocampal deficits associated with schizophrenia, which can be reversed by chronic peripheral D-serine treatment...
  6. doi request reprint D-serine deficiency attenuates the behavioral and cellular effects induced by the hallucinogenic 5-HT2A receptor agonist DOI
    Martin A Santini
    Neurobiology Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Behav Brain Res 259:242-6. 2014
    ..Together, these findings suggest that D-serine-dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation. ..
  7. pmc Glutamate receptor composition of the post-synaptic density is altered in genetic mouse models of NMDA receptor hypo- and hyperfunction
    Darrick T Balu
    Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Brain Res 1392:1-7. 2011
    ..Similar to SR-/- mice, there were no protein changes observed in the PFC. These findings illustrate the complexity of synaptic adaptation to altered NMDAR function...