R J Baldessarini

Summary

Affiliation: Harvard Medical School
Country: USA

Publications

  1. ncbi request reprint Ecological studies of antidepressant treatment and suicidal risks
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and International Psychopharmacology Program, McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 15:133-45. 2007
  2. ncbi request reprint Cycloid psychoses revisited: case reports, literature review, and commentary
    Paola Salvatore
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Harv Rev Psychiatry 16:167-80. 2008
  3. ncbi request reprint Correlation of initial wellness with long-term morbidity in recurrent major affective disorder patients as a test of survival analysis
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 30:72-5. 2010
  4. ncbi request reprint Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications
    R J Baldessarini
    The International Consortium for Bipolar Disorders Research, Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 1:17-24. 1999
  5. ncbi request reprint Factors associated with treatment nonadherence among US bipolar disorder patients
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Hum Psychopharmacol 23:95-105. 2008
  6. ncbi request reprint Olanzapine versus placebo in acute mania: treatment responses in subgroups
    Ross J Baldessarini
    International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 23:370-6. 2003
  7. ncbi request reprint Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatr Serv 58:85-91. 2007
  8. ncbi request reprint Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disorders
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
    Bipolar Disord 1:91-7. 1999
  9. doi request reprint Bipolar depression: overview and commentary
    Ross J Baldessarini
    Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Harv Rev Psychiatry 18:143-57. 2010
  10. ncbi request reprint Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, Boston, USA
    J Affect Disord 61:13-22. 2000

Research Grants

  1. Course and Morbidity in Bipolar I Disorder
    Ross Baldessarini; Fiscal Year: 2006
  2. Antidepressant discontinuation effects
    Ross Baldessarini; Fiscal Year: 2007

Collaborators

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Ecological studies of antidepressant treatment and suicidal risks
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and International Psychopharmacology Program, McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 15:133-45. 2007
    ..Overall, as with findings from randomized trials and cohort or case-control studies, evidence of specific antisuicidal effects of antidepressant treatment from ecological analyses remains elusive...
  2. ncbi request reprint Cycloid psychoses revisited: case reports, literature review, and commentary
    Paola Salvatore
    Department of Psychiatry, Harvard Medical School, Massachusetts, USA
    Harv Rev Psychiatry 16:167-80. 2008
    ..We present two cases of probable cycloid psychosis, review the history of the concept, and propose that it be reconsidered as a clinically useful category whose validity and utility for prognosis and treatment can be further tested...
  3. ncbi request reprint Correlation of initial wellness with long-term morbidity in recurrent major affective disorder patients as a test of survival analysis
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 30:72-5. 2010
    ..These findings provide moderate support for a basic assumption underlying the use of survival analysis for psychopharmacology research and suggest that clinical outcomes might be predictable from initial wellness intervals...
  4. ncbi request reprint Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications
    R J Baldessarini
    The International Consortium for Bipolar Disorders Research, Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 1:17-24. 1999
    ..To review research findings on clinical effects of discontinuing lithium maintenance treatment...
  5. ncbi request reprint Factors associated with treatment nonadherence among US bipolar disorder patients
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Hum Psychopharmacol 23:95-105. 2008
    ..Since sustained treatment-adherence is often problematic and may limit clinical outcomes among bipolar disorder (BPD) patients, we sought risk factors to guide clinical prediction of nonadherence...
  6. ncbi request reprint Olanzapine versus placebo in acute mania: treatment responses in subgroups
    Ross J Baldessarini
    International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 23:370-6. 2003
    ..5-1.7, all P < 0.01). These well-powered comparisons of subgroups of interest indicate broad efficacy of olanzapine in the treatment of acute mania...
  7. ncbi request reprint Patterns of psychotropic drug prescription for U.S. patients with diagnoses of bipolar disorders
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatr Serv 58:85-91. 2007
    ..A growing number of psychotropic drugs are used to treat bipolar disorder, often off-label and in untested, complex combinations...
  8. ncbi request reprint Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disorders
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
    Bipolar Disord 1:91-7. 1999
    ..To test whether longer treatment-delays or more pretreatment illness episodes are followed by diminished response to lithium maintenance...
  9. doi request reprint Bipolar depression: overview and commentary
    Ross J Baldessarini
    Harvard Medical School, McLean Hospital, Belmont, MA, USA
    Harv Rev Psychiatry 18:143-57. 2010
    ..Interest in recognizing bipolar depression and seeking more effective, specific, and safer treatments for it are growing...
  10. ncbi request reprint Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, Boston, USA
    J Affect Disord 61:13-22. 2000
    ..Rapid cycling (RC) in bipolar disorders is widely believed to predict future morbidity and poor treatment response, although empirical testing of its predictive utility remains limited...
  11. doi request reprint Psychotropic medications for patients with bipolar disorder in the United States: polytherapy and adherence
    Ross Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Psychiatr Serv 59:1175-83. 2008
    ..Because treatments for bipolar disorder include a growing number of psychotropic agents, the authors evaluated psychotropic polytherapy and adherence to treatment among U.S. patients with bipolar disorder...
  12. ncbi request reprint Treatment-latency and previous episodes: relationships to pretreatment morbidity and response to maintenance treatment in bipolar I and II disorders
    Ross J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Bipolar Disord 5:169-79. 2003
    ..To clarify relationships of treatment delay and pretreatment episode count with pretreatment morbidity and responses to maintenance treatments in bipolar disorders...
  13. ncbi request reprint Illness risk following rapid versus gradual discontinuation of antidepressants
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 167:934-41. 2010
    ..Recurrence occurs earlier after rapid than after gradual discontinuation with lithium and antipsychotics. The authors compared illness recurrence after rapid versus gradual discontinuation of antidepressants...
  14. ncbi request reprint Treating the suicidal patient with bipolar disorder. Reducing suicide risk with lithium
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and Bipolar and Psychotic Disorders Program, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 932:24-38; discussion 39-43. 2001
    ..Studies of commonly used, but incompletely evaluated, alternative treatments are required, and further protection against premature mortality can be anticipated with better protection against bipolar depression...
  15. ncbi request reprint Lithium treatment and suicide risk in major affective disorders: update and new findings
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 64:44-52. 2003
    ..An exception is growing evidence for such suicidal risk reduction with long-term lithium maintenance. This report updates and extends analyses of lithium treatment and suicides and attempts...
  16. ncbi request reprint Treatment research in bipolar disorder: issues and recommendations
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    CNS Drugs 16:721-9. 2002
    ....
  17. ncbi request reprint Is lithium still worth using? An update of selected recent research
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    Harv Rev Psychiatry 10:59-75. 2002
    ....
  18. ncbi request reprint Suicide in bipolar disorder: Risks and management
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    CNS Spectr 11:465-71. 2006
    ..Applying available knowledge systematically, with close and sustained clinical supervision, can enhance management of suicidal risk in bipolar disorders patients...
  19. ncbi request reprint Genetics of suicide: an overview
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    Harv Rev Psychiatry 12:1-13. 2004
    ....
  20. ncbi request reprint Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review
    Ross J Baldessarini
    International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:625-39. 2006
    ..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment...
  21. doi request reprint Onset-age of bipolar disorders at six international sites
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    J Affect Disord 121:143-6. 2010
    ....
  22. ncbi request reprint Effects of treatment latency on response to maintenance treatment in manic-depressive disorders
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 9:386-93. 2007
    ..To further test the hypothesis that past illness episodes and delay of long-term treatment do not limit maintenance treatment response among patients with manic-depressive illnesses (MDI)...
  23. ncbi request reprint Assessment of treatment response in mania: commentary and new findings
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 5:79-84. 2003
    ..Chengappa et al. (1). propose operational criteria for specific outcomes based on rating-scale data from two placebo-controlled trials of olanzapine in mania...
  24. doi request reprint Morbidity in 303 first-episode bipolar I disorder patients
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 12:264-70. 2010
    ....
  25. ncbi request reprint Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neurosci Lett 287:81-4. 2000
    ....
  26. ncbi request reprint Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: comparison of NMDA, AMPA, and kainate receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Synapse 30:227-35. 1998
    ..Conversely, the loss of all three GLU receptor subtypes after lesioning DA neurons supports their role as excitatory heteroceptors promoting DA release from nigrostriatal neurons...
  27. ncbi request reprint Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone
    K Zhang
    Neuropharmacology Laboratory, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02478, USA
    Neurosci Lett 274:155-8. 1999
    ..The findings demonstrate that NIPS selectively alkylates D2 and D4 receptors, indicating its potential utility for studies of these receptors...
  28. doi request reprint Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  29. ncbi request reprint Dopamine D(4) receptors in rat forebrain: unchanged with amphetamine-induced behavioral sensitization
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neuroscience 97:211-3. 2000
    ..The findings indicate that expression of amphetamine-induced behavioral sensitization is not associated with altered D(4) (or D(2)) receptor density in rat forebrain...
  30. ncbi request reprint Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
    ..In contrast to reported elimination of excessive receptors in CPu and NAc during maturation, there was no evidence of pruning of DAT or 5-HTT in these regions of rat forebrain...
  31. ncbi request reprint Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 118:106-15. 2008
    ..Relationships between antidepressant treatment and suicidality remain uncertain in major depressive disorder (MDD), and rarely evaluated in bipolar disorder (BPD)...
  32. ncbi request reprint Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Brain Res 792:324-6. 1998
    ....
  33. ncbi request reprint Suicide attempts in major affective disorder patients with comorbid substance use disorders
    L Tondo
    International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999
    ..The widely accepted impression that substance abuse and dependence are associated with increased suicidal risk was evaluated by literature review and with new data...
  34. pmc Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks
    S N Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA 02111, USA
    Acta Psychiatr Scand 118:347-56. 2008
    ..Long-term antidepressant (AD) treatment for depression in bipolar disorder (BPD) patients is highly prevalent, but its benefits and risks remain uncertain, encouraging this meta-analysis of available research...
  35. ncbi request reprint Long-term combination therapy versus monotherapy with lithium and carbamazepine in 46 bipolar I patients
    Christopher Baethge
    Department of Psychiatry, Harvard Medical School, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 66:174-82. 2005
    ..These trials suggest added benefit of combination treatment over use of either agent alone but also indicate the need for further studies...
  36. doi request reprint Changes in medication practices for hospitalized psychiatric patients: 2009 versus 2004
    Franca Centorrino
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    Hum Psychopharmacol 25:179-86. 2010
    ..We tested the hypothesis that combinations and total daily doses of psychotropics for hospitalized patients diagnosed with major psychiatric disorders are rising...
  37. ncbi request reprint Age at onset in 3014 Sardinian bipolar and major depressive disorder patients
    L Tondo
    Department of Psychiatry, Harvard Medical School and International Consortium for Psychotic and Mood Disorders Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:446-52. 2010
    ..To test if onset age in major affective illnesses is younger in bipolar disorder (BPD) than unipolar-major depressive disorder (UP-MDD), and is a useful measure...
  38. ncbi request reprint Comorbid substance-use in schizophrenia: relation to positive and negative symptoms
    A Talamo
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 86:251-5. 2006
    ..Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified...
  39. ncbi request reprint Suicidal risks among 2826 Sardinian major affective disorder patients
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 116:419-28. 2007
    ..We estimated risks of suicidal behaviors in 2826 mood-disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years...
  40. ncbi request reprint Response to lithium maintenance treatment in bipolar disorders: comparison of women and men
    A C Viguera
    The International Consortium for Bipolar Disorder Research, Boston, Massachusetts, USA
    Bipolar Disord 3:245-52. 2001
    ..Since women with bipolar disorder reportedly have more features that may predict a poor prognosis (depression and rapid cycling), we tested the hypothesis that women respond less well to lithium maintenance treatment...
  41. ncbi request reprint Effects of alkylating agents on dopamine D(3) receptors in rat brain: selective protection by dopamine
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA, USA
    Brain Res 847:32-7. 1999
    ..The findings are consistent with the view that alkylation of D(3) receptors in vivo is prevented by its high affinity for even minor concentrations of endogenous dopamine...
  42. ncbi request reprint Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders
    L Tondo
    Department of Psychology, University of Cagliari, Sardinia, Italy and McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
    Br J Psychiatry Suppl 41:s184-90. 2001
    ..The effectiveness of lithium is being questioned increasingly and requires clarification...
  43. ncbi request reprint Factors associated with noncompliance with psychiatric outpatient visits
    F Centorrino
    Department of Psychiatry at Harvard Medical School, Belmont, Massachusetts, USA
    Psychiatr Serv 52:378-80. 2001
    ..Adherence was also higher when visits were routinely scheduled, when the intervisit interval was shorter, and when the visit entailed psychotherapy rather than pharmacotherapy...
  44. doi request reprint Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders
    L Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 127:355-64. 2013
    ..Whether responses to antidepressants differ in bipolar and unipolar depression remains unresolved...
  45. doi request reprint Predominant recurrence polarity among 928 adult international bipolar I disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, USA
    Acta Psychiatr Scand 125:293-302. 2012
    ..To test the hypothesis that patients with bipolar disorder (BPD) differ demographically and clinically within subgroups based on the predominant-polarity of major recurrences...
  46. ncbi request reprint Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, USA
    Am J Psychiatry 154:551-3. 1997
    ..The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment...
  47. ncbi request reprint Postnatal development of dopamine D4-like receptors in rat forebrain regions: comparison with D2-like receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02178, USA
    Brain Res Dev Brain Res 110:227-33. 1998
    ....
  48. ncbi request reprint Antagonism of limbic and extrapyramidal actions of intracerebrally injected dopamine by ergolines with partial D2 agonist activity in the rat
    A Campbell
    Department of Psychiatry, Harvard Medical School, Belmont, MA
    Brain Res 592:348-52. 1992
    ....
  49. ncbi request reprint Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Neurosci Lett 236:147-50. 1997
    ..These results support the impression that transporter proteins for these monoamines are not regulated by increased ligand abundance...
  50. ncbi request reprint Dopamine D1 receptor development depends on endogenous dopamine
    H A Gelbard
    Department of Neurology, Harvard Medical School, Boston, MA
    Brain Res Dev Brain Res 56:137-40. 1990
    ..Thus, D1 receptor density may be regulated by reciprocal regulatory processes during normal development, but may fail to develop in the absence of an adequate level of stimulation...
  51. ncbi request reprint Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
    S N Ghaemi
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 62:565-9. 2001
    ..We sought to review research on use of antidepressants for long-term treatment of bipolar depression...
  52. ncbi request reprint Aripiprazole: initial clinical experience with 142 hospitalized psychiatric patients
    Franca Centorrino
    Harvard Medical School and McLean Hospital, Belmont, MA 02478 9106, USA
    J Psychiatr Pract 11:241-7. 2005
    ..We considered the first 6 months of experience with aripiprazole in psychiatric inpatients with a range of disorders...
  53. ncbi request reprint Prophylaxis latency and outcome in bipolar disorders
    Christopher Baethge
    Consolidated Department of Psychiatry, Harvard Medical School, Bipolar and Psychotic Disorders Program, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts, USA
    Can J Psychiatry 48:449-57. 2003
    ..To analyze new and reviewed findings to evaluate relations between treatment response and latency from onset of bipolar disorder (BD) to the start of mood-stabilizer prophylaxis...
  54. pmc Antecedents of manic versus other first psychotic episodes in 263 bipolar I disorder patients
    P Salvatore
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA International Consortium for Psychotic and Bipolar Disorders Research, Mailman Research Center, McLean Hospital, Belmont, MA, USA Section of Psychiatry, Department of Neuroscience, University of Parma, Parma, Italy
    Acta Psychiatr Scand 129:275-85. 2014
    ..As initial episode type can predict later morbidity in bipolar disorder, we tested the hypothesis that clinical antecedents might predict initial episode types...
  55. doi request reprint Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients
    R J Baldessarini
    Department of Psychiatry, Harvard Medical School, International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    J Affect Disord 136:149-54. 2012
    ....
  56. ncbi request reprint Mania associated with antidepressant treatment: comprehensive meta-analytic review
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:404-14. 2010
    ..To review available data pertaining to risk of mania-hypomania among bipolar (BPD) and major depressive disorder (MDD) patients with vs. without exposure to antidepressant drugs (ADs) and consider effects of mood stabilizers...
  57. ncbi request reprint Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysis
    L Tondo
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Acta Psychiatr Scand 104:163-72. 2001
    ..CONCLUSION: Suicide risk was consistently lower during long-term treatment of major affective illnesses with lithium in all studies in the meta-analysis, including the few involving treatment-randomization...
  58. ncbi request reprint Psychopathology factors in first-episode affective and non-affective psychotic disorders
    P Salvatore
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 41:724-36. 2007
    ....
  59. ncbi request reprint Sex differences in response to lithium treatment
    A C Viguera
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1509-11. 2000
    ..The authors' goal was to investigate whether there are differences between the sexes in response to lithium...
  60. doi request reprint Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders
    L Tondo
    International Consortium for Psychotic and Mood Disorder Research, McLean Hospital and Harvard Medical School, Boston, MA, USA
    Acta Psychiatr Scand 123:283-9. 2011
    ..It may include reproductive functioning, which has rarely been studied systematically...
  61. ncbi request reprint Regional localization of dopamine and ionotropic glutamate receptor subtypes in striatolimbic brain regions
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Neurosci Res 55:401-10. 1999
    ..Further localization of these receptor subtypes in striatolimbic forebrain should help to clarify their contributions to the pathophysiology of neuropsychiatric disorders and their treatment...
  62. ncbi request reprint Effects of hippocampal lesions on striatolimbic ionotropic glutamatergic receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Neurosci Lett 250:13-6. 1998
    ....
  63. pmc McLean-Harvard International First-Episode Project: two-year stability of DSM-IV diagnoses in 500 first-episode psychotic disorder patients
    Paola Salvatore
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 70:458-66. 2009
    ..Since stability of DSM-IV diagnoses of disorders with psychotic features requires validation, we evaluated psychotic patients followed systematically in the McLean-Harvard International First Episode Project...
  64. ncbi request reprint Hospital use of antipsychotic drugs: polytherapy
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA 02115, USA
    Compr Psychiatry 49:65-9. 2008
    ..Growing acceptance of new psychotropic drugs encouraged a survey of current use of antipsychotic drugs alone and in combinations, with comparisons with previous findings...
  65. ncbi request reprint Comparative postnatal development of dopamine D(1), D(2) and D(4) receptors in rat forebrain
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, USA
    Int J Dev Neurosci 18:29-37. 2000
    ....
  66. ncbi request reprint Postnatal development of dopamine D1-like receptors in rat cortical and striatolimbic brain regions: An autoradiographic study
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Mass, 02178, USA
    Dev Neurosci 21:43-9. 1999
    ..Postnatal D1-like receptor development in rat forebrain paralleled that of D2- and D4-like receptors in the same regions...
  67. ncbi request reprint Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02748, USA
    Neuropharmacology 39:2133-8. 2000
    ..EEDQ is an effective alkylating agent for DA(T) in vitro, but not to evaluate metabolic turnover or function of DA(T) in vivo. The results encourage development of selective and in vivo-active DA(T)-alkylating agents...
  68. doi request reprint Lamotrigine in bipolar disorder: efficacy during pregnancy
    D Jeffrey Newport
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bipolar Disord 10:432-6. 2008
    ..The high risk of bipolar depression during pregnancy encourages consideration of lamotrigine (LTG). We therefore compared recurrence risks among pregnant women with BPD treated with LTG to those discontinuing mood stabilizer therapies...
  69. ncbi request reprint Lithium treatment reduces suicide risk in recurrent major depressive disorder
    Francesca Guzzetta
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 68:380-3. 2007
    ..Since lithium shows major antisuicidal effects in bipolar disorders and in heterogeneous mood disorder samples, we evaluated evidence of antisuicidal effects of lithium in patients with recurrent MDD...
  70. ncbi request reprint Disability and its treatment in bipolar disorder patients
    Nancy Huxley
    The International Consortium for Bipolar Disorder Research, Department of Psychiatry, Harvard Medical School, McLean Division of Massachusetts General Hospital, Belmont, MA, USA
    Bipolar Disord 9:183-96. 2007
    ..Much less is known about how these and more specific rehabilitative interventions might improve vocational functioning in BPD patients...
  71. doi request reprint Sequencing of substance use and affective morbidity in 166 first-episode bipolar I disorder patients
    Christopher Baethge
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 10:738-41. 2008
    ..Since bipolar disorder (BPD) patients have high rates of comorbid substance abuse, and the temporal relationships involved are unclear, we evaluated the sequencing of specific substance use and affective morbidity...
  72. ncbi request reprint Use of combinations of antipsychotics: McLean Hospital inpatients, 2002
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA 02478 9106, USA
    Hum Psychopharmacol 20:485-92. 2005
    ..Such treatment was evaluated in hospitalized psychiatric patients...
  73. ncbi request reprint Anticonvulsants in the treatment of major depressive disorder: an overview
    Daniel V Vigo
    Department of Psychiatry, Harvard Medical School, MA, USA
    Harv Rev Psychiatry 17:231-41. 2009
    ....
  74. ncbi request reprint Ziprasidone: first year experience in a hospital setting
    Franca Centorrino
    Schizophrenia and Bipolar Disorder Clinic, McLean Hospital, Belmont, MA 02478 9106, USA
    J Psychiatr Pract 10:361-7. 2004
    ....
  75. ncbi request reprint Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia
    R J Baldessarini
    Department of Psychiatry and Neurology, Harvard Medical School, Boston, Mass, USA
    Am J Psychiatry 154:861-3. 1997
    ..To evaluate the hypothesis that patients with schizophrenia who have been treated with neuroleptics have a high rate of Alzheimer's disease-like neuropathology...
  76. ncbi request reprint Release of 3H-dopamine and analogous monoamines from rat striatal tissue
    R J Baldessarini
    Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts
    Cell Mol Neurobiol 8:205-16. 1988
    ..Electrical release and that induced by 50 mM K+ or 100 microM veratridine was blocked by the omission of Ca2+ (with EDTA added) and that induced by veratridine was blocked by tetrodotoxin (30 microM)...
  77. ncbi request reprint Dopamine D4 receptors: significance for molecular psychiatry at the millennium
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Mol Psychiatry 4:529-38. 1999
    ..D4 receptors appear to have broad implications for the pathophysiology of neuropsychiatric illnesses and their improved treatment...
  78. ncbi request reprint Suicidal events and accidents in 216 first-episode bipolar I disorder patients: predictive factors
    Hari Mandir Kaur Khalsa
    Department of Psychiatry, Harvard Medical School, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
    J Affect Disord 106:179-84. 2008
    ..Risks of life-threatening behaviors are high among bipolar disorder (BPD) patients, but early rates and associated risk factors for suicides and accidents remain ill-defined...
  79. ncbi request reprint Oxcarbazepine: clinical experience with hospitalized psychiatric patients
    Franca Centorrino
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 5:370-4. 2003
    ....
  80. pmc Comparison of mania patients suitable for treatment trials versus clinical treatment
    Alessandra Talamo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Hum Psychopharmacol 23:447-54. 2008
    ..The pilot study is limited in numbers and exposure times with which to test for the minor differences between "research subjects" and "clinical patients."..
  81. ncbi request reprint Pilot comparison of extended-release and standard preparations of divalproex sodium in patients with bipolar and schizoaffective disorders
    Franca Centorrino
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 160:1348-50. 2003
    ..The authors compared the new extended-release and standard preparations of divalproex sodium...
  82. ncbi request reprint Advances in atypical antipsychotics for the treatment of schizophrenia: new formulations and new agents
    James P Kelleher
    Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
    CNS Drugs 16:249-61. 2002
    ..These new formulations and agents should broaden options for the treatment of psychosis...
  83. ncbi request reprint Managing bipolar disorder during pregnancy: weighing the risks and benefits
    Adele C Viguera
    Perinatal and Reproductive Psychiatry Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Can J Psychiatry 47:426-36. 2002
    ..Challenges for the clinical management of bipolar disorder (BD) during pregnancy are multiple and complex and include competing risks to mother and offspring...
  84. ncbi request reprint Inpatient antipsychotic drug use in 1998, 1993, and 1989
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA 02478 9106, USA
    Am J Psychiatry 159:1932-5. 2002
    ..Patterns of clinical use of antipsychotic agents have changed greatly in the past decade. The authors' goal was to examine these patterns...
  85. ncbi request reprint Multiple versus single antipsychotic agents for hospitalized psychiatric patients: case-control study of risks versus benefits
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and Bipolar and Psychotic Disorders Clinic, McLean Hospital, Boston, MA USA
    Am J Psychiatry 161:700-6. 2004
    ....
  86. ncbi request reprint Clinical outcome in patients with bipolar I disorder, obsessive compulsive disorder or both
    Franca Centorrino
    Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont 02478, and Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    Hum Psychopharmacol 21:189-93. 2006
    ..Bipolar disorder (BPD) is often comorbid with obsessive-compulsive (OCD) and other anxiety disorders, but the impact of such comorbidity on long-term outcome has not been evaluated systematically...
  87. ncbi request reprint EEG abnormalities during treatment with typical and atypical antipsychotics
    Franca Centorrino
    Bipolar and Psychotic Disorder Program, McLean Hospital, MA 02478, USA
    Am J Psychiatry 159:109-15. 2002
    ..Much less is known about EEG effects of newer antipsychotics. The present study therefore examined the risk of EEG abnormalities associated with various antipsychotic drugs...
  88. ncbi request reprint Antipsychotic drug use: McLean Hospital, 2002
    Franca Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, USA
    Hum Psychopharmacol 20:355-8. 2005
    ..Major changes in antipsychotic treatment in recent years encouraged a survey of inpatient practice in 2002, compared with earlier samples...
  89. ncbi request reprint Weight gain during treatment of bipolar I patients with olanzapine
    John Hennen
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Clin Psychiatry 65:1679-87. 2004
    ..Body weight increase during long-term treatment with olanzapine in schizophrenia patients is well documented, but weight gain and its association with other medical measures are less well evaluated in bipolar disorder patients...
  90. ncbi request reprint Hallucinations in bipolar disorder: characteristics and comparison to unipolar depression and schizophrenia
    Christopher Baethge
    Department of Psychiatry, International Consortium for Bipolar Disorder Research, Harvard Medical School, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
    Bipolar Disord 7:136-45. 2005
    ..As there is very little research on the topic, we compared the frequency and the type hallucinations among hospitalized patients diagnosed with bipolar disorder (BPD) versus other major psychiatric illnesses...
  91. ncbi request reprint Delirium during clozapine treatment: incidence and associated risk factors
    F Centorrino
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Pharmacopsychiatry 36:156-60. 2003
    ..Incidence and risk factors for delirium during clozapine treatment require further clarification...
  92. ncbi request reprint Weight loss in overweight patients maintained on atypical antipsychotic agents
    F Centorrino
    Consolidated Department of Psychiatry, McLean Hospital, Harvard Medical School, Boston, MA, USA
    Int J Obes (Lond) 30:1011-6. 2006
    ..Weight gain and associated medical morbidity offset the reduction of extrapyramidal side effects associated with atypical antipsychotics. Efforts to control weight in antipsychotic-treated patients have yielded limited success...
  93. ncbi request reprint Rapid-cycling bipolar disorder: effects of long-term treatments
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    Acta Psychiatr Scand 108:4-14. 2003
    ..To compare responses to long-term treatment of rapid-cycling (RC) vs. non-RC bipolar disorder patients and assess relative effectiveness of specific agents in RC patients...
  94. ncbi request reprint GABA(B) receptors: altered coupling to G-proteins in rats sensitized to amphetamine
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 101:5-10. 2000
    ....
  95. ncbi request reprint Long-term effects of olanzapine, risperidone, and quetiapine on dopamine receptor types in regions of rat brain: implications for antipsychotic drug treatment
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA
    J Pharmacol Exp Ther 297:711-7. 2001
    ..Inability of quetiapine to alter DA receptors suggests that nondopaminergic mechanisms contribute to its antipsychotic effects...
  96. ncbi request reprint Substance abuse in first-episode bipolar I disorder: indications for early intervention
    Christopher Baethge
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Am J Psychiatry 162:1008-10. 2005
    ..This study clarified the early characteristics of substance use disorders in patients with first-episode bipolar I disorder...
  97. doi request reprint Neurosyphilis, malaria, and the discovery of antipsychotic agents
    Frances R Frankenburg
    Department of Psychiatry, Boston University School of Medicine, USA
    Harv Rev Psychiatry 16:299-307. 2008
    ..Chlorpromazine has antipsychotic and antimanic properties, and it revolutionized the therapeutics of psychotic illnesses...
  98. doi request reprint Circadian activity rhythm abnormalities in ill and recovered bipolar I disorder patients
    Paola Salvatore
    Schizophrenia and Bipolar Disorder Program and International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478 9106, USA
    Bipolar Disord 10:256-65. 2008
    ..Activity rhythms are highly abnormal in acute phases of BPD; we compared circadian activity rhythms in BPD I patients during ill and recovered states to those of normal controls to test the hypothesis that some abnormalities may persist...
  99. doi request reprint Psychosis NOS: search for diagnostic clarity
    Sherry A Nykiel
    Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 16:55-65. 2008
  100. pmc Dissimilar morbidity following initial mania versus mixed-states in type-I bipolar disorder
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Affect Disord 126:299-302. 2010
    ..Mixed-states of bipolar disorders (BPD) may predict worse future illness and more depressive than manic morbidity, challenging a tendency to conflate mixed-states and mania...
  101. ncbi request reprint Antidepressant treatment in bipolar versus unipolar depression
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, MA 02139, USA
    Am J Psychiatry 161:163-5. 2004
    ..Antidepressant responses were compared in DSM-IV bipolar and unipolar depression...

Research Grants2

  1. Course and Morbidity in Bipolar I Disorder
    Ross Baldessarini; Fiscal Year: 2006
    ..Anticipated findings should contribute important new information to guide effective interventions and allocation of increasingly limited treatment resources for BPD patients. ..
  2. Antidepressant discontinuation effects
    Ross Baldessarini; Fiscal Year: 2007
    ..bipolar depressive subjects separately. The findings expected should contribute to improved safety of antidepressant treatment and reduced morbid and mortal risks following its discontinuation. [unreadable] [unreadable]..