R J Baldessarini

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Affect Disord 148:129-35. 2013
  2. doi request reprint Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients
    R J Baldessarini
    Department of Psychiatry, Harvard Medical School, International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    J Affect Disord 136:149-54. 2012
  3. doi request reprint Predominant recurrence polarity among 928 adult international bipolar I disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, USA
    Acta Psychiatr Scand 125:293-302. 2012
  4. ncbi request reprint Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: comparison of NMDA, AMPA, and kainate receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Synapse 30:227-35. 1998
  5. ncbi request reprint Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone
    K Zhang
    Neuropharmacology Laboratory, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02478, USA
    Neurosci Lett 274:155-8. 1999
  6. ncbi request reprint Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neurosci Lett 287:81-4. 2000
  7. ncbi request reprint Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
  8. ncbi request reprint Dopamine D(4) receptors in rat forebrain: unchanged with amphetamine-induced behavioral sensitization
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neuroscience 97:211-3. 2000
  9. ncbi request reprint Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Brain Res 792:324-6. 1998
  10. ncbi request reprint Suicide attempts in major affective disorder patients with comorbid substance use disorders
    L Tondo
    International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999

Detail Information

Publications50

  1. doi request reprint Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review
    Ross J Baldessarini
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Affect Disord 148:129-35. 2013
    ..Compare reported rates of mood-shifts from major depression to mania/hypomania/mixed-states during antidepressant (AD)-treatment and rates of diagnostic change from major depressive disorder (MDD) to bipolar disorder (BPD)...
  2. doi request reprint Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients
    R J Baldessarini
    Department of Psychiatry, Harvard Medical School, International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    J Affect Disord 136:149-54. 2012
    ....
  3. doi request reprint Predominant recurrence polarity among 928 adult international bipolar I disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, McLean Division of Massachusetts General Hospital, Belmont, USA
    Acta Psychiatr Scand 125:293-302. 2012
    ..To test the hypothesis that patients with bipolar disorder (BPD) differ demographically and clinically within subgroups based on the predominant-polarity of major recurrences...
  4. ncbi request reprint Localization of ionotropic glutamate receptors in caudate-putamen and nucleus accumbens septi of rat brain: comparison of NMDA, AMPA, and kainate receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Synapse 30:227-35. 1998
    ..Conversely, the loss of all three GLU receptor subtypes after lesioning DA neurons supports their role as excitatory heteroceptors promoting DA release from nigrostriatal neurons...
  5. ncbi request reprint Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone
    K Zhang
    Neuropharmacology Laboratory, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02478, USA
    Neurosci Lett 274:155-8. 1999
    ..The findings demonstrate that NIPS selectively alkylates D2 and D4 receptors, indicating its potential utility for studies of these receptors...
  6. ncbi request reprint Olanzapine, quetiapine, and risperidone: long-term effects on monoamine transporters in rat forebrain
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neurosci Lett 287:81-4. 2000
    ....
  7. ncbi request reprint Postnatal development of dopamine and serotonin transporters in rat caudate-putamen and nucleus accumbens septi
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Harvard Medical School Belmont 02178, USA
    Neurosci Lett 254:21-4. 1998
    ..In contrast to reported elimination of excessive receptors in CPu and NAc during maturation, there was no evidence of pruning of DAT or 5-HTT in these regions of rat forebrain...
  8. ncbi request reprint Dopamine D(4) receptors in rat forebrain: unchanged with amphetamine-induced behavioral sensitization
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neuroscience 97:211-3. 2000
    ..The findings indicate that expression of amphetamine-induced behavioral sensitization is not associated with altered D(4) (or D(2)) receptor density in rat forebrain...
  9. ncbi request reprint Local injection of alkylating and nonalkylating dopamine receptor antagonists into rat basal forebrain: autoradiographic assessment of D2-like and D3 sites
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Brain Res 792:324-6. 1998
    ....
  10. ncbi request reprint Suicide attempts in major affective disorder patients with comorbid substance use disorders
    L Tondo
    International Consortium for Research on Bipolar Disorders the Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 60:63-9; discussion 75-6, 113-6. 1999
    ..The widely accepted impression that substance abuse and dependence are associated with increased suicidal risk was evaluated by literature review and with new data...
  11. ncbi request reprint Effects of rapid cycling on response to lithium maintenance treatment in 360 bipolar I and II disorder patients
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, Boston, USA
    J Affect Disord 61:13-22. 2000
    ..Rapid cycling (RC) in bipolar disorders is widely believed to predict future morbidity and poor treatment response, although empirical testing of its predictive utility remains limited...
  12. ncbi request reprint Latency and episodes before treatment: response to lithium maintenance in bipolar I and II disorders
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School and Bipolar and Psychotic Disorders Program, McLean Massachusetts General Hospitals, Boston, USA
    Bipolar Disord 1:91-7. 1999
    ..To test whether longer treatment-delays or more pretreatment illness episodes are followed by diminished response to lithium maintenance...
  13. doi request reprint Age at onset in 3014 Sardinian bipolar and major depressive disorder patients
    L Tondo
    Department of Psychiatry, Harvard Medical School and International Consortium for Psychotic and Mood Disorders Research, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:446-52. 2010
    ..To test if onset age in major affective illnesses is younger in bipolar disorder (BPD) than unipolar-major depressive disorder (UP-MDD), and is a useful measure...
  14. ncbi request reprint Discontinuing lithium maintenance treatment in bipolar disorders: risks and implications
    R J Baldessarini
    The International Consortium for Bipolar Disorders Research, Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 1:17-24. 1999
    ..To review research findings on clinical effects of discontinuing lithium maintenance treatment...
  15. ncbi request reprint Effects of alkylating agents on dopamine D(3) receptors in rat brain: selective protection by dopamine
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA, USA
    Brain Res 847:32-7. 1999
    ..The findings are consistent with the view that alkylation of D(3) receptors in vivo is prevented by its high affinity for even minor concentrations of endogenous dopamine...
  16. doi request reprint Clinical responses to antidepressants among 1036 acutely depressed patients with bipolar or unipolar major affective disorders
    L Tondo
    International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 127:355-64. 2013
    ..Whether responses to antidepressants differ in bipolar and unipolar depression remains unresolved...
  17. ncbi request reprint Response to lithium maintenance treatment in bipolar disorders: comparison of women and men
    A C Viguera
    The International Consortium for Bipolar Disorder Research, Boston, Massachusetts, USA
    Bipolar Disord 3:245-52. 2001
    ..Since women with bipolar disorder reportedly have more features that may predict a poor prognosis (depression and rapid cycling), we tested the hypothesis that women respond less well to lithium maintenance treatment...
  18. doi request reprint Onset-age of bipolar disorders at six international sites
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    J Affect Disord 121:143-6. 2010
    ....
  19. ncbi request reprint Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Neurosci Lett 236:147-50. 1997
    ..These results support the impression that transporter proteins for these monoamines are not regulated by increased ligand abundance...
  20. ncbi request reprint Antagonism of limbic and extrapyramidal actions of intracerebrally injected dopamine by ergolines with partial D2 agonist activity in the rat
    A Campbell
    Department of Psychiatry, Harvard Medical School, Belmont, MA
    Brain Res 592:348-52. 1992
    ....
  21. ncbi request reprint Postnatal development of dopamine D4-like receptors in rat forebrain regions: comparison with D2-like receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02178, USA
    Brain Res Dev Brain Res 110:227-33. 1998
    ....
  22. ncbi request reprint Dopamine D1 receptor development depends on endogenous dopamine
    H A Gelbard
    Department of Neurology, Harvard Medical School, Boston, MA
    Brain Res Dev Brain Res 56:137-40. 1990
    ..Thus, D1 receptor density may be regulated by reciprocal regulatory processes during normal development, but may fail to develop in the absence of an adequate level of stimulation...
  23. doi request reprint Reproduction among 1975 Sardinian women and men diagnosed with major mood disorders
    L Tondo
    International Consortium for Psychotic and Mood Disorder Research, McLean Hospital and Harvard Medical School, Boston, MA, USA
    Acta Psychiatr Scand 123:283-9. 2011
    ..It may include reproductive functioning, which has rarely been studied systematically...
  24. pmc Long-term antidepressant treatment in bipolar disorder: meta-analyses of benefits and risks
    S N Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Boston, MA 02111, USA
    Acta Psychiatr Scand 118:347-56. 2008
    ..Long-term antidepressant (AD) treatment for depression in bipolar disorder (BPD) patients is highly prevalent, but its benefits and risks remain uncertain, encouraging this meta-analysis of available research...
  25. doi request reprint Mania associated with antidepressant treatment: comprehensive meta-analytic review
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 121:404-14. 2010
    ..To review available data pertaining to risk of mania-hypomania among bipolar (BPD) and major depressive disorder (MDD) patients with vs. without exposure to antidepressant drugs (ADs) and consider effects of mood stabilizers...
  26. ncbi request reprint Effects of hippocampal lesions on striatolimbic ionotropic glutamatergic receptors
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02178, USA
    Neurosci Lett 250:13-6. 1998
    ....
  27. doi request reprint Suicidal status during antidepressant treatment in 789 Sardinian patients with major affective disorder
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 118:106-15. 2008
    ..Relationships between antidepressant treatment and suicidality remain uncertain in major depressive disorder (MDD), and rarely evaluated in bipolar disorder (BPD)...
  28. ncbi request reprint Reduced morbidity after gradual discontinuation of lithium treatment for bipolar I and II disorders: a replication study
    R J Baldessarini
    International Consortium for Bipolar Disorder Research, MA, USA
    Am J Psychiatry 154:551-3. 1997
    ..The aim of this study was to verify reduction of early affective morbidity by gradual, rather than rapid, discontinuation of lithium treatment...
  29. ncbi request reprint Effectiveness and safety of long-term antidepressant treatment in bipolar disorder
    S N Ghaemi
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, Mass, USA
    J Clin Psychiatry 62:565-9. 2001
    ..We sought to review research on use of antidepressants for long-term treatment of bipolar depression...
  30. ncbi request reprint Treating the suicidal patient with bipolar disorder. Reducing suicide risk with lithium
    R J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and Bipolar and Psychotic Disorders Program, Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Massachusetts 02478, USA
    Ann N Y Acad Sci 932:24-38; discussion 39-43. 2001
    ..Studies of commonly used, but incompletely evaluated, alternative treatments are required, and further protection against premature mortality can be anticipated with better protection against bipolar depression...
  31. ncbi request reprint Regional localization of dopamine and ionotropic glutamate receptor subtypes in striatolimbic brain regions
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    J Neurosci Res 55:401-10. 1999
    ..Further localization of these receptor subtypes in striatolimbic forebrain should help to clarify their contributions to the pathophysiology of neuropsychiatric disorders and their treatment...
  32. ncbi request reprint Sex differences in response to lithium treatment
    A C Viguera
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1509-11. 2000
    ..The authors' goal was to investigate whether there are differences between the sexes in response to lithium...
  33. ncbi request reprint Suicidal risks among 2826 Sardinian major affective disorder patients
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School and McLean Division of Massachusetts General Hospital, Boston, MA, USA
    Acta Psychiatr Scand 116:419-28. 2007
    ..We estimated risks of suicidal behaviors in 2826 mood-disorder patients evaluated and followed in a Sardinian mood disorders research center over the past 30 years...
  34. ncbi request reprint Psychopathology factors in first-episode affective and non-affective psychotic disorders
    P Salvatore
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 41:724-36. 2007
    ....
  35. ncbi request reprint Long-term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders
    L Tondo
    Department of Psychology, University of Cagliari, Sardinia, Italy and McLean Hospital, Department of Psychiatry, Harvard Medical School, Boston, USA
    Br J Psychiatry Suppl 41:s184-90. 2001
    ..The effectiveness of lithium is being questioned increasingly and requires clarification...
  36. ncbi request reprint Postnatal development of dopamine D1-like receptors in rat cortical and striatolimbic brain regions: An autoradiographic study
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, Mass, 02178, USA
    Dev Neurosci 21:43-9. 1999
    ..Postnatal D1-like receptor development in rat forebrain paralleled that of D2- and D4-like receptors in the same regions...
  37. ncbi request reprint Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02748, USA
    Neuropharmacology 39:2133-8. 2000
    ..EEDQ is an effective alkylating agent for DA(T) in vitro, but not to evaluate metabolic turnover or function of DA(T) in vivo. The results encourage development of selective and in vivo-active DA(T)-alkylating agents...
  38. ncbi request reprint Meta-analysis of postmortem studies of Alzheimer's disease-like neuropathology in schizophrenia
    R J Baldessarini
    Department of Psychiatry and Neurology, Harvard Medical School, Boston, Mass, USA
    Am J Psychiatry 154:861-3. 1997
    ..To evaluate the hypothesis that patients with schizophrenia who have been treated with neuroleptics have a high rate of Alzheimer's disease-like neuropathology...
  39. ncbi request reprint Release of 3H-dopamine and analogous monoamines from rat striatal tissue
    R J Baldessarini
    Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts
    Cell Mol Neurobiol 8:205-16. 1988
    ..Electrical release and that induced by 50 mM K+ or 100 microM veratridine was blocked by the omission of Ca2+ (with EDTA added) and that induced by veratridine was blocked by tetrodotoxin (30 microM)...
  40. ncbi request reprint Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysis
    L Tondo
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Acta Psychiatr Scand 104:163-72. 2001
    ..CONCLUSION: Suicide risk was consistently lower during long-term treatment of major affective illnesses with lithium in all studies in the meta-analysis, including the few involving treatment-randomization...
  41. ncbi request reprint Factors associated with noncompliance with psychiatric outpatient visits
    F Centorrino
    Department of Psychiatry at Harvard Medical School, Belmont, Massachusetts, USA
    Psychiatr Serv 52:378-80. 2001
    ..Adherence was also higher when visits were routinely scheduled, when the intervisit interval was shorter, and when the visit entailed psychotherapy rather than pharmacotherapy...
  42. ncbi request reprint Dopamine D4 receptors: significance for molecular psychiatry at the millennium
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Mol Psychiatry 4:529-38. 1999
    ..D4 receptors appear to have broad implications for the pathophysiology of neuropsychiatric illnesses and their improved treatment...
  43. ncbi request reprint Comparative postnatal development of dopamine D(1), D(2) and D(4) receptors in rat forebrain
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, USA
    Int J Dev Neurosci 18:29-37. 2000
    ....
  44. doi request reprint Course sequences in bipolar disorder: Depressions preceding or following manias or hypomanias
    A Koukopoulos
    Lucio Bini Mood Disorder Centers, Rome and Cagliari, Italy International Consortium for Bipolar Disorder Research, Mailman Research Center, McLean Hospital, Belmont, MA, USA
    J Affect Disord 151:105-10. 2013
    ..However, additional characteristics of BD course-patterns require further assessment...
  45. ncbi request reprint Comorbid substance-use in schizophrenia: relation to positive and negative symptoms
    A Talamo
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Schizophr Res 86:251-5. 2006
    ..Comorbid SUD in schizophrenia patients was associated with male sex and higher PANSS positive to lower negative scores. Cause-effect relationships remain to be clarified...
  46. ncbi request reprint Effects of dopamine partial-agonist aminoergolines on dopamine metabolism in limbic and extrapyramidal regions of rat brain
    R J Baldessarini
    Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA
    Biochem Pharmacol 47:1917-9. 1994
    ....
  47. ncbi request reprint Effects of nigrostriatal dopamine denervation on ionotropic glutamate receptors in rat caudate-putamen
    F I Tarazi
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res 881:69-72. 2000
    ....
  48. ncbi request reprint Research reports on treatments for bipolar disorder: preliminary assessment of methodological quality
    F Soldani
    Department of Psychiatry, Harvard Medical School, Boston, MA 02478, USA
    Acta Psychiatr Scand 112:72-4. 2005
    ..To assess frequencies of types of publications about bipolar disorder (BD) and evaluate methodological quality of treatment studies...
  49. ncbi request reprint Rapid-cycling bipolar disorder: effects of long-term treatments
    L Tondo
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, USA
    Acta Psychiatr Scand 108:4-14. 2003
    ..To compare responses to long-term treatment of rapid-cycling (RC) vs. non-RC bipolar disorder patients and assess relative effectiveness of specific agents in RC patients...
  50. ncbi request reprint GABA(B) receptors: altered coupling to G-proteins in rats sensitized to amphetamine
    K Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 101:5-10. 2000
    ....