Research Topics
Genomes and GenesSpecies | Robin E BachelderSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and functionValentina Folgiero
Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
Cancer Res 67:1645-52. 2007..These findings provide one mechanism to account for the activation of PI3K by alpha(6)beta(4) and they also provide insight into the regulation of ErbB-3 in carcinoma cells...- Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transitionRobin E Bachelder
Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Cell Biol 168:29-33. 2005..These findings indicate that epithelial cells must sustain activation of a specific kinase to impede a mesenchymal transition... - Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cellsJun Chung
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
J Cell Biol 158:165-74. 2002..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression... - Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cellsHongjie Pan
Department of Pathology, Duke University Medical Center, D U M C, Durham, NC 27715, USA
Exp Cell Res 316:2825-32. 2010..These findings identify common signaling pathways that regulate the navigation of neurons and breast cancer cells, thus suggesting novel targets for suppressing breast tumor cell migration... - Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progressionLuke S Wanami
Duke University Medical Center, Department of Pathology, D U M C P O Box 3712, Durham, NC 27710, USA
Exp Cell Res 314:2448-53. 2008..Based on our demonstration that Avastin reduces Snail expression in breast tumor cells, we propose that the treatment of early stage breast cancer patients with Avastin may impede tumor progression... - Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cellsHongjie Pan
Department of Pathology, Duke University Medical Center, P O Box 3712 D U M C, Durham, NC, 27710, USA
Breast Cancer Res Treat 118:197-205. 2009..Our studies indicate that expression of the alpha2beta1 integrin, a suppressor of metastatic breast tumor growth, is stimulated in breast tumor cells by an autocrine SEMA3A pathway... - Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomasJoseph Geradts
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Hum Pathol 42:1125-31. 2011..Collectively, our studies demonstrate frequent expression of nuclear Snail1, but not nuclear ZEB1, in invasive, triple-negative breast cancers as well as in intraductal carcinomas... - Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cellsRobin E Bachelder
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Cancer Res 63:5230-3. 2003..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis... - Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4Robin E Bachelder
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Cancer Res 62:7203-6. 2002..Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines... - Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrinArthur M Mercurio
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Semin Cancer Biol 14:115-22. 2004.... - Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoidsRichard C Bates
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Curr Biol 13:1721-7. 2003..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development... - Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cellsJun Chung
Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Cancer Res 64:4711-6. 2004.... - Non-angiogenic functions of VEGF in breast cancerArthur M Mercurio
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Mammary Gland Biol Neoplasia 10:283-90. 2005..These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly...