Robin E Bachelder

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function
    Valentina Folgiero
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 67:1645-52. 2007
  2. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
  3. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
  4. pmc Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells
    Hongjie Pan
    Department of Pathology, Duke University Medical Center, D U M C, Durham, NC 27715, USA
    Exp Cell Res 316:2825-32. 2010
  5. pmc Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression
    Luke S Wanami
    Duke University Medical Center, Department of Pathology, D U M C P O Box 3712, Durham, NC 27710, USA
    Exp Cell Res 314:2448-53. 2008
  6. pmc Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells
    Hongjie Pan
    Department of Pathology, Duke University Medical Center, P O Box 3712 D U M C, Durham, NC, 27710, USA
    Breast Cancer Res Treat 118:197-205. 2009
  7. pmc Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas
    Joseph Geradts
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 42:1125-31. 2011
  8. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
  9. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
  10. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function
    Valentina Folgiero
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 67:1645-52. 2007
    ..These findings provide one mechanism to account for the activation of PI3K by alpha(6)beta(4) and they also provide insight into the regulation of ErbB-3 in carcinoma cells...
  2. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
    ..These findings indicate that epithelial cells must sustain activation of a specific kinase to impede a mesenchymal transition...
  3. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression...
  4. pmc Autocrine Semaphorin3A stimulates eukaryotic initiation factor 4E-dependent RhoA translation in breast tumor cells
    Hongjie Pan
    Department of Pathology, Duke University Medical Center, D U M C, Durham, NC 27715, USA
    Exp Cell Res 316:2825-32. 2010
    ..These findings identify common signaling pathways that regulate the navigation of neurons and breast cancer cells, thus suggesting novel targets for suppressing breast tumor cell migration...
  5. pmc Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression
    Luke S Wanami
    Duke University Medical Center, Department of Pathology, D U M C P O Box 3712, Durham, NC 27710, USA
    Exp Cell Res 314:2448-53. 2008
    ..Based on our demonstration that Avastin reduces Snail expression in breast tumor cells, we propose that the treatment of early stage breast cancer patients with Avastin may impede tumor progression...
  6. pmc Autocrine semaphorin3A stimulates alpha2 beta1 integrin expression/function in breast tumor cells
    Hongjie Pan
    Department of Pathology, Duke University Medical Center, P O Box 3712 D U M C, Durham, NC, 27710, USA
    Breast Cancer Res Treat 118:197-205. 2009
    ..Our studies indicate that expression of the alpha2beta1 integrin, a suppressor of metastatic breast tumor growth, is stimulated in breast tumor cells by an autocrine SEMA3A pathway...
  7. pmc Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas
    Joseph Geradts
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Pathol 42:1125-31. 2011
    ..Collectively, our studies demonstrate frequent expression of nuclear Snail1, but not nuclear ZEB1, in invasive, triple-negative breast cancers as well as in intraductal carcinomas...
  8. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    ..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...
  9. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
    ..Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines...
  10. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
    ....
  11. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003
    ..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development...
  12. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
    ....
  13. ncbi request reprint Non-angiogenic functions of VEGF in breast cancer
    Arthur M Mercurio
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Mammary Gland Biol Neoplasia 10:283-90. 2005
    ..These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly...