R E Bachelder

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
  2. ncbi request reprint The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:34702-7. 2001
  3. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
  4. ncbi request reprint The metastatic odyssey: the integrin connection
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Surg Oncol Clin N Am 10:313-28, viii-ix. 2001
  5. ncbi request reprint Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 61:5736-40. 2001
  6. ncbi request reprint Integrin laminin receptors and breast carcinoma progression
    A M Mercurio
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 6:299-309. 2001
  7. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
  8. ncbi request reprint Postbinding functions of CD4 in HIV infection
    R E Bachelder
    Dept of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Trends Microbiol 4:359-63. 1996
  9. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
  10. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Cancer Res 63:5230-3. 2003
    ..Our findings lead to the surprising conclusion that opposing autocrine loops involving NP1 regulate the chemotaxis of breast carcinoma cells. Moreover, our data indicate a novel autocrine function for VEGF in chemotaxis...
  2. ncbi request reprint The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 276:34702-7. 2001
    ..These studies suggest that members of the death receptor family promote the caspase-mediated cleavage of Akt/PKB and that this event contributes to anoikis...
  3. ncbi request reprint Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4
    Robin E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cancer Res 62:7203-6. 2002
    ..Our findings indicate that a VEGF autocrine pathway induces chemokine receptor expression in breast carcinoma cells, thus promoting their directed migration toward specific chemokines...
  4. ncbi request reprint The metastatic odyssey: the integrin connection
    A M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Surg Oncol Clin N Am 10:313-28, viii-ix. 2001
    ..Numerous studies have implicated these integrins in cancer progression and have provided a rationale for studying the mechanistic basis of their contribution to aggressive disease...
  5. ncbi request reprint Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 61:5736-40. 2001
    ..The identification of this VEGF autocrine signaling pathway has important implications for tumor metastasis and therapeutic intervention...
  6. ncbi request reprint Integrin laminin receptors and breast carcinoma progression
    A M Mercurio
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Mammary Gland Biol Neoplasia 6:299-309. 2001
    ..Recent work by our group and others on mechanisms of breast carcinoma invasion and survival that are influenced by the alpha6 integrins are discussed...
  7. pmc p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB
    R E Bachelder
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Cell Biol 147:1063-72. 1999
    ..These studies demonstrate that the p53 tumor suppressor can inhibit integrin-associated survival signaling pathways...
  8. ncbi request reprint Postbinding functions of CD4 in HIV infection
    R E Bachelder
    Dept of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215, USA
    Trends Microbiol 4:359-63. 1996
    ..The CD4 molecule has been shown to assume an altered conformation on the T-cell surface following HIV binding, which may be involved in these postbinding events...
  9. pmc Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 158:165-74. 2002
    ..These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression...
  10. ncbi request reprint Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    Richard C Bates
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Biol 13:1721-7. 2003
    ..A role for Flt-1 in cell survival is unprecedented and has significant implications for Flt-1 function in tumor progression, as well as in other biological processes, including angiogenesis and development...
  11. ncbi request reprint Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
    Arthur M Mercurio
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Semin Cancer Biol 14:115-22. 2004
    ....
  12. ncbi request reprint Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells
    Jun Chung
    Division of Cancer Biology and Angiogenesis, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Cancer Res 64:4711-6. 2004
    ....
  13. pmc Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition
    Robin E Bachelder
    Department of Pathology, Division of Cancer Biology and Angiogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Cell Biol 168:29-33. 2005
    ..These findings indicate that epithelial cells must sustain activation of a specific kinase to impede a mesenchymal transition...
  14. ncbi request reprint Non-angiogenic functions of VEGF in breast cancer
    Arthur M Mercurio
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Mammary Gland Biol Neoplasia 10:283-90. 2005
    ..These findings imply that VEGF and VEGF receptor-based therapeutics, in addition to targeting angiogenesis, may also target tumor cells directly...
  15. ncbi request reprint The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function
    Valentina Folgiero
    Molecular Oncogenesis Laboratory, Department of Experimental Oncology, Regina Elena Cancer Institute, Via della Messi d Oro 156, 00158 Rome, Italy
    Cancer Res 67:1645-52. 2007
    ..These findings provide one mechanism to account for the activation of PI3K by alpha(6)beta(4) and they also provide insight into the regulation of ErbB-3 in carcinoma cells...
  16. pmc Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression
    Luke S Wanami
    Duke University Medical Center, Department of Pathology, D U M C P O Box 3712, Durham, NC 27710, USA
    Exp Cell Res 314:2448-53. 2008
    ..Based on our demonstration that Avastin reduces Snail expression in breast tumor cells, we propose that the treatment of early stage breast cancer patients with Avastin may impede tumor progression...