Jerry Avorn

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Adverse Drug Reactions in Elderly People: A substantial cause of preventable illness
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
    BMJ 336:956-7. 2008
  2. doi request reprint 'Bench to behavior': translating comparative effectiveness research into improved clinical practice
    Jerry Avorn
    Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 29:1891-900. 2010
  3. ncbi request reprint Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 46:1080-7. 2005
  4. pmc Risk of ischemic cerebrovascular and coronary events in adult users of anticonvulsant medications in routine care settings
    Elisabetta Patorno
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    J Am Heart Assoc 2:e000208. 2013
  5. pmc Can improved prescription medication labeling influence adherence to chronic medications? An evaluation of the Target pharmacy label
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 24:570-8. 2009
  6. doi request reprint Patient, physician, and payment predictors of statin adherence
    David C Chan
    Department of Medicine, Division of General Internal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Med Care 48:196-202. 2010
  7. doi request reprint Untangling the relationship between medication adherence and post-myocardial infarction outcomes: medication adherence and clinical outcomes
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Electronic address
    Am Heart J 167:51-58.e5. 2014
  8. pmc Supplementing claims data with outpatient laboratory test results to improve confounding adjustment in effectiveness studies of lipid-lowering treatments
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    BMC Med Res Methodol 12:180. 2012
  9. pmc Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
  10. doi request reprint Warnings without guidance: patient responses to an FDA warning about ezetimibe
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston 02120, USA
    Med Care 50:479-84. 2012

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. pmc Adverse Drug Reactions in Elderly People: A substantial cause of preventable illness
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02120, USA
    BMJ 336:956-7. 2008
  2. doi request reprint 'Bench to behavior': translating comparative effectiveness research into improved clinical practice
    Jerry Avorn
    Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 29:1891-900. 2010
    ..Such strategies can lead to policies that could encourage the uptake of new comparative effectiveness data and encourage their translation into better clinical practice...
  3. ncbi request reprint Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 46:1080-7. 2005
    ..However, little is known about the adequacy of adherence to these guidelines in elderly patients with diabetes and predictors of such appropriate ACE-inhibitor or ARB use...
  4. pmc Risk of ischemic cerebrovascular and coronary events in adult users of anticonvulsant medications in routine care settings
    Elisabetta Patorno
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
    J Am Heart Assoc 2:e000208. 2013
    ....
  5. pmc Can improved prescription medication labeling influence adherence to chronic medications? An evaluation of the Target pharmacy label
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 24:570-8. 2009
    ..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve readability and understanding...
  6. doi request reprint Patient, physician, and payment predictors of statin adherence
    David C Chan
    Department of Medicine, Division of General Internal Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Med Care 48:196-202. 2010
    ..Although many patient, physician, and payment predictors of adherence have been described, knowledge of their relative strength and overall ability to explain adherence is limited...
  7. doi request reprint Untangling the relationship between medication adherence and post-myocardial infarction outcomes: medication adherence and clinical outcomes
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Electronic address
    Am Heart J 167:51-58.e5. 2014
    ..This study quantifies the relationship between medication adherence and post-myocardial infarction (MI) adverse coronary events...
  8. pmc Supplementing claims data with outpatient laboratory test results to improve confounding adjustment in effectiveness studies of lipid-lowering treatments
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    BMC Med Res Methodol 12:180. 2012
    ..Adjusting for laboratory test results may result in better confounding control when added to administrative claims data in the study of treatment effects. However, missing values can arise through several mechanisms...
  9. pmc Improved comorbidity adjustment for predicting mortality in Medicare populations
    Sebastian Schneeweiss
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Health Serv Res 38:1103-20. 2003
    ..To define and improve the performance of existing comorbidity scores in predicting mortality in Medicare enrollees...
  10. doi request reprint Warnings without guidance: patient responses to an FDA warning about ezetimibe
    William H Shrank
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston 02120, USA
    Med Care 50:479-84. 2012
    ..We investigated the proportion of patients who discontinued therapy and switched to a clinically appropriate alternative after the FDA communication...
  11. doi request reprint The association between statin use and outcomes potentially attributable to an unhealthy lifestyle in older adults
    Amanda R Patrick
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Value Health 14:513-20. 2011
    ..To explore the "healthy user" and "healthy adherer" effects-hypothetical sources of bias thought to arise when patients who initiate and adhere to preventive therapies are more likely to engage in healthy behaviors than are other subjects...
  12. doi request reprint At Pitney Bowes, value-based insurance design cut copayments and increased drug adherence
    Niteesh K Choudhry
    Harvard Medical School, USA
    Health Aff (Millwood) 29:1995-2001. 2010
    ..Our study thus provides an empirical basis for the use of this approach to improve the quality of health care...
  13. doi request reprint Full coverage for preventive medications after myocardial infarction
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 365:2088-97. 2011
    ..Adherence to medications that are prescribed after myocardial infarction is poor. Eliminating out-of-pocket costs may increase adherence and improve outcomes...
  14. pmc Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillation
    Sebastian Schneeweiss
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Circ Cardiovasc Qual Outcomes 5:480-6. 2012
    ..We sought to compare the efficacy and safety of the 3 new agents based on data from their published warfarin-controlled randomized trials, using the method of adjusted indirect comparisons...
  15. doi request reprint Patterns of medication initiation in newly diagnosed diabetes mellitus: quality and cost implications
    Nihar R Desai
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 125:302.e1-7. 2012
    ..We aimed to evaluate temporal trends in the use of specific drugs for the initial management of type 2 diabetes and to estimate the economic consequences of non-recommended care...
  16. pmc The implications of propensity score variable selection strategies in pharmacoepidemiology: an empirical illustration
    Amanda R Patrick
    Division of Pharmacoepidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 20:551-9. 2011
    ....
  17. ncbi request reprint Determinants of selective cyclooxygenase-2 inhibitor prescribing: are patient or physician characteristics more important?
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Med 115:715-20. 2003
    ..We examined the relative effects of patient risk factors for gastrointestinal toxicity, other patient characteristics, and physician prescribing preferences on the decision to prescribe a selective COX-2 inhibitor...
  18. pmc Comparative cost-effectiveness of interventions to improve medication adherence after myocardial infarction
    Kouta Ito
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Health Serv Res 47:2097-117. 2012
    ..To evaluate the comparative cost-effectiveness of interventions to improve adherence to evidence-based medications among postmyocardial infarction (MI) patients...
  19. pmc The prevalence and cost of unapproved uses of top-selling orphan drugs
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e31894. 2012
    ..However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved uses of orphan drugs with the highest unit sales...
  20. pmc High-dimensional propensity score adjustment in studies of treatment effects using health care claims data
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Epidemiology 20:512-22. 2009
    ..Here, we develop and test an algorithm that empirically identifies candidate covariates, prioritizes covariates, and integrates them into a propensity-score-based confounder adjustment model...
  21. pmc Is there a relationship between patient beliefs or communication about generic drugs and medication utilization?
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Med Care 47:319-25. 2009
    ..Insurers and policymakers strive to stimulate more cost-effective prescribing and, increasingly, are educating beneficiaries about generics...
  22. pmc Development of a health care utilisation data-based index for rheumatoid arthritis severity: a preliminary study
    Gladys Ting
    Department of Medicine, Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Arthritis Res Ther 10:R95. 2008
    ....
  23. pmc Cardiovascular outcomes and mortality in patients using clopidogrel with proton pump inhibitors after percutaneous coronary intervention or acute coronary syndrome
    Jeremy A Rassen
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Circulation 120:2322-9. 2009
    ..Recent studies have raised concerns about the reduced efficacy of clopidogrel when used concurrently with proton pump inhibitors (PPIs), but those studies may have overestimated the risk...
  24. pmc Subgroup analyses to determine cardiovascular risk associated with nonsteroidal antiinflammatory drugs and coxibs in specific patient groups
    Daniel H Solomon
    Brigham and Women s Hospital, 1620 Tremont Street, Boston, MA 02120, USA
    Arthritis Rheum 59:1097-104. 2008
    ..There is substantial concern regarding the potential cardiovascular adverse effects of selective coxibs and nonselective NSAIDs, but many patients with arthritis experience important clinical benefits from these agents...
  25. doi request reprint NSAID switching and short-term gastrointestinal outcome rates after the withdrawal of rofecoxib
    Sebastian Schneeweiss
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 021205, USA
    Pharmacoepidemiol Drug Saf 18:1134-42. 2009
    ....
  26. doi request reprint Trouble getting started: predictors of primary medication nonadherence
    Michael A Fischer
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 124:1081.e9-22. 2011
    ..The advent of electronic prescribing (e-prescribing) systems provides the opportunity to track initial prescriptions and identify nonadherence that may have previously been undetected...
  27. ncbi request reprint The implications of therapeutic complexity on adherence to cardiovascular medications
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 171:814-22. 2011
    ..Our objective was to estimate the extent of prescribing and filling complexity in patients prescribed a cardiovascular medication and to evaluate its association with adherence...
  28. pmc Rationale and design of the Post-MI FREEE trial: a randomized evaluation of first-dollar drug coverage for post-myocardial infarction secondary preventive therapies
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 156:31-6. 2008
    ..Removing patient out-of-pocket drug costs may increase adherence, improve clinical outcomes, and even reduce overall health costs for high-risk patients. The existing data are inadequate to assess whether this strategy is effective...
  29. ncbi request reprint Should patients receive secondary prevention medications for free after a myocardial infarction? An economic analysis
    Niteesh K Choudhry
    Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:186-94. 2007
    ..Our analysis suggests that covering combination therapy for such patients will save both lives and money...
  30. ncbi request reprint Keeping science on top in drug evaluation
    Jerry Avorn
    Harvard Medical School and Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women s Hospital, Boston, USA
    N Engl J Med 357:633-5. 2007
  31. ncbi request reprint The implications of choice: prescribing generic or preferred pharmaceuticals improves medication adherence for chronic conditions
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Arch Intern Med 166:332-7. 2006
    ..We studied whether patients enrolled in such plans who receive generic or preferred brand-name agents when initiating chronic therapy were more adherent to treatment than those who received nonpreferred brand-name medications...
  32. ncbi request reprint Identification of individuals with CKD from Medicare claims data: a validation study
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Kidney Dis 46:225-32. 2005
    ..The validity of this approach to identify patients with CKD has not been sufficiently studied...
  33. ncbi request reprint Immunosuppressive medications and hospitalization for cardiovascular events in patients with rheumatoid arthritis
    Daniel H Solomon
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Arthritis Rheum 54:3790-8. 2006
    ..This study was undertaken to investigate the effects of various immunosuppressive medications on the risk of cardiovascular events among a group of older patients with RA...
  34. ncbi request reprint Relationship between COX-2 specific inhibitors and hypertension
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Hypertension 44:140-5. 2004
    ..1; 95% CI, 1.0 to 4.3). In this retrospective case-control study of patients aged > or =65 years, rofecoxib use was associated with an increased relative risk of new onset hypertension; this was not seen in patients taking celecoxib...
  35. ncbi request reprint Relationship between selective cyclooxygenase-2 inhibitors and acute myocardial infarction in older adults
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, Mass 02120, USA
    Circulation 109:2068-73. 2004
    ..We studied the relative risk of acute myocardial infarction (AMI) among users of celecoxib, rofecoxib, and NSAIDs in Medicare beneficiaries with a comprehensive drug benefit...
  36. doi request reprint Early steps in the development of a claims-based targeted healthcare safety monitoring system and application to three empirical examples
    Peter M Wahl
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02120, USA
    Drug Saf 35:407-16. 2012
    ..Prospective monitoring systems must incorporate signalling algorithms and techniques to mitigate confounding in order to minimize false positive and false negative signals due to chance and bias...
  37. pmc A randomized study of how physicians interpret research funding disclosures
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    N Engl J Med 367:1119-27. 2012
    ..The effects of clinical-trial funding on the interpretation of trial results are poorly understood. We examined how such support affects physicians' reactions to trials with a high, medium, or low level of methodologic rigor...
  38. pmc Comparative safety of antipsychotic medications in nursing home residents
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Geriatr Soc 60:420-9. 2012
    ..To compare the risk of major medical events in nursing home residents newly initiated on conventional or atypical antipsychotic medications (APMs)...
  39. pmc Rationale and design of the Study Assessing the Effect of Cardiovascular Medications Provided as Low-cost, Evidence-based Generic Samples (SAMPLES) trial
    William H Shrank
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 157:613-9. 2009
    ..Highly effective generic cardiovascular medications are frequently underused, leading to greater overall drug costs and cost-related nonadherence...
  40. pmc High-risk patients' readiness to undergo BMD testing for osteoporosis diagnosis in Pennsylvania
    Jennifer M Polinski
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Int Q Community Health Educ 29:223-40. 2008
    ..We found several correlates of readiness to undergo BMD screening that may be used to design effective interventions...
  41. doi request reprint The epidemiology of prescriptions abandoned at the pharmacy
    William H Shrank
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Ann Intern Med 153:633-40. 2010
    ..Understanding the epidemiology and correlates of prescription abandonment may have an important effect on health care quality...
  42. doi request reprint The consequences of requesting "dispense as written"
    William H Shrank
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Med 124:309-17. 2011
    ..Patients also can make these requests. Little is known about the frequency and correlates of dispense as written requests or their association with medication filling...
  43. doi request reprint Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses
    Soko Setoguchi
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am Heart J 159:428-33. 2010
    ..We tested this hypothesis in a large population to assess whether (1) propranolol use is associated with an increased risk of myopathy and (2) the concurrent use of propranolol with a statin may further increase risk of myopathy...
  44. pmc Seizure outcomes following the use of generic versus brand-name antiepileptic drugs: a systematic review and meta-analysis
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Drugs 70:605-21. 2010
    ..In the absence of better data, physicians may want to consider more intensive monitoring of high-risk patients taking AEDs when any switch occurs...
  45. doi request reprint Anticonvulsant medications and the risk of suicide, attempted suicide, or violent death
    Elisabetta Patorno
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    JAMA 303:1401-9. 2010
    ..The decision was based on a meta-analysis not sufficiently large to investigate individual drugs...
  46. pmc Correlations of nursing home characteristics with prescription of osteoporosis medications
    Seema Parikh
    Harvard Medical School, Boston, MA, USA
    Bone 48:1164-8. 2011
    ..NH characteristics have been associated with prescription of some medications. We examined associations of NH-level characteristics with osteoporosis treatment in elderly patients admitted to a NH after a fracture...
  47. pmc Economic consequences of underuse of generic drugs: evidence from Medicaid and implications for prescription drug benefit plans
    Michael A Fischer
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Health Serv Res 38:1051-63. 2003
    ..To calculate the financial impact of underuse of generic medications in state Medicaid programs...
  48. ncbi request reprint Compliance with osteoporosis medications
    Daniel H Solomon
    Divisions of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, MA 02120, USA
    Arch Intern Med 165:2414-9. 2005
    ..This study was undertaken to assess the level and determinants of compliance with drugs prescribed for osteoporosis...
  49. ncbi request reprint The costs and benefits of enhanced depression care to employers
    Philip S Wang
    Department of Psychiatry, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Arch Gen Psychiatry 63:1345-53. 2006
    ..Although outreach and enhanced treatment interventions improve depression outcomes, uptake has been poor in part because purchasers lack information on their return on investment...
  50. pmc Trends in insulin initiation and treatment intensification among patients with type 2 diabetes
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA, 02120, USA
    J Gen Intern Med 29:320-7. 2014
    ....
  51. pmc Effect of smoking on comparative efficacy of antiplatelet agents: systematic review, meta-analysis, and indirect comparison
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    BMJ 347:f5307. 2013
    ..To evaluate whether smoking status is associated with the efficacy of antiplatelet treatment in the prevention of cardiovascular events...
  52. ncbi request reprint Variations in pill appearance of antiepileptic drugs and the risk of nonadherence
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    JAMA Intern Med 173:202-8. 2013
    ..We sought to determine whether switching among different-appearing antiepileptic drugs (AEDs) is associated with increased rates of medication nonpersistence, which can have serious medical, financial, and social consequences...
  53. pmc Conflict of interest reporting by authors involved in promotion of off-label drug use: an analysis of journal disclosures
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 9:e1001280. 2012
    ..It is unknown whether physicians and scientists who have such conflicts of interest adequately disclose such relationships in the scientific publications they author...
  54. pmc Osteoporosis telephonic intervention to improve medication regimen adherence: a large, pragmatic, randomized controlled trial
    Daniel H Solomon
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Arch Intern Med 172:477-83. 2012
    ..We examined the effectiveness of a telephone-based counseling program rooted in motivational interviewing to improve adherence to a medication regimen for osteoporosis...
  55. doi request reprint False Claims Act prosecution did not deter off-label drug use in the case of neurontin
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 30:2318-27. 2011
    ....
  56. pmc Multivariate-adjusted pharmacoepidemiologic analyses of confidential information pooled from multiple health care utilization databases
    Jeremy A Rassen
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 19:848-57. 2010
    ..We sought to create a method to conduct pooled analyses while keeping information private and allowing for full confounder adjustment...
  57. pmc Tumor necrosis factor-alpha antagonist use and heart failure in elderly patients with rheumatoid arthritis
    Soko Setoguchi
    Divisions of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard MedicalSchool, Boston, MA 02130, USA
    Am Heart J 156:336-41. 2008
    ..Although TNFAs had significant benefits in treating rheumatoid arthritis (RA), little is known whether the drugs pose an increased risk of HF in older patients with RA...
  58. pmc A combined comorbidity score predicted mortality in elderly patients better than existing scores
    Joshua J Gagne
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Clin Epidemiol 64:749-59. 2011
    ..To develop and validate a single numerical comorbidity score for predicting short- and long-term mortality, by combining conditions in the Charlson and Elixhauser measures...
  59. doi request reprint Drug warnings that can cause fits--communicating risks in a data-poor environment
    Jerry Avorn
    Harvard Medical School, and Brigham and Women s Hospital, Boston, USA
    N Engl J Med 359:991-4. 2008
  60. doi request reprint Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillation
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Circ Cardiovasc Qual Outcomes 2:429-36. 2009
    ..However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550...
  61. ncbi request reprint Tumor necrosis factor alpha antagonist use and cancer in patients with rheumatoid arthritis
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02130, USA
    Arthritis Rheum 54:2757-64. 2006
    ..This study was undertaken to estimate the association between treatment with biologic disease-modifying antirheumatic drugs (DMARDs) and development of cancer in patients with RA...
  62. ncbi request reprint Dopamine antagonists and the development of breast cancer
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 221 Longwood Ave, Boston, MA 02115, USA
    Arch Gen Psychiatry 59:1147-54. 2002
    ..Although animal studies have raised the possibility that prolactin-elevating dopamine antagonists used to treat psychotic disorders may initiate and promote breast cancers, epidemiologic studies in humans have been limited and inconsistent...
  63. ncbi request reprint Prescription opioid use among older adults with arthritis or low back pain
    Daniel H Solomon
    Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Ste, 3030, Boston, MA 02120, USA
    Arthritis Rheum 55:35-41. 2006
    ..To examine patterns of chronic opioid use in selected groups with arthritis and low back pain and compare them with patterns among persons with ischemic heart disease...
  64. ncbi request reprint Ten-year trends of cardiovascular drug use after myocardial infarction among community-dwelling persons > or =65 years of age
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1061-7. 2007
    ..The underuse of statins and BBs was marked in black patients and did not improve over time...
  65. ncbi request reprint Nephrologist care and mortality in patients with chronic renal insufficiency
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:2002-6. 2002
    ..We sought to determine whether early or frequent access to nephrologist care prior to the initiation of dialysis was associated with a difference in mortality rates in the first year after dialysis began...
  66. ncbi request reprint Medicaid prior-authorization programs and the use of cyclooxygenase-2 inhibitors
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 351:2187-94. 2004
    ..To control these expenses, many state Medicaid programs have implemented prior-authorization requirements before coxibs can be prescribed. We evaluated the effect of such programs on the use of coxibs by Medicaid beneficiaries...
  67. ncbi request reprint Nonsteroidal anti-inflammatory drug use and acute myocardial infarction
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:1099-104. 2002
    ..Although aspirin has been shown to protect patients from acute myocardial infarction (AMI), the effect of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is not clear...
  68. pmc Changing interactions between physician trainees and the pharmaceutical industry: a national survey
    Kirsten E Austad
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    J Gen Intern Med 28:1064-71. 2013
    ..Increasingly, medical school policies limit pharmaceutical representatives' access to students and gifts from drugmakers, but little is known about how these policies affect student attitudes toward industry...
  69. ncbi request reprint Methylergonovine maleate and the risk of myocardial ischemia and infarction
    Brian T Bateman
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA Department of Anesthesiology, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA Harvard Medical School, Boston, MA
    Am J Obstet Gynecol 209:459.e1-459.e13. 2013
    ....
  70. doi request reprint Cost-effectiveness of oral anticoagulants for treatment of atrial fibrillation
    William J Canestaro
    Department of Medicine, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, MA
    Circ Cardiovasc Qual Outcomes 6:724-31. 2013
    ..New anticoagulants may improve health outcomes in patients with atrial fibrillation, but it is unclear whether their use is cost-effective...
  71. pmc Treatment effects in the presence of unmeasured confounding: dealing with observations in the tails of the propensity score distribution--a simulation study
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Epidemiol 172:843-54. 2010
    ..Increasing validity based on PS trimming may be a unique advantage of PS's over conventional outcome models...
  72. pmc Angiotensin inhibition after myocardial infarction: does drug class matter?
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Gen Intern Med 21:1242-7. 2006
    ..Little is known about their relative use after MI in typical care settings, and about their relative effectiveness outside the clinical trial setting...
  73. ncbi request reprint Pharmacoepidemiology and rheumatic diseases: 2001-2002
    Daniel H Solomon
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Rheumatol 15:122-6. 2003
    ....
  74. ncbi request reprint Prior authorization policies for selective cyclooxygenase-2 inhibitors in Medicaid: a policy review
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    Med Care 44:658-63. 2006
    ..However, the evidence base for the prior authorization criteria has not been examined previously...
  75. ncbi request reprint Torcetrapib and atorvastatin--should marketing drive the research agenda?
    Jerry Avorn
    Harvard Medical School, Boston, USA
    N Engl J Med 352:2573-6. 2005
  76. ncbi request reprint Highlights and a hidden hazard--the FDA's new labeling regulations
    Jerry Avorn
    Harvard Medical School and Division of Pharmacoepidemiology and Pharmacoeconomics at Brigham and Women s Hospital, Boston, USA
    N Engl J Med 354:2409-11. 2006
  77. ncbi request reprint Osteoporosis action: design of the healthy bones project trial
    Daniel H Solomon
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA, USA
    Contemp Clin Trials 26:78-94. 2005
    ..All outcomes will be analyzed using random effects models accounting for clustering of subjects within physicians' practices...
  78. ncbi request reprint Accuracy of Medicare claims-based diagnosis of acute myocardial infarction: estimating positive predictive value on the basis of review of hospital records
    Yuka Kiyota
    Division of Pharmacoepidemiology and Pharmacoeconomics, Boston, Mass USA
    Am Heart J 148:99-104. 2004
    ....
  79. ncbi request reprint Speaking the same language? International variations in the safety information accompanying top-selling prescription drugs
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    BMJ Qual Saf 22:727-34. 2013
    ..The official prescribing information document distributed with a prescription drug is a key source of safety information, but it may include excessive or insufficient details...
  80. pmc National trends in antidepressant medication treatment among publicly insured pregnant women
    Krista F Huybrechts
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Gen Hosp Psychiatry 35:265-71. 2013
    ..The risk of depression in women is greatest at childbearing age. We sought to examine and explain national trends in antidepressant use in pregnant women...
  81. doi request reprint The most transformative drugs of the past 25 years: a survey of physicians
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont St, Suite 3030, Boston, Massachusetts 02120, USA
    Nat Rev Drug Discov 12:425-31. 2013
    ..Participants were also asked how various factors affected their opinion; they most often invoked the effectiveness and superiority of the drugs over existing alternatives when identifying transformative drug innovation...
  82. doi request reprint The Food and Drug Administration has the legal basis to restrict promotion of flawed comparative effectiveness research
    Aaron S Kesselheim
    Harvard Medical School, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Health Aff (Millwood) 31:2200-5. 2012
    ..At that point, the FDA will need to issue formal guidance to minimize confusion on what kinds of observational research can meet its evidentiary standards...
  83. doi request reprint Characteristics of clinical trials to support approval of orphan vs nonorphan drugs for cancer
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    JAMA 305:2320-6. 2011
    ..Orphan products constitute most new drug approvals in oncology, but safety and efficacy questions have emerged about some of these agents...
  84. doi request reprint The cost-effectiveness of C-reactive protein testing and rosuvastatin treatment for patients with normal cholesterol levels
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 57:784-91. 2011
    ..We sought to evaluate the cost-effectiveness of applying the JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial results into clinical practice...
  85. doi request reprint Conflict of interest in oncology publications: a survey of disclosure policies and statements
    Aaron S Kesselheim
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Cancer 118:188-95. 2012
    ..The authors sought to define current disclosure policies and how they relate to disclosure statements provided by authors in major oncology journals...
  86. doi request reprint The economic consequences of non-evidence-based clopidogrel use
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Am Heart J 155:904-9. 2008
    ..However, little is known about the appropriateness of that use. Overuse of clopidogrel could have important implications for health care quality and drug expenditures...
  87. doi request reprint Comparison of the impact of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management trial on prescribing patterns: a time-series analysis
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Ann Pharmacother 42:1563-72. 2008
    ..Because of superior safety and lower cost, rate control is now the recommended strategy for the management of most elderly, high-risk AF patients...
  88. doi request reprint Using patent data to assess the value of pharmaceutical innovation
    Aaron S Kesselheim
    Department of Health Policy and Management, Harvard School of Public Health, Harvard Medical School, USA
    J Law Med Ethics 37:176-83. 2009
    ....
  89. pmc An evaluation of the relationship between the implementation of a newly designed prescription drug label at Target pharmacies and health outcomes
    William H Shrank
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Med Care 47:1031-5. 2009
    ..A new prescription medication labeling system was implemented by Target pharmacies in May 2005 and aimed to improve health outcomes...
  90. ncbi request reprint Risk of death in elderly users of conventional vs. atypical antipsychotic medications
    Philip S Wang
    Department of Psychiatry, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    N Engl J Med 353:2335-41. 2005
    ..However, the advisory did not apply to conventional antipsychotic medications; the risk of death with these older agents is not known...
  91. ncbi request reprint Chronic kidney disease as a risk factor for bleeding complications after coronary artery bypass surgery
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 41:84-9. 2003
    ..The aim of the study is to define the role of chronic kidney disease (CKD) as a risk factor for postoperative bleeding in patients undergoing coronary artery bypass graft (CABG) surgery...
  92. pmc Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, Mass 02115, USA
    J Gen Intern Med 17:504-11. 2002
    ..Addressing the epidemic of poor compliance with antihypertensive medications will require identifying factors associated with poor adherence, including modifiable psychosocial and behavioral characteristics of patients...
  93. ncbi request reprint Admissions caused by adverse drug events to internal medicine and emergency departments in hospitals: a longitudinal population-based study
    Sebastian Schneeweiss
    Department of Medical Informatics, Biometry and Epidemiology, Pharmacoepidemiology Research Group, Ludwig Maximilians University, Munich, Germany
    Eur J Clin Pharmacol 58:285-91. 2002
    ..To estimate incidence rates of drug-related hospitalizations (DRHs) in a longitudinal population-based study with prospective event assessment...
  94. ncbi request reprint Hetastarch and bleeding complications after coronary artery surgery
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 124:1437-42. 2003
    ..To determine whether intraoperative HES use is associated with an increased risk of postoperative bleeding following coronary artery bypass graft (CABG) surgery...
  95. ncbi request reprint Economic implications of evidence-based prescribing for hypertension: can better care cost less?
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    JAMA 291:1850-6. 2004
    ..Suboptimal prescribing patterns contribute to the high cost of medications for elderly patients as well as the difficulty in providing affordable prescription drug benefits for older Americans...
  96. ncbi request reprint Underuse of osteoporosis medications in elderly patients with fractures
    Daniel H Solomon
    Division of Pharmacoepidemiology, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Am J Med 115:398-400. 2003
  97. ncbi request reprint How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 13:11-9. 2004
    ..Although self-reports are often the only means available in routine practice, their accuracy and agreement with other data sources remain questionable...
  98. ncbi request reprint Balancing the cost and value of medications: the dilemma facing clinicians
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, USA
    Pharmacoeconomics 20:67-72. 2002
    ....
  99. ncbi request reprint Measuring the cost-effectiveness of lipid-lowering drugs in the elderly: the outcomes research and economic analysis components of the PROSPER trial
    Jerry Avorn
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Control Clin Trials 23:757-73. 2002
    ....
  100. ncbi request reprint Suboptimal antidepressant use in the elderly
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    J Clin Psychopharmacol 25:118-26. 2005
    ..Suboptimal antidepressant use remains common in the elderly, especially the use of inadequately intensive regimens. Interventions are needed to improve the quality and outcomes of antidepressant use in this vulnerable population...
  101. pmc Pharmacoepidemiology and "in silico" drug evaluation: is there common ground?
    TIL STURMER
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Boston, MA 02120, USA
    J Clin Epidemiol 61:205-6. 2008